4ilq - Revision history

OCA at 15:25, 20 September 2023

OCA — Wed, 20 Sep 2023 15:25:23 GMT

←Older revision		Revision as of 15:25, 20 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ilq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Chlamydia_trachomatis_434/Bu Chlamydia trachomatis 434/Bu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ILQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ILQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ilq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Chlamydia_trachomatis_434/Bu Chlamydia trachomatis 434/Bu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ILQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ILQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ilq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ilq OCA], [https://pdbe.org/4ilq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ilq RCSB], [https://www.ebi.ac.uk/pdbsum/4ilq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ilq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ilq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ilq OCA], [https://pdbe.org/4ilq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ilq RCSB], [https://www.ebi.ac.uk/pdbsum/4ilq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ilq ProSAT]</span></td></tr>
	</table>		</table>

OCA at 20:54, 16 November 2022

OCA — Wed, 16 Nov 2022 20:54:28 GMT

←Older revision		Revision as of 20:54, 16 November 2022
Line 1:		Line 1:

	==2.60A resolution structure of CT771 from Chlamydia trachomatis==		==2.60A resolution structure of CT771 from Chlamydia trachomatis==
-	<StructureSection load='4ilq' size='340' side='right' caption='[[4ilq]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='4ilq' size='340' side='right'caption='[[4ilq]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ilq]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Chlt2 Chlt2~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ILQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ILQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ilq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Chlamydia_trachomatis_434/Bu Chlamydia trachomatis 434/Bu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ILQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ILQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4mpo\|4mpo]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ilq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ilq OCA], [https://pdbe.org/4ilq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ilq RCSB], [https://www.ebi.ac.uk/pdbsum/4ilq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ilq ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTL0140 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=471472 CHLT2])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ilq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ilq OCA], [~~http~~://pdbe.org/4ilq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ilq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ilq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ilq ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A0H3MCJ9_CHLT2 A0A0H3MCJ9_CHLT2]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Chlt2~~]]	+	[[Category: Chlamydia trachomatis 434/Bu]]
-	[[Category: ~~Barta, M L~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Battaile, K P~~]]	+	[[Category: Barta ML]]
-	[[Category: ~~Hefty, P S~~]]	+	[[Category: Battaile KP]]
-	[[Category: ~~Lovell, S~~]]	+	[[Category: Hefty PS]]
-	[[Category: ~~Hydrolase]]~~	+	[[Category: Lovell S]]
-	~~[[Category: Hypothetical protein]]~~	+
-	~~[[Category: Structural proteomic~~]]	+

OCA at 02:38, 5 August 2016

OCA — Fri, 05 Aug 2016 02:38:46 GMT

←Older revision		Revision as of 02:38, 5 August 2016
Line 1:		Line 1:
		+
	==2.60A resolution structure of CT771 from Chlamydia trachomatis==		==2.60A resolution structure of CT771 from Chlamydia trachomatis==
	<StructureSection load='4ilq' size='340' side='right' caption='[[4ilq]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='4ilq' size='340' side='right' caption='[[4ilq]], [[Resolution\|resolution]] 2.60Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4mpo\|4mpo]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4mpo\|4mpo]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTL0140 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=471472 CHLT2])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTL0140 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=471472 CHLT2])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ilq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ilq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ilq RCSB], [http://www.ebi.ac.uk/pdbsum/4ilq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ilq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ilq OCA], [http://pdbe.org/4ilq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ilq RCSB], [http://www.ebi.ac.uk/pdbsum/4ilq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ilq ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4ilq" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:17, 21 December 2014

OCA — Sun, 21 Dec 2014 16:17:54 GMT

←Older revision		Revision as of 16:17, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4ilq\| PDB=4ilq \| SCENE= }}~~	+	==2.60A resolution structure of CT771 from Chlamydia trachomatis==
-	===2.60A resolution structure of CT771 from Chlamydia trachomatis===	+	<StructureSection load='4ilq' size='340' side='right' caption='[[4ilq]], [[Resolution\|resolution]] 2.60Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24354275}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4ilq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chlt2 Chlt2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ILQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ILQ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4mpo\|4mpo]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTL0140 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=471472 CHLT2])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ilq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ilq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ilq RCSB], [http://www.ebi.ac.uk/pdbsum/4ilq PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Asymmetric diadenosine 5',5'''-P(1),P(4)-tetraphosphate (Ap4A) hydrolases are members of the Nudix superfamily that asymmetrically cleave the metabolite Ap4A into ATP and AMP while facilitating homeostasis. The obligate intracellular mammalian pathogen Chlamydia trachomatis possesses a single Nudix family protein, CT771. As pathogens that rely on a host for replication and dissemination typically have one or zero Nudix family proteins, this suggests that CT771 could be critical for chlamydial biology and pathogenesis. We identified orthologues to CT771 within environmental Chlamydiales that share active site residues suggesting a common function. Crystal structures of both apo- and ligand-bound CT771 were determined to 2.6 A and 1.9 A resolution, respectively. The structure of CT771 shows a alphabetaalpha-sandwich motif with many conserved elements lining the putative Nudix active site. Numerous aspects of the ligand-bound CT771 structure mirror those observed in the ligand-bound structure of the Ap4A hydrolase from Caenorhabditis elegans. These structures represent only the second Ap4A hydrolase enzyme member determined from eubacteria and suggest that mammalian and bacterial Ap4A hydrolases might be more similar than previously thought. The aforementioned structural similarities, in tandem with molecular docking, guided the enzymatic characterization of CT771. Together, these studies provide the molecular details for substrate binding and specificity, supporting the analysis that CT771 is an Ap4A hydrolase (nudH).

-	~~==About this Structure==~~	+	Chlamydia trachomatis CT771 (nudH) Is an Asymmetric Ap4A Hydrolase.,Barta ML, Lovell S, Sinclair AN, Battaile KP, Hefty PS Biochemistry. 2014 Jan 14;53(1):214-24. doi: 10.1021/bi401473e. Epub 2013 Dec 31. PMID:24354275<ref>PMID:24354275</ref>
-	~~[[4ilq]] is a~~ 1 ~~chain structure~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4ILQ OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024354275</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
-	[[Category: Barta, M L.]]	+	== References ==
-	[[Category: Battaile, K P.]]	+	<references/>
-	[[Category: Hefty, P S.]]	+	__TOC__
-	[[Category: Lovell, S.]]	+	</StructureSection>
		+	[[Category: Chlt2]]
		+	[[Category: Barta, M L]]
		+	[[Category: Battaile, K P]]
		+	[[Category: Hefty, P S]]
		+	[[Category: Lovell, S]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Hypothetical protein]]		[[Category: Hypothetical protein]]
	[[Category: Structural proteomic]]		[[Category: Structural proteomic]]

OCA at 05:48, 22 January 2014

OCA — Wed, 22 Jan 2014 05:48:10 GMT

←Older revision		Revision as of 05:48, 22 January 2014
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	{{STRUCTURE_4ilq\| PDB=4ilq \| SCENE= }}		{{STRUCTURE_4ilq\| PDB=4ilq \| SCENE= }}
	===2.60A resolution structure of CT771 from Chlamydia trachomatis===		===2.60A resolution structure of CT771 from Chlamydia trachomatis===
		+	{{ABSTRACT_PUBMED_24354275}}

	==About this Structure==		==About this Structure==
	[[4ilq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ILQ OCA].		[[4ilq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ILQ OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:024354275</ref><references group="xtra"/><references/>
	[[Category: Barta, M L.]]		[[Category: Barta, M L.]]
	[[Category: Battaile, K P.]]		[[Category: Battaile, K P.]]

OCA at 12:12, 1 January 2014

OCA — Wed, 01 Jan 2014 12:12:37 GMT

←Older revision		Revision as of 12:12, 1 January 2014
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-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4ilq\| PDB=4ilq \| SCENE= }}
		+	===2.60A resolution structure of CT771 from Chlamydia trachomatis===

-	~~The entry~~ 4ilq is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
-		+	[[4ilq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ILQ OCA].
-	~~Authors~~: Barta, M.L.~~, Lovell, S.,~~ Battaile, K.P., Hefty, P.S.	+	[[Category: Barta, M L.]]
-		+	[[Category: Battaile, K P.]]
-	~~Description~~: ~~2.60A resolution structure of CT771 from Chlamydia trachomatis~~	+	[[Category: Hefty, P S.]]
		+	[[Category: Lovell, S.]]
		+	[[Category: Hydrolase]]
		+	[[Category: Hypothetical protein]]
		+	[[Category: Structural proteomic]]

OCA at 07:12, 16 October 2013

OCA — Wed, 16 Oct 2013 07:12:16 GMT

←Older revision		Revision as of 07:12, 16 October 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4ilq is ON HOLD	+	The entry 4ilq is ON HOLD until Paper Publication

	Authors: Barta, M.L., Lovell, S., Battaile, K.P., Hefty, P.S.		Authors: Barta, M.L., Lovell, S., Battaile, K.P., Hefty, P.S.

	Description: 2.60A resolution structure of CT771 from Chlamydia trachomatis		Description: 2.60A resolution structure of CT771 from Chlamydia trachomatis

OCA at 07:19, 29 September 2013

OCA — Sun, 29 Sep 2013 07:19:50 GMT

←Older revision		Revision as of 07:19, 29 September 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4ilq is ON HOLD ~~until Paper Publication~~	+	The entry 4ilq is ON HOLD

	Authors: Barta, M.L., Lovell, S., Battaile, K.P., Hefty, P.S.		Authors: Barta, M.L., Lovell, S., Battaile, K.P., Hefty, P.S.

	Description: 2.60A resolution structure of CT771 from Chlamydia trachomatis		Description: 2.60A resolution structure of CT771 from Chlamydia trachomatis

OCA at 08:25, 16 January 2013

OCA — Wed, 16 Jan 2013 08:25:45 GMT

←Older revision		Revision as of 08:25, 16 January 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4ilq is ON HOLD	+	The entry 4ilq is ON HOLD until Paper Publication

	Authors: Barta, M.L., Lovell, S., Battaile, K.P., Hefty, P.S.		Authors: Barta, M.L., Lovell, S., Battaile, K.P., Hefty, P.S.

	Description: 2.60A resolution structure of CT771 from Chlamydia trachomatis		Description: 2.60A resolution structure of CT771 from Chlamydia trachomatis

OCA: Protected "4ilq" [edit=sysop:move=sysop]

OCA — Wed, 09 Jan 2013 07:51:58 GMT

Protected "4ilq" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:51, 9 January 2013