4j4q - Revision history

OCA at 14:20, 8 November 2023

OCA — Wed, 08 Nov 2023 14:20:42 GMT

←Older revision		Revision as of 14:20, 8 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4j4q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J4Q FirstGlance]. <br>		<table><tr><td colspan='2'>[[4j4q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J4Q FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=PRD_900006:trehalose'>PRD_900006</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.65Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=PRD_900006:trehalose'>PRD_900006</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j4q OCA], [https://pdbe.org/4j4q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j4q RCSB], [https://www.ebi.ac.uk/pdbsum/4j4q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j4q ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j4q OCA], [https://pdbe.org/4j4q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j4q RCSB], [https://www.ebi.ac.uk/pdbsum/4j4q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j4q ProSAT]</span></td></tr>
	</table>		</table>

OCA at 21:32, 16 November 2022

OCA — Wed, 16 Nov 2022 21:32:27 GMT

←Older revision		Revision as of 21:32, 16 November 2022
Line 3:		Line 3:
	<StructureSection load='4j4q' size='340' side='right'caption='[[4j4q]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='4j4q' size='340' side='right'caption='[[4j4q]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4j4q]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4Q OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4J4Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4j4q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J4Q FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=~~SO4~~:~~SULFATE+ION~~'>~~SO4~~</scene>, <scene name='pdbligand=~~TRE~~:~~TREHALOSE~~'>~~TRE~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=PRD_900006:trehalose'>PRD_900006</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4j4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j4q OCA], [~~http~~://pdbe.org/4j4q PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4j4q RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4j4q PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4j4q ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j4q OCA], [https://pdbe.org/4j4q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j4q RCSB], [https://www.ebi.ac.uk/pdbsum/4j4q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j4q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/OPSD_BOVIN OPSD_BOVIN]] Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).<ref>PMID:16908857</ref> <ref>PMID:17060607</ref> [[http://www.uniprot.org/uniprot/GNAT1_BOVIN GNAT1_BOVIN]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.	+	[https://www.uniprot.org/uniprot/OPSD_BOVIN OPSD_BOVIN] Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).<ref>PMID:16908857</ref> <ref>PMID:17060607</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[Rhodopsin\|Rhodopsin]]	+	*[[Rhodopsin 3D structures\|Rhodopsin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 27:
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Choe~~, H W~~]]	+	[[Category: Choe HW]]
-	[[Category: Ernst~~, O P~~]]	+	[[Category: Ernst OP]]
-	[[Category: Hofmann~~, K P~~]]	+	[[Category: Hofmann KP]]
-	[[Category: Hong~~, J E~~]]	+	[[Category: Hong JE]]
-	[[Category: Li, Y]]	+	[[Category: Li Y]]
-	[[Category: Morizumi, T]]	+	[[Category: Morizumi T]]
-	[[Category: Pai~~, E F~~]]	+	[[Category: Pai EF]]
-	[[Category: Park~~, J H]]~~	+	[[Category: Park JH]]
-	~~[[Category: G-protein coupled receptor]]~~	+
-	~~[[Category: Galpha subunit]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Gtp-binding]]~~	+
-	~~[[Category: Lipoprotein]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Myristate]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Photoreceptor protein]]~~	+
-	~~[[Category: Receptor retinal protein]]~~	+
-	~~[[Category: Retinal binding]]~~	+
-	~~[[Category: Sensory transduction]]~~	+
-	~~[[Category: Signaling protein]]~~	+
-	~~[[Category: Transducer]]~~	+
-	~~[[Category: Transmembrane~~]]	+

OCA at 09:48, 3 April 2019

OCA — Wed, 03 Apr 2019 09:48:55 GMT

←Older revision		Revision as of 09:48, 3 April 2019
Line 1:		Line 1:

	==Crystal structure of active conformation of GPCR opsin stabilized by octylglucoside==		==Crystal structure of active conformation of GPCR opsin stabilized by octylglucoside==
-	<StructureSection load='4j4q' size='340' side='right' caption='[[4j4q]], [[Resolution\|resolution]] 2.65Å' scene=''>	+	<StructureSection load='4j4q' size='340' side='right'caption='[[4j4q]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4j4q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J4Q FirstGlance]. <br>		<table><tr><td colspan='2'>[[4j4q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J4Q FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=~~PLM~~:~~PALMITIC+ACID~~'>~~PLM~~</scene>, <scene name='pdbligand=~~SO4~~:~~SULFATE+ION~~'>~~SO4~~</scene>, <scene name='pdbligand=~~TRE~~:~~TREHALOSE~~'>~~TRE~~</scene>, <scene name='pdbligand=~~MAN~~:~~ALPHA-D-MANNOSE~~'>~~MAN~~</scene>, <scene name='pdbligand=~~NAG~~:~~N-ACETYL-D-GLUCOSAMINE~~'>~~NAG~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRE:TREHALOSE'>TRE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j4q OCA], [http://pdbe.org/4j4q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4j4q RCSB], [http://www.ebi.ac.uk/pdbsum/4j4q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4j4q ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j4q OCA], [http://pdbe.org/4j4q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4j4q RCSB], [http://www.ebi.ac.uk/pdbsum/4j4q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4j4q ProSAT]</span></td></tr>
	</table>		</table>
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
		+	[[Category: Large Structures]]
	[[Category: Choe, H W]]		[[Category: Choe, H W]]
	[[Category: Ernst, O P]]		[[Category: Ernst, O P]]

OCA at 11:43, 5 August 2016

OCA — Fri, 05 Aug 2016 11:43:16 GMT

←Older revision		Revision as of 11:43, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of active conformation of GPCR opsin stabilized by octylglucoside==		==Crystal structure of active conformation of GPCR opsin stabilized by octylglucoside==
	<StructureSection load='4j4q' size='340' side='right' caption='[[4j4q]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='4j4q' size='340' side='right' caption='[[4j4q]], [[Resolution\|resolution]] 2.65Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4j4q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J4Q FirstGlance]. <br>		<table><tr><td colspan='2'>[[4j4q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J4Q FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRE:TREHALOSE'>TRE</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRE:TREHALOSE'>TRE</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j4q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4j4q RCSB], [http://www.ebi.ac.uk/pdbsum/4j4q PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j4q OCA], [http://pdbe.org/4j4q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4j4q RCSB], [http://www.ebi.ac.uk/pdbsum/4j4q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4j4q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4j4q" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 18:32, 25 December 2014

OCA — Thu, 25 Dec 2014 18:32:13 GMT

←Older revision		Revision as of 18:32, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j4q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4j4q RCSB], [http://www.ebi.ac.uk/pdbsum/4j4q PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j4q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4j4q RCSB], [http://www.ebi.ac.uk/pdbsum/4j4q PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/OPSD_BOVIN OPSD_BOVIN]] Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).<ref>PMID:16908857</ref> <ref>PMID:17060607</ref> [[http://www.uniprot.org/uniprot/GNAT1_BOVIN GNAT1_BOVIN]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 13:12, 21 December 2014

OCA — Sun, 21 Dec 2014 13:12:13 GMT

←Older revision		Revision as of 13:12, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4j4q\| PDB=4j4q \| SCENE= }}~~	+	==Crystal structure of active conformation of GPCR opsin stabilized by octylglucoside==
-	===Crystal structure of active conformation of GPCR opsin stabilized by octylglucoside===	+	<StructureSection load='4j4q' size='340' side='right' caption='[[4j4q]], [[Resolution\|resolution]] 2.65Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24038729}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4j4q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J4Q FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRE:TREHALOSE'>TRE</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j4q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4j4q RCSB], [http://www.ebi.ac.uk/pdbsum/4j4q PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Receptor-ligand interaction: Olfactory receptors (ORs) are G-protein-coupled receptors (GPCRs), which detect signaling molecules such as hormones and odorants. The structure of opsin, the GPCR employed in vision, with a detergent molecule bound deep in its orthosteric ligand-binding pocket provides a template for OR homology modeling, thus enabling investigation of the structural basis of the mechanism of odorant-receptor recognition.

-	~~==Function==~~	+	Opsin, a structural model for olfactory receptors?,Park JH, Morizumi T, Li Y, Hong JE, Pai EF, Hofmann KP, Choe HW, Ernst OP Angew Chem Int Ed Engl. 2013 Oct 11;52(42):11021-4. doi: 10.1002/anie.201302374. , Epub 2013 Aug 26. PMID:24038729<ref>PMID:24038729</ref>
-	~~[[http~~:~~//www~~.~~uniprot~~.~~org~~/~~uniprot/OPSD_BOVIN OPSD_BOVIN]] Photoreceptor required for image-forming vision at low light intensity~~. ~~Required for photoreceptor cell viability after birth~~. ~~Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity)~~.~~<ref>~~PMID:~~16908857</ref>~~ <ref>PMID:~~17060607~~</ref> [[http://www.uniprot.org/uniprot/GNAT1_BOVIN GNAT1_BOVIN]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4j4q]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bos_taurus Bos taurus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4J4Q OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:024038729</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Rhodopsin\|Rhodopsin]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
-	[[Category: Choe, H W.]]	+	[[Category: Choe, H W]]
-	[[Category: Ernst, O P.]]	+	[[Category: Ernst, O P]]
-	[[Category: Hofmann, K P.]]	+	[[Category: Hofmann, K P]]
-	[[Category: Hong, J E.]]	+	[[Category: Hong, J E]]
-	[[Category: Li, Y.]]	+	[[Category: Li, Y]]
-	[[Category: Morizumi, T.]]	+	[[Category: Morizumi, T]]
-	[[Category: Pai, E F.]]	+	[[Category: Pai, E F]]
-	[[Category: Park, J H.]]	+	[[Category: Park, J H]]
	[[Category: G-protein coupled receptor]]		[[Category: G-protein coupled receptor]]
	[[Category: Galpha subunit]]		[[Category: Galpha subunit]]

OCA at 09:44, 30 October 2013

OCA — Wed, 30 Oct 2013 09:44:10 GMT

←Older revision		Revision as of 09:44, 30 October 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4j4q\| PDB=4j4q \| SCENE= }}
		+	===Crystal structure of active conformation of GPCR opsin stabilized by octylglucoside===
		+	{{ABSTRACT_PUBMED_24038729}}

-	~~The entry 4j4q is ON HOLD~~ ~~until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/OPSD_BOVIN OPSD_BOVIN]] Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).<ref>PMID:16908857</ref> <ref>PMID:17060607</ref> [[http://www.uniprot.org/uniprot/GNAT1_BOVIN GNAT1_BOVIN]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.

-	~~Authors~~: ~~Park, J~~.H.~~, Morizumi, T~~.~~, Li, Y., Hong, J.E., Pai, E.F., Hofmann, K.P., Choe, H~~.W.~~, Ernst, O~~.P.	+	==About this Structure==
		+	[[4j4q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4Q OCA].

-	~~Description~~: ~~Crystal structure of active conformation of GPCR opsin stabilized by octylglucoside~~	+	==Reference==
		+	<ref group="xtra">PMID:024038729</ref><references group="xtra"/><references/>
		+	[[Category: Bos taurus]]
		+	[[Category: Choe, H W.]]
		+	[[Category: Ernst, O P.]]
		+	[[Category: Hofmann, K P.]]
		+	[[Category: Hong, J E.]]
		+	[[Category: Li, Y.]]
		+	[[Category: Morizumi, T.]]
		+	[[Category: Pai, E F.]]
		+	[[Category: Park, J H.]]
		+	[[Category: G-protein coupled receptor]]
		+	[[Category: Galpha subunit]]
		+	[[Category: Glycoprotein]]
		+	[[Category: Gtp-binding]]
		+	[[Category: Lipoprotein]]
		+	[[Category: Membrane]]
		+	[[Category: Myristate]]
		+	[[Category: Nucleotide-binding]]
		+	[[Category: Photoreceptor protein]]
		+	[[Category: Receptor retinal protein]]
		+	[[Category: Retinal binding]]
		+	[[Category: Sensory transduction]]
		+	[[Category: Signaling protein]]
		+	[[Category: Transducer]]
		+	[[Category: Transmembrane]]

OCA at 19:52, 17 April 2013

OCA — Wed, 17 Apr 2013 19:52:08 GMT

←Older revision		Revision as of 19:52, 17 April 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4j4q is ON HOLD	+	The entry 4j4q is ON HOLD until Paper Publication

	Authors: Park, J.H., Morizumi, T., Li, Y., Hong, J.E., Pai, E.F., Hofmann, K.P., Choe, H.W., Ernst, O.P.		Authors: Park, J.H., Morizumi, T., Li, Y., Hong, J.E., Pai, E.F., Hofmann, K.P., Choe, H.W., Ernst, O.P.

	Description: Crystal structure of active conformation of GPCR opsin stabilized by octylglucoside		Description: Crystal structure of active conformation of GPCR opsin stabilized by octylglucoside

OCA: Protected "4j4q" [edit=sysop:move=sysop]

OCA — Wed, 13 Feb 2013 10:12:50 GMT

Protected "4j4q" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:12, 13 February 2013

OCA: New page: '''Unreleased structure''' The entry 4j4q is ON HOLD Authors: Park, J.H., Morizumi, T., Li, Y., Hong, J.E., Pai, E.F., Hofmann, K.P., Choe, H.W., Ernst, O.P. Description: Crystal struc...

OCA — Wed, 13 Feb 2013 10:12:49 GMT

New page: '''Unreleased structure''' The entry 4j4q is ON HOLD Authors: Park, J.H., Morizumi, T., Li, Y., Hong, J.E., Pai, E.F., Hofmann, K.P., Choe, H.W., Ernst, O.P. Description: Crystal struc...

New page

'''Unreleased structure'''

The entry 4j4q is ON HOLD

Authors: Park, J.H., Morizumi, T., Li, Y., Hong, J.E., Pai, E.F., Hofmann, K.P., Choe, H.W., Ernst, O.P.

Description: Crystal structure of active conformation of GPCR opsin stabilized by octylglucoside