4imv - Revision history

OCA at 20:56, 16 November 2022

OCA — Wed, 16 Nov 2022 20:56:52 GMT

←Older revision		Revision as of 20:56, 16 November 2022
Line 3:		Line 3:
	<StructureSection load='4imv' size='340' side='right'caption='[[4imv]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='4imv' size='340' side='right'caption='[[4imv]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4imv]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Castor_bean Castor bean~~]. The May 2013 RCSB PDB [~~http~~://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Ricin'' by David Goodsell is [~~http~~://dx.doi.org/10.2210/rcsb_pdb/mom_2013_5 10.2210/rcsb_pdb/mom_2013_5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IMV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4IMV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4imv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ricinus_communis Ricinus communis]. The May 2013 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Ricin'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2013_5 10.2210/rcsb_pdb/mom_2013_5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IMV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IMV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3lc9\|3lc9]], [[3mk9\|3mk9]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4imv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4imv OCA], [https://pdbe.org/4imv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4imv RCSB], [https://www.ebi.ac.uk/pdbsum/4imv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4imv ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/rRNA_N-glycosylase rRNA N-glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.22 3.2.2.22] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4imv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4imv OCA], [~~http~~://pdbe.org/4imv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4imv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4imv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4imv ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/RICI_RICCO RICI_RICCO]] Ricin is highly toxic to animal cells and to a lesser extent to plant cells. The A chain acts as a glycosidase that removes a specific adenine residue from an exposed loop of the 28S rRNA (A4324 in mammals), leading to rRNA breakage. As this loop is involved in elongation factor binding, modified ribosomes are catalytically inactive and unable to support protein synthesis. The A chain can inactivate a few thousand ribosomes per minute, faster than the cell can make new ones. Therefore a single A chain molecule can kill an animal cell. The B chain binds to beta-D-galactopyranoside moieties on cell surface glycoproteins and glycolipids and facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (Lectin activity).	+	[https://www.uniprot.org/uniprot/RICI_RICCO RICI_RICCO] Ricin is highly toxic to animal cells and to a lesser extent to plant cells. The A chain acts as a glycosidase that removes a specific adenine residue from an exposed loop of the 28S rRNA (A4324 in mammals), leading to rRNA breakage. As this loop is involved in elongation factor binding, modified ribosomes are catalytically inactive and unable to support protein synthesis. The A chain can inactivate a few thousand ribosomes per minute, faster than the cell can make new ones. Therefore a single A chain molecule can kill an animal cell. The B chain binds to beta-D-galactopyranoside moieties on cell surface glycoproteins and glycolipids and facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (Lectin activity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 20:

	==See Also==		==See Also==
-	*[[Ricin\|Ricin]]	+	*[[Ricin 3D structures\|Ricin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Castor bean]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: RCSB PDB Molecule of the Month]]		[[Category: RCSB PDB Molecule of the Month]]
	[[Category: Ricin]]		[[Category: Ricin]]
-	[[Category: ~~RRNA N-glycosylase~~]]	+	[[Category: Ricinus communis]]
-	[[Category: Compton~~, J R~~]]	+	[[Category: Compton JR]]
-	[[Category: Legler~~, P M~~]]	+	[[Category: Legler PM]]
-	[[Category: Millard~~, C B]]~~	+	[[Category: Millard CB]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Immunogen]]~~	+
-	~~[[Category: Thermal stable]]~~	+
-	~~[[Category: Vaccine~~]]	+

OCA at 08:08, 27 March 2019

OCA — Wed, 27 Mar 2019 08:08:59 GMT

←Older revision		Revision as of 08:08, 27 March 2019
Line 1:		Line 1:

	==Ricin A-chain variant 1-33/44-198 with engineered disulfide bond, R48C/T77C/D75N==		==Ricin A-chain variant 1-33/44-198 with engineered disulfide bond, R48C/T77C/D75N==
-	<StructureSection load='4imv' size='340' side='right' caption='[[4imv]], [[Resolution\|resolution]] 2.25Å' scene=''>	+	<StructureSection load='4imv' size='340' side='right'caption='[[4imv]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4imv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Castor_bean Castor bean]. The May 2013 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Ricin'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2013_5 10.2210/rcsb_pdb/mom_2013_5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IMV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IMV FirstGlance]. <br>		<table><tr><td colspan='2'>[[4imv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Castor_bean Castor bean]. The May 2013 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Ricin'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2013_5 10.2210/rcsb_pdb/mom_2013_5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IMV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IMV FirstGlance]. <br>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Castor bean]]		[[Category: Castor bean]]
		+	[[Category: Large Structures]]
	[[Category: RCSB PDB Molecule of the Month]]		[[Category: RCSB PDB Molecule of the Month]]
	[[Category: Ricin]]		[[Category: Ricin]]

OCA at 15:15, 5 August 2016

OCA — Fri, 05 Aug 2016 15:15:53 GMT

←Older revision		Revision as of 15:15, 5 August 2016
Line 1:		Line 1:
		+
	==Ricin A-chain variant 1-33/44-198 with engineered disulfide bond, R48C/T77C/D75N==		==Ricin A-chain variant 1-33/44-198 with engineered disulfide bond, R48C/T77C/D75N==
	<StructureSection load='4imv' size='340' side='right' caption='[[4imv]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='4imv' size='340' side='right' caption='[[4imv]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4imv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Ricinus_communis Ricinus communis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IMV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IMV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4imv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Castor_bean Castor bean]. The May 2013 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Ricin'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2013_5 10.2210/rcsb_pdb/mom_2013_5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IMV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IMV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3lc9\|3lc9]], [[3mk9\|3mk9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3lc9\|3lc9]], [[3mk9\|3mk9]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/rRNA_N-glycosylase rRNA N-glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.22 3.2.2.22] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/rRNA_N-glycosylase rRNA N-glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.22 3.2.2.22] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4imv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4imv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4imv RCSB], [http://www.ebi.ac.uk/pdbsum/4imv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4imv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4imv OCA], [http://pdbe.org/4imv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4imv RCSB], [http://www.ebi.ac.uk/pdbsum/4imv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4imv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4imv" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Ricinus communis~~]]	+	[[Category: Castor bean]]
		+	[[Category: RCSB PDB Molecule of the Month]]
		+	[[Category: Ricin]]
	[[Category: RRNA N-glycosylase]]		[[Category: RRNA N-glycosylase]]
	[[Category: Compton, J R]]		[[Category: Compton, J R]]
Line 32:		Line 36:
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Immunogen]]		[[Category: Immunogen]]
-	[[Category: Ricin]]
	[[Category: Thermal stable]]		[[Category: Thermal stable]]
	[[Category: Vaccine]]		[[Category: Vaccine]]

OCA at 19:51, 25 December 2014

OCA — Thu, 25 Dec 2014 19:51:54 GMT

←Older revision		Revision as of 19:51, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4imv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4imv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4imv RCSB], [http://www.ebi.ac.uk/pdbsum/4imv PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4imv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4imv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4imv RCSB], [http://www.ebi.ac.uk/pdbsum/4imv PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RICI_RICCO RICI_RICCO]] Ricin is highly toxic to animal cells and to a lesser extent to plant cells. The A chain acts as a glycosidase that removes a specific adenine residue from an exposed loop of the 28S rRNA (A4324 in mammals), leading to rRNA breakage. As this loop is involved in elongation factor binding, modified ribosomes are catalytically inactive and unable to support protein synthesis. The A chain can inactivate a few thousand ribosomes per minute, faster than the cell can make new ones. Therefore a single A chain molecule can kill an animal cell. The B chain binds to beta-D-galactopyranoside moieties on cell surface glycoproteins and glycolipids and facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (Lectin activity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 16:56, 10 December 2014

OCA — Wed, 10 Dec 2014 16:56:44 GMT

←Older revision		Revision as of 16:56, 10 December 2014
Line 1:		Line 1:
-	[[~~Image:~~4imv.~~jpg~~\|~~left~~\|~~200px~~]]	+	==Ricin A-chain variant 1-33/44-198 with engineered disulfide bond, R48C/T77C/D75N==
		+	<StructureSection load='4imv' size='340' side='right' caption='[[4imv]], [[Resolution\|resolution]] 2.25Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4imv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ricinus_communis Ricinus communis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IMV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IMV FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3lc9\|3lc9]], [[3mk9\|3mk9]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/rRNA_N-glycosylase rRNA N-glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.22 3.2.2.22] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4imv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4imv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4imv RCSB], [http://www.ebi.ac.uk/pdbsum/4imv PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Vitetta and colleagues identified and characterized a putative vascular leak peptide (VLP) consensus sequence in recombinant ricin toxin A-chain (RTA) that contributed to dose-limiting human toxicity when RTA was administered intravenously in large quantities during chemotherapy. We disrupted this potentially toxic site within the more stable RTA1-33/44-198 vaccine immunogen and determined the impact of these mutations on protein stability, structure and protective immunogenicity using an experimental intranasal ricin challenge model in BALB/c mice to determine if the mutations were compatible. Single amino acid substitutions at the positions corresponding with RTA D75 (to A, or N) and V76 (to I, or M) had minor effects on the apparent protein melting temperature of RTA1-33/44-198 but all four variants retained greater apparent stability than the parent RTA. Moreover, each VLP(-) variant tested provided protection comparable with that of RTA1-33/44-198 against supralethal intranasal ricin challenge as judged by animal survival and several biomarkers. To understand better how VLP substitutions and mutations near the VLP site impact epitope structure, we introduced a previously described thermal stabilizing disulfide bond (R48C/T77C) along with the D75N or V76I substitutions in RTA1-33/44-198. The D75N mutation was compatible with the adjacent stabilizing R48C/T77C disulfide bond and the T(m) was unaffected, whereas the V76I mutation was less compatible with the adjacent disulfide bond involving C77. A crystal structure of the RTA1-33/44-198 R48C/T77C/D75N variant showed that the structural integrity of the immunogen was largely conserved and that a stable immunogen could be produced from E. coli. We conclude that it is feasible to disrupt the VLP site in RTA1-33/44-198 with little or no impact on apparent protein stability or protective efficacy in mice and such variants can be stabilized further by introduction of a disulfide bond.

-	~~{{STRUCTURE_4imv\| PDB=4imv \| SCENE= }}~~	+	Disruption of the Putative Vascular Leak Peptide Sequence in the Stabilized Ricin Vaccine Candidate RTA1-33/44-198.,Janosi L, Compton JR, Legler PM, Steele KE, Davis JM, Matyas GR, Millard CB Toxins (Basel). 2013 Jan 30;5(2):224-48. doi: 10.3390/toxins5020224. PMID:23364220<ref>PMID:23364220</ref>

-	~~===Ricin A-chain variant 1-33~~/~~44-198 with engineered disulfide bond~~, ~~R48C~~/~~T77C/D75N===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_23364220}}~~	+	==See Also==
-		+	*[[Ricin\|Ricin]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~4imv~~]] ~~is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Ricinus_communis Ricinus communis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IMV OCA].~~	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Ricinus communis]]		[[Category: Ricinus communis]]
	[[Category: RRNA N-glycosylase]]		[[Category: RRNA N-glycosylase]]
-	[[Category: Compton, J R.]]	+	[[Category: Compton, J R]]
-	[[Category: Legler, P M.]]	+	[[Category: Legler, P M]]
-	[[Category: Millard, C B.]]	+	[[Category: Millard, C B]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Immunogen]]		[[Category: Immunogen]]

OCA at 10:26, 13 February 2013

OCA — Wed, 13 Feb 2013 10:26:03 GMT

←Older revision		Revision as of 10:26, 13 February 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:4imv.jpg\|left\|200px]]

-	~~The entry~~ 4imv ~~is ON HOLD~~	+	{{STRUCTURE_4imv\| PDB=4imv \| SCENE= }}

-	~~Authors: Legler~~, ~~P.M., Compton, J.R., Millard, C.B.~~	+	===Ricin A-chain variant 1-33/44-198 with engineered disulfide bond, R48C/T77C/D75N===

-	~~Description~~: ~~Ricin A~~-~~chain variant 1-33~~/44-~~198 with engineered disulfide bond~~, ~~R48C/T77C/D75N~~	+	{{ABSTRACT_PUBMED_23364220}}
		+
		+	==About this Structure==
		+	[[4imv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ricinus_communis Ricinus communis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IMV OCA].
		+	[[Category: Ricinus communis]]
		+	[[Category: RRNA N-glycosylase]]
		+	[[Category: Compton, J R.]]
		+	[[Category: Legler, P M.]]
		+	[[Category: Millard, C B.]]
		+	[[Category: Hydrolase]]
		+	[[Category: Immunogen]]
		+	[[Category: Ricin]]
		+	[[Category: Thermal stable]]
		+	[[Category: Vaccine]]

OCA at 08:26, 16 January 2013

OCA — Wed, 16 Jan 2013 08:26:16 GMT

←Older revision		Revision as of 08:26, 16 January 2013
Line 3:		Line 3:
	The entry 4imv is ON HOLD		The entry 4imv is ON HOLD

-	Authors: Legler, P. M., Compton, J.R., Millard, C.B.	+	Authors: Legler, P.M., Compton, J.R., Millard, C.B.

	Description: Ricin A-chain variant 1-33/44-198 with engineered disulfide bond, R48C/T77C/D75N		Description: Ricin A-chain variant 1-33/44-198 with engineered disulfide bond, R48C/T77C/D75N

OCA: Protected "4imv" [edit=sysop:move=sysop]

OCA — Wed, 09 Jan 2013 07:53:19 GMT

Protected "4imv" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:53, 9 January 2013

OCA: New page: '''Unreleased structure''' The entry 4imv is ON HOLD Authors: Legler, P. M., Compton, J.R., Millard, C.B. Description: Ricin A-chain variant 1-33/44-198 with engineered disulfide bond,...

OCA — Wed, 09 Jan 2013 07:53:18 GMT

New page: '''Unreleased structure''' The entry 4imv is ON HOLD Authors: Legler, P. M., Compton, J.R., Millard, C.B. Description: Ricin A-chain variant 1-33/44-198 with engineered disulfide bond,...

New page

'''Unreleased structure'''

The entry 4imv is ON HOLD

Authors: Legler, P. M., Compton, J.R., Millard, C.B.

Description: Ricin A-chain variant 1-33/44-198 with engineered disulfide bond, R48C/T77C/D75N