4j1y - Revision history

OCA at 15:35, 20 September 2023

OCA — Wed, 20 Sep 2023 15:35:06 GMT

←Older revision		Revision as of 15:35, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4j1y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J1Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J1Y FirstGlance]. <br>		<table><tr><td colspan='2'>[[4j1y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J1Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J1Y FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j1y OCA], [https://pdbe.org/4j1y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j1y RCSB], [https://www.ebi.ac.uk/pdbsum/4j1y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j1y ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6645Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j1y OCA], [https://pdbe.org/4j1y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j1y RCSB], [https://www.ebi.ac.uk/pdbsum/4j1y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j1y ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 21:25, 16 November 2022

OCA — Wed, 16 Nov 2022 21:25:23 GMT

←Older revision		Revision as of 21:25, 16 November 2022
Line 1:		Line 1:

	==The X-ray crystal structure of human complement protease C1s zymogen==		==The X-ray crystal structure of human complement protease C1s zymogen==
-	<StructureSection load='4j1y' size='340' side='right' caption='[[4j1y]], [[Resolution\|resolution]] 2.66Å' scene=''>	+	<StructureSection load='4j1y' size='340' side='right'caption='[[4j1y]], [[Resolution\|resolution]] 2.66Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4j1y]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J1Y OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4J1Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4j1y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J1Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J1Y FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1elv\|1elv]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j1y OCA], [https://pdbe.org/4j1y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j1y RCSB], [https://www.ebi.ac.uk/pdbsum/4j1y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j1y ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C1S ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Complement_subcomponent_C1s Complement subcomponent C1s], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.42 3.4.21.42] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4j1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j1y OCA], [~~http~~://pdbe.org/4j1y PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4j1y RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4j1y PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4j1y ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/C1S_HUMAN C1S_HUMAN]] Defects in C1S are the cause of complement component C1s deficiency (C1SD) [MIM:[~~http~~://omim.org/entry/613783 613783]]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.	+	[https://www.uniprot.org/uniprot/C1S_HUMAN C1S_HUMAN] Defects in C1S are the cause of complement component C1s deficiency (C1SD) [MIM:[https://omim.org/entry/613783 613783]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/C1S_HUMAN C1S_HUMAN]] C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.	+	[https://www.uniprot.org/uniprot/C1S_HUMAN C1S_HUMAN] C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Complement subcomponent C1s~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Human~~]]	+	[[Category: Large Structures]]
-	[[Category: Andrea, L D]]	+	[[Category: D'Andrea L]]
-	[[Category: Duncan~~, R C~~]]	+	[[Category: Duncan RC]]
-	[[Category: Gunzburg~~, M J~~]]	+	[[Category: Gunzburg MJ]]
-	[[Category: Irving~~, J A~~]]	+	[[Category: Irving JA]]
-	[[Category: Pang~~, S S~~]]	+	[[Category: Pang SS]]
-	[[Category: Perry~~, A J~~]]	+	[[Category: Perry AJ]]
-	[[Category: Pike~~, R N~~]]	+	[[Category: Pike RN]]
-	[[Category: Whisstock~~, J C~~]]	+	[[Category: Whisstock JC]]
-	[[Category: Wijeyewickrema~~, L C~~]]	+	[[Category: Wijeyewickrema LC]]
-	[[Category: Wilce~~, J A~~]]	+	[[Category: Wilce JA]]
-	[[Category: Wilmann~~, P G]]~~	+	[[Category: Wilmann PG]]
-	~~[[Category: C2]]~~	+
-	~~[[Category: C4]]~~	+
-	~~[[Category: Extracellular]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Hydrolysis~~]]	+

OCA at 15:16, 4 August 2016

OCA — Thu, 04 Aug 2016 15:16:45 GMT

←Older revision		Revision as of 15:16, 4 August 2016
Line 1:		Line 1:
		+
	==The X-ray crystal structure of human complement protease C1s zymogen==		==The X-ray crystal structure of human complement protease C1s zymogen==
	<StructureSection load='4j1y' size='340' side='right' caption='[[4j1y]], [[Resolution\|resolution]] 2.66Å' scene=''>		<StructureSection load='4j1y' size='340' side='right' caption='[[4j1y]], [[Resolution\|resolution]] 2.66Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4j1y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J1Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J1Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4j1y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J1Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J1Y FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1elv\|1elv]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1elv\|1elv]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C1S ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C1S ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Complement_subcomponent_C1s Complement subcomponent C1s], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.42 3.4.21.42] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Complement_subcomponent_C1s Complement subcomponent C1s], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.42 3.4.21.42] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j1y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4j1y RCSB], [http://www.ebi.ac.uk/pdbsum/4j1y PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j1y OCA], [http://pdbe.org/4j1y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4j1y RCSB], [http://www.ebi.ac.uk/pdbsum/4j1y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4j1y ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 21:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4j1y" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 25:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Complement subcomponent C1s]]		[[Category: Complement subcomponent C1s]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Andrea, L D]]		[[Category: Andrea, L D]]
	[[Category: Duncan, R C]]		[[Category: Duncan, R C]]

OCA at 12:54, 21 December 2014

OCA — Sun, 21 Dec 2014 12:54:22 GMT

←Older revision		Revision as of 12:54, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4j1y\| PDB=4j1y \| SCENE= }}~~	+	==The X-ray crystal structure of human complement protease C1s zymogen==
-	===The X-ray crystal structure of human complement protease C1s zymogen===	+	<StructureSection load='4j1y' size='340' side='right' caption='[[4j1y]], [[Resolution\|resolution]] 2.66Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23592783}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4j1y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J1Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J1Y FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1elv\|1elv]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C1S ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Complement_subcomponent_C1s Complement subcomponent C1s], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.42 3.4.21.42] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j1y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4j1y RCSB], [http://www.ebi.ac.uk/pdbsum/4j1y PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/C1S_HUMAN C1S_HUMAN]] Defects in C1S are the cause of complement component C1s deficiency (C1SD) [MIM:[http://omim.org/entry/613783 613783]]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.		[[http://www.uniprot.org/uniprot/C1S_HUMAN C1S_HUMAN]] Defects in C1S are the cause of complement component C1s deficiency (C1SD) [MIM:[http://omim.org/entry/613783 613783]]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.
-		+	== Function ==
-	==Function==	+
	[[http://www.uniprot.org/uniprot/C1S_HUMAN C1S_HUMAN]] C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.		[[http://www.uniprot.org/uniprot/C1S_HUMAN C1S_HUMAN]] C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The complement system is an ancient innate immune defense pathway that plays a front-line role in eliminating microbial pathogens. Recognition of foreign targets by antibodies drives sequential activation of two serine proteases, C1r and C1s, which reside within the complement Component 1 (C1) complex. Active C1s propagates the immune response through its ability to bind and cleave the effector molecule complement Component 4 (C4). Currently, the precise structural and biochemical basis for the control of the interaction between C1s and C4 is unclear. Here, using surface plasmon resonance, we show that the transition of the C1s zymogen to the active form is essential for C1s binding to C4. To understand this, we determined the crystal structure of a zymogen C1s construct [comprising two Complement Control Protein (CCP) domains and the serine protease (SP) domain]. These data reveal that two loops (492-499 and 573-580) in the zymogen SP domain adopt a conformation that would be predicted to sterically abrogate C4 binding. The transition from zymogen to active C1s repositions both loops such that they would be able to interact with sulfotyrosine residues on C4. The structure also shows the junction of the CCP1 and CCP2 domains of C1s for the first time, yielding valuable information about the exosite for C4 binding located at this position. Together, these data provide a structural explanation for the control of the interaction with C1s and C4 and, furthermore, point to alternative strategies for developing therapeutic approaches for controlling activation of the complement cascade.

-	~~==About this Structure==~~	+	A molecular switch governs the interaction between human complement protease C1s and its substrate, complement C4.,Perry AJ, Wijeyewickrema LC, Wilmann PG, Gunzburg MJ, D'Andrea L, Irving JA, Pang SS, Duncan RC, Wilce JA, Whisstock JC, Pike RN J Biol Chem. 2013 Apr 16. PMID:23592783<ref>PMID:23592783</ref>
-	~~[[4j1y]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4J1Y OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:023592783</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Complement subcomponent C1s]]		[[Category: Complement subcomponent C1s]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Andrea, L D.]]	+	[[Category: Andrea, L D]]
-	[[Category: Duncan, R C.]]	+	[[Category: Duncan, R C]]
-	[[Category: Gunzburg, M J.]]	+	[[Category: Gunzburg, M J]]
-	[[Category: Irving, J A.]]	+	[[Category: Irving, J A]]
-	[[Category: Pang, S S.]]	+	[[Category: Pang, S S]]
-	[[Category: Perry, A J.]]	+	[[Category: Perry, A J]]
-	[[Category: Pike, R N.]]	+	[[Category: Pike, R N]]
-	[[Category: Whisstock, J C.]]	+	[[Category: Whisstock, J C]]
-	[[Category: Wijeyewickrema, L C.]]	+	[[Category: Wijeyewickrema, L C]]
-	[[Category: Wilce, J A.]]	+	[[Category: Wilce, J A]]
-	[[Category: Wilmann, P G.]]	+	[[Category: Wilmann, P G]]
	[[Category: C2]]		[[Category: C2]]
	[[Category: C4]]		[[Category: C4]]

OCA at 11:21, 3 July 2013

OCA — Wed, 03 Jul 2013 11:21:57 GMT

←Older revision		Revision as of 11:21, 3 July 2013
Line 16:		Line 16:
	[[Category: Complement subcomponent C1s]]		[[Category: Complement subcomponent C1s]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
		+	[[Category: Andrea, L D.]]
	[[Category: Duncan, R C.]]		[[Category: Duncan, R C.]]
		+	[[Category: Gunzburg, M J.]]
	[[Category: Irving, J A.]]		[[Category: Irving, J A.]]
	[[Category: Pang, S S.]]		[[Category: Pang, S S.]]
Line 23:		Line 25:
	[[Category: Whisstock, J C.]]		[[Category: Whisstock, J C.]]
	[[Category: Wijeyewickrema, L C.]]		[[Category: Wijeyewickrema, L C.]]
-	[[Category: Wilmann, P M.]]	+	[[Category: Wilce, J A.]]
		+	[[Category: Wilmann, P G.]]
	[[Category: C2]]		[[Category: C2]]
	[[Category: C4]]		[[Category: C4]]

OCA at 08:44, 19 June 2013

OCA — Wed, 19 Jun 2013 08:44:28 GMT

←Older revision		Revision as of 08:44, 19 June 2013
Line 11:		Line 11:
	==About this Structure==		==About this Structure==
	[[4j1y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J1Y OCA].		[[4j1y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J1Y OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:023592783</ref><references group="xtra"/><references/>
	[[Category: Complement subcomponent C1s]]		[[Category: Complement subcomponent C1s]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 06:46, 2 May 2013

OCA — Thu, 02 May 2013 06:46:05 GMT

←Older revision		Revision as of 06:46, 2 May 2013
Line 1:		Line 1:
	{{STRUCTURE_4j1y\| PDB=4j1y \| SCENE= }}		{{STRUCTURE_4j1y\| PDB=4j1y \| SCENE= }}
	===The X-ray crystal structure of human complement protease C1s zymogen===		===The X-ray crystal structure of human complement protease C1s zymogen===
		+	{{ABSTRACT_PUBMED_23592783}}

	==Disease==		==Disease==

OCA at 11:31, 24 April 2013

OCA — Wed, 24 Apr 2013 11:31:44 GMT

←Older revision		Revision as of 11:31, 24 April 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4j1y\| PDB=4j1y \| SCENE= }}
		+	===The X-ray crystal structure of human complement protease C1s zymogen===

-	~~The~~ entry ~~4j1y is ON HOLD until Paper Publication~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/C1S_HUMAN C1S_HUMAN]] Defects in C1S are the cause of complement component C1s deficiency (C1SD) [MIM:[http://omim.org/entry/613783 613783]]. A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.

-	~~Authors~~: ~~Perry, A~~.J., ~~Wilmann, P.M~~., ~~Wijeyewickrema~~, ~~L.C., Irving, J.A., Duncan, R.C., Pang, S.S., Pike, R.N., Whisstock, J.C~~.	+	==Function==
		+	[[http://www.uniprot.org/uniprot/C1S_HUMAN C1S_HUMAN]] C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.

-	~~Description~~: ~~The X~~-~~ray crystal structure of human complement protease~~ C1s ~~zymogen~~	+	==About this Structure==
		+	[[4j1y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J1Y OCA].
		+	[[Category: Complement subcomponent C1s]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Duncan, R C.]]
		+	[[Category: Irving, J A.]]
		+	[[Category: Pang, S S.]]
		+	[[Category: Perry, A J.]]
		+	[[Category: Pike, R N.]]
		+	[[Category: Whisstock, J C.]]
		+	[[Category: Wijeyewickrema, L C.]]
		+	[[Category: Wilmann, P M.]]
		+	[[Category: C2]]
		+	[[Category: C4]]
		+	[[Category: Extracellular]]
		+	[[Category: Hydrolase]]
		+	[[Category: Hydrolysis]]

OCA at 19:51, 17 April 2013

OCA — Wed, 17 Apr 2013 19:51:54 GMT

←Older revision		Revision as of 19:51, 17 April 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4j1y is ON HOLD	+	The entry 4j1y is ON HOLD until Paper Publication

	Authors: Perry, A.J., Wilmann, P.M., Wijeyewickrema, L.C., Irving, J.A., Duncan, R.C., Pang, S.S., Pike, R.N., Whisstock, J.C.		Authors: Perry, A.J., Wilmann, P.M., Wijeyewickrema, L.C., Irving, J.A., Duncan, R.C., Pang, S.S., Pike, R.N., Whisstock, J.C.

	Description: The X-ray crystal structure of human complement protease C1s zymogen		Description: The X-ray crystal structure of human complement protease C1s zymogen

OCA: Protected "4j1y" [edit=sysop:move=sysop]

OCA — Wed, 13 Feb 2013 10:09:42 GMT

Protected "4j1y" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:09, 13 February 2013