4j7t - Revision history

OCA at 15:37, 20 September 2023

OCA — Wed, 20 Sep 2023 15:37:40 GMT

←Older revision		Revision as of 15:37, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4j7t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J7T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J7T FirstGlance]. <br>		<table><tr><td colspan='2'>[[4j7t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J7T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J7T FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1JO:D-GAMMA-GLUTAMYL-S-(4-PHENYLBUTYL)-L-CYSTEINYLGLYCINE'>1JO</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.203Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1JO:D-GAMMA-GLUTAMYL-S-(4-PHENYLBUTYL)-L-CYSTEINYLGLYCINE'>1JO</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j7t OCA], [https://pdbe.org/4j7t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j7t RCSB], [https://www.ebi.ac.uk/pdbsum/4j7t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j7t ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j7t OCA], [https://pdbe.org/4j7t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j7t RCSB], [https://www.ebi.ac.uk/pdbsum/4j7t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j7t ProSAT]</span></td></tr>
	</table>		</table>

OCA at 10:57, 24 November 2022

OCA — Thu, 24 Nov 2022 10:57:24 GMT

←Older revision		Revision as of 10:57, 24 November 2022
Line 1:		Line 1:

	==Human LTC4 synthase in complex with product analogs - implications for enzyme catalysis==		==Human LTC4 synthase in complex with product analogs - implications for enzyme catalysis==
-	<StructureSection load='4j7t' size='340' side='right' caption='[[4j7t]], [[Resolution\|resolution]] 3.20Å' scene=''>	+	<StructureSection load='4j7t' size='340' side='right'caption='[[4j7t]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4j7t]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J7T OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4J7T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4j7t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J7T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J7T FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1JO:D-GAMMA-GLUTAMYL-S-(4-PHENYLBUTYL)-L-CYSTEINYLGLYCINE'>1JO</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1JO:D-GAMMA-GLUTAMYL-S-(4-PHENYLBUTYL)-L-CYSTEINYLGLYCINE'>1JO</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2uui\|2uui]], [[2uuh\|2uuh]], [[4j7y\|4j7y]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j7t OCA], [https://pdbe.org/4j7t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j7t RCSB], [https://www.ebi.ac.uk/pdbsum/4j7t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j7t ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LTC4S ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leukotriene-C(4)_synthase Leukotriene-C(4) synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.4.1.20 4.4.1.20] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4j7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j7t OCA], [~~http~~://pdbe.org/4j7t PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4j7t RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4j7t PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4j7t ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN]] Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency) [MIM:[~~http~~://omim.org/entry/246530 246530]]. LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly.	+	[https://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN] Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency) [MIM:[https://omim.org/entry/246530 246530]. LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN]] Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.	+	[https://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN] Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4j7t" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4j7t" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Leukotriene C4 synthase\|Leukotriene C4 synthase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: Haeggstrom~~, J Z~~]]	+	[[Category: Large Structures]]
-	[[Category: Niegowski, D]]	+	[[Category: Haeggstrom JZ]]
-	[[Category: Rinaldo-Matthis, A]]	+	[[Category: Niegowski D]]
-	~~[[Category: Leukotriene c4 synthase]]~~	+	[[Category: Rinaldo-Matthis A]]
-	~~[[Category: Lipid biosynthesis]]~~	+
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: Product analog~~]]	+

OCA at 15:03, 15 November 2017

OCA — Wed, 15 Nov 2017 15:03:04 GMT

←Older revision		Revision as of 15:03, 15 November 2017
Line 23:		Line 23:
	</div>		</div>
	<div class="pdbe-citations 4j7t" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4j7t" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Leukotriene C4 synthase\|Leukotriene C4 synthase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:20, 4 August 2016

OCA — Thu, 04 Aug 2016 10:20:44 GMT

←Older revision		Revision as of 10:20, 4 August 2016
Line 1:		Line 1:
		+
	==Human LTC4 synthase in complex with product analogs - implications for enzyme catalysis==		==Human LTC4 synthase in complex with product analogs - implications for enzyme catalysis==
	<StructureSection load='4j7t' size='340' side='right' caption='[[4j7t]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='4j7t' size='340' side='right' caption='[[4j7t]], [[Resolution\|resolution]] 3.20Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LTC4S ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LTC4S ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leukotriene-C(4)_synthase Leukotriene-C(4) synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.4.1.20 4.4.1.20] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leukotriene-C(4)_synthase Leukotriene-C(4) synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.4.1.20 4.4.1.20] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j7t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4j7t RCSB], [http://www.ebi.ac.uk/pdbsum/4j7t PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j7t OCA], [http://pdbe.org/4j7t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4j7t RCSB], [http://www.ebi.ac.uk/pdbsum/4j7t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4j7t ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 21:		Line 22:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4j7t" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 17:05, 21 December 2014

OCA — Sun, 21 Dec 2014 17:05:28 GMT

←Older revision		Revision as of 17:05, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4j7t\| PDB=4j7t \| SCENE= }}~~	+	==Human LTC4 synthase in complex with product analogs - implications for enzyme catalysis==
-	===Human LTC4 synthase in complex with product analogs - implications for enzyme catalysis===	+	<StructureSection load='4j7t' size='340' side='right' caption='[[4j7t]], [[Resolution\|resolution]] 3.20Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24366866}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4j7t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J7T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J7T FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1JO:D-GAMMA-GLUTAMYL-S-(4-PHENYLBUTYL)-L-CYSTEINYLGLYCINE'>1JO</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2uui\|2uui]], [[2uuh\|2uuh]], [[4j7y\|4j7y]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LTC4S ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leukotriene-C(4)_synthase Leukotriene-C(4) synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.4.1.20 4.4.1.20] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j7t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4j7t RCSB], [http://www.ebi.ac.uk/pdbsum/4j7t PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN]] Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency) [MIM:[http://omim.org/entry/246530 246530]]. LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly.		[[http://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN]] Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency) [MIM:[http://omim.org/entry/246530 246530]]. LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN]] Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Leukotriene (LT) C4 synthase (LTC4S) catalyzes the conjugation of the fatty acid LTA4 with the tripeptide GSH to produce LTC4, the parent compound of the cysteinyl-leukotrienes, important mediators of asthma. Here we mutated Trp116 in human LTC4S, a residue proposed to play a key role in substrate binding, into an Ala or Phe. Biochemical and structural characterization of these mutants along with crystal structures of the wild type and mutated enzymes in complex with three product analogs, viz. S-hexyl-, 4- phenyl-butyl-, and 2-hydroxy-4-phenyl-butyl-glutathione, provide new insights to binding of substrates and product, identifies a new conformation of the GSH moiety at the active site, and suggests a route for product release, aided by Trp116.

-	~~==Function==~~	+	Crystal structures of Leukotriene C4 synthase in complex with product analogs, implications for the enzyme mechanism.,Niegowski D, Kleinschmidt T, Olsson U, Ahmad S, Rinaldo-Matthis A, Haeggstrom JZ J Biol Chem. 2013 Dec 23. PMID:24366866<ref>PMID:24366866</ref>
-	~~[[http://www~~.~~uniprot~~.~~org~~/~~uniprot/LTC4S_HUMAN LTC4S_HUMAN]] Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.~~	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4j7t]] is~~ a ~~1 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4J7T OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:024366866</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Leukotriene C4 synthase\|Leukotriene C4 synthase]]
-	[[Category: Haeggstrom, J Z.]]	+	== References ==
-	[[Category: Niegowski, D.]]	+	<references/>
-	[[Category: Rinaldo-Matthis, A.]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Haeggstrom, J Z]]
		+	[[Category: Niegowski, D]]
		+	[[Category: Rinaldo-Matthis, A]]
	[[Category: Leukotriene c4 synthase]]		[[Category: Leukotriene c4 synthase]]
	[[Category: Lipid biosynthesis]]		[[Category: Lipid biosynthesis]]
	[[Category: Lyase]]		[[Category: Lyase]]
	[[Category: Product analog]]		[[Category: Product analog]]

OCA at 05:44, 22 January 2014

OCA — Wed, 22 Jan 2014 05:44:46 GMT

←Older revision		Revision as of 05:44, 22 January 2014
Line 1:		Line 1:
	{{STRUCTURE_4j7t\| PDB=4j7t \| SCENE= }}		{{STRUCTURE_4j7t\| PDB=4j7t \| SCENE= }}
	===Human LTC4 synthase in complex with product analogs - implications for enzyme catalysis===		===Human LTC4 synthase in complex with product analogs - implications for enzyme catalysis===
		+	{{ABSTRACT_PUBMED_24366866}}

	==Disease==		==Disease==
Line 10:		Line 11:
	==About this Structure==		==About this Structure==
	[[4j7t]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J7T OCA].		[[4j7t]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J7T OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:024366866</ref><references group="xtra"/><references/>
	[[Category: Haeggstrom, J Z.]]		[[Category: Haeggstrom, J Z.]]
	[[Category: Niegowski, D.]]		[[Category: Niegowski, D.]]

OCA at 12:12, 1 January 2014

OCA — Wed, 01 Jan 2014 12:12:57 GMT

←Older revision		Revision as of 12:12, 1 January 2014
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4j7t\| PDB=4j7t \| SCENE= }}
		+	===Human LTC4 synthase in complex with product analogs - implications for enzyme catalysis===

-	~~The~~ entry ~~4j7t~~ is ~~ON HOLD until Paper Publication~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN]] Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency) [MIM:[http://omim.org/entry/246530 246530]]. LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly.

-	~~Authors~~: ~~Niegowski, D~~.~~, Rinaldo-Matthis, A~~.~~, Haeggstrom, J.Z~~.	+	==Function==
		+	[[http://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN]] Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.

-	~~Description~~: ~~Human LTC4 synthase in complex with product analogs~~ -~~implications for enzyme catalysis~~	+	==About this Structure==
		+	[[4j7t]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J7T OCA].
		+	[[Category: Haeggstrom, J Z.]]
		+	[[Category: Niegowski, D.]]
		+	[[Category: Rinaldo-Matthis, A.]]
		+	[[Category: Leukotriene c4 synthase]]
		+	[[Category: Lipid biosynthesis]]
		+	[[Category: Lyase]]
		+	[[Category: Product analog]]

OCA at 11:17, 19 June 2013

OCA — Wed, 19 Jun 2013 11:17:20 GMT

←Older revision		Revision as of 11:17, 19 June 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4j7t is ON HOLD	+	The entry 4j7t is ON HOLD until Paper Publication

	Authors: Niegowski, D., Rinaldo-Matthis, A., Haeggstrom, J.Z.		Authors: Niegowski, D., Rinaldo-Matthis, A., Haeggstrom, J.Z.

	Description: Human LTC4 synthase in complex with product analogs -implications for enzyme catalysis		Description: Human LTC4 synthase in complex with product analogs -implications for enzyme catalysis

OCA at 14:25, 27 February 2013

OCA — Wed, 27 Feb 2013 14:25:05 GMT

←Older revision		Revision as of 14:25, 27 February 2013
Line 3:		Line 3:
	The entry 4j7t is ON HOLD		The entry 4j7t is ON HOLD

-	Authors: Niegowski, D., Rinaldo-Matthis, A., Haeggstrom, J. Z.	+	Authors: Niegowski, D., Rinaldo-Matthis, A., Haeggstrom, J.Z.

	Description: Human LTC4 synthase in complex with product analogs -implications for enzyme catalysis		Description: Human LTC4 synthase in complex with product analogs -implications for enzyme catalysis

OCA: Protected "4j7t" [edit=sysop:move=sysop]

OCA — Wed, 20 Feb 2013 13:33:32 GMT

Protected "4j7t" [edit=sysop:move=sysop]

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Revision as of 13:33, 20 February 2013