4ijn - Revision history

OCA at 15:24, 20 September 2023

OCA — Wed, 20 Sep 2023 15:24:58 GMT

←Older revision		Revision as of 15:24, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ijn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_155 Mycolicibacterium smegmatis MC2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IJN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IJN FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ijn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_155 Mycolicibacterium smegmatis MC2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IJN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IJN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ijn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ijn OCA], [https://pdbe.org/4ijn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ijn RCSB], [https://www.ebi.ac.uk/pdbsum/4ijn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ijn ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ijn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ijn OCA], [https://pdbe.org/4ijn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ijn RCSB], [https://www.ebi.ac.uk/pdbsum/4ijn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ijn ProSAT]</span></td></tr>
	</table>		</table>

OCA at 20:51, 16 November 2022

OCA — Wed, 16 Nov 2022 20:51:26 GMT

←Older revision		Revision as of 20:51, 16 November 2022
Line 1:		Line 1:

	==Crystal structure of an acetate kinase from Mycobacterium smegmatis bound to AMP and sulfate==		==Crystal structure of an acetate kinase from Mycobacterium smegmatis bound to AMP and sulfate==
-	<StructureSection load='4ijn' size='340' side='right' caption='[[4ijn]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='4ijn' size='340' side='right'caption='[[4ijn]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ijn]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Mycs2 Mycs2~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IJN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4IJN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ijn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_155 Mycolicibacterium smegmatis MC2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IJN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IJN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3r9p\|3r9p]], [[3p4i\|3p4i]], [[4dq8\|4dq8]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ijn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ijn OCA], [https://pdbe.org/4ijn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ijn RCSB], [https://www.ebi.ac.uk/pdbsum/4ijn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ijn ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ackA, MSMEG_0784, MSMEI_0768 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=246196 MYCS2])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetate_kinase Acetate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.1 2.7.2.1] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ijn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ijn OCA], [~~http~~://pdbe.org/4ijn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ijn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ijn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ijn ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ACKA_MYCS2 ACKA_MYCS2]] Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.[HAMAP-Rule:MF_00020]	+	[https://www.uniprot.org/uniprot/ACKA_MYCS2 ACKA_MYCS2] Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.[HAMAP-Rule:MF_00020]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Acetate kinase~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Mycs2]]~~	+	[[Category: Mycolicibacterium smegmatis MC2 155]]
-	~~[[Category: Structural genomic]]~~	+
-	~~[[Category: Acetyl-coa biosynthesis]]~~	+
-	~~[[Category: Atp-dependent]]~~	+
-	~~[[Category: Hydrolysis]]~~	+
-	~~[[Category: Metabolic intermediate biosynthesis]]~~	+
-	~~[[Category: Proprionate kinase]]~~	+
-	~~[[Category: Ssgcid]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 18:52, 1 February 2017

OCA — Wed, 01 Feb 2017 18:52:34 GMT

←Older revision		Revision as of 18:52, 1 February 2017
Line 1:		Line 1:
		+
	==Crystal structure of an acetate kinase from Mycobacterium smegmatis bound to AMP and sulfate==		==Crystal structure of an acetate kinase from Mycobacterium smegmatis bound to AMP and sulfate==
	<StructureSection load='4ijn' size='340' side='right' caption='[[4ijn]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='4ijn' size='340' side='right' caption='[[4ijn]], [[Resolution\|resolution]] 1.70Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ackA, MSMEG_0784, MSMEI_0768 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=246196 MYCS2])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ackA, MSMEG_0784, MSMEI_0768 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=246196 MYCS2])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetate_kinase Acetate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.1 2.7.2.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetate_kinase Acetate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.1 2.7.2.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ijn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ijn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ijn RCSB], [http://www.ebi.ac.uk/pdbsum/4ijn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ijn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ijn OCA], [http://pdbe.org/4ijn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ijn RCSB], [http://www.ebi.ac.uk/pdbsum/4ijn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ijn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4ijn" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:26, 22 April 2015

OCA — Wed, 22 Apr 2015 07:26:30 GMT

←Older revision		Revision as of 07:26, 22 April 2015
Line 2:		Line 2:
	<StructureSection load='4ijn' size='340' side='right' caption='[[4ijn]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='4ijn' size='340' side='right' caption='[[4ijn]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ijn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_smegmatis_str._mc2_155 Mycobacterium smegmatis str. mc2 155~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IJN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IJN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ijn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycs2 Mycs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IJN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IJN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3r9p\|3r9p]], [[3p4i\|3p4i]], [[4dq8\|4dq8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3r9p\|3r9p]], [[3p4i\|3p4i]], [[4dq8\|4dq8]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ackA, MSMEG_0784, MSMEI_0768 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=246196 ~~Mycobacterium smegmatis str. MC2 155~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ackA, MSMEG_0784, MSMEI_0768 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=246196 MYCS2])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetate_kinase Acetate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.1 2.7.2.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetate_kinase Acetate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.1 2.7.2.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ijn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ijn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ijn RCSB], [http://www.ebi.ac.uk/pdbsum/4ijn PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ijn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ijn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ijn RCSB], [http://www.ebi.ac.uk/pdbsum/4ijn PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~A0QQK1_MYCS2 A0QQK1_MYCS2~~]] Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.[HAMAP-Rule:MF_00020]	+	[[http://www.uniprot.org/uniprot/ACKA_MYCS2 ACKA_MYCS2]] Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.[HAMAP-Rule:MF_00020]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	High-resolution three-dimensional structures of essential Mycobacterium tuberculosis (Mtb) proteins provide templates for TB drug design, but are available for only a small fraction of the Mtb proteome. Here we evaluate an intra-genus "homolog-rescue" strategy to increase the structural information available for TB drug discovery by using mycobacterial homologs with conserved active sites. Of 179 potential TB drug targets selected for x-ray structure determination, only 16 yielded a crystal structure. By adding 1675 homologs from nine other mycobacterial species to the pipeline, structures representing an additional 52 otherwise intractable targets were solved. To determine whether these homolog structures would be useful surrogates in TB drug design, we compared the active sites of 106 pairs of Mtb and non-TB mycobacterial (NTM) enzyme homologs with experimentally determined structures, using three metrics of active site similarity, including superposition of continuous pharmacophoric property distributions. Pair-wise structural comparisons revealed that 19/22 pairs with >55% overall sequence identity had active site Calpha RMSD <1 A, >85% side chain identity, and >/=80% PSAPF (similarity based on pharmacophoric properties) indicating highly conserved active site shape and chemistry. Applying these results to the 52 NTM structures described above, 41 shared >55% sequence identity with the Mtb target, thus increasing the effective structural coverage of the 179 Mtb targets over three-fold (from 9% to 32%). The utility of these structures in TB drug design can be tested by designing inhibitors using the homolog structure and assaying the cognate Mtb enzyme; a promising test case, Mtb cytidylate kinase, is described. The homolog-rescue strategy evaluated here for TB is also generalizable to drug targets for other diseases.
		+
		+	Increasing the structural coverage of tuberculosis drug targets.,Baugh L, Phan I, Begley DW, Clifton MC, Armour B, Dranow DM, Taylor BM, Muruthi MM, Abendroth J, Fairman JW, Fox D 3rd, Dieterich SH, Staker BL, Gardberg AS, Choi R, Hewitt SN, Napuli AJ, Myers J, Barrett LK, Zhang Y, Ferrell M, Mundt E, Thompkins K, Tran N, Lyons-Abbott S, Abramov A, Sekar A, Serbzhinskiy D, Lorimer D, Buchko GW, Stacy R, Stewart LJ, Edwards TE, Van Voorhis WC, Myler PJ Tuberculosis (Edinb). 2014 Dec 19. pii: S1472-9792(14)20565-8. doi:, 10.1016/j.tube.2014.12.003. PMID:25613812<ref>PMID:25613812</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Acetate kinase]]		[[Category: Acetate kinase]]
-	[[Category: ~~Mycobacterium smegmatis str. mc2 155~~]]	+	[[Category: Mycs2]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Acetyl-coa biosynthesis]]		[[Category: Acetyl-coa biosynthesis]]

OCA at 12:52, 4 January 2015

OCA — Sun, 04 Jan 2015 12:52:00 GMT

←Older revision		Revision as of 12:52, 4 January 2015
Line 1:		Line 1:
-	~~[[Image:4ijn.jpg\|left\|200px]]~~	+	==Crystal structure of an acetate kinase from Mycobacterium smegmatis bound to AMP and sulfate==
-		+	<StructureSection load='4ijn' size='340' side='right' caption='[[4ijn]], [[Resolution\|resolution]] 1.70Å' scene=''>
-	~~{{STRUCTURE_4ijn\| PDB=4ijn \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4ijn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis_str._mc2_155 Mycobacterium smegmatis str. mc2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IJN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IJN FirstGlance]. <br>
-	===Crystal structure of an acetate kinase from Mycobacterium smegmatis bound to AMP and sulfate===	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3r9p\|3r9p]], [[3p4i\|3p4i]], [[4dq8\|4dq8]]</td></tr>
-		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ackA, MSMEG_0784, MSMEI_0768 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=246196 Mycobacterium smegmatis str. MC2 155])</td></tr>
-	==~~About this Structure~~==	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetate_kinase Acetate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.1 2.7.2.1] </span></td></tr>
-	[[4ijn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis_str._mc2_155 Mycobacterium smegmatis str. mc2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IJN OCA].	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ijn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ijn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ijn RCSB], [http://www.ebi.ac.uk/pdbsum/4ijn PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/A0QQK1_MYCS2 A0QQK1_MYCS2]] Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.[HAMAP-Rule:MF_00020]
		+	__TOC__
		+	</StructureSection>
	[[Category: Acetate kinase]]		[[Category: Acetate kinase]]
	[[Category: Mycobacterium smegmatis str. mc2 155]]		[[Category: Mycobacterium smegmatis str. mc2 155]]
-	[[Category: ~~SSGCID, Seattle~~ Structural ~~Genomics Center for Infectious Disease.~~]]	+	[[Category: Structural genomic]]
	[[Category: Acetyl-coa biosynthesis]]		[[Category: Acetyl-coa biosynthesis]]
	[[Category: Atp-dependent]]		[[Category: Atp-dependent]]
Line 16:		Line 21:
	[[Category: Metabolic intermediate biosynthesis]]		[[Category: Metabolic intermediate biosynthesis]]
	[[Category: Proprionate kinase]]		[[Category: Proprionate kinase]]
-	[[Category: Seattle structural genomics center for infectious disease]]
	[[Category: Ssgcid]]		[[Category: Ssgcid]]
-	[[Category: Structural genomic]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 09:13, 16 January 2013

OCA — Wed, 16 Jan 2013 09:13:59 GMT

←Older revision		Revision as of 09:13, 16 January 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4ijn.jpg\|left\|200px]]

-	~~The entry~~ 4ijn ~~is ON HOLD~~	+	{{STRUCTURE_4ijn\| PDB=4ijn \| SCENE= }}

-	~~Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID)~~	+	===Crystal structure of an acetate kinase from Mycobacterium smegmatis bound to AMP and sulfate===

-	~~Description: Crystal~~ structure ~~of an acetate kinase~~ from Mycobacterium smegmatis ~~bound to AMP and sulfate~~	+
		+	==About this Structure==
		+	[[4ijn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis_str._mc2_155 Mycobacterium smegmatis str. mc2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IJN OCA].
		+	[[Category: Acetate kinase]]
		+	[[Category: Mycobacterium smegmatis str. mc2 155]]
		+	[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]
		+	[[Category: Acetyl-coa biosynthesis]]
		+	[[Category: Atp-dependent]]
		+	[[Category: Hydrolysis]]
		+	[[Category: Metabolic intermediate biosynthesis]]
		+	[[Category: Proprionate kinase]]
		+	[[Category: Seattle structural genomics center for infectious disease]]
		+	[[Category: Ssgcid]]
		+	[[Category: Structural genomic]]
		+	[[Category: Transferase]]

OCA at 07:50, 9 January 2013

OCA — Wed, 09 Jan 2013 07:50:45 GMT

←Older revision		Revision as of 07:50, 9 January 2013
Line 5:		Line 5:
	Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID)		Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID)

-	Description: Crystal structure of an acetate kinase from Mycobacterium smegmatis bound to ~~ADP~~ and sulfate	+	Description: Crystal structure of an acetate kinase from Mycobacterium smegmatis bound to AMP and sulfate

OCA: Protected "4ijn" [edit=sysop:move=sysop]

OCA — Wed, 02 Jan 2013 09:00:58 GMT

Protected "4ijn" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:00, 2 January 2013

OCA: New page: '''Unreleased structure''' The entry 4ijn is ON HOLD Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Description: Crystal structure of an acetate kinase fro...

OCA — Wed, 02 Jan 2013 09:00:56 GMT

New page: '''Unreleased structure''' The entry 4ijn is ON HOLD Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Description: Crystal structure of an acetate kinase fro...

New page

'''Unreleased structure'''

The entry 4ijn is ON HOLD

Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID)

Description: Crystal structure of an acetate kinase from Mycobacterium smegmatis bound to ADP and sulfate