4ixf - Revision history

OCA at 15:32, 20 September 2023

OCA — Wed, 20 Sep 2023 15:32:38 GMT

←Older revision		Revision as of 15:32, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ixf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pneumocystis_carinii Pneumocystis carinii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IXF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IXF FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ixf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pneumocystis_carinii Pneumocystis carinii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IXF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IXF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IXF:N~6~-METHYL-N~6~-[4-(PROPAN-2-YL)PHENYL]PYRIDO[2,3-D]PYRIMIDINE-2,4,6-TRIAMINE'>IXF</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IXF:N~6~-METHYL-N~6~-[4-(PROPAN-2-YL)PHENYL]PYRIDO[2,3-D]PYRIMIDINE-2,4,6-TRIAMINE'>IXF</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ixf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ixf OCA], [https://pdbe.org/4ixf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ixf RCSB], [https://www.ebi.ac.uk/pdbsum/4ixf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ixf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ixf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ixf OCA], [https://pdbe.org/4ixf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ixf RCSB], [https://www.ebi.ac.uk/pdbsum/4ixf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ixf ProSAT]</span></td></tr>
	</table>		</table>

OCA at 21:17, 16 November 2022

OCA — Wed, 16 Nov 2022 21:17:46 GMT

←Older revision		Revision as of 21:17, 16 November 2022
Line 3:		Line 3:
	<StructureSection load='4ixf' size='340' side='right'caption='[[4ixf]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='4ixf' size='340' side='right'caption='[[4ixf]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ixf]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Pneca Pneca~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IXF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4IXF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ixf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pneumocystis_carinii Pneumocystis carinii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IXF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IXF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IXF:N~6~-METHYL-N~6~-[4-(PROPAN-2-YL)PHENYL]PYRIDO[2,3-D]PYRIMIDINE-2,4,6-TRIAMINE'>IXF</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IXF:N~6~-METHYL-N~6~-[4-(PROPAN-2-YL)PHENYL]PYRIDO[2,3-D]PYRIMIDINE-2,4,6-TRIAMINE'>IXF</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cd2\|3cd2]], [[4ixe\|4ixe]], [[4ixg\|4ixg]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ixf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ixf OCA], [https://pdbe.org/4ixf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ixf RCSB], [https://www.ebi.ac.uk/pdbsum/4ixf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ixf ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ixf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ixf OCA], [~~http~~://pdbe.org/4ixf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ixf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ixf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ixf ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/DYR_PNECA DYR_PNECA]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.	+	[https://www.uniprot.org/uniprot/DYR_PNECA DYR_PNECA] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Dihydrofolate reductase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Pneca~~]]	+	[[Category: Pneumocystis carinii]]
-	[[Category: Cody, V]]	+	[[Category: Cody V]]
-	~~[[Category: Oxidoreductase-inhibitor complex]]~~	+
-	~~[[Category: Pcdhfr-269-nadph f69n ternary complex]]~~	+
-	~~[[Category: Reductase~~]]	+

OCA at 05:22, 13 February 2020

OCA — Thu, 13 Feb 2020 05:22:32 GMT

←Older revision		Revision as of 05:22, 13 February 2020
Line 1:		Line 1:

	==pcDHFR-269 F69N variant==		==pcDHFR-269 F69N variant==
-	<StructureSection load='4ixf' size='340' side='right' caption='[[4ixf]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='4ixf' size='340' side='right'caption='[[4ixf]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ixf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pneca Pneca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IXF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IXF FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ixf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pneca Pneca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IXF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IXF FirstGlance]. <br>
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4ixf" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4ixf" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Dihydrofolate reductase 3D structures\|Dihydrofolate reductase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 25:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Dihydrofolate reductase]]		[[Category: Dihydrofolate reductase]]
		+	[[Category: Large Structures]]
	[[Category: Pneca]]		[[Category: Pneca]]
	[[Category: Cody, V]]		[[Category: Cody, V]]

OCA at 09:03, 15 November 2017

OCA — Wed, 15 Nov 2017 09:03:42 GMT

←Older revision		Revision as of 09:03, 15 November 2017
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4ixf" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4ixf" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Dihydrofolate reductase\|Dihydrofolate reductase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:48, 5 August 2016

OCA — Fri, 05 Aug 2016 17:48:11 GMT

←Older revision		Revision as of 17:48, 5 August 2016
Line 1:		Line 1:
		+
	==pcDHFR-269 F69N variant==		==pcDHFR-269 F69N variant==
	<StructureSection load='4ixf' size='340' side='right' caption='[[4ixf]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='4ixf' size='340' side='right' caption='[[4ixf]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ixf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Pneumocystis_carinii Pneumocystis carinii~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IXF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IXF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ixf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pneca Pneca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IXF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IXF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IXF:N~6~-METHYL-N~6~-[4-(PROPAN-2-YL)PHENYL]PYRIDO[2,3-D]PYRIMIDINE-2,4,6-TRIAMINE'>IXF</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IXF:N~6~-METHYL-N~6~-[4-(PROPAN-2-YL)PHENYL]PYRIDO[2,3-D]PYRIMIDINE-2,4,6-TRIAMINE'>IXF</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cd2\|3cd2]], [[4ixe\|4ixe]], [[4ixg\|4ixg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cd2\|3cd2]], [[4ixe\|4ixe]], [[4ixg\|4ixg]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ixf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ixf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ixf RCSB], [http://www.ebi.ac.uk/pdbsum/4ixf PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ixf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ixf OCA], [http://pdbe.org/4ixf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ixf RCSB], [http://www.ebi.ac.uk/pdbsum/4ixf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ixf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4ixf" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Dihydrofolate reductase]]		[[Category: Dihydrofolate reductase]]
-	[[Category: ~~Pneumocystis carinii~~]]	+	[[Category: Pneca]]
	[[Category: Cody, V]]		[[Category: Cody, V]]
	[[Category: Oxidoreductase-inhibitor complex]]		[[Category: Oxidoreductase-inhibitor complex]]
	[[Category: Pcdhfr-269-nadph f69n ternary complex]]		[[Category: Pcdhfr-269-nadph f69n ternary complex]]
	[[Category: Reductase]]		[[Category: Reductase]]

OCA at 20:45, 25 December 2014

OCA — Thu, 25 Dec 2014 20:45:00 GMT

←Older revision		Revision as of 20:45, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ixf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ixf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ixf RCSB], [http://www.ebi.ac.uk/pdbsum/4ixf PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ixf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ixf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ixf RCSB], [http://www.ebi.ac.uk/pdbsum/4ixf PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DYR_PNECA DYR_PNECA]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:53, 21 December 2014

OCA — Sun, 21 Dec 2014 12:53:44 GMT

←Older revision		Revision as of 12:53, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4ixf~~\| ~~PDB~~=4ixf \| ~~SCENE~~= }}	+	==pcDHFR-269 F69N variant==
-	===~~pcDHFR~~-~~269 F69N variant~~===	+	<StructureSection load='4ixf' size='340' side='right' caption='[[4ixf]], [[Resolution\|resolution]] 1.70Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23627352}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4ixf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pneumocystis_carinii Pneumocystis carinii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IXF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IXF FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IXF:N~6~-METHYL-N~6~-[4-(PROPAN-2-YL)PHENYL]PYRIDO[2,3-D]PYRIMIDINE-2,4,6-TRIAMINE'>IXF</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cd2\|3cd2]], [[4ixe\|4ixe]], [[4ixg\|4ixg]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ixf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ixf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ixf RCSB], [http://www.ebi.ac.uk/pdbsum/4ixf PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Opportunistic infections caused by Pneumocystis jirovecii (P. jirovecii, pj), Toxoplasma gondii (T. gondii, tg) and Mycobacterium avium (M. avium, ma) are the principal causes of morbidity and mortality in patients with acquired immunodeficiency syndrome (AIDS). The absence of any animal models for human Pneumocystis jirovecii pneumonia and the lack of crystal structures of pjDHFR and tgDHFR make the design of inhibitors challenging. A novel series of pyrido[2,3-d]pyrimidines as selective and potent DHFR inhibitors against these opportunistic infections are presented. Buchwald-Hartwig coupling reaction of substituted anilines with pivaloyl protected 2,4-diamino-6-bromo-pyrido[2,3-d]pyrimidine was successfully explored to synthesize these analogs. Compound 26 was the most selective inhibitor with excellent potency against pjDHFR. Molecular modeling studies with a pjDHFR homology model explained the potency and selectivity of 26. Structural data are also reported for 26 with pcDHFR and 16 and 22 with variants of pcDHFR.

-	~~==Function==~~	+	Design, synthesis and molecular modeling of novel pyrido[2,3-d]pyrimidine analogs as antifolates: Application of Buchwald-Hartwig aminations of heterocycles.,Gangjee A, Namjoshi OA, Raghavan S, Queener SF, Kisliuk RL, Cody V J Med Chem. 2013 Apr 29. PMID:23627352<ref>PMID:23627352</ref>
-	[~~[http~~:~~//www~~.~~uniprot.org/uniprot/DYR_PNECA DYR_PNECA]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis~~, ~~and for DNA precursor synthesis~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4ixf]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Pneumocystis_carinii Pneumocystis carinii]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4IXF OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:023627352</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Dihydrofolate reductase\|Dihydrofolate reductase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Dihydrofolate reductase]]		[[Category: Dihydrofolate reductase]]
	[[Category: Pneumocystis carinii]]		[[Category: Pneumocystis carinii]]
-	[[Category: Cody, V.]]	+	[[Category: Cody, V]]
	[[Category: Oxidoreductase-inhibitor complex]]		[[Category: Oxidoreductase-inhibitor complex]]
	[[Category: Pcdhfr-269-nadph f69n ternary complex]]		[[Category: Pcdhfr-269-nadph f69n ternary complex]]
	[[Category: Reductase]]		[[Category: Reductase]]

OCA at 15:57, 19 June 2013

OCA — Wed, 19 Jun 2013 15:57:11 GMT

←Older revision		Revision as of 15:57, 19 June 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4ixf\| PDB=4ixf \| SCENE= }}
		+	===pcDHFR-269 F69N variant===
		+	{{ABSTRACT_PUBMED_23627352}}

-	~~The entry 4ixf is ON HOLD~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/DYR_PNECA DYR_PNECA]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

-	~~Authors~~: ~~Cody, V~~.	+	==About this Structure==
		+	[[4ixf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pneumocystis_carinii Pneumocystis carinii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IXF OCA].

-	~~Description~~: ~~pcDHFR~~-269 ~~F69N variant~~	+	==Reference==
		+	<ref group="xtra">PMID:023627352</ref><references group="xtra"/><references/>
		+	[[Category: Dihydrofolate reductase]]
		+	[[Category: Pneumocystis carinii]]
		+	[[Category: Cody, V.]]
		+	[[Category: Oxidoreductase-inhibitor complex]]
		+	[[Category: Pcdhfr-269-nadph f69n ternary complex]]
		+	[[Category: Reductase]]

OCA at 13:27, 20 February 2013

OCA — Wed, 20 Feb 2013 13:27:21 GMT

←Older revision		Revision as of 13:27, 20 February 2013
Line 3:		Line 3:
	The entry 4ixf is ON HOLD		The entry 4ixf is ON HOLD

-	Authors: Cody, ~~Vivian~~	+	Authors: Cody, V.

	Description: pcDHFR-269 F69N variant		Description: pcDHFR-269 F69N variant

OCA: Protected "4ixf" [edit=sysop:move=sysop]

OCA — Wed, 06 Feb 2013 12:30:25 GMT

Protected "4ixf" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:30, 6 February 2013