4j4d - Revision history

OCA at 15:36, 20 September 2023

OCA — Wed, 20 Sep 2023 15:36:02 GMT

←Older revision		Revision as of 15:36, 20 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4j4d]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Nostoc_ellipsosporum Nostoc ellipsosporum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J4D FirstGlance]. <br>		<table><tr><td colspan='2'>[[4j4d]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Nostoc_ellipsosporum Nostoc ellipsosporum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J4D FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j4d OCA], [https://pdbe.org/4j4d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j4d RCSB], [https://www.ebi.ac.uk/pdbsum/4j4d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j4d ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j4d OCA], [https://pdbe.org/4j4d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j4d RCSB], [https://www.ebi.ac.uk/pdbsum/4j4d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j4d ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 21:31, 16 November 2022

OCA — Wed, 16 Nov 2022 21:31:49 GMT

←Older revision		Revision as of 21:31, 16 November 2022
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	<StructureSection load='4j4d' size='340' side='right'caption='[[4j4d]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4j4d' size='340' side='right'caption='[[4j4d]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4j4d]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Anabaena_variabilis_var._ellipsospora Anabaena variabilis var. ellipsospora~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4D OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4J4D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4j4d]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Nostoc_ellipsosporum Nostoc ellipsosporum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J4D FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4j4c\|4j4c]], [[4j4e\|4j4e]], [[4j4f\|4j4f]], [[4j4g\|4j4g]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j4d OCA], [https://pdbe.org/4j4d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j4d RCSB], [https://www.ebi.ac.uk/pdbsum/4j4d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j4d ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4j4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j4d OCA], [~~http~~://pdbe.org/4j4d PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4j4d RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4j4d PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4j4d ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CVN_NOSEL CVN_NOSEL]] Mannose-binding lectin.<ref>PMID:9210678</ref> <ref>PMID:12678493</ref>	+	[https://www.uniprot.org/uniprot/CVN_NOSEL CVN_NOSEL] Mannose-binding lectin.<ref>PMID:9210678</ref> <ref>PMID:12678493</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Anabaena variabilis var. ellipsospora]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Gronenborn, A M~~]]	+	[[Category: Nostoc ellipsosporum]]
-	[[Category: ~~Koharudin, L M.I~~]]	+	[[Category: Gronenborn AM]]
-	[[Category: ~~Liu, L~~]]	+	[[Category: Koharudin LMI]]
-	[[Category: ~~Antiviral protein]]~~	+	[[Category: Liu L]]
-	~~[[Category: Carbohydrate binding protein]]~~	+
-	~~[[Category: Cvnh fold]]~~	+
-	~~[[Category: Sugar binding protein~~]]	+

OCA at 08:45, 3 April 2019

OCA — Wed, 03 Apr 2019 08:45:34 GMT

←Older revision		Revision as of 08:45, 3 April 2019
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	==Structure of P51G Cyanovirin-N swapped dimer in the P21212 space group==		==Structure of P51G Cyanovirin-N swapped dimer in the P21212 space group==
-	<StructureSection load='4j4d' size='340' side='right' caption='[[4j4d]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='4j4d' size='340' side='right'caption='[[4j4d]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4j4d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Anabaena_variabilis_var._ellipsospora Anabaena variabilis var. ellipsospora]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J4D FirstGlance]. <br>		<table><tr><td colspan='2'>[[4j4d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Anabaena_variabilis_var._ellipsospora Anabaena variabilis var. ellipsospora]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J4D FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Anabaena variabilis var. ellipsospora]]		[[Category: Anabaena variabilis var. ellipsospora]]
		+	[[Category: Large Structures]]
	[[Category: Gronenborn, A M]]		[[Category: Gronenborn, A M]]
	[[Category: Koharudin, L M.I]]		[[Category: Koharudin, L M.I]]

OCA at 00:05, 5 August 2016

OCA — Fri, 05 Aug 2016 00:05:05 GMT

←Older revision		Revision as of 00:05, 5 August 2016
Line 1:		Line 1:
		+
	==Structure of P51G Cyanovirin-N swapped dimer in the P21212 space group==		==Structure of P51G Cyanovirin-N swapped dimer in the P21212 space group==
	<StructureSection load='4j4d' size='340' side='right' caption='[[4j4d]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4j4d' size='340' side='right' caption='[[4j4d]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4j4d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Nostoc_ellipsosporum Nostoc ellipsosporum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J4D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4j4d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Anabaena_variabilis_var._ellipsospora Anabaena variabilis var. ellipsospora]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J4D FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4j4c\|4j4c]], [[4j4e\|4j4e]], [[4j4f\|4j4f]], [[4j4g\|4j4g]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4j4c\|4j4c]], [[4j4e\|4j4e]], [[4j4f\|4j4f]], [[4j4g\|4j4g]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j4d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4j4d RCSB], [http://www.ebi.ac.uk/pdbsum/4j4d PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j4d OCA], [http://pdbe.org/4j4d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4j4d RCSB], [http://www.ebi.ac.uk/pdbsum/4j4d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4j4d ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4j4d" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Nostoc ellipsosporum~~]]	+	[[Category: Anabaena variabilis var. ellipsospora]]
	[[Category: Gronenborn, A M]]		[[Category: Gronenborn, A M]]
	[[Category: Koharudin, L M.I]]		[[Category: Koharudin, L M.I]]

OCA at 21:01, 24 December 2014

OCA — Wed, 24 Dec 2014 21:01:19 GMT

←Older revision		Revision as of 21:01, 24 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j4d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4j4d RCSB], [http://www.ebi.ac.uk/pdbsum/4j4d PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j4d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4j4d RCSB], [http://www.ebi.ac.uk/pdbsum/4j4d PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CVN_NOSEL CVN_NOSEL]] Mannose-binding lectin.<ref>PMID:9210678</ref> <ref>PMID:12678493</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:16, 21 December 2014

OCA — Sun, 21 Dec 2014 12:16:35 GMT

←Older revision		Revision as of 12:16, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4j4d\| PDB=4j4d \| SCENE= }}~~	+	==Structure of P51G Cyanovirin-N swapped dimer in the P21212 space group==
-	===Structure of P51G Cyanovirin-N swapped dimer in the P21212 space group===	+	<StructureSection load='4j4d' size='340' side='right' caption='[[4j4d]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23610431}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4j4d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Nostoc_ellipsosporum Nostoc ellipsosporum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J4D FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4j4c\|4j4c]], [[4j4e\|4j4e]], [[4j4f\|4j4f]], [[4j4g\|4j4g]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j4d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4j4d RCSB], [http://www.ebi.ac.uk/pdbsum/4j4d PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Although it has long been established that the amino acid sequence encodes the fold of a protein, how individual proteins arrive at their final conformation is still difficult to predict, especially for oligomeric structures. Here, we present a comprehensive characterization of oligomeric species of cyanovirin-N that all are formed by a polypeptide chain with the identical amino acid sequence. Structures of the oligomers were determined by X-ray crystallography, and each one exhibits 3D domain swapping. One unique 3D domain-swapped structure is observed for the trimer, while for both dimer and tetramer, two different 3D domain-swapped structures were obtained. In addition to the previously identified hinge-loop region of the 3D domain-swapped dimer, which resides between strands beta5 and beta6 in the middle of the polypeptide sequence, another hinge-loop region is observed between strands beta7 and beta8 in the structures. Plasticity in these two regions allows for variability in dihedral angles and concomitant differences in chain conformation that results in the differently 3D domain-swapped multimers. Based on all of the different structures, we propose possible folding pathways for this protein. Altogether, our results illuminate the amazing ability of cyanovirin-N to proceed down different folding paths and provide general insights into oligomer formation via 3D domain swapping.

-	~~==Function==~~	+	Different 3D domain-swapped oligomeric cyanovirin-N structures suggest trapped folding intermediates.,Koharudin LM, Liu L, Gronenborn AM Proc Natl Acad Sci U S A. 2013 Apr 22. PMID:23610431<ref>PMID:23610431</ref>
-	~~[[http://www~~.~~uniprot~~.~~org/uniprot/CVN_NOSEL CVN_NOSEL]] Mannose-binding lectin~~.~~<ref>~~PMID:~~9210678</ref>~~ <ref>PMID:~~12678493~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4j4d]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Nostoc_ellipsosporum Nostoc ellipsosporum]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4J4D OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:023610431</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Nostoc ellipsosporum]]		[[Category: Nostoc ellipsosporum]]
-	[[Category: Gronenborn, A M.]]	+	[[Category: Gronenborn, A M]]
-	[[Category: Koharudin, L M.I.]]	+	[[Category: Koharudin, L M.I]]
-	[[Category: Liu, L.]]	+	[[Category: Liu, L]]
	[[Category: Antiviral protein]]		[[Category: Antiviral protein]]
	[[Category: Carbohydrate binding protein]]		[[Category: Carbohydrate binding protein]]
	[[Category: Cvnh fold]]		[[Category: Cvnh fold]]
	[[Category: Sugar binding protein]]		[[Category: Sugar binding protein]]

OCA at 06:40, 20 June 2013

OCA — Thu, 20 Jun 2013 06:40:13 GMT

←Older revision		Revision as of 06:40, 20 June 2013
Line 10:		Line 10:

	==Reference==		==Reference==
-	<references group="xtra"/><references/>	+	<ref group="xtra">PMID:023610431</ref><references group="xtra"/><references/>
	[[Category: Nostoc ellipsosporum]]		[[Category: Nostoc ellipsosporum]]
	[[Category: Gronenborn, A M.]]		[[Category: Gronenborn, A M.]]

OCA at 06:55, 8 May 2013

OCA — Wed, 08 May 2013 06:55:08 GMT

←Older revision		Revision as of 06:55, 8 May 2013
Line 1:		Line 1:
	{{STRUCTURE_4j4d\| PDB=4j4d \| SCENE= }}		{{STRUCTURE_4j4d\| PDB=4j4d \| SCENE= }}
	===Structure of P51G Cyanovirin-N swapped dimer in the P21212 space group===		===Structure of P51G Cyanovirin-N swapped dimer in the P21212 space group===
		+	{{ABSTRACT_PUBMED_23610431}}

	==Function==		==Function==

OCA at 01:52, 4 April 2013

OCA — Thu, 04 Apr 2013 01:52:43 GMT

←Older revision		Revision as of 01:52, 4 April 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4j4d\| PDB=4j4d \| SCENE= }}
		+	===Structure of P51G Cyanovirin-N swapped dimer in the P21212 space group===

-	~~The entry 4j4d is ON HOLD~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/CVN_NOSEL CVN_NOSEL]] Mannose-binding lectin.<ref>PMID:9210678</ref> <ref>PMID:12678493</ref>

-	~~Authors~~: ~~Koharudin, L~~.M.I.~~, Liu, L~~.~~, Gronenborn, A~~.M.	+	==About this Structure==
		+	[[4j4d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Nostoc_ellipsosporum Nostoc ellipsosporum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4D OCA].

-	~~Description: Structure of P51G Cyanovirin-N swapped dimer in the P21212 space~~ group	+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Nostoc ellipsosporum]]
		+	[[Category: Gronenborn, A M.]]
		+	[[Category: Koharudin, L M.I.]]
		+	[[Category: Liu, L.]]
		+	[[Category: Antiviral protein]]
		+	[[Category: Carbohydrate binding protein]]
		+	[[Category: Cvnh fold]]
		+	[[Category: Sugar binding protein]]

OCA: Protected "4j4d" [edit=sysop:move=sysop]

OCA — Wed, 13 Feb 2013 10:12:26 GMT

Protected "4j4d" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:12, 13 February 2013