4j51 - Revision history

OCA at 15:36, 20 September 2023

OCA — Wed, 20 Sep 2023 15:36:08 GMT

←Older revision		Revision as of 15:36, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4j51]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J51 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J51 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4j51]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J51 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J51 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=N75:3-[(3-CHLOROPHENYL)ETHYNYL]-2-{4-[2-(CYCLOPROPYLAMINO)-2-OXOETHOXY]PHENYL}-6-HYDROXY-1-BENZOFURAN-5-CARBOXYLIC+ACID'>N75</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=N75:3-[(3-CHLOROPHENYL)ETHYNYL]-2-{4-[2-(CYCLOPROPYLAMINO)-2-OXOETHOXY]PHENYL}-6-HYDROXY-1-BENZOFURAN-5-CARBOXYLIC+ACID'>N75</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j51 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j51 OCA], [https://pdbe.org/4j51 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j51 RCSB], [https://www.ebi.ac.uk/pdbsum/4j51 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j51 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j51 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j51 OCA], [https://pdbe.org/4j51 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j51 RCSB], [https://www.ebi.ac.uk/pdbsum/4j51 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j51 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 21:32, 16 November 2022

OCA — Wed, 16 Nov 2022 21:32:57 GMT

←Older revision		Revision as of 21:32, 16 November 2022
Line 1:		Line 1:

	==Cyrstal structure of protein tyrosine phosphatase Lyp catalytic domain complex with small molecular inhibitor L75N04==		==Cyrstal structure of protein tyrosine phosphatase Lyp catalytic domain complex with small molecular inhibitor L75N04==
-	<StructureSection load='4j51' size='340' side='right' caption='[[4j51]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='4j51' size='340' side='right'caption='[[4j51]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4j51]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J51 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4J51 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4j51]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J51 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J51 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=N75:3-[(3-CHLOROPHENYL)ETHYNYL]-2-{4-[2-(CYCLOPROPYLAMINO)-2-OXOETHOXY]PHENYL}-6-HYDROXY-1-BENZOFURAN-5-CARBOXYLIC+ACID'>N75</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=N75:3-[(3-CHLOROPHENYL)ETHYNYL]-2-{4-[2-(CYCLOPROPYLAMINO)-2-OXOETHOXY]PHENYL}-6-HYDROXY-1-BENZOFURAN-5-CARBOXYLIC+ACID'>N75</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PTPN22, PTPN8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j51 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j51 OCA], [https://pdbe.org/4j51 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j51 RCSB], [https://www.ebi.ac.uk/pdbsum/4j51 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j51 ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4j51 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j51 OCA], [~~http~~://pdbe.org/4j51 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4j51 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4j51 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4j51 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/PTN22_HUMAN PTN22_HUMAN]] Defects in PTPN22 are a cause of susceptibility to systemic lupus erythematosus (SLE) [MIM:[~~http~~://omim.org/entry/152700 152700]]. SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.<ref>PMID:15273934</ref>	+	[https://www.uniprot.org/uniprot/PTN22_HUMAN PTN22_HUMAN] Defects in PTPN22 are a cause of susceptibility to systemic lupus erythematosus (SLE) [MIM:[https://omim.org/entry/152700 152700]. SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.<ref>PMID:15273934</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PTN22_HUMAN PTN22_HUMAN]] Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules. Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue. Dephosphorylates ZAP70 at its activating 'Tyr-493' residue. Dephosphorylates the immune system activator SKAP2.<ref>PMID:16461343</ref> <ref>PMID:18056643</ref> <ref>PMID:19167335</ref> <ref>PMID:21719704</ref>	+	[https://www.uniprot.org/uniprot/PTN22_HUMAN PTN22_HUMAN] Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules. Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue. Dephosphorylates ZAP70 at its activating 'Tyr-493' residue. Dephosphorylates the immune system activator SKAP2.<ref>PMID:16461343</ref> <ref>PMID:18056643</ref> <ref>PMID:19167335</ref> <ref>PMID:21719704</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 22:

	==See Also==		==See Also==
-	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]	+	*[[Tyrosine phosphatase 3D structures\|Tyrosine phosphatase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Protein-tyrosine-phosphatase~~]]	+	[[Category: Large Structures]]
-	[[Category: He, Y]]	+	[[Category: He Y]]
-	[[Category: Liu, D]]	+	[[Category: Liu D]]
-	[[Category: Zhang, Z Y]]	+	[[Category: Zhang Z-Y]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Inhibitor design]]~~	+
-	~~[[Category: Tyrosine phosphatase~~]]	+

OCA at 01:49, 5 August 2016

OCA — Fri, 05 Aug 2016 01:49:51 GMT

←Older revision		Revision as of 01:49, 5 August 2016
Line 1:		Line 1:
		+
	==Cyrstal structure of protein tyrosine phosphatase Lyp catalytic domain complex with small molecular inhibitor L75N04==		==Cyrstal structure of protein tyrosine phosphatase Lyp catalytic domain complex with small molecular inhibitor L75N04==
	<StructureSection load='4j51' size='340' side='right' caption='[[4j51]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4j51' size='340' side='right' caption='[[4j51]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4j51]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J51 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J51 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4j51]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J51 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J51 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=N75:3-[(3-CHLOROPHENYL)ETHYNYL]-2-{4-[2-(CYCLOPROPYLAMINO)-2-OXOETHOXY]PHENYL}-6-HYDROXY-1-BENZOFURAN-5-CARBOXYLIC+ACID'>N75</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=N75:3-[(3-CHLOROPHENYL)ETHYNYL]-2-{4-[2-(CYCLOPROPYLAMINO)-2-OXOETHOXY]PHENYL}-6-HYDROXY-1-BENZOFURAN-5-CARBOXYLIC+ACID'>N75</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PTPN22, PTPN8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PTPN22, PTPN8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j51 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j51 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4j51 RCSB], [http://www.ebi.ac.uk/pdbsum/4j51 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j51 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j51 OCA], [http://pdbe.org/4j51 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4j51 RCSB], [http://www.ebi.ac.uk/pdbsum/4j51 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4j51 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 21:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4j51" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 27:		Line 29:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Protein-tyrosine-phosphatase]]		[[Category: Protein-tyrosine-phosphatase]]
	[[Category: He, Y]]		[[Category: He, Y]]

OCA at 12:38, 21 December 2014

OCA — Sun, 21 Dec 2014 12:38:30 GMT

←Older revision		Revision as of 12:38, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4j51\| PDB=4j51 \| SCENE= }}~~	+	==Cyrstal structure of protein tyrosine phosphatase Lyp catalytic domain complex with small molecular inhibitor L75N04==
-	===Cyrstal structure of protein tyrosine phosphatase Lyp catalytic domain complex with small molecular inhibitor L75N04===	+	<StructureSection load='4j51' size='340' side='right' caption='[[4j51]], [[Resolution\|resolution]] 2.30Å' scene=''>
-	{~~{ABSTRACT_PUBMED_23713581}~~}	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4j51]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J51 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J51 FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=N75:3-[(3-CHLOROPHENYL)ETHYNYL]-2-{4-[2-(CYCLOPROPYLAMINO)-2-OXOETHOXY]PHENYL}-6-HYDROXY-1-BENZOFURAN-5-CARBOXYLIC+ACID'>N75</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PTPN22, PTPN8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j51 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j51 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4j51 RCSB], [http://www.ebi.ac.uk/pdbsum/4j51 PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/PTN22_HUMAN PTN22_HUMAN]] Defects in PTPN22 are a cause of susceptibility to systemic lupus erythematosus (SLE) [MIM:[http://omim.org/entry/152700 152700]]. SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.<ref>PMID:15273934</ref>		[[http://www.uniprot.org/uniprot/PTN22_HUMAN PTN22_HUMAN]] Defects in PTPN22 are a cause of susceptibility to systemic lupus erythematosus (SLE) [MIM:[http://omim.org/entry/152700 152700]]. SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.<ref>PMID:15273934</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PTN22_HUMAN PTN22_HUMAN]] Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules. Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue. Dephosphorylates ZAP70 at its activating 'Tyr-493' residue. Dephosphorylates the immune system activator SKAP2.<ref>PMID:16461343</ref> <ref>PMID:18056643</ref> <ref>PMID:19167335</ref> <ref>PMID:21719704</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Lymphoid-specific tyrosine phosphatase (LYP), a member of the protein tyrosine phosphatase (PTP) family of signaling enzymes, is associated with a broad spectrum of autoimmune diseases. Herein we describe our structure-based lead optimization efforts within a 6-hydroxy-benzofuran-5-carboxylic acid series culminating in the identification of compound 8b, a potent and selective inhibitor of LYP with a Ki value of 110 nM and more than 9-fold selectivity over a large panel of PTPs. The structure of LYP in complex with 8b was obtained by X-ray crystallography, providing detailed information about the molecular recognition of small-molecule ligands binding LYP. Importantly, compound 8b possesses highly efficacious cellular activity in both T- and mast cells and is capable of blocking anaphylaxis in mice. Discovery of 8b establishes a starting point for the development of clinically useful LYP inhibitors for treating a wide range of autoimmune disorders.

-	~~==Function==~~	+	A Potent and Selective Small-Molecule Inhibitor for the Lymphoid-Specific Tyrosine Phosphatase (LYP), a Target Associated with Autoimmune Diseases.,He Y, Liu S, Menon A, Stanford S, Oppong E, Gunawan AM, Wu L, Wu DJ, Barrios AM, Bottini N, Cato AC, Zhang ZY J Med Chem. 2013 Jun 27;56(12):4990-5008. doi: 10.1021/jm400248c. Epub 2013 Jun, 6. PMID:23713581<ref>PMID:23713581</ref>
-	~~[[http://www.uniprot.org/uniprot/PTN22_HUMAN PTN22_HUMAN]] Acts as negative regulator of T~~-~~cell receptor~~ (~~TCR~~) ~~signaling by direct dephosphorylation of the Src family kinases LCK and FYN~~, ~~ITAMs of the TCRz/CD3 complex~~, ~~as well as ZAP70~~, ~~VAV~~, ~~VCP and other key signaling molecules~~. ~~Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr~~-~~394' residue~~. ~~Dephosphorylates ZAP70 at its activating 'Tyr-493' residue~~. ~~Dephosphorylates the immune system activator SKAP2~~.~~<ref>~~PMID:~~16461343</ref> <ref>PMID:18056643</ref> <ref>PMID:19167335</ref>~~ <ref>PMID:~~21719704~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4j51]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4J51 OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:023713581</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Protein-tyrosine-phosphatase]]		[[Category: Protein-tyrosine-phosphatase]]
-	[[Category: He, Y.]]	+	[[Category: He, Y]]
-	[[Category: Liu, D.]]	+	[[Category: Liu, D]]
-	[[Category: Zhang, Z Y.]]	+	[[Category: Zhang, Z Y]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]
	[[Category: Inhibitor design]]		[[Category: Inhibitor design]]
	[[Category: Tyrosine phosphatase]]		[[Category: Tyrosine phosphatase]]

OCA at 12:58, 24 July 2013

OCA — Wed, 24 Jul 2013 12:58:41 GMT

←Older revision		Revision as of 12:58, 24 July 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4j51\| PDB=4j51 \| SCENE= }}
		+	===Cyrstal structure of protein tyrosine phosphatase Lyp catalytic domain complex with small molecular inhibitor L75N04===
		+	{{ABSTRACT_PUBMED_23713581}}

-	~~The~~ entry ~~4j51~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/PTN22_HUMAN PTN22_HUMAN]] Defects in PTPN22 are a cause of susceptibility to systemic lupus erythematosus (SLE) [MIM:[http://omim.org/entry/152700 152700]]. SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.<ref>PMID:15273934</ref>

-	~~Authors~~: ~~Liu, D~~., He, Y., ~~Zhang~~, Z.-Y.	+	==Function==
		+	[[http://www.uniprot.org/uniprot/PTN22_HUMAN PTN22_HUMAN]] Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules. Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue. Dephosphorylates ZAP70 at its activating 'Tyr-493' residue. Dephosphorylates the immune system activator SKAP2.<ref>PMID:16461343</ref> <ref>PMID:18056643</ref> <ref>PMID:19167335</ref> <ref>PMID:21719704</ref>

-	~~Description: Cyrstal~~ structure ~~of protein~~ tyrosine phosphatase ~~Lyp catalytic domain complex with small molecular~~ inhibitor ~~L75N04~~	+	==About this Structure==
		+	[[4j51]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J51 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:023713581</ref><references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Protein-tyrosine-phosphatase]]
		+	[[Category: He, Y.]]
		+	[[Category: Liu, D.]]
		+	[[Category: Zhang, Z Y.]]
		+	[[Category: Hydrolase]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
		+	[[Category: Inhibitor design]]
		+	[[Category: Tyrosine phosphatase]]

OCA at 04:43, 18 July 2013

OCA — Thu, 18 Jul 2013 04:43:05 GMT

←Older revision		Revision as of 04:43, 18 July 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4j51 is ON HOLD	+	The entry 4j51 is ON HOLD until Paper Publication

	Authors: Liu, D., He, Y., Zhang, Z.-Y.		Authors: Liu, D., He, Y., Zhang, Z.-Y.

	Description: Cyrstal structure of protein tyrosine phosphatase Lyp catalytic domain complex with small molecular inhibitor L75N04		Description: Cyrstal structure of protein tyrosine phosphatase Lyp catalytic domain complex with small molecular inhibitor L75N04

OCA at 14:23, 27 February 2013

OCA — Wed, 27 Feb 2013 14:23:52 GMT

←Older revision		Revision as of 14:23, 27 February 2013
Line 3:		Line 3:
	The entry 4j51 is ON HOLD		The entry 4j51 is ON HOLD

-	Authors: Liu,D, He, Y, Zhang, Z-Y	+	Authors: Liu, D., He, Y., Zhang, Z.-Y.

	Description: Cyrstal structure of protein tyrosine phosphatase Lyp catalytic domain complex with small molecular inhibitor L75N04		Description: Cyrstal structure of protein tyrosine phosphatase Lyp catalytic domain complex with small molecular inhibitor L75N04

OCA: Protected "4j51" [edit=sysop:move=sysop]

OCA — Wed, 13 Feb 2013 10:13:11 GMT

Protected "4j51" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:13, 13 February 2013

OCA: New page: '''Unreleased structure''' The entry 4j51 is ON HOLD Authors: Liu,D, He, Y, Zhang, Z-Y Description: Cyrstal structure of protein tyrosine phosphatase Lyp catalytic domain complex with ...

OCA — Wed, 13 Feb 2013 10:13:10 GMT

New page: '''Unreleased structure''' The entry 4j51 is ON HOLD Authors: Liu,D, He, Y, Zhang, Z-Y Description: Cyrstal structure of protein tyrosine phosphatase Lyp catalytic domain complex with ...

New page

'''Unreleased structure'''

The entry 4j51 is ON HOLD

Authors: Liu,D, He, Y, Zhang, Z-Y

Description: Cyrstal structure of protein tyrosine phosphatase Lyp catalytic domain complex with small molecular inhibitor L75N04