4j5u - Revision history

OCA at 15:36, 20 September 2023

OCA — Wed, 20 Sep 2023 15:36:24 GMT

←Older revision		Revision as of 15:36, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4j5u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rickettsia_rickettsii_str._'Sheila_Smith' Rickettsia rickettsii str. 'Sheila Smith']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J5U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J5U FirstGlance]. <br>		<table><tr><td colspan='2'>[[4j5u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rickettsia_rickettsii_str._'Sheila_Smith' Rickettsia rickettsii str. 'Sheila Smith']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J5U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J5U FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j5u OCA], [https://pdbe.org/4j5u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j5u RCSB], [https://www.ebi.ac.uk/pdbsum/4j5u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j5u ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j5u OCA], [https://pdbe.org/4j5u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j5u RCSB], [https://www.ebi.ac.uk/pdbsum/4j5u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j5u ProSAT]</span></td></tr>
	</table>		</table>

OCA at 21:34, 16 November 2022

OCA — Wed, 16 Nov 2022 21:34:09 GMT

←Older revision		Revision as of 21:34, 16 November 2022
Line 1:		Line 1:

	==X-ray crystal structure of a serine hydroxymethyltransferase with covalently bound PLP from Rickettsia rickettsii str. Sheila Smith==		==X-ray crystal structure of a serine hydroxymethyltransferase with covalently bound PLP from Rickettsia rickettsii str. Sheila Smith==
-	<StructureSection load='4j5u' size='340' side='right' caption='[[4j5u]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='4j5u' size='340' side='right'caption='[[4j5u]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4j5u]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Ricrs Ricrs~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J5U OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4J5U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4j5u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rickettsia_rickettsii_str._'Sheila_Smith' Rickettsia rickettsii str. 'Sheila Smith']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J5U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J5U FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">glyA, A1G_06305 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=392021 RICRS])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j5u OCA], [https://pdbe.org/4j5u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j5u RCSB], [https://www.ebi.ac.uk/pdbsum/4j5u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j5u ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycine_hydroxymethyltransferase Glycine hydroxymethyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.1 2.1.2.1] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4j5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j5u OCA], [~~http~~://pdbe.org/4j5u PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4j5u RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4j5u PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4j5u ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/GLYA_RICRS GLYA_RICRS]] Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.[HAMAP-Rule:MF_00051]	+	[https://www.uniprot.org/uniprot/GLYA_RICRS GLYA_RICRS] Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.[HAMAP-Rule:MF_00051]

	==See Also==		==See Also==
-	*[[Serine hydroxymethyltransferase\|Serine hydroxymethyltransferase]]	+	*[[Serine hydroxymethyltransferase 3D structures\|Serine hydroxymethyltransferase 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Glycine hydroxymethyltransferase~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Ricrs]]~~	+	[[Category: Rickettsia rickettsii str. 'Sheila Smith']]
-	~~[[Category: Structural genomic]]~~	+
-	~~[[Category: National institute of allergy and infectious disease]]~~	+
-	~~[[Category: Niaid]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 10:12, 5 August 2016

OCA — Fri, 05 Aug 2016 10:12:59 GMT

←Older revision		Revision as of 10:12, 5 August 2016
Line 1:		Line 1:
		+
	==X-ray crystal structure of a serine hydroxymethyltransferase with covalently bound PLP from Rickettsia rickettsii str. Sheila Smith==		==X-ray crystal structure of a serine hydroxymethyltransferase with covalently bound PLP from Rickettsia rickettsii str. Sheila Smith==
	<StructureSection load='4j5u' size='340' side='right' caption='[[4j5u]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='4j5u' size='340' side='right' caption='[[4j5u]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4j5u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rickettsia_rickettsii_str._'sheila_smith' Rickettsia rickettsii str. 'sheila smith'~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J5U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J5U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4j5u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ricrs Ricrs]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J5U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J5U FirstGlance]. <br>
-	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:2-~~LYSINE(~~3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-~~YLMETHANE)~~'>LLP</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">glyA, A1G_06305 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=392021 ~~Rickettsia rickettsii str. 'Sheila Smith'~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">glyA, A1G_06305 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=392021 RICRS])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycine_hydroxymethyltransferase Glycine hydroxymethyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.1 2.1.2.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycine_hydroxymethyltransferase Glycine hydroxymethyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.1 2.1.2.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j5u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4j5u RCSB], [http://www.ebi.ac.uk/pdbsum/4j5u PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j5u OCA], [http://pdbe.org/4j5u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4j5u RCSB], [http://www.ebi.ac.uk/pdbsum/4j5u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4j5u ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	</StructureSection>		</StructureSection>
	[[Category: Glycine hydroxymethyltransferase]]		[[Category: Glycine hydroxymethyltransferase]]
-	[[Category: ~~Rickettsia rickettsii str. 'sheila smith'~~]]	+	[[Category: Ricrs]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: National institute of allergy and infectious disease]]		[[Category: National institute of allergy and infectious disease]]
	[[Category: Niaid]]		[[Category: Niaid]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 01:30, 25 December 2014

OCA — Thu, 25 Dec 2014 01:30:25 GMT

←Older revision		Revision as of 01:30, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4j5u\| PDB=4j5u \| SCENE= }}~~	+	==X-ray crystal structure of a serine hydroxymethyltransferase with covalently bound PLP from Rickettsia rickettsii str. Sheila Smith==
-	===X-ray crystal structure of a serine hydroxymethyltransferase with covalently bound PLP from Rickettsia rickettsii str. Sheila Smith===	+	<StructureSection load='4j5u' size='340' side='right' caption='[[4j5u]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4j5u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rickettsia_rickettsii_str._'sheila_smith' Rickettsia rickettsii str. 'sheila smith']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J5U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J5U FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:2-LYSINE(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHANE)'>LLP</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">glyA, A1G_06305 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=392021 Rickettsia rickettsii str. 'Sheila Smith'])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycine_hydroxymethyltransferase Glycine hydroxymethyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.1 2.1.2.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j5u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4j5u RCSB], [http://www.ebi.ac.uk/pdbsum/4j5u PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GLYA_RICRS GLYA_RICRS]] Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.[HAMAP-Rule:MF_00051]

-	==~~About this Structure~~==	+	==See Also==
-	[[~~4j5u~~]] ~~is a 2 chain structure with sequence from [http:~~//en.wikipedia.org/wiki/Rickettsia_rickettsii_str._'sheila_smith' Rickettsia rickettsii str. 'sheila smith']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J5U OCA].	+	*[[Serine hydroxymethyltransferase\|Serine hydroxymethyltransferase]]
		+	__TOC__
		+	</StructureSection>
	[[Category: Glycine hydroxymethyltransferase]]		[[Category: Glycine hydroxymethyltransferase]]
	[[Category: Rickettsia rickettsii str. 'sheila smith']]		[[Category: Rickettsia rickettsii str. 'sheila smith']]
-	[[Category: ~~SSGCID, Seattle~~ Structural ~~Genomics Center for Infectious Disease.~~]]	+	[[Category: Structural genomic]]
	[[Category: National institute of allergy and infectious disease]]		[[Category: National institute of allergy and infectious disease]]
	[[Category: Niaid]]		[[Category: Niaid]]
-	[[Category: Seattle structural genomics center for infectious disease]]
-	[[Category: Structural genomic]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 10:32, 13 March 2013

OCA — Wed, 13 Mar 2013 10:32:36 GMT

←Older revision		Revision as of 10:32, 13 March 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4j5u\| PDB=4j5u \| SCENE= }}
		+	===X-ray crystal structure of a serine hydroxymethyltransferase with covalently bound PLP from Rickettsia rickettsii str. Sheila Smith===

-	~~The entry~~ 4j5u is ~~ON HOLD~~	+	==About this Structure==
-		+	[[4j5u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rickettsia_rickettsii_str._'sheila_smith' Rickettsia rickettsii str. 'sheila smith']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J5U OCA].
-	~~Authors~~: Seattle Structural Genomics Center for Infectious Disease ~~(SSGCID)~~	+	[[Category: Glycine hydroxymethyltransferase]]
-		+	[[Category: Rickettsia rickettsii str. 'sheila smith']]
-	~~Description~~: ~~X-ray crystal structure~~ of ~~a serine hydroxymethyltransferase with covalently bound PLP from Rickettsia rickettsii str. Sheila Smith~~	+	[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]
		+	[[Category: National institute of allergy and infectious disease]]
		+	[[Category: Niaid]]
		+	[[Category: Seattle structural genomics center for infectious disease]]
		+	[[Category: Structural genomic]]
		+	[[Category: Transferase]]

OCA: Protected "4j5u" [edit=sysop:move=sysop]

OCA — Wed, 20 Feb 2013 13:31:19 GMT

Protected "4j5u" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:31, 20 February 2013

OCA: New page: '''Unreleased structure''' The entry 4j5u is ON HOLD Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Description: X-ray crystal structure of a serine hydrox...

OCA — Wed, 20 Feb 2013 13:31:18 GMT

New page: '''Unreleased structure''' The entry 4j5u is ON HOLD Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Description: X-ray crystal structure of a serine hydrox...

New page

'''Unreleased structure'''

The entry 4j5u is ON HOLD

Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID)

Description: X-ray crystal structure of a serine hydroxymethyltransferase with covalently bound PLP from Rickettsia rickettsii str. Sheila Smith