4ipx - Revision history

OCA at 15:28, 20 September 2023

OCA — Wed, 20 Sep 2023 15:28:39 GMT

←Older revision		Revision as of 15:28, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ipx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IPX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IPX FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ipx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IPX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IPX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ipx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ipx OCA], [https://pdbe.org/4ipx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ipx RCSB], [https://www.ebi.ac.uk/pdbsum/4ipx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ipx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ipx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ipx OCA], [https://pdbe.org/4ipx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ipx RCSB], [https://www.ebi.ac.uk/pdbsum/4ipx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ipx ProSAT]</span></td></tr>
	</table>		</table>

OCA at 21:02, 16 November 2022

OCA — Wed, 16 Nov 2022 21:02:42 GMT

←Older revision		Revision as of 21:02, 16 November 2022
Line 1:		Line 1:

	==Analyzing the visible conformational substates of the FK506 binding protein FKBP12==		==Analyzing the visible conformational substates of the FK506 binding protein FKBP12==
-	<StructureSection load='4ipx' size='340' side='right' caption='[[4ipx]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='4ipx' size='340' side='right'caption='[[4ipx]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ipx]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IPX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4IPX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ipx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IPX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IPX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FKBP1A, FKBP1, FKBP12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ipx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ipx OCA], [https://pdbe.org/4ipx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ipx RCSB], [https://www.ebi.ac.uk/pdbsum/4ipx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ipx ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ipx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ipx OCA], [~~http~~://pdbe.org/4ipx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ipx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ipx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ipx ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/FKB1A_HUMAN FKB1A_HUMAN]] Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.<ref>PMID:9233797</ref> <ref>PMID:16720724</ref>	+	[https://www.uniprot.org/uniprot/FKB1A_HUMAN FKB1A_HUMAN] Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.<ref>PMID:9233797</ref> <ref>PMID:16720724</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 20:

	==See Also==		==See Also==
-	*[[~~FK506 binding protein~~\|~~FK506 binding protein~~]]	+	*[[FKBP 3D structures\|FKBP 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Peptidylprolyl isomerase~~]]	+	[[Category: Large Structures]]
-	[[Category: Chen, H]]	+	[[Category: Chen H]]
-	[[Category: Hernandez, G]]	+	[[Category: Hernandez G]]
-	[[Category: LeMaster~~, D M~~]]	+	[[Category: LeMaster DM]]
-	[[Category: Li~~, H M~~]]	+	[[Category: Li HM]]
-	[[Category: Mustafi~~, S M]]~~	+	[[Category: Mustafi SM]]
-	~~[[Category: Isomerase~~]]	+

OCA at 14:03, 5 August 2016

OCA — Fri, 05 Aug 2016 14:03:44 GMT

←Older revision		Revision as of 14:03, 5 August 2016
Line 1:		Line 1:
		+
	==Analyzing the visible conformational substates of the FK506 binding protein FKBP12==		==Analyzing the visible conformational substates of the FK506 binding protein FKBP12==
	<StructureSection load='4ipx' size='340' side='right' caption='[[4ipx]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='4ipx' size='340' side='right' caption='[[4ipx]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ipx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IPX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IPX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ipx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IPX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IPX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FKBP1A, FKBP1, FKBP12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FKBP1A, FKBP1, FKBP12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ipx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ipx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ipx RCSB], [http://www.ebi.ac.uk/pdbsum/4ipx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ipx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ipx OCA], [http://pdbe.org/4ipx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ipx RCSB], [http://www.ebi.ac.uk/pdbsum/4ipx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ipx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4ipx" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]
	[[Category: Chen, H]]		[[Category: Chen, H]]

OCA at 03:06, 25 December 2014

OCA — Thu, 25 Dec 2014 03:06:09 GMT

←Older revision		Revision as of 03:06, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ipx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ipx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ipx RCSB], [http://www.ebi.ac.uk/pdbsum/4ipx PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ipx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ipx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ipx RCSB], [http://www.ebi.ac.uk/pdbsum/4ipx PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FKB1A_HUMAN FKB1A_HUMAN]] Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.<ref>PMID:9233797</ref> <ref>PMID:16720724</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 13:05, 21 December 2014

OCA — Sun, 21 Dec 2014 13:05:04 GMT

←Older revision		Revision as of 13:05, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4ipx\| PDB=4ipx \| SCENE= }}~~	+	==Analyzing the visible conformational substates of the FK506 binding protein FKBP12==
-	===Analyzing the visible conformational substates of the FK506 binding protein FKBP12===	+	<StructureSection load='4ipx' size='340' side='right' caption='[[4ipx]], [[Resolution\|resolution]] 1.70Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23688288}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4ipx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IPX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IPX FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FKBP1A, FKBP1, FKBP12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ipx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ipx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ipx RCSB], [http://www.ebi.ac.uk/pdbsum/4ipx PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The 1H-15N 2D NMR correlation spectrum of the widely studied FK506-binding protein FKBP12 contains previously unreported peak doublings for at least 31 residues that arise from a minor conformational state (12% of total) which exchanges with the major conformation with a time constant of 3.0 s at 43oC. The largest differences in chemical shift occur for the 80's loop that forms critical recognition interactions with many of the protein partners for the FKBP family. The residues exhibiting doubling extend into the adjacent strands of the beta sheet, across the active site to the alpha helix and into the 50's loop. Each of the seven proline residues adopts a trans peptide linkage in both the major and minor conformations, indicating that this slow transition is not the result of prolyl isomerization. Many of the residues exhibiting resonance doubling also participate in conformational linebroadening transition(s) that occur ~105-fold more rapidly, previously proposed to arise from a single global process. The 1.70 A resolution X-ray structure of the H87V variant is strikingly similar to that of FKBP12, yet this substitution quenches the slow conformational transition throughout the protein while quenching the linebroadening transition for residues near the 80's loop. Linebroadening was also decreased for the residues in the alpha-helix and 50's loop, while linebroadening in the 40's loop was unaffected. The K44V mutation selectively reduces the linebroadening in the 40's loop, verifying that at least three distinct conformational transitions underlie the linebroadening processes of FKBP12.

-	~~==Function==~~	+	Analyzing the visible conformational substates of the FK506-binding protein FKBP12.,Mustafi SM, Chen H, Li H, Lemaster DM, Hernandez G Biochem J. 2013 May 21. PMID:23688288<ref>PMID:23688288</ref>
-	~~[[http://www.uniprot.org/uniprot/FKB1A_HUMAN FKB1A_HUMAN]] Keeps in an inactive conformation TGFBR1,~~ the ~~TGF~~-~~beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand~~. ~~Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex~~, ~~thereby blocking the activin signal~~. May ~~modulate the RYR1 calcium channel activity~~. ~~PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.<ref>~~PMID:~~9233797</ref>~~ <ref>PMID:~~16720724~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4ipx]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4IPX OCA].~~	+	</div>

	==See Also==		==See Also==
	*[[FK506 binding protein\|FK506 binding protein]]		*[[FK506 binding protein\|FK506 binding protein]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:023688288</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]
-	[[Category: Chen, H.]]	+	[[Category: Chen, H]]
-	[[Category: Hernandez, G.]]	+	[[Category: Hernandez, G]]
-	[[Category: LeMaster, D M.]]	+	[[Category: LeMaster, D M]]
-	[[Category: Li, H M.]]	+	[[Category: Li, H M]]
-	[[Category: Mustafi, S M.]]	+	[[Category: Mustafi, S M]]
	[[Category: Isomerase]]		[[Category: Isomerase]]

OCA at 03:38, 1 August 2013

OCA — Thu, 01 Aug 2013 03:38:12 GMT

←Older revision		Revision as of 03:38, 1 August 2013
Line 8:		Line 8:
	==About this Structure==		==About this Structure==
	[[4ipx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IPX OCA].		[[4ipx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IPX OCA].
		+
		+	==See Also==
		+	*[[FK506 binding protein\|FK506 binding protein]]

	==Reference==		==Reference==

OCA at 17:58, 19 June 2013

OCA — Wed, 19 Jun 2013 17:58:30 GMT

←Older revision		Revision as of 17:58, 19 June 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4ipx\| PDB=4ipx \| SCENE= }}
		+	===Analyzing the visible conformational substates of the FK506 binding protein FKBP12===
		+	{{ABSTRACT_PUBMED_23688288}}

-	~~The entry 4ipx is ON HOLD~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/FKB1A_HUMAN FKB1A_HUMAN]] Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.<ref>PMID:9233797</ref> <ref>PMID:16720724</ref>

-	~~Authors~~: ~~Chen, H~~.~~, Mustafi, S~~.M.~~, Li, H.M~~.~~, LeMaster, D~~.M.~~, Hernandez, G~~.	+	==About this Structure==
		+	[[4ipx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IPX OCA].

-	~~Description~~: ~~Analyzing the visible conformational substates of the FK506 binding protein FKBP12~~	+	==Reference==
		+	<ref group="xtra">PMID:023688288</ref><references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Peptidylprolyl isomerase]]
		+	[[Category: Chen, H.]]
		+	[[Category: Hernandez, G.]]
		+	[[Category: LeMaster, D M.]]
		+	[[Category: Li, H M.]]
		+	[[Category: Mustafi, S M.]]
		+	[[Category: Isomerase]]

OCA at 11:12, 23 January 2013

OCA — Wed, 23 Jan 2013 11:12:59 GMT

←Older revision		Revision as of 11:12, 23 January 2013
Line 3:		Line 3:
	The entry 4ipx is ON HOLD		The entry 4ipx is ON HOLD

-	Authors: Chen, H., Mustafi, S.M., Li, H.M., LeMaster, D.M., Hernandez, G	+	Authors: Chen, H., Mustafi, S.M., Li, H.M., LeMaster, D.M., Hernandez, G.

	Description: Analyzing the visible conformational substates of the FK506 binding protein FKBP12		Description: Analyzing the visible conformational substates of the FK506 binding protein FKBP12

OCA: Protected "4ipx" [edit=sysop:move=sysop]

OCA — Wed, 16 Jan 2013 08:29:28 GMT

Protected "4ipx" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:29, 16 January 2013

OCA: New page: '''Unreleased structure''' The entry 4ipx is ON HOLD Authors: Chen, H., Mustafi, S.M., Li, H.M., LeMaster, D.M., Hernandez, G Description: Analyzing the visible conformational substate...

OCA — Wed, 16 Jan 2013 08:29:26 GMT

New page: '''Unreleased structure''' The entry 4ipx is ON HOLD Authors: Chen, H., Mustafi, S.M., Li, H.M., LeMaster, D.M., Hernandez, G Description: Analyzing the visible conformational substate...

New page

'''Unreleased structure'''

The entry 4ipx is ON HOLD

Authors: Chen, H., Mustafi, S.M., Li, H.M., LeMaster, D.M., Hernandez, G

Description: Analyzing the visible conformational substates of the FK506 binding protein FKBP12