4j4l - Revision history

OCA at 14:20, 8 November 2023

OCA — Wed, 08 Nov 2023 14:20:36 GMT

←Older revision		Revision as of 14:20, 8 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4j4l]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Eptatretus_burgeri Eptatretus burgeri], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogenes] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J4L FirstGlance]. <br>		<table><tr><td colspan='2'>[[4j4l]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Eptatretus_burgeri Eptatretus burgeri], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogenes] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J4L FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j4l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j4l OCA], [https://pdbe.org/4j4l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j4l RCSB], [https://www.ebi.ac.uk/pdbsum/4j4l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j4l ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j4l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j4l OCA], [https://pdbe.org/4j4l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j4l RCSB], [https://www.ebi.ac.uk/pdbsum/4j4l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j4l ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 21:32, 16 November 2022

OCA — Wed, 16 Nov 2022 21:32:07 GMT

←Older revision		Revision as of 21:32, 16 November 2022
Line 3:		Line 3:
	<StructureSection load='4j4l' size='340' side='right'caption='[[4j4l]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4j4l' size='340' side='right'caption='[[4j4l]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4j4l]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4L OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4J4L FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4j4l]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Eptatretus_burgeri Eptatretus burgeri], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogenes] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J4L FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4j4l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j4l OCA], [~~http~~://pdbe.org/4j4l PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4j4l RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4j4l PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4j4l ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j4l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j4l OCA], [https://pdbe.org/4j4l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j4l RCSB], [https://www.ebi.ac.uk/pdbsum/4j4l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j4l ProSAT]</span></td></tr>
	</table>		</table>
-	== Disease ==
-	[[http://www.uniprot.org/uniprot/IL6_HUMAN IL6_HUMAN]] Genetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[http://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis. Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~IL6_HUMAN IL6_HUMAN~~]~~] Cytokine with a wide variety of biological functions~~. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance.	+	[https://www.uniprot.org/uniprot/Q4G1L3_EPTBU Q4G1L3_EPTBU] [https://www.uniprot.org/uniprot/A4L9V2_LISMN A4L9V2_LISMN]

	==See Also==		==See Also==
	*[[Interleukin 3D structures\|Interleukin 3D structures]]		*[[Interleukin 3D structures\|Interleukin 3D structures]]
-	*[[Variable lymphocyte receptor\|Variable lymphocyte receptor]]	+	*[[Variable lymphocyte receptor 3D structures\|Variable lymphocyte receptor 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Eptatretus burgeri]]
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Cheong, H K~~]]	+	[[Category: Listeria monocytogenes]]
-	[[Category: ~~Kim, H J~~]]	+	[[Category: Synthetic construct]]
-	[[Category: ~~Extracellular matrix~~]]	+	[[Category: Cheong HK]]
-	[[Category: ~~Il-6 binding]]~~	+	[[Category: Kim HJ]]
-	~~[[Category: Interleukin 6]]~~	+
-	~~[[Category: Lrr]]~~	+
-	~~[[Category: Protein binding-cytokine complex~~]]	+

OCA at 05:15, 13 February 2020

OCA — Thu, 13 Feb 2020 05:15:15 GMT

←Older revision		Revision as of 05:15, 13 February 2020
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	==Modular evolution and design of the protein binding interface==		==Modular evolution and design of the protein binding interface==
-	<StructureSection load='4j4l' size='340' side='right' caption='[[4j4l]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='4j4l' size='340' side='right'caption='[[4j4l]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4j4l]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J4L FirstGlance]. <br>		<table><tr><td colspan='2'>[[4j4l]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J4L FirstGlance]. <br>
Line 12:		Line 12:

	==See Also==		==See Also==
-	*[[Interleukin\|Interleukin]]	+	*[[Interleukin 3D structures\|Interleukin 3D structures]]
		+	*[[Variable lymphocyte receptor\|Variable lymphocyte receptor]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Cheong, H K]]		[[Category: Cheong, H K]]
	[[Category: Kim, H J]]		[[Category: Kim, H J]]

OCA at 11:12, 16 November 2017

OCA — Thu, 16 Nov 2017 11:12:36 GMT

←Older revision		Revision as of 11:12, 16 November 2017
Line 13:		Line 13:
	==See Also==		==See Also==
	*[[Interleukin\|Interleukin]]		*[[Interleukin\|Interleukin]]
-	*[[Variable lymphocyte receptor\|Variable lymphocyte receptor]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 09:09, 3 August 2017

OCA — Thu, 03 Aug 2017 09:09:13 GMT

←Older revision		Revision as of 09:09, 3 August 2017
Line 3:		Line 3:
	<StructureSection load='4j4l' size='340' side='right' caption='[[4j4l]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4j4l' size='340' side='right' caption='[[4j4l]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4j4l]] is a 4 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Bdellostoma_burgeri Bdellostoma burgeri] and [http://en.wikipedia.org/wiki/Human Human]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J4L FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4j4l]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J4L FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">inlB, VLRB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7764 Bdellostoma burgeri]), IL6, IFNB2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j4l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j4l OCA], [http://pdbe.org/4j4l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4j4l RCSB], [http://www.ebi.ac.uk/pdbsum/4j4l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4j4l ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j4l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j4l OCA], [http://pdbe.org/4j4l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4j4l RCSB], [http://www.ebi.ac.uk/pdbsum/4j4l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4j4l ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
Line 17:		Line 16:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bdellostoma burgeri]]
-	[[Category: Human]]
	[[Category: Cheong, H K]]		[[Category: Cheong, H K]]
	[[Category: Kim, H J]]		[[Category: Kim, H J]]

OCA at 11:09, 5 August 2016

OCA — Fri, 05 Aug 2016 11:09:19 GMT

←Older revision		Revision as of 11:09, 5 August 2016
Line 1:		Line 1:
-	{{STRUCTURE_4j4l\| PDB=4j4l \| SCENE= }}
-	===Modular evolution and design of the protein binding interface===

-	==Disease==	+	==Modular evolution and design of the protein binding interface==
		+	<StructureSection load='4j4l' size='340' side='right' caption='[[4j4l]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4j4l]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bdellostoma_burgeri Bdellostoma burgeri] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J4L FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">inlB, VLRB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7764 Bdellostoma burgeri]), IL6, IFNB2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j4l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j4l OCA], [http://pdbe.org/4j4l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4j4l RCSB], [http://www.ebi.ac.uk/pdbsum/4j4l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4j4l ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/IL6_HUMAN IL6_HUMAN]] Genetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[http://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis. Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men.		[[http://www.uniprot.org/uniprot/IL6_HUMAN IL6_HUMAN]] Genetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[http://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis. Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men.
-		+	== Function ==
-	==Function==	+
	[[http://www.uniprot.org/uniprot/IL6_HUMAN IL6_HUMAN]] Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance.		[[http://www.uniprot.org/uniprot/IL6_HUMAN IL6_HUMAN]] Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance.

-	==~~About this Structure~~==	+	==See Also==
-	[[~~4j4l~~]] ~~is a 4 chain structure. Full crystallographic information is available from~~ [~~http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4J4L OCA~~].	+	*[[Interleukin\|Interleukin]]
-	[[Category: Cheong, H K.]]	+	*[[Variable lymphocyte receptor\|Variable lymphocyte receptor]]
-	[[Category: Kim, H J.]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Bdellostoma burgeri]]
		+	[[Category: Human]]
		+	[[Category: Cheong, H K]]
		+	[[Category: Kim, H J]]
	[[Category: Extracellular matrix]]		[[Category: Extracellular matrix]]
	[[Category: Il-6 binding]]		[[Category: Il-6 binding]]

OCA at 05:17, 13 February 2014

OCA — Thu, 13 Feb 2014 05:17:10 GMT

←Older revision		Revision as of 05:17, 13 February 2014
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4j4l\| PDB=4j4l \| SCENE= }}
		+	===Modular evolution and design of the protein binding interface===

-	~~The~~ entry ~~4j4l is ON HOLD~~ ~~until Paper Publication~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/IL6_HUMAN IL6_HUMAN]] Genetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[http://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis. Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men.

-	~~Authors~~: ~~Cheong, H~~.K., ~~Kim~~, H.J.	+	==Function==
		+	[[http://www.uniprot.org/uniprot/IL6_HUMAN IL6_HUMAN]] Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance.

-	~~Description~~: ~~Modulating the affinity of protein binders by modular design and evolution~~	+	==About this Structure==
		+	[[4j4l]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4L OCA].
		+	[[Category: Cheong, H K.]]
		+	[[Category: Kim, H J.]]
		+	[[Category: Extracellular matrix]]
		+	[[Category: Il-6 binding]]
		+	[[Category: Interleukin 6]]
		+	[[Category: Lrr]]
		+	[[Category: Protein binding-cytokine complex]]

OCA at 14:23, 27 February 2013

OCA — Wed, 27 Feb 2013 14:23:37 GMT

←Older revision		Revision as of 14:23, 27 February 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4j4l is ON HOLD	+	The entry 4j4l is ON HOLD until Paper Publication

	Authors: Cheong, H.K., Kim, H.J.		Authors: Cheong, H.K., Kim, H.J.

	Description: Modulating the affinity of protein binders by modular design and evolution		Description: Modulating the affinity of protein binders by modular design and evolution

OCA: Protected "4j4l" [edit=sysop:move=sysop]

OCA — Wed, 13 Feb 2013 10:12:41 GMT

Protected "4j4l" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:12, 13 February 2013

OCA: New page: '''Unreleased structure''' The entry 4j4l is ON HOLD Authors: Cheong, H.K., Kim, H.J. Description: Modulating the affinity of protein binders by modular design and evolution

OCA — Wed, 13 Feb 2013 10:12:40 GMT

New page: '''Unreleased structure''' The entry 4j4l is ON HOLD Authors: Cheong, H.K., Kim, H.J. Description: Modulating the affinity of protein binders by modular design and evolution

New page

'''Unreleased structure'''

The entry 4j4l is ON HOLD

Authors: Cheong, H.K., Kim, H.J.

Description: Modulating the affinity of protein binders by modular design and evolution