4iks - Revision history

OCA at 08:53, 20 March 2024

OCA — Wed, 20 Mar 2024 08:53:15 GMT

←Older revision		Revision as of 08:53, 20 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4iks]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IKS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IKS FirstGlance]. <br>		<table><tr><td colspan='2'>[[4iks]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IKS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IKS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=TFD:N-[5-CHLORO-6-METHYL-2-(PYRIDIN-2-YL)PYRIMIDIN-4-YL]-N-[6-(TRIFLUOROMETHYL)PYRIDIN-2-YL]ETHANE-1,2-DIAMINE'>TFD</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=TFD:N-[5-CHLORO-6-METHYL-2-(PYRIDIN-2-YL)PYRIMIDIN-4-YL]-N-[6-(TRIFLUOROMETHYL)PYRIDIN-2-YL]ETHANE-1,2-DIAMINE'>TFD</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iks OCA], [https://pdbe.org/4iks PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iks RCSB], [https://www.ebi.ac.uk/pdbsum/4iks PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iks ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iks OCA], [https://pdbe.org/4iks PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iks RCSB], [https://www.ebi.ac.uk/pdbsum/4iks PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iks ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/MAP11_HUMAN MAP11_HUMAN] Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle.[HAMAP-Rule:MF_03174]<ref>PMID:16274222</ref> <ref>PMID:17114291</ref>		[https://www.uniprot.org/uniprot/MAP11_HUMAN MAP11_HUMAN] Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle.[HAMAP-Rule:MF_03174]<ref>PMID:16274222</ref> <ref>PMID:17114291</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Methionine aminopeptidases (MetAPs) are essential enzymes that make them good drug targets in cancer and microbial infections. MetAPs remove the initiator methionine from newly synthesized peptides in every living cell. MetAPs are broadly divided into type I and type II classes. Both prokaryotes and eukaryotes contain type I MetAPs, while eukaryotes have additional type II MetAP enzyme. Although several inhibitors have been reported against type I enzymes, subclass specificity is scarce. Here, using the fine differences in the entrance of the active sites of MetAPs from Mycobacterium tuberculosis , Enterococcus faecalis , and human, three hotspots have been identified and pyridinylpyrimidine-based molecules were selected from a commercial source to target these hotspots. In the biochemical evaluation, many of the 38 compounds displayed differential behavior against these three enzymes. Crystal structures of four selected inhibitors in complex with human MetAP1b and molecular modeling studies provided the basis for the binding specificity.
-
-	Identification, Biochemical and Structural Evaluation of Species-Specific Inhibitors against Type I Methionine Aminopeptidases.,Kishor C, Arya T, Reddi R, Chen X, Saddanapu V, Marapaka AK, Gumpena R, Ma D, Liu JO, Addlagatta A J Med Chem. 2013 Jun 27. PMID:23767698<ref>PMID:23767698</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4iks" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 20:52, 16 November 2022

OCA — Wed, 16 Nov 2022 20:52:49 GMT

←Older revision		Revision as of 20:52, 16 November 2022
Line 3:		Line 3:
	<StructureSection load='4iks' size='340' side='right'caption='[[4iks]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='4iks' size='340' side='right'caption='[[4iks]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4iks]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IKS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4IKS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4iks]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IKS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IKS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=TFD:N-[5-CHLORO-6-METHYL-2-(PYRIDIN-2-YL)PYRIMIDIN-4-YL]-N-[6-(TRIFLUOROMETHYL)PYRIDIN-2-YL]ETHANE-1,2-DIAMINE'>TFD</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=TFD:N-[5-CHLORO-6-METHYL-2-(PYRIDIN-2-YL)PYRIMIDIN-4-YL]-N-[6-(TRIFLUOROMETHYL)PYRIDIN-2-YL]ETHANE-1,2-DIAMINE'>TFD</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ikr\|4ikr]], [[4ikt\|4ikt]], [[4iku\|4iku]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iks OCA], [https://pdbe.org/4iks PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iks RCSB], [https://www.ebi.ac.uk/pdbsum/4iks PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iks ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">METAP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionyl_aminopeptidase Methionyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.18 3.4.11.18] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4iks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iks OCA], [~~http~~://pdbe.org/4iks PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4iks RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4iks PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4iks ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~AMPM1_HUMAN AMPM1_HUMAN~~]~~] Removes~~ the N-terminal methionine from nascent proteins. Required for normal progression through the cell cycle.<ref>PMID:16274222</ref> <ref>PMID:17114291</ref>	+	[https://www.uniprot.org/uniprot/MAP11_HUMAN MAP11_HUMAN] Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle.[HAMAP-Rule:MF_03174]<ref>PMID:16274222</ref> <ref>PMID:17114291</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Methionyl aminopeptidase]]~~	+	[[Category: Addlagatta A]]
-	[[Category: Addlagatta, A]]	+	[[Category: Arya T]]
-	[[Category: Arya, T]]	+	[[Category: Kishor C]]
-	[[Category: Kishor, C]]	+
-	~~[[Category: Aminopeptidase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Pita-bread fold]]~~	+
-	~~[[Category: Ribosome~~]]	+

OCA at 15:57, 20 November 2019

OCA — Wed, 20 Nov 2019 15:57:20 GMT

←Older revision		Revision as of 15:57, 20 November 2019
Line 1:		Line 1:

	==Crystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with N1-(5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl)-N2-(6-(trifluoromethyl)pyridin-2-yl)ethane-1,2-diamine==		==Crystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with N1-(5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl)-N2-(6-(trifluoromethyl)pyridin-2-yl)ethane-1,2-diamine==
-	<StructureSection load='4iks' size='340' side='right' caption='[[4iks]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='4iks' size='340' side='right'caption='[[4iks]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4iks]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IKS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IKS FirstGlance]. <br>		<table><tr><td colspan='2'>[[4iks]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IKS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IKS FirstGlance]. <br>
Line 23:		Line 23:

	==See Also==		==See Also==
-	*[[Aminopeptidase\|Aminopeptidase]]	+	*[[Aminopeptidase 3D structures\|Aminopeptidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Methionyl aminopeptidase]]		[[Category: Methionyl aminopeptidase]]
	[[Category: Addlagatta, A]]		[[Category: Addlagatta, A]]

OCA at 16:50, 5 August 2016

OCA — Fri, 05 Aug 2016 16:50:40 GMT

←Older revision		Revision as of 16:50, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with N1-(5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl)-N2-(6-(trifluoromethyl)pyridin-2-yl)ethane-1,2-diamine==		==Crystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with N1-(5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl)-N2-(6-(trifluoromethyl)pyridin-2-yl)ethane-1,2-diamine==
	<StructureSection load='4iks' size='340' side='right' caption='[[4iks]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='4iks' size='340' side='right' caption='[[4iks]], [[Resolution\|resolution]] 1.70Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">METAP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">METAP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionyl_aminopeptidase Methionyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.18 3.4.11.18] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionyl_aminopeptidase Methionyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.18 3.4.11.18] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iks OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4iks RCSB], [http://www.ebi.ac.uk/pdbsum/4iks PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iks OCA], [http://pdbe.org/4iks PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4iks RCSB], [http://www.ebi.ac.uk/pdbsum/4iks PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4iks ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4iks" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 20:25, 25 December 2014

OCA — Thu, 25 Dec 2014 20:25:38 GMT

←Older revision		Revision as of 20:25, 25 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iks OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4iks RCSB], [http://www.ebi.ac.uk/pdbsum/4iks PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iks OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4iks RCSB], [http://www.ebi.ac.uk/pdbsum/4iks PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/AMPM1_HUMAN AMPM1_HUMAN]] Removes the N-terminal methionine from nascent proteins. Required for normal progression through the cell cycle.<ref>PMID:16274222</ref> <ref>PMID:17114291</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 17:38, 21 December 2014

OCA — Sun, 21 Dec 2014 17:38:44 GMT

←Older revision		Revision as of 17:38, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4iks\| PDB=4iks \| SCENE= }}~~	+	==Crystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with N1-(5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl)-N2-(6-(trifluoromethyl)pyridin-2-yl)ethane-1,2-diamine==
-	===Crystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with N1-(5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl)-N2-(6-(trifluoromethyl)pyridin-2-yl)ethane-1,2-diamine===	+	<StructureSection load='4iks' size='340' side='right' caption='[[4iks]], [[Resolution\|resolution]] 1.70Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23767698}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4iks]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IKS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IKS FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=TFD:N-[5-CHLORO-6-METHYL-2-(PYRIDIN-2-YL)PYRIMIDIN-4-YL]-N-[6-(TRIFLUOROMETHYL)PYRIDIN-2-YL]ETHANE-1,2-DIAMINE'>TFD</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ikr\|4ikr]], [[4ikt\|4ikt]], [[4iku\|4iku]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">METAP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionyl_aminopeptidase Methionyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.18 3.4.11.18] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iks OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4iks RCSB], [http://www.ebi.ac.uk/pdbsum/4iks PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Methionine aminopeptidases (MetAPs) are essential enzymes that make them good drug targets in cancer and microbial infections. MetAPs remove the initiator methionine from newly synthesized peptides in every living cell. MetAPs are broadly divided into type I and type II classes. Both prokaryotes and eukaryotes contain type I MetAPs, while eukaryotes have additional type II MetAP enzyme. Although several inhibitors have been reported against type I enzymes, subclass specificity is scarce. Here, using the fine differences in the entrance of the active sites of MetAPs from Mycobacterium tuberculosis , Enterococcus faecalis , and human, three hotspots have been identified and pyridinylpyrimidine-based molecules were selected from a commercial source to target these hotspots. In the biochemical evaluation, many of the 38 compounds displayed differential behavior against these three enzymes. Crystal structures of four selected inhibitors in complex with human MetAP1b and molecular modeling studies provided the basis for the binding specificity.

-	~~==Function==~~	+	Identification, Biochemical and Structural Evaluation of Species-Specific Inhibitors against Type I Methionine Aminopeptidases.,Kishor C, Arya T, Reddi R, Chen X, Saddanapu V, Marapaka AK, Gumpena R, Ma D, Liu JO, Addlagatta A J Med Chem. 2013 Jun 27. PMID:23767698<ref>PMID:23767698</ref>
-	~~[[http://www~~.~~uniprot~~.~~org/uniprot/AMPM1_HUMAN AMPM1_HUMAN]] Removes the N-terminal methionine from nascent proteins~~. ~~Required for normal progression through the cell cycle.<ref>~~PMID:~~16274222</ref>~~ <ref>PMID:~~17114291~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4iks]] is~~ a ~~1 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4IKS OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:023767698</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Aminopeptidase\|Aminopeptidase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Human]]
	[[Category: Methionyl aminopeptidase]]		[[Category: Methionyl aminopeptidase]]
-	[[Category: Addlagatta, A.]]	+	[[Category: Addlagatta, A]]
-	[[Category: Arya, T.]]	+	[[Category: Arya, T]]
-	[[Category: Kishor, C.]]	+	[[Category: Kishor, C]]
	[[Category: Aminopeptidase]]		[[Category: Aminopeptidase]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Pita-bread fold]]		[[Category: Pita-bread fold]]
	[[Category: Ribosome]]		[[Category: Ribosome]]

OCA at 13:40, 11 December 2013

OCA — Wed, 11 Dec 2013 13:40:30 GMT

←Older revision		Revision as of 13:40, 11 December 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4iks\| PDB=4iks \| SCENE= }}
		+	===Crystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with N1-(5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl)-N2-(6-(trifluoromethyl)pyridin-2-yl)ethane-1,2-diamine===
		+	{{ABSTRACT_PUBMED_23767698}}

-	~~The entry 4iks is ON HOLD~~ ~~until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/AMPM1_HUMAN AMPM1_HUMAN]] Removes the N-terminal methionine from nascent proteins. Required for normal progression through the cell cycle.<ref>PMID:16274222</ref> <ref>PMID:17114291</ref>

-	~~Authors~~: ~~Addlagatta, A~~.~~, Kishor, C~~.~~, Arya, T~~.	+	==About this Structure==
		+	[[4iks]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IKS OCA].

-	~~Description~~: ~~Crystal structure of truncated (delta 1-89) human methionine~~ aminopeptidase ~~Type 1 in complex with N1-(5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl)-N2-(6-(trifluoromethyl)pyridin-2-yl)ethane-1~~,2-~~diamine~~	+	==Reference==
		+	<ref group="xtra">PMID:023767698</ref><references group="xtra"/><references/>
		+	[[Category: Methionyl aminopeptidase]]
		+	[[Category: Addlagatta, A.]]
		+	[[Category: Arya, T.]]
		+	[[Category: Kishor, C.]]
		+	[[Category: Aminopeptidase]]
		+	[[Category: Hydrolase]]
		+	[[Category: Pita-bread fold]]
		+	[[Category: Ribosome]]

OCA at 09:52, 13 March 2013

OCA — Wed, 13 Mar 2013 09:52:58 GMT

←Older revision		Revision as of 09:52, 13 March 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4iks is ON HOLD	+	The entry 4iks is ON HOLD until Paper Publication

	Authors: Addlagatta, A., Kishor, C., Arya, T.		Authors: Addlagatta, A., Kishor, C., Arya, T.

	Description: Crystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with N1-(5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl)-N2-(6-(trifluoromethyl)pyridin-2-yl)ethane-1,2-diamine		Description: Crystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with N1-(5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl)-N2-(6-(trifluoromethyl)pyridin-2-yl)ethane-1,2-diamine

OCA: Protected "4iks" [edit=sysop:move=sysop]

OCA — Wed, 02 Jan 2013 09:02:11 GMT

Protected "4iks" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:02, 2 January 2013

OCA: New page: '''Unreleased structure''' The entry 4iks is ON HOLD Authors: Addlagatta, A., Kishor, C., Arya, T. Description: Crystal structure of truncated (delta 1-89) human methionine aminopeptid...

OCA — Wed, 02 Jan 2013 09:02:10 GMT

New page: '''Unreleased structure''' The entry 4iks is ON HOLD Authors: Addlagatta, A., Kishor, C., Arya, T. Description: Crystal structure of truncated (delta 1-89) human methionine aminopeptid...

New page

'''Unreleased structure'''

The entry 4iks is ON HOLD

Authors: Addlagatta, A., Kishor, C., Arya, T.

Description: Crystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with N1-(5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl)-N2-(6-(trifluoromethyl)pyridin-2-yl)ethane-1,2-diamine