4ip9 - Revision history

OCA at 11:58, 1 March 2024

OCA — Fri, 01 Mar 2024 11:58:41 GMT

←Older revision		Revision as of 11:58, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ip9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IP9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IP9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ip9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IP9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IP9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P4C:O-ACETALDEHYDYL-HEXAETHYLENE+GLYCOL'>P4C</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P4C:O-ACETALDEHYDYL-HEXAETHYLENE+GLYCOL'>P4C</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ip9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ip9 OCA], [https://pdbe.org/4ip9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ip9 RCSB], [https://www.ebi.ac.uk/pdbsum/4ip9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ip9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ip9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ip9 OCA], [https://pdbe.org/4ip9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ip9 RCSB], [https://www.ebi.ac.uk/pdbsum/4ip9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ip9 ProSAT]</span></td></tr>
	</table>		</table>
Line 11:		Line 12:
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/SAA1_HUMAN SAA1_HUMAN] Major acute phase reactant. Apolipoprotein of the HDL complex.		[https://www.uniprot.org/uniprot/SAA1_HUMAN SAA1_HUMAN] Major acute phase reactant. Apolipoprotein of the HDL complex.
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Serum amyloid A (SAA) represents an evolutionarily conserved family of inflammatory acute-phase proteins. It is also a major constituent of secondary amyloidosis. To understand its function and structural transition to amyloid, we determined a structure of human SAA1.1 in two crystal forms, representing a prototypic member of the family. Native SAA1.1 exists as a hexamer, with subunits displaying a unique four-helix bundle fold stabilized by its long C-terminal tail. Structure-based mutational studies revealed two positive-charge clusters, near the center and apex of the hexamer, that are involved in SAA association with heparin. The binding of high-density lipoprotein involves only the apex region of SAA and can be inhibited by heparin. Peptide amyloid formation assays identified the N-terminal helices 1 and 3 as amyloidogenic peptides of SAA1.1. Both peptides are secluded in the hexameric structure of SAA1.1, suggesting that the native SAA is nonpathogenic. Furthermore, dissociation of the SAA hexamer appears insufficient to initiate amyloidogenic transition, and proteolytic cleavage or removal of the C-terminal tail of SAA resulted in formation of various-sized structural aggregates containing approximately 5-nm regular repeating protofibril-like units. The combined structural and functional studies provide mechanistic insights into the pathogenic contribution of glycosaminoglycan in SAA1.1-mediated AA amyloid formation.
-
-	Structural mechanism of serum amyloid A-mediated inflammatory amyloidosis.,Lu J, Yu Y, Zhu I, Cheng Y, Sun PD Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5189-94. doi:, 10.1073/pnas.1322357111. Epub 2014 Mar 24. PMID:24706838<ref>PMID:24706838</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4ip9" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 21:02, 16 November 2022

OCA — Wed, 16 Nov 2022 21:02:04 GMT

←Older revision		Revision as of 21:02, 16 November 2022
Line 1:		Line 1:

	==Structure of native human serum amyloid A1==		==Structure of native human serum amyloid A1==
-	<StructureSection load='4ip9' size='340' side='right' caption='[[4ip9]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='4ip9' size='340' side='right'caption='[[4ip9]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ip9]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IP9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4IP9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ip9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IP9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IP9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P4C:O-ACETALDEHYDYL-HEXAETHYLENE+GLYCOL'>P4C</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P4C:O-ACETALDEHYDYL-HEXAETHYLENE+GLYCOL'>P4C</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ip8\|4ip8]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ip9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ip9 OCA], [https://pdbe.org/4ip9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ip9 RCSB], [https://www.ebi.ac.uk/pdbsum/4ip9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ip9 ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SAA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ip9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ip9 OCA], [~~http~~://pdbe.org/4ip9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ip9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ip9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ip9 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/SAA1_HUMAN SAA1_HUMAN]] Secondary amyloidosis. Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA1 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function. Elevated serum SAA1 protein levels may be associated with lung cancer.	+	[https://www.uniprot.org/uniprot/SAA1_HUMAN SAA1_HUMAN] Secondary amyloidosis. Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA1 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function. Elevated serum SAA1 protein levels may be associated with lung cancer.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SAA1_HUMAN SAA1_HUMAN]] Major acute phase reactant. Apolipoprotein of the HDL complex.	+	[https://www.uniprot.org/uniprot/SAA1_HUMAN SAA1_HUMAN] Major acute phase reactant. Apolipoprotein of the HDL complex.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Lu, J~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Sun, P D~~]]	+	[[Category: Lu J]]
-	[[Category: ~~Double layer hexameric structure]]~~	+	[[Category: Sun PD]]
-	~~[[Category: High density lipoprotein]]~~	+
-	~~[[Category: Human serum]]~~	+
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: Secondary amyloid~~]]	+

OCA at 13:58, 11 August 2016

OCA — Thu, 11 Aug 2016 13:58:33 GMT

←Older revision		Revision as of 13:58, 11 August 2016
Line 1:		Line 1:
		+
	==Structure of native human serum amyloid A1==		==Structure of native human serum amyloid A1==
	<StructureSection load='4ip9' size='340' side='right' caption='[[4ip9]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='4ip9' size='340' side='right' caption='[[4ip9]], [[Resolution\|resolution]] 2.50Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ip8\|4ip8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ip8\|4ip8]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SAA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SAA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ip9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ip9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ip9 RCSB], [http://www.ebi.ac.uk/pdbsum/4ip9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ip9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ip9 OCA], [http://pdbe.org/4ip9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ip9 RCSB], [http://www.ebi.ac.uk/pdbsum/4ip9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ip9 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 21:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4ip9" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:24, 4 January 2015

OCA — Sun, 04 Jan 2015 14:24:12 GMT

←Older revision		Revision as of 14:24, 4 January 2015
Line 2:		Line 2:
	<StructureSection load='4ip9' size='340' side='right' caption='[[4ip9]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='4ip9' size='340' side='right' caption='[[4ip9]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ip9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IP9 OCA]. <br>	+	<table><tr><td colspan='2'>[[4ip9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IP9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IP9 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P4C:O-ACETALDEHYDYL-HEXAETHYLENE+GLYCOL'>P4C</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P4C:O-ACETALDEHYDYL-HEXAETHYLENE+GLYCOL'>P4C</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ip8\|4ip8]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ip8\|4ip8]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SAA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SAA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr~~><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class~~='~~plainlinks~~'~~>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ip9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ip9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ip9 RCSB], [http://www.ebi.ac.uk/pdbsum/4ip9 PDBsum]</span></td></tr>
-	~~<tr~~><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ip9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ip9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ip9 RCSB], [http://www.ebi.ac.uk/pdbsum/4ip9 PDBsum]</span></td></tr>	+	</table>
-	<table>	+
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/SAA1_HUMAN SAA1_HUMAN]] Secondary amyloidosis. Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA1 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function. Elevated serum SAA1 protein levels may be associated with lung cancer.		[[http://www.uniprot.org/uniprot/SAA1_HUMAN SAA1_HUMAN]] Secondary amyloidosis. Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA1 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function. Elevated serum SAA1 protein levels may be associated with lung cancer.
Line 19:		Line 18:
	Structural mechanism of serum amyloid A-mediated inflammatory amyloidosis.,Lu J, Yu Y, Zhu I, Cheng Y, Sun PD Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5189-94. doi:, 10.1073/pnas.1322357111. Epub 2014 Mar 24. PMID:24706838<ref>PMID:24706838</ref>		Structural mechanism of serum amyloid A-mediated inflammatory amyloidosis.,Lu J, Yu Y, Zhu I, Cheng Y, Sun PD Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5189-94. doi:, 10.1073/pnas.1322357111. Epub 2014 Mar 24. PMID:24706838<ref>PMID:24706838</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 26:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
-	[[Category: Lu, J.]]	+	[[Category: Lu, J]]
	[[Category: Sun, P D]]		[[Category: Sun, P D]]
	[[Category: Double layer hexameric structure]]		[[Category: Double layer hexameric structure]]

OCA at 06:49, 14 May 2014

OCA — Wed, 14 May 2014 06:49:34 GMT

←Older revision		Revision as of 06:49, 14 May 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4ip9\| PDB=4ip9 \| SCENE= }}~~	+	==Structure of native human serum amyloid A1==
-	===Structure of native human serum amyloid A1===	+	<StructureSection load='4ip9' size='340' side='right' caption='[[4ip9]], [[Resolution\|resolution]] 2.50Å' scene=''>
-		+	== Structural highlights ==
-	==Disease==	+	<table><tr><td colspan='2'>[[4ip9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IP9 OCA]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P4C:O-ACETALDEHYDYL-HEXAETHYLENE+GLYCOL'>P4C</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ip8\|4ip8]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SAA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ip9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ip9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ip9 RCSB], [http://www.ebi.ac.uk/pdbsum/4ip9 PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/SAA1_HUMAN SAA1_HUMAN]] Secondary amyloidosis. Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA1 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function. Elevated serum SAA1 protein levels may be associated with lung cancer.		[[http://www.uniprot.org/uniprot/SAA1_HUMAN SAA1_HUMAN]] Secondary amyloidosis. Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA1 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function. Elevated serum SAA1 protein levels may be associated with lung cancer.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SAA1_HUMAN SAA1_HUMAN]] Major acute phase reactant. Apolipoprotein of the HDL complex.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Serum amyloid A (SAA) represents an evolutionarily conserved family of inflammatory acute-phase proteins. It is also a major constituent of secondary amyloidosis. To understand its function and structural transition to amyloid, we determined a structure of human SAA1.1 in two crystal forms, representing a prototypic member of the family. Native SAA1.1 exists as a hexamer, with subunits displaying a unique four-helix bundle fold stabilized by its long C-terminal tail. Structure-based mutational studies revealed two positive-charge clusters, near the center and apex of the hexamer, that are involved in SAA association with heparin. The binding of high-density lipoprotein involves only the apex region of SAA and can be inhibited by heparin. Peptide amyloid formation assays identified the N-terminal helices 1 and 3 as amyloidogenic peptides of SAA1.1. Both peptides are secluded in the hexameric structure of SAA1.1, suggesting that the native SAA is nonpathogenic. Furthermore, dissociation of the SAA hexamer appears insufficient to initiate amyloidogenic transition, and proteolytic cleavage or removal of the C-terminal tail of SAA resulted in formation of various-sized structural aggregates containing approximately 5-nm regular repeating protofibril-like units. The combined structural and functional studies provide mechanistic insights into the pathogenic contribution of glycosaminoglycan in SAA1.1-mediated AA amyloid formation.

-	~~==Function==~~	+	Structural mechanism of serum amyloid A-mediated inflammatory amyloidosis.,Lu J, Yu Y, Zhu I, Cheng Y, Sun PD Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5189-94. doi:, 10.1073/pnas.1322357111. Epub 2014 Mar 24. PMID:24706838<ref>PMID:24706838</ref>
-	~~[[http~~:~~//www~~.~~uniprot~~.~~org~~/~~uniprot/SAA1_HUMAN SAA1_HUMAN]] Major acute phase reactant~~. ~~Apolipoprotein of the HDL complex~~.	+

-	==~~About this Structure~~==	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-	[[~~4ip9]] is a 2 chain structure. Full crystallographic information is available from [http~~:~~//oca.weizmann.ac.il/oca-bin/ocashort?id=4IP9 OCA~~].	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Human]]
	[[Category: Lu, J.]]		[[Category: Lu, J.]]
	[[Category: Sun, P D]]		[[Category: Sun, P D]]

OCA at 09:31, 26 March 2014

OCA — Wed, 26 Mar 2014 09:31:23 GMT

←Older revision		Revision as of 09:31, 26 March 2014
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4ip9\| PDB=4ip9 \| SCENE= }}
		+	===Structure of native human serum amyloid A1===

-	~~The entry 4ip9~~ is ~~ON HOLD~~ ~~until Mar 26 2015~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/SAA1_HUMAN SAA1_HUMAN]] Secondary amyloidosis. Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA1 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function. Elevated serum SAA1 protein levels may be associated with lung cancer.

-	~~Authors~~: ~~Lu, J~~.~~, Sun, P~~.D	+	==Function==
		+	[[http://www.uniprot.org/uniprot/SAA1_HUMAN SAA1_HUMAN]] Major acute phase reactant. Apolipoprotein of the HDL complex.

-	~~Description:~~ Structure ~~of native human~~ serum amyloid A1	+	==About this Structure==
		+	[[4ip9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IP9 OCA].
		+	[[Category: Lu, J.]]
		+	[[Category: Sun, P D]]
		+	[[Category: Double layer hexameric structure]]
		+	[[Category: High density lipoprotein]]
		+	[[Category: Human serum]]
		+	[[Category: Protein binding]]
		+	[[Category: Secondary amyloid]]

OCA at 06:53, 19 March 2014

OCA — Wed, 19 Mar 2014 06:53:55 GMT

←Older revision		Revision as of 06:53, 19 March 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4ip9 is ON HOLD until ~~Paper Publication~~	+	The entry 4ip9 is ON HOLD until Mar 26 2015

	Authors: Lu, J., Sun, P.D		Authors: Lu, J., Sun, P.D

	Description: Structure of native human serum amyloid A1		Description: Structure of native human serum amyloid A1

OCA at 14:19, 27 February 2013

OCA — Wed, 27 Feb 2013 14:19:37 GMT

←Older revision		Revision as of 14:19, 27 February 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4ip9 is ON HOLD	+	The entry 4ip9 is ON HOLD until Paper Publication

	Authors: Lu, J., Sun, P.D		Authors: Lu, J., Sun, P.D

	Description: Structure of native human serum amyloid A1		Description: Structure of native human serum amyloid A1

OCA at 11:12, 23 January 2013

OCA — Wed, 23 Jan 2013 11:12:38 GMT

←Older revision		Revision as of 11:12, 23 January 2013
Line 3:		Line 3:
	The entry 4ip9 is ON HOLD		The entry 4ip9 is ON HOLD

-	Authors: ~~Jinghua~~ Lu, ~~Peter D~~. Sun	+	Authors: Lu, J., Sun, P.D

-	Description: ~~structure~~ of native human serum amyloid A1	+	Description: Structure of native human serum amyloid A1

OCA: Protected "4ip9" [edit=sysop:move=sysop]

OCA — Wed, 16 Jan 2013 08:28:43 GMT

Protected "4ip9" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:28, 16 January 2013