4j7l - Revision history

OCA at 12:01, 1 March 2024

OCA — Fri, 01 Mar 2024 12:01:56 GMT

←Older revision		Revision as of 12:01, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4j7l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J7L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J7L FirstGlance]. <br>		<table><tr><td colspan='2'>[[4j7l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J7L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J7L FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UBD:URIDINE+3,5-BIS(DIHYDROGEN+PHOSPHATE)'>UBD</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UBD:URIDINE+3,5-BIS(DIHYDROGEN+PHOSPHATE)'>UBD</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j7l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j7l OCA], [https://pdbe.org/4j7l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j7l RCSB], [https://www.ebi.ac.uk/pdbsum/4j7l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j7l ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j7l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j7l OCA], [https://pdbe.org/4j7l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j7l RCSB], [https://www.ebi.ac.uk/pdbsum/4j7l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j7l ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/DXO_MOUSE DXO_MOUSE] Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping, pyrophosphohydrolase and 5'-3' exonuclease activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. The 5' end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates.<ref>PMID:23523372</ref>		[https://www.uniprot.org/uniprot/DXO_MOUSE DXO_MOUSE] Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping, pyrophosphohydrolase and 5'-3' exonuclease activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. The 5' end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates.<ref>PMID:23523372</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Recently, we reported that two homologous yeast proteins, Rai1 and Dxo1, function in a quality control mechanism to clear cells of incompletely 5' end-capped messenger RNAs (mRNAs). Here, we report that their mammalian homolog, Dom3Z (referred to as DXO), possesses pyrophosphohydrolase, decapping, and 5'-to-3' exoribonuclease activities. Surprisingly, we found that DXO preferentially degrades defectively capped pre-mRNAs in cells. Additional studies show that incompletely capped pre-mRNAs are inefficiently spliced at all introns, a fact that contrasts with current understanding, and are also poorly cleaved for polyadenylation. Crystal structures of DXO in complex with substrate mimic and products at a resolution of up to 1.5A provide elegant insights into the catalytic mechanism and molecular basis for their three apparently distinct activities. Our data reveal a pre-mRNA 5' end capping quality control mechanism in mammalian cells, indicating DXO as the central player for this mechanism, and demonstrate an unexpected intimate link between proper 5' end capping and subsequent pre-mRNA processing.
-
-	A mammalian pre-mRNA 5' end capping quality control mechanism and an unexpected link of capping to pre-mRNA processing.,Jiao X, Chang JH, Kilic T, Tong L, Kiledjian M Mol Cell. 2013 Apr 11;50(1):104-15. doi: 10.1016/j.molcel.2013.02.017. Epub 2013 , Mar 21. PMID:23523372<ref>PMID:23523372</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4j7l" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:57, 24 November 2022

OCA — Thu, 24 Nov 2022 10:57:12 GMT

←Older revision		Revision as of 10:57, 24 November 2022
Line 1:		Line 1:

	==Crystal structure of mouse DXO in complex with PRODUCT RNA AND two MAGNESIUM ions==		==Crystal structure of mouse DXO in complex with PRODUCT RNA AND two MAGNESIUM ions==
-	<StructureSection load='4j7l' size='340' side='right' caption='[[4j7l]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='4j7l' size='340' side='right'caption='[[4j7l]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4j7l]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J7L OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4J7L FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4j7l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J7L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J7L FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UBD:URIDINE+3,5-BIS(DIHYDROGEN+PHOSPHATE)'>UBD</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UBD:URIDINE+3,5-BIS(DIHYDROGEN+PHOSPHATE)'>UBD</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4j7m\|4j7m]], [[4j7n\|4j7n]], [[3fqi\|3fqi]], [[3fqj\|3fqj]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j7l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j7l OCA], [https://pdbe.org/4j7l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j7l RCSB], [https://www.ebi.ac.uk/pdbsum/4j7l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j7l ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Dom3z, Ng6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4j7l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j7l OCA], [~~http~~://pdbe.org/4j7l PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4j7l RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4j7l PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4j7l ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~DOM3Z_MOUSE DOM3Z_MOUSE~~]~~] May possess~~ pyrophosphohydrolase activity ~~towards~~ 5' ~~triphosphorylated~~ RNA ~~(By similarity)~~.	+	[https://www.uniprot.org/uniprot/DXO_MOUSE DXO_MOUSE] Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping, pyrophosphohydrolase and 5'-3' exonuclease activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. The 5' end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates.<ref>PMID:23523372</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Chang, J H~~]]	+	[[Category: Mus musculus]]
-	[[Category: ~~Tong, L~~]]	+	[[Category: Synthetic construct]]
-	[[Category: ~~5'-3' exoribonuclease~~]]	+	[[Category: Chang JH]]
-	[[Category: ~~Decapping]]~~	+	[[Category: Tong L]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Hydrolase-rna complex~~]]	+

OCA at 21:06, 4 August 2016

OCA — Thu, 04 Aug 2016 21:06:50 GMT

←Older revision		Revision as of 21:06, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of mouse DXO in complex with PRODUCT RNA AND two MAGNESIUM ions==		==Crystal structure of mouse DXO in complex with PRODUCT RNA AND two MAGNESIUM ions==
	<StructureSection load='4j7l' size='340' side='right' caption='[[4j7l]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4j7l' size='340' side='right' caption='[[4j7l]], [[Resolution\|resolution]] 1.80Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4j7m\|4j7m]], [[4j7n\|4j7n]], [[3fqi\|3fqi]], [[3fqj\|3fqj]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4j7m\|4j7m]], [[4j7n\|4j7n]], [[3fqi\|3fqi]], [[3fqj\|3fqj]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Dom3z, Ng6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Dom3z, Ng6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j7l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j7l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4j7l RCSB], [http://www.ebi.ac.uk/pdbsum/4j7l PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j7l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j7l OCA], [http://pdbe.org/4j7l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4j7l RCSB], [http://www.ebi.ac.uk/pdbsum/4j7l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4j7l ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4j7l" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:09, 25 December 2014

OCA — Thu, 25 Dec 2014 13:09:40 GMT

←Older revision		Revision as of 13:09, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4j7l\| PDB=4j7l \| SCENE= }}~~	+	==Crystal structure of mouse DXO in complex with PRODUCT RNA AND two MAGNESIUM ions==
-	===Crystal structure of mouse DXO in complex with PRODUCT RNA AND two MAGNESIUM ions===	+	<StructureSection load='4j7l' size='340' side='right' caption='[[4j7l]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23523372}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4j7l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J7L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J7L FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UBD:URIDINE+3,5-BIS(DIHYDROGEN+PHOSPHATE)'>UBD</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4j7m\|4j7m]], [[4j7n\|4j7n]], [[3fqi\|3fqi]], [[3fqj\|3fqj]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Dom3z, Ng6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j7l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j7l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4j7l RCSB], [http://www.ebi.ac.uk/pdbsum/4j7l PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/DOM3Z_MOUSE DOM3Z_MOUSE]] May possess pyrophosphohydrolase activity towards 5' triphosphorylated RNA (By similarity).		[[http://www.uniprot.org/uniprot/DOM3Z_MOUSE DOM3Z_MOUSE]] May possess pyrophosphohydrolase activity towards 5' triphosphorylated RNA (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Recently, we reported that two homologous yeast proteins, Rai1 and Dxo1, function in a quality control mechanism to clear cells of incompletely 5' end-capped messenger RNAs (mRNAs). Here, we report that their mammalian homolog, Dom3Z (referred to as DXO), possesses pyrophosphohydrolase, decapping, and 5'-to-3' exoribonuclease activities. Surprisingly, we found that DXO preferentially degrades defectively capped pre-mRNAs in cells. Additional studies show that incompletely capped pre-mRNAs are inefficiently spliced at all introns, a fact that contrasts with current understanding, and are also poorly cleaved for polyadenylation. Crystal structures of DXO in complex with substrate mimic and products at a resolution of up to 1.5A provide elegant insights into the catalytic mechanism and molecular basis for their three apparently distinct activities. Our data reveal a pre-mRNA 5' end capping quality control mechanism in mammalian cells, indicating DXO as the central player for this mechanism, and demonstrate an unexpected intimate link between proper 5' end capping and subsequent pre-mRNA processing.

-	~~==About this Structure==~~	+	A mammalian pre-mRNA 5' end capping quality control mechanism and an unexpected link of capping to pre-mRNA processing.,Jiao X, Chang JH, Kilic T, Tong L, Kiledjian M Mol Cell. 2013 Apr 11;50(1):104-15. doi: 10.1016/j.molcel.2013.02.017. Epub 2013 , Mar 21. PMID:23523372<ref>PMID:23523372</ref>
-	~~[[4j7l]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.~~il/oca-bin/ocashort?id=4J7L OCA]~~.	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:023523372</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
-	[[Category: Chang, J H.]]	+	[[Category: Chang, J H]]
-	[[Category: Tong, L.]]	+	[[Category: Tong, L]]
	[[Category: 5'-3' exoribonuclease]]		[[Category: 5'-3' exoribonuclease]]
	[[Category: Decapping]]		[[Category: Decapping]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Hydrolase-rna complex]]		[[Category: Hydrolase-rna complex]]

OCA at 13:49, 12 March 2014

OCA — Wed, 12 Mar 2014 13:49:31 GMT

←Older revision		Revision as of 13:49, 12 March 2014
Line 1:		Line 1:
	{{STRUCTURE_4j7l\| PDB=4j7l \| SCENE= }}		{{STRUCTURE_4j7l\| PDB=4j7l \| SCENE= }}
	===Crystal structure of mouse DXO in complex with PRODUCT RNA AND two MAGNESIUM ions===		===Crystal structure of mouse DXO in complex with PRODUCT RNA AND two MAGNESIUM ions===
		+	{{ABSTRACT_PUBMED_23523372}}

	==Function==		==Function==
Line 6:		Line 7:

	==About this Structure==		==About this Structure==
-	[[4j7l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J7L OCA].	+	[[4j7l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J7L OCA].
-	[[Category: ~~Mus musculus~~]]	+
		+	==Reference==
		+	<ref group="xtra">PMID:023523372</ref><references group="xtra"/><references/>
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Chang, J H.]]		[[Category: Chang, J H.]]
	[[Category: Tong, L.]]		[[Category: Tong, L.]]

OCA at 09:02, 27 March 2013

OCA — Wed, 27 Mar 2013 09:02:48 GMT

←Older revision		Revision as of 09:02, 27 March 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4j7l\| PDB=4j7l \| SCENE= }}
		+	===Crystal structure of mouse DXO in complex with PRODUCT RNA AND two MAGNESIUM ions===

-	~~The entry 4j7l is ON HOLD until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/DOM3Z_MOUSE DOM3Z_MOUSE]] May possess pyrophosphohydrolase activity towards 5' triphosphorylated RNA (By similarity).

-	~~Authors~~: Chang, J.H., Tong, L.	+	==About this Structure==
-		+	[[4j7l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J7L OCA].
-	~~Description~~: ~~Crystal structure of mouse DXO in~~ complex ~~with PRODUCT RNA AND two MAGNESIUM ions~~	+	[[Category: Mus musculus]]
		+	[[Category: Chang, J H.]]
		+	[[Category: Tong, L.]]
		+	[[Category: 5'-3' exoribonuclease]]
		+	[[Category: Decapping]]
		+	[[Category: Hydrolase]]
		+	[[Category: Hydrolase-rna complex]]

OCA at 16:16, 20 March 2013

OCA — Wed, 20 Mar 2013 16:16:41 GMT

←Older revision		Revision as of 16:16, 20 March 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4j7l is ON HOLD	+	The entry 4j7l is ON HOLD until Paper Publication

-	Authors: Chang, J.H~~., Kilic, T~~., Tong, L.	+	Authors: Chang, J.H., Tong, L.

-	Description: Crystal structure of mouse DXO in complex with ~~product~~ RNA ~~and magnesium~~	+	Description: Crystal structure of mouse DXO in complex with PRODUCT RNA AND two MAGNESIUM ions

OCA: Protected "4j7l" [edit=sysop:move=sysop]

OCA — Wed, 20 Feb 2013 13:33:17 GMT

Protected "4j7l" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:33, 20 February 2013

OCA: New page: '''Unreleased structure''' The entry 4j7l is ON HOLD Authors: Chang, J.H., Kilic, T., Tong, L. Description: Crystal structure of mouse DXO in complex with product RNA and magnesium

OCA — Wed, 20 Feb 2013 13:33:16 GMT

New page: '''Unreleased structure''' The entry 4j7l is ON HOLD Authors: Chang, J.H., Kilic, T., Tong, L. Description: Crystal structure of mouse DXO in complex with product RNA and magnesium

New page

'''Unreleased structure'''

The entry 4j7l is ON HOLD

Authors: Chang, J.H., Kilic, T., Tong, L.

Description: Crystal structure of mouse DXO in complex with product RNA and magnesium