4iqv - Revision history

OCA at 15:29, 20 September 2023

OCA — Wed, 20 Sep 2023 15:29:10 GMT

←Older revision		Revision as of 15:29, 20 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4iqv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IQV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IQV FirstGlance]. <br>		<table><tr><td colspan='2'>[[4iqv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IQV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IQV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1FO:6-[4-(3-FLUOROBENZOYL)-1H-PYRROL-2-YL]-2-HYDROXY-4-OXOHEXA-2,5-DIENOIC+ACID'>1FO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.9Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1FO:6-[4-(3-FLUOROBENZOYL)-1H-PYRROL-2-YL]-2-HYDROXY-4-OXOHEXA-2,5-DIENOIC+ACID'>1FO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iqv OCA], [https://pdbe.org/4iqv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iqv RCSB], [https://www.ebi.ac.uk/pdbsum/4iqv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iqv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iqv OCA], [https://pdbe.org/4iqv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iqv RCSB], [https://www.ebi.ac.uk/pdbsum/4iqv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iqv ProSAT]</span></td></tr>
	</table>		</table>
Line 18:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4iqv" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4iqv" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[DNA polymerase 3D structures\|DNA polymerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 21:05, 16 November 2022

OCA — Wed, 16 Nov 2022 21:05:04 GMT

←Older revision		Revision as of 21:05, 16 November 2022
Line 1:		Line 1:

	==Tdt core in complex with inhibitor 6-[4-(3-fluorobenzoyl)-1H-pyrrol-2-yl]-2-hydroxy-4-oxohexa-2,5-dienoic acid and ssDNA==		==Tdt core in complex with inhibitor 6-[4-(3-fluorobenzoyl)-1H-pyrrol-2-yl]-2-hydroxy-4-oxohexa-2,5-dienoic acid and ssDNA==
-	<StructureSection load='4iqv' size='340' side='right' caption='[[4iqv]], [[Resolution\|resolution]] 2.90Å' scene=''>	+	<StructureSection load='4iqv' size='340' side='right'caption='[[4iqv]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4iqv]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IQV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4IQV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4iqv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IQV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IQV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1FO:6-[4-(3-FLUOROBENZOYL)-1H-PYRROL-2-YL]-2-HYDROXY-4-OXOHEXA-2,5-DIENOIC+ACID'>1FO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1FO:6-[4-(3-FLUOROBENZOYL)-1H-PYRROL-2-YL]-2-HYDROXY-4-OXOHEXA-2,5-DIENOIC+ACID'>1FO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4iqt\|4iqt]], [[4iqu\|4iqu]], [[4iqw\|4iqw]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iqv OCA], [https://pdbe.org/4iqv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iqv RCSB], [https://www.ebi.ac.uk/pdbsum/4iqv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iqv ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Dntt, Tdt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_nucleotidylexotransferase DNA nucleotidylexotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.31 2.7.7.31] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4iqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iqv OCA], [~~http~~://pdbe.org/4iqv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4iqv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4iqv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4iqv ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TDT_MOUSE TDT_MOUSE]] Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.	+	[https://www.uniprot.org/uniprot/TDT_MOUSE TDT_MOUSE] Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~DNA nucleotidylexotransferase~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Delarue, M]]	+	[[Category: Delarue M]]
-	[[Category: Gouge, J]]	+	[[Category: Gouge J]]
-	~~[[Category: Terminal transferase]]~~	+
-	~~[[Category: Transferase-transferase inhibitor-dna complex~~]]	+

OCA at 05:39, 16 November 2017

OCA — Thu, 16 Nov 2017 05:39:53 GMT

←Older revision		Revision as of 05:39, 16 November 2017
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 4iqv" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4iqv" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[DNA polymerase\|DNA polymerase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 22:36, 5 August 2016

OCA — Fri, 05 Aug 2016 22:36:03 GMT

←Older revision		Revision as of 22:36, 5 August 2016
Line 1:		Line 1:
		+
	==Tdt core in complex with inhibitor 6-[4-(3-fluorobenzoyl)-1H-pyrrol-2-yl]-2-hydroxy-4-oxohexa-2,5-dienoic acid and ssDNA==		==Tdt core in complex with inhibitor 6-[4-(3-fluorobenzoyl)-1H-pyrrol-2-yl]-2-hydroxy-4-oxohexa-2,5-dienoic acid and ssDNA==
	<StructureSection load='4iqv' size='340' side='right' caption='[[4iqv]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='4iqv' size='340' side='right' caption='[[4iqv]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4iqv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IQV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IQV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4iqv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IQV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IQV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1FO:6-[4-(3-FLUOROBENZOYL)-1H-PYRROL-2-YL]-2-HYDROXY-4-OXOHEXA-2,5-DIENOIC+ACID'>1FO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1FO:6-[4-(3-FLUOROBENZOYL)-1H-PYRROL-2-YL]-2-HYDROXY-4-OXOHEXA-2,5-DIENOIC+ACID'>1FO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4iqt\|4iqt]], [[4iqu\|4iqu]], [[4iqw\|4iqw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4iqt\|4iqt]], [[4iqu\|4iqu]], [[4iqw\|4iqw]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Dntt, Tdt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Dntt, Tdt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_nucleotidylexotransferase DNA nucleotidylexotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.31 2.7.7.31] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_nucleotidylexotransferase DNA nucleotidylexotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.31 2.7.7.31] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iqv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4iqv RCSB], [http://www.ebi.ac.uk/pdbsum/4iqv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iqv OCA], [http://pdbe.org/4iqv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4iqv RCSB], [http://www.ebi.ac.uk/pdbsum/4iqv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4iqv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4iqv" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 27:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: DNA nucleotidylexotransferase]]		[[Category: DNA nucleotidylexotransferase]]
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Delarue, M]]		[[Category: Delarue, M]]
	[[Category: Gouge, J]]		[[Category: Gouge, J]]
	[[Category: Terminal transferase]]		[[Category: Terminal transferase]]
	[[Category: Transferase-transferase inhibitor-dna complex]]		[[Category: Transferase-transferase inhibitor-dna complex]]

OCA at 22:30, 25 December 2014

OCA — Thu, 25 Dec 2014 22:30:58 GMT

←Older revision		Revision as of 22:30, 25 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iqv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4iqv RCSB], [http://www.ebi.ac.uk/pdbsum/4iqv PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iqv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4iqv RCSB], [http://www.ebi.ac.uk/pdbsum/4iqv PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TDT_MOUSE TDT_MOUSE]] Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:25, 21 December 2014

OCA — Sun, 21 Dec 2014 12:25:01 GMT

←Older revision		Revision as of 12:25, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4iqv\| PDB=4iqv \| SCENE= }}~~	+	==Tdt core in complex with inhibitor 6-[4-(3-fluorobenzoyl)-1H-pyrrol-2-yl]-2-hydroxy-4-oxohexa-2,5-dienoic acid and ssDNA==
-	===Tdt core in complex with inhibitor 6-[4-(3-fluorobenzoyl)-1H-pyrrol-2-yl]-2-hydroxy-4-oxohexa-2,5-dienoic acid and ssDNA===	+	<StructureSection load='4iqv' size='340' side='right' caption='[[4iqv]], [[Resolution\|resolution]] 2.90Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23968551}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4iqv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IQV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IQV FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1FO:6-[4-(3-FLUOROBENZOYL)-1H-PYRROL-2-YL]-2-HYDROXY-4-OXOHEXA-2,5-DIENOIC+ACID'>1FO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4iqt\|4iqt]], [[4iqu\|4iqu]], [[4iqw\|4iqw]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Dntt, Tdt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_nucleotidylexotransferase DNA nucleotidylexotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.31 2.7.7.31] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iqv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4iqv RCSB], [http://www.ebi.ac.uk/pdbsum/4iqv PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Terminal deoxynucletidyl transferase (TdT) is overexpressed in some cancer types, where it might compete with pol mu driving the mutagenic repair of double strand breaks (DSBs) through the non homologous end joining (NHEJ) pathway. Here we report the discovery and characterization of pyrrolyl and indolyl diketo acids that specifically target TdT and behave as nucleotide-competitive inhibitors. These compounds show a selective toxicity towards MOLT-4 compared to HeLa cells that correlate well with in vitro selectivity for TdT. The binding site of two of these inhibitors was determined by co-crystallization with TdT, explaining why these compounds are competitive inhibitors of the deoxynucleotide triphosphate (dNTP). In addition, because of the observed dual localization of the phenyl substituent, these studies open the possibility to rationally design more potent compounds.

-	~~==Function==~~	+	New Nucleotide-Competitive Non-Nucleoside Inhibitors of Terminal Deoxynucleotidyl Transferase: Discovery, Characterization and Crystal Structure in Complex with the Target.,Costi R, Cuzzucoli Crucitti G, Pescatori L, Messore A, Scipione L, Tortorella S, Amoroso A, Crespan E, Campiglia P, Maresca B, Novellino E, Gouge J, Delarue MH, Maga G, Di Santo R J Med Chem. 2013 Aug 22. PMID:23968551<ref>PMID:23968551</ref>
-	~~[[http://www.uniprot.org/uniprot/TDT_MOUSE TDT_MOUSE]] Template~~-~~independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'~~-~~triphosphate to the 3'-end~~ of ~~a DNA initiator. One of the~~ in ~~vivo functions of this enzyme is~~ the ~~addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of~~ B~~- and T-cells~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4iqv]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4IQV OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:023968551</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[DNA polymerase\|DNA polymerase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: DNA nucleotidylexotransferase]]		[[Category: DNA nucleotidylexotransferase]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Delarue, M.]]	+	[[Category: Delarue, M]]
-	[[Category: Gouge, J.]]	+	[[Category: Gouge, J]]
	[[Category: Terminal transferase]]		[[Category: Terminal transferase]]
	[[Category: Transferase-transferase inhibitor-dna complex]]		[[Category: Transferase-transferase inhibitor-dna complex]]

OCA at 10:41, 4 September 2013

OCA — Wed, 04 Sep 2013 10:41:14 GMT

←Older revision		Revision as of 10:41, 4 September 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4iqv\| PDB=4iqv \| SCENE= }}
		+	===Tdt core in complex with inhibitor 6-[4-(3-fluorobenzoyl)-1H-pyrrol-2-yl]-2-hydroxy-4-oxohexa-2,5-dienoic acid and ssDNA===
		+	{{ABSTRACT_PUBMED_23968551}}

-	~~The entry 4iqv~~ is ~~ON HOLD until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/TDT_MOUSE TDT_MOUSE]] Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.

-	~~Authors~~: ~~Gouge, J~~.~~, Delarue, M~~.	+	==About this Structure==
		+	[[4iqv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IQV OCA].

-	~~Description~~:	+	==Reference==
		+	<ref group="xtra">PMID:023968551</ref><references group="xtra"/><references/>
		+	[[Category: DNA nucleotidylexotransferase]]
		+	[[Category: Mus musculus]]
		+	[[Category: Delarue, M.]]
		+	[[Category: Gouge, J.]]
		+	[[Category: Terminal transferase]]
		+	[[Category: Transferase-transferase inhibitor-dna complex]]

OCA at 08:38, 30 June 2013

OCA — Sun, 30 Jun 2013 08:38:30 GMT

←Older revision		Revision as of 08:38, 30 June 2013
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4iqv is ON HOLD	+	The entry 4iqv is ON HOLD until Paper Publication

	Authors: Gouge, J., Delarue, M.		Authors: Gouge, J., Delarue, M.

	Description:		Description:

OCA: Protected "4iqv" [edit=sysop:move=sysop]

OCA — Wed, 23 Jan 2013 11:13:39 GMT

Protected "4iqv" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:13, 23 January 2013

OCA: New page: '''Unreleased structure''' The entry 4iqv is ON HOLD Authors: Gouge, J., Delarue, M. Description:

OCA — Wed, 23 Jan 2013 11:13:38 GMT

New page: '''Unreleased structure''' The entry 4iqv is ON HOLD Authors: Gouge, J., Delarue, M. Description:

New page

'''Unreleased structure'''

The entry 4iqv is ON HOLD

Authors: Gouge, J., Delarue, M.

Description: