4ize - Revision history

OCA at 21:21, 16 November 2022

OCA — Wed, 16 Nov 2022 21:21:21 GMT

←Older revision		Revision as of 21:21, 16 November 2022
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	<StructureSection load='4ize' size='340' side='right'caption='[[4ize]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4ize' size='340' side='right'caption='[[4ize]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ize]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IZE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4IZE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ize]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IZE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IZE FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1md6\|1md6]], [[4izf\|4izf]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ize FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ize OCA], [https://pdbe.org/4ize PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ize RCSB], [https://www.ebi.ac.uk/pdbsum/4ize PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ize ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IL1E, IL1F9, IL1H1, IL1RP2, IL36G, UNQ2456/PRO5737 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ize FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ize OCA], [~~http~~://pdbe.org/4ize PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ize RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ize PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ize ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/IL36G_HUMAN IL36G_HUMAN]] Function as an agonist of NF-kappa B activation through the orphan IL-1-receptor-related protein 2/IL1RL2. Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and takes part in local inflammatory response.	+	[https://www.uniprot.org/uniprot/IL36G_HUMAN IL36G_HUMAN] Function as an agonist of NF-kappa B activation through the orphan IL-1-receptor-related protein 2/IL1RL2. Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and takes part in local inflammatory response.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
-	*[[Interleukin\|Interleukin]]	+	*[[Interleukin 3D structures\|Interleukin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Guenther, S]]	+	[[Category: Guenther S]]
-	[[Category: Sundberg~~, E J]]~~	+	[[Category: Sundberg EJ]]
-	~~[[Category: Beta trefoil]]~~	+
-	~~[[Category: Innate immune signaling]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 08:40, 3 April 2019

OCA — Wed, 03 Apr 2019 08:40:23 GMT

←Older revision		Revision as of 08:40, 3 April 2019
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	==Crystal Structure of IL-36gamma==		==Crystal Structure of IL-36gamma==
-	<StructureSection load='4ize' size='340' side='right' caption='[[4ize]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='4ize' size='340' side='right'caption='[[4ize]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ize]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IZE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IZE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ize]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IZE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IZE FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1md6\|1md6]], [[4izf\|4izf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1md6\|1md6]], [[4izf\|4izf]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IL1E, IL1F9, IL1H1, IL1RP2, IL36G, UNQ2456/PRO5737 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ize FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ize OCA], [http://pdbe.org/4ize PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ize RCSB], [http://www.ebi.ac.uk/pdbsum/4ize PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ize ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ize FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ize OCA], [http://pdbe.org/4ize PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ize RCSB], [http://www.ebi.ac.uk/pdbsum/4ize PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ize ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Guenther, S]]		[[Category: Guenther, S]]
	[[Category: Sundberg, E J]]		[[Category: Sundberg, E J]]

OCA at 02:42, 5 August 2016

OCA — Fri, 05 Aug 2016 02:42:11 GMT

←Older revision		Revision as of 02:42, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of IL-36gamma==		==Crystal Structure of IL-36gamma==
	<StructureSection load='4ize' size='340' side='right' caption='[[4ize]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4ize' size='340' side='right' caption='[[4ize]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1md6\|1md6]], [[4izf\|4izf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1md6\|1md6]], [[4izf\|4izf]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ize FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ize OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ize RCSB], [http://www.ebi.ac.uk/pdbsum/4ize PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ize FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ize OCA], [http://pdbe.org/4ize PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ize RCSB], [http://www.ebi.ac.uk/pdbsum/4ize PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ize ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4ize" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Interleukin\|Interleukin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 22:07, 24 December 2014

OCA — Wed, 24 Dec 2014 22:07:17 GMT

←Older revision		Revision as of 22:07, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ize]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IZE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IZE FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ize]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IZE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IZE FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1md6\|1md6]], [[4izf\|4izf]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1md6\|1md6]], [[4izf\|4izf]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ize FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ize OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ize RCSB], [http://www.ebi.ac.uk/pdbsum/4ize PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ize FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ize OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ize RCSB], [http://www.ebi.ac.uk/pdbsum/4ize PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/IL36G_HUMAN IL36G_HUMAN]] Function as an agonist of NF-kappa B activation through the orphan IL-1-receptor-related protein 2/IL1RL2. Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and takes part in local inflammatory response.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Guenther, S.]]	+	[[Category: Guenther, S]]
-	[[Category: Sundberg, E J.]]	+	[[Category: Sundberg, E J]]
	[[Category: Beta trefoil]]		[[Category: Beta trefoil]]
	[[Category: Innate immune signaling]]		[[Category: Innate immune signaling]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]

OCA at 06:24, 25 June 2014

OCA — Wed, 25 Jun 2014 06:24:59 GMT

←Older revision		Revision as of 06:24, 25 June 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal Structure of IL-36gamma==
		+	<StructureSection load='4ize' size='340' side='right' caption='[[4ize]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4ize]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IZE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IZE FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1md6\|1md6]], [[4izf\|4izf]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ize FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ize OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ize RCSB], [http://www.ebi.ac.uk/pdbsum/4ize PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The IL-1 family consists of 11 cytokines that control a complex network of proinflammatory signals critical for regulating immune responses to infections. They also play a central role in numerous chronic inflammatory disorders. Accordingly, inhibiting the activities of these cytokines is an important therapeutic strategy for treating autoimmune diseases and lymphomas. Agonist cytokines in the IL-1 family activate signaling by binding their cognate receptor and then recruiting a receptor accessory protein. Conversely, antagonist cytokines bind their cognate receptor but prohibit recruitment of receptor accessory protein, which precludes functional signaling complexes. The IL-36 subfamily of cytokines is the most diverse, including three agonists and at least one antagonist, and is the least well-characterized group within this family. Signaling through the IL-36 receptor directly stimulates dendritic cells and primes naive CD4 T cells for Th1 responses. Appropriately balanced IL-36 signaling is a critical determinant of skin and lung health. IL-36 signaling has been presumed to function analogously to IL-1 signaling. In this study, we have defined molecular determinants of agonist and antagonist signaling through the IL-36 receptor. We present the crystal structure of IL-36gamma, which, to our knowledge, is the first reported structure of an IL-36 agonist. Using this structure as a guide, we designed a comprehensive series of IL-36 agonist/antagonist chimeric proteins for which we measured binding to the IL-36 receptor/IL-1 receptor accessory protein complex and functional activation and inhibition of signaling. Our data reveal how the fine specificity of IL-36 signaling is distinct from that of IL-1.

-	~~The entry 4ize is ON HOLD until Jul 30 2015~~	+	Molecular Determinants of Agonist and Antagonist Signaling through the IL-36 Receptor.,Gunther S, Sundberg EJ J Immunol. 2014 Jun 16. pii: 1400538. PMID:24935927<ref>PMID:24935927</ref>

-	~~Authors~~: Guenther, S., Sundberg, E.J.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal Structure of IL-36gamma~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Guenther, S.]]
		+	[[Category: Sundberg, E J.]]
		+	[[Category: Beta trefoil]]
		+	[[Category: Innate immune signaling]]
		+	[[Category: Signaling protein]]

OCA at 08:50, 8 January 2014

OCA — Wed, 08 Jan 2014 08:50:46 GMT

←Older revision		Revision as of 08:50, 8 January 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4ize is ON HOLD until ~~Paper Publication~~	+	The entry 4ize is ON HOLD until Jul 30 2015

	Authors: Guenther, S., Sundberg, E.J.		Authors: Guenther, S., Sundberg, E.J.

	Description: Crystal Structure of IL-36gamma		Description: Crystal Structure of IL-36gamma

OCA at 00:49, 4 April 2013

OCA — Thu, 04 Apr 2013 00:49:49 GMT

←Older revision		Revision as of 00:49, 4 April 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4ize is ON HOLD	+	The entry 4ize is ON HOLD until Paper Publication

	Authors: Guenther, S., Sundberg, E.J.		Authors: Guenther, S., Sundberg, E.J.

	Description: Crystal Structure of IL-36gamma		Description: Crystal Structure of IL-36gamma

OCA: Protected "4ize" [edit=sysop:move=sysop]

OCA — Wed, 06 Feb 2013 12:32:38 GMT

Protected "4ize" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:32, 6 February 2013

OCA: New page: '''Unreleased structure''' The entry 4ize is ON HOLD Authors: Guenther, S., Sundberg, E.J. Description: Crystal Structure of IL-36gamma

OCA — Wed, 06 Feb 2013 12:32:37 GMT

New page: '''Unreleased structure''' The entry 4ize is ON HOLD Authors: Guenther, S., Sundberg, E.J. Description: Crystal Structure of IL-36gamma

New page

'''Unreleased structure'''

The entry 4ize is ON HOLD

Authors: Guenther, S., Sundberg, E.J.

Description: Crystal Structure of IL-36gamma