4iyg - Revision history

OCA at 21:20, 16 November 2022

OCA — Wed, 16 Nov 2022 21:20:30 GMT

←Older revision		Revision as of 21:20, 16 November 2022
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	==Structure of strictosidine synthase in complex with 2-(1H-INDOL-3-YL)-N-METHYLETHANAMINE==		==Structure of strictosidine synthase in complex with 2-(1H-INDOL-3-YL)-N-METHYLETHANAMINE==
-	<StructureSection load='4iyg' size='340' side='right' caption='[[4iyg]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='4iyg' size='340' side='right'caption='[[4iyg]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4iyg]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Devilpepper Devilpepper~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IYG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4IYG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4iyg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rauvolfia_serpentina Rauvolfia serpentina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IYG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IYG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1HU:2-(1H-INDOL-3-YL)-N-METHYLETHANAMINE'>1HU</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1HU:2-(1H-INDOL-3-YL)-N-METHYLETHANAMINE'>1HU</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">STR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4060 Devilpepper])</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iyg OCA], [https://pdbe.org/4iyg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iyg RCSB], [https://www.ebi.ac.uk/pdbsum/4iyg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iyg ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Strictosidine_synthase Strictosidine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.3.2 4.3.3.2] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4iyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iyg OCA], [~~http~~://pdbe.org/4iyg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4iyg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4iyg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4iyg ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/STSY_RAUSE STSY_RAUSE]] Catalyzes the stereospecific condensation of tryptamine with secologanin to form strictosidine, the key intermediate of indole alkaloid biosynthesis.	+	[https://www.uniprot.org/uniprot/STSY_RAUSE STSY_RAUSE] Catalyzes the stereospecific condensation of tryptamine with secologanin to form strictosidine, the key intermediate of indole alkaloid biosynthesis.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Devilpepper~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Strictosidine synthase~~]]	+	[[Category: Rauvolfia serpentina]]
-	[[Category: Fangrui, W]]	+	[[Category: Fangrui W]]
-	[[Category: Rajendran, C]]	+	[[Category: Rajendran C]]
-	[[Category: Stoeckigt, J]]	+	[[Category: Stoeckigt J]]
-	[[Category: Wang, M]]	+	[[Category: Wang M]]
-	~~[[Category: Lyase-lyase inhibitor complex~~]]	+

OCA at 20:38, 3 August 2016

OCA — Wed, 03 Aug 2016 20:38:04 GMT

←Older revision		Revision as of 20:38, 3 August 2016
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	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">STR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4060 Devilpepper])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">STR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4060 Devilpepper])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Strictosidine_synthase Strictosidine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.3.2 4.3.3.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Strictosidine_synthase Strictosidine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.3.2 4.3.3.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iyg OCA], [http://pdbe.org/4iyg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4iyg RCSB], [http://www.ebi.ac.uk/pdbsum/4iyg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iyg OCA], [http://pdbe.org/4iyg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4iyg RCSB], [http://www.ebi.ac.uk/pdbsum/4iyg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4iyg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 10:18, 26 February 2016

OCA — Fri, 26 Feb 2016 10:18:47 GMT

←Older revision		Revision as of 10:18, 26 February 2016
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		+
	==Structure of strictosidine synthase in complex with 2-(1H-INDOL-3-YL)-N-METHYLETHANAMINE==		==Structure of strictosidine synthase in complex with 2-(1H-INDOL-3-YL)-N-METHYLETHANAMINE==
	<StructureSection load='4iyg' size='340' side='right' caption='[[4iyg]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='4iyg' size='340' side='right' caption='[[4iyg]], [[Resolution\|resolution]] 2.70Å' scene=''>

OCA at 07:07, 16 December 2015

OCA — Wed, 16 Dec 2015 07:07:42 GMT

←Older revision		Revision as of 07:07, 16 December 2015
Line 6:		Line 6:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">STR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4060 Devilpepper])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">STR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4060 Devilpepper])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Strictosidine_synthase Strictosidine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.3.2 4.3.3.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Strictosidine_synthase Strictosidine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.3.2 4.3.3.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iyg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4iyg RCSB], [http://www.ebi.ac.uk/pdbsum/4iyg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iyg OCA], [http://pdbe.org/4iyg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4iyg RCSB], [http://www.ebi.ac.uk/pdbsum/4iyg PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4iyg" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 07:37, 10 June 2015

OCA — Wed, 10 Jun 2015 07:37:05 GMT

←Older revision		Revision as of 07:37, 10 June 2015
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	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/STSY_RAUSE STSY_RAUSE]] Catalyzes the stereospecific condensation of tryptamine with secologanin to form strictosidine, the key intermediate of indole alkaloid biosynthesis.		[[http://www.uniprot.org/uniprot/STSY_RAUSE STSY_RAUSE]] Catalyzes the stereospecific condensation of tryptamine with secologanin to form strictosidine, the key intermediate of indole alkaloid biosynthesis.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Pictet-Spenglerasestrictosidine synthase (STR) has been characterized as the central enzyme in the biosynthesis of around 2000 monoterpenoid indole alkaloids in plants. In the light of a high therapeutic value and huge scaffold diversity these alkaloids represent, STR as an enzyme has attracted great attentions in recent years, intending to be utilized in the formation of new interesting alkaloids with unusual substitution pattern or even with novel scaffolds. For outlining the application potential that STR possesses, together with insight into the reaction mechanism catalyzed by STR, strategies and methods for exploring the applicability of STR have been updated in this article by taking R. serpertina STR(RS-STR) and C. roseus.STR (CR-STR) as representative models, followed by introducing the latest released complex structures of RS-STR with new substrates. Examples provided here, including substrate scaffold tailoring, X-ray crystal complex structure comparison, protein engineering and biosynthetic pathway reprogramming, pave the way to finally construct novel alkaloids libraries by chemo-enzymatic approaches.
		+
		+	Using Strictosidine Synthase to Prepare Novel Alkaloids.,Zhu H, Kercmar P, Wu F, Rajendran C, Sun L, Wang M, Stockigt J Curr Med Chem. 2015 Apr 8. PMID:25850764<ref>PMID:25850764</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Strictosidine Synthase\|Strictosidine Synthase]]		*[[Strictosidine Synthase\|Strictosidine Synthase]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 21:54, 25 December 2014

OCA — Thu, 25 Dec 2014 21:54:51 GMT

←Older revision		Revision as of 21:54, 25 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iyg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4iyg RCSB], [http://www.ebi.ac.uk/pdbsum/4iyg PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iyg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4iyg RCSB], [http://www.ebi.ac.uk/pdbsum/4iyg PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/STSY_RAUSE STSY_RAUSE]] Catalyzes the stereospecific condensation of tryptamine with secologanin to form strictosidine, the key intermediate of indole alkaloid biosynthesis.

	==See Also==		==See Also==

OCA at 16:20, 21 December 2014

OCA — Sun, 21 Dec 2014 16:20:59 GMT

←Older revision		Revision as of 16:20, 21 December 2014
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-	~~{{STRUCTURE_4iyg\| PDB=4iyg \| SCENE= }}~~	+	==Structure of strictosidine synthase in complex with 2-(1H-INDOL-3-YL)-N-METHYLETHANAMINE==
-	===Structure of strictosidine synthase in complex with 2-(1H-INDOL-3-YL)-N-METHYLETHANAMINE===	+	<StructureSection load='4iyg' size='340' side='right' caption='[[4iyg]], [[Resolution\|resolution]] 2.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4iyg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Devilpepper Devilpepper]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IYG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IYG FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1HU:2-(1H-INDOL-3-YL)-N-METHYLETHANAMINE'>1HU</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">STR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4060 Devilpepper])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Strictosidine_synthase Strictosidine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.3.2 4.3.3.2] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iyg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4iyg RCSB], [http://www.ebi.ac.uk/pdbsum/4iyg PDBsum]</span></td></tr>
		+	</table>

-	==~~Function~~==	+	==See Also==
-	[[~~http://www.uniprot.org/uniprot/STSY_RAUSE STSY_RAUSE~~]] ~~Catalyzes the stereospecific condensation of tryptamine with secologanin to form strictosidine, the key intermediate of indole alkaloid biosynthesis.~~	+	*[[Strictosidine Synthase\|Strictosidine Synthase]]
-		+	__TOC__
-	~~==About this Structure==~~	+	</StructureSection>
-	[[~~4iyg~~]] ~~is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IYG OCA].~~	+	[[Category: Devilpepper]]
	[[Category: Strictosidine synthase]]		[[Category: Strictosidine synthase]]
-	[[Category: Fangrui, W.]]	+	[[Category: Fangrui, W]]
-	[[Category: Rajendran, C.]]	+	[[Category: Rajendran, C]]
-	[[Category: Stoeckigt, J.]]	+	[[Category: Stoeckigt, J]]
-	[[Category: Wang, M.]]	+	[[Category: Wang, M]]
	[[Category: Lyase-lyase inhibitor complex]]		[[Category: Lyase-lyase inhibitor complex]]
-	[[Category: Strictosidine synthase]]

OCA at 07:46, 29 January 2014

OCA — Wed, 29 Jan 2014 07:46:35 GMT

←Older revision		Revision as of 07:46, 29 January 2014
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4iyg\| PDB=4iyg \| SCENE= }}
		+	===Structure of strictosidine synthase in complex with 2-(1H-INDOL-3-YL)-N-METHYLETHANAMINE===

-	~~The entry 4iyg is ON HOLD until Jan 29 2015~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/STSY_RAUSE STSY_RAUSE]] Catalyzes the stereospecific condensation of tryptamine with secologanin to form strictosidine, the key intermediate of indole alkaloid biosynthesis.

-	~~Authors~~: ~~Stoeckigt, J~~., Fangrui, W., Wang, M.~~, Rajendran, C.~~	+	==About this Structure==
-		+	[[4iyg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IYG OCA].
-	~~Description~~: ~~structure of STR1 ligand complexes~~	+	[[Category: Strictosidine synthase]]
		+	[[Category: Fangrui, W.]]
		+	[[Category: Rajendran, C.]]
		+	[[Category: Stoeckigt, J.]]
		+	[[Category: Wang, M.]]
		+	[[Category: Lyase-lyase inhibitor complex]]
		+	[[Category: Strictosidine synthase]]

OCA at 08:53, 18 December 2013

OCA — Wed, 18 Dec 2013 08:53:27 GMT

←Older revision		Revision as of 08:53, 18 December 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4iyg is ON HOLD until ~~Paper Publication~~	+	The entry 4iyg is ON HOLD until Jan 29 2015

	Authors: Stoeckigt, J., Fangrui, W., Wang, M., Rajendran, C.		Authors: Stoeckigt, J., Fangrui, W., Wang, M., Rajendran, C.

	Description: structure of STR1 ligand complexes		Description: structure of STR1 ligand complexes

OCA at 14:21, 27 February 2013

OCA — Wed, 27 Feb 2013 14:21:47 GMT

←Older revision		Revision as of 14:21, 27 February 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4iyg is ON HOLD	+	The entry 4iyg is ON HOLD until Paper Publication

	Authors: Stoeckigt, J., Fangrui, W., Wang, M., Rajendran, C.		Authors: Stoeckigt, J., Fangrui, W., Wang, M., Rajendran, C.

	Description: structure of STR1 ligand complexes		Description: structure of STR1 ligand complexes