4iyr - Revision history

OCA at 14:18, 8 November 2023

OCA — Wed, 08 Nov 2023 14:18:34 GMT

←Older revision		Revision as of 14:18, 8 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4iyr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IYR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IYR FirstGlance]. <br>		<table><tr><td colspan='2'>[[4iyr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IYR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IYR FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iyr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iyr OCA], [https://pdbe.org/4iyr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iyr RCSB], [https://www.ebi.ac.uk/pdbsum/4iyr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iyr ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.697Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iyr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iyr OCA], [https://pdbe.org/4iyr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iyr RCSB], [https://www.ebi.ac.uk/pdbsum/4iyr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iyr ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 21:20, 16 November 2022

OCA — Wed, 16 Nov 2022 21:20:56 GMT

←Older revision		Revision as of 21:20, 16 November 2022
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	<StructureSection load='4iyr' size='340' side='right'caption='[[4iyr]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='4iyr' size='340' side='right'caption='[[4iyr]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4iyr]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IYR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4IYR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4iyr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IYR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IYR FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3nr2\|3nr2]], [[3v6l\|3v6l]], [[3v6m\|3v6m]], [[3od5\|3od5]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iyr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iyr OCA], [https://pdbe.org/4iyr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iyr RCSB], [https://www.ebi.ac.uk/pdbsum/4iyr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iyr ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-6 Caspase-6], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.59 3.4.22.59] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4iyr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iyr OCA], [~~http~~://pdbe.org/4iyr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4iyr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4iyr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4iyr ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CASP6_HUMAN CASP6_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.	+	[https://www.uniprot.org/uniprot/CASP6_HUMAN CASP6_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Caspase-6]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cao, Q]]	+	[[Category: Cao Q]]
-	[[Category: Li, L F]]	+	[[Category: Li L-F]]
-	[[Category: Su, X D]]	+	[[Category: Su X-D]]
-	[[Category: Wang, X J]]	+	[[Category: Wang X-J]]
-	~~[[Category: Caspase fold]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Protease~~]]	+

OCA at 08:37, 1 January 2020

OCA — Wed, 01 Jan 2020 08:37:46 GMT

←Older revision		Revision as of 08:37, 1 January 2020
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	==Crystal structure of full-length caspase-6 zymogen==		==Crystal structure of full-length caspase-6 zymogen==
-	<StructureSection load='4iyr' size='340' side='right' caption='[[4iyr]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='4iyr' size='340' side='right'caption='[[4iyr]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4iyr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IYR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IYR FirstGlance]. <br>		<table><tr><td colspan='2'>[[4iyr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IYR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IYR FirstGlance]. <br>
Line 11:		Line 11:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/CASP6_HUMAN CASP6_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.		[[http://www.uniprot.org/uniprot/CASP6_HUMAN CASP6_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Caspase 6 (CASP6) is a neuron degeneration-related protease and is widely considered to be a potential drug-design target against neurodegenerative diseases such as Huntington's disease and Alzheimer's disease. The N-terminal pro-peptide of CASP6, also referred to as the pro-domain, contains 23 residues and its functional role remains elusive. In this study, the crystal structure of a full-length CASP6 zymogen mutant, proCASP6H121A, was solved. Although the pro-domain was flexible in the crystal, without visible electron density, structural analyses combined with biochemical assays revealed that the pro-domain inhibited CASP6 auto-activation by inhibiting intramolecular cleavage at the intersubunit cleavage site TEVD(193) and also by preventing this site from intermolecular cleavage at low protein concentration through a so-called `suicide-protection' mechanism. Further experiments showed that the length of the pro-domain and the side chain of Asn18 played critical roles in suicide protection. These results disclosed a new inhibitory mechanism of CASP6 and shed light on the pathogenesis and therapeutically relevant study of CASP6-related neurodegenerative diseases.
		+
		+	The regulatory mechanism of the caspase 6 pro-domain revealed by crystal structure and biochemical assays.,Cao Q, Wang XJ, Li LF, Su XD Acta Crystallogr D Biol Crystallogr. 2014 Jan;70(Pt 1):58-67. doi:, 10.1107/S1399004713024218. Epub 2013 Dec 24. PMID:24419379<ref>PMID:24419379</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4iyr" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
-	*[[Caspase\|Caspase]]	+	*[[Caspase 3D structures\|Caspase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Caspase-6]]		[[Category: Caspase-6]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Cao, Q]]		[[Category: Cao, Q]]
	[[Category: Li, L F]]		[[Category: Li, L F]]

OCA at 14:41, 5 August 2016

OCA — Fri, 05 Aug 2016 14:41:14 GMT

←Older revision		Revision as of 14:41, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of full-length caspase-6 zymogen==		==Crystal structure of full-length caspase-6 zymogen==
	<StructureSection load='4iyr' size='340' side='right' caption='[[4iyr]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='4iyr' size='340' side='right' caption='[[4iyr]], [[Resolution\|resolution]] 2.70Å' scene=''>
Line 6:		Line 7:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-6 Caspase-6], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.59 3.4.22.59] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-6 Caspase-6], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.59 3.4.22.59] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iyr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iyr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4iyr RCSB], [http://www.ebi.ac.uk/pdbsum/4iyr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iyr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iyr OCA], [http://pdbe.org/4iyr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4iyr RCSB], [http://www.ebi.ac.uk/pdbsum/4iyr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4iyr ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 03:19, 25 December 2014

OCA — Thu, 25 Dec 2014 03:19:54 GMT

←Older revision		Revision as of 03:19, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4iyr\| PDB=4iyr \| SCENE= }}~~	+	==Crystal structure of full-length caspase-6 zymogen==
-	===Crystal structure of full-length caspase-6 zymogen===	+	<StructureSection load='4iyr' size='340' side='right' caption='[[4iyr]], [[Resolution\|resolution]] 2.70Å' scene=''>
-		+	== Structural highlights ==
-	==Function==	+	<table><tr><td colspan='2'>[[4iyr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IYR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IYR FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3nr2\|3nr2]], [[3v6l\|3v6l]], [[3v6m\|3v6m]], [[3od5\|3od5]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-6 Caspase-6], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.59 3.4.22.59] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iyr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iyr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4iyr RCSB], [http://www.ebi.ac.uk/pdbsum/4iyr PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/CASP6_HUMAN CASP6_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.		[[http://www.uniprot.org/uniprot/CASP6_HUMAN CASP6_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.

-	==~~About this Structure~~==	+	==See Also==
-	[[~~4iyr~~]] ~~is a 2 chain structure. Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4IYR OCA].~~	+	*[[Caspase\|Caspase]]
		+	__TOC__
		+	</StructureSection>
	[[Category: Caspase-6]]		[[Category: Caspase-6]]
-	[[Category: Cao, Q.]]	+	[[Category: Human]]
-	[[Category: Li, L F.]]	+	[[Category: Cao, Q]]
-	[[Category: Su, X D.]]	+	[[Category: Li, L F]]
-	[[Category: Wang, X J.]]	+	[[Category: Su, X D]]
		+	[[Category: Wang, X J]]
	[[Category: Caspase fold]]		[[Category: Caspase fold]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Protease]]		[[Category: Protease]]

OCA at 08:22, 15 January 2014

OCA — Wed, 15 Jan 2014 08:22:51 GMT

←Older revision		Revision as of 08:22, 15 January 2014
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-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4iyr\| PDB=4iyr \| SCENE= }}
		+	===Crystal structure of full-length caspase-6 zymogen===

-	~~The entry 4iyr is ON HOLD until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/CASP6_HUMAN CASP6_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.

-	~~Authors~~: ~~Cao, Q~~.~~, Wang, X~~.J., Li, L.F., Su, X.D.	+	==About this Structure==
-		+	[[4iyr]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IYR OCA].
-	~~Description~~: ~~Crystal structure of full-length caspase-6 zymogen~~	+	[[Category: Caspase-6]]
		+	[[Category: Cao, Q.]]
		+	[[Category: Li, L F.]]
		+	[[Category: Su, X D.]]
		+	[[Category: Wang, X J.]]
		+	[[Category: Caspase fold]]
		+	[[Category: Hydrolase]]
		+	[[Category: Protease]]

OCA at 10:07, 13 February 2013

OCA — Wed, 13 Feb 2013 10:07:54 GMT

←Older revision		Revision as of 10:07, 13 February 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4iyr is ON HOLD	+	The entry 4iyr is ON HOLD until Paper Publication

	Authors: Cao, Q., Wang, X.J., Li, L.F., Su, X.D.		Authors: Cao, Q., Wang, X.J., Li, L.F., Su, X.D.

	Description: Crystal structure of full-length caspase-6 zymogen		Description: Crystal structure of full-length caspase-6 zymogen

OCA: Protected "4iyr" [edit=sysop:move=sysop]

OCA — Wed, 06 Feb 2013 12:31:56 GMT

Protected "4iyr" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:31, 6 February 2013

OCA: New page: '''Unreleased structure''' The entry 4iyr is ON HOLD Authors: Cao, Q., Wang, X.J., Li, L.F., Su, X.D. Description: Crystal structure of full-length caspase-6 zymogen

OCA — Wed, 06 Feb 2013 12:31:55 GMT

New page: '''Unreleased structure''' The entry 4iyr is ON HOLD Authors: Cao, Q., Wang, X.J., Li, L.F., Su, X.D. Description: Crystal structure of full-length caspase-6 zymogen

New page

'''Unreleased structure'''

The entry 4iyr is ON HOLD

Authors: Cao, Q., Wang, X.J., Li, L.F., Su, X.D.

Description: Crystal structure of full-length caspase-6 zymogen