4ja1 - Revision history

OCA at 15:38, 20 September 2023

OCA — Wed, 20 Sep 2023 15:38:44 GMT

←Older revision		Revision as of 15:38, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ja1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JA1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JA1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ja1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JA1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JA1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NGH:N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL+HYDROXAMIC+ACID'>NGH</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.96Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NGH:N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL+HYDROXAMIC+ACID'>NGH</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ja1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ja1 OCA], [https://pdbe.org/4ja1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ja1 RCSB], [https://www.ebi.ac.uk/pdbsum/4ja1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ja1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ja1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ja1 OCA], [https://pdbe.org/4ja1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ja1 RCSB], [https://www.ebi.ac.uk/pdbsum/4ja1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ja1 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 11:01, 24 November 2022

OCA — Thu, 24 Nov 2022 11:01:32 GMT

←Older revision		Revision as of 11:01, 24 November 2022
Line 1:		Line 1:

	==Structure of MMP3 complexed with a platinum-based inhibitor==		==Structure of MMP3 complexed with a platinum-based inhibitor==
-	<StructureSection load='4ja1' size='340' side='right' caption='[[4ja1]], [[Resolution\|resolution]] 1.96Å' scene=''>	+	<StructureSection load='4ja1' size='340' side='right'caption='[[4ja1]], [[Resolution\|resolution]] 1.96Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ja1]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JA1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4JA1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ja1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JA1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JA1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NGH:N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL+HYDROXAMIC+ACID'>NGH</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NGH:N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL+HYDROXAMIC+ACID'>NGH</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4dpe\|4dpe]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ja1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ja1 OCA], [https://pdbe.org/4ja1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ja1 RCSB], [https://www.ebi.ac.uk/pdbsum/4ja1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ja1 ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MMP3, STMY1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Stromelysin_1 Stromelysin 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.17 3.4.24.17] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ja1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ja1 OCA], [~~http~~://pdbe.org/4ja1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ja1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ja1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ja1 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/MMP3_HUMAN MMP3_HUMAN]] Defects in MMP3 are the cause of susceptibility to coronary heart disease type 6 (CHDS6) [MIM:[~~http~~://omim.org/entry/614466 614466]]. A multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of the coronary arteries. Note=A polymorphism in the MMP3 promoter region is associated with the risk of coronary heart disease and myocardial infarction, due to lower MMP3 proteolytic activity and higher extracellular matrix deposition in atherosclerotic lesions.<ref>PMID:8662692</ref> <ref>PMID:12477941</ref>	+	[https://www.uniprot.org/uniprot/MMP3_HUMAN MMP3_HUMAN] Defects in MMP3 are the cause of susceptibility to coronary heart disease type 6 (CHDS6) [MIM:[https://omim.org/entry/614466 614466]. A multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of the coronary arteries. Note=A polymorphism in the MMP3 promoter region is associated with the risk of coronary heart disease and myocardial infarction, due to lower MMP3 proteolytic activity and higher extracellular matrix deposition in atherosclerotic lesions.<ref>PMID:8662692</ref> <ref>PMID:12477941</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MMP3_HUMAN MMP3_HUMAN]] Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.	+	[https://www.uniprot.org/uniprot/MMP3_HUMAN MMP3_HUMAN] Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 22:

	==See Also==		==See Also==
-	*[[Matrix metalloproteinase\|Matrix metalloproteinase]]	+	*[[Matrix metalloproteinase 3D structures\|Matrix metalloproteinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Stromelysin 1~~]]	+	[[Category: Large Structures]]
-	[[Category: Arnesano, F]]	+	[[Category: Arnesano F]]
-	[[Category: Belviso~~, B D~~]]	+	[[Category: Belviso BD]]
-	[[Category: Calderone, V]]	+	[[Category: Calderone V]]
-	[[Category: Caliandro, R]]	+	[[Category: Caliandro R]]
-	[[Category: Natile, G]]	+	[[Category: Natile G]]
-	[[Category: Siliqi, D]]	+	[[Category: Siliqi D]]
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Matrix metalloprotease~~]]	+

OCA at 22:02, 4 August 2016

OCA — Thu, 04 Aug 2016 22:02:32 GMT

←Older revision		Revision as of 22:02, 4 August 2016
Line 1:		Line 1:
		+
	==Structure of MMP3 complexed with a platinum-based inhibitor==		==Structure of MMP3 complexed with a platinum-based inhibitor==
	<StructureSection load='4ja1' size='340' side='right' caption='[[4ja1]], [[Resolution\|resolution]] 1.96Å' scene=''>		<StructureSection load='4ja1' size='340' side='right' caption='[[4ja1]], [[Resolution\|resolution]] 1.96Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ja1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JA1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JA1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ja1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JA1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JA1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NGH:N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL+HYDROXAMIC+ACID'>NGH</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NGH:N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL+HYDROXAMIC+ACID'>NGH</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4dpe\|4dpe]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4dpe\|4dpe]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MMP3, STMY1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MMP3, STMY1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Stromelysin_1 Stromelysin 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.17 3.4.24.17] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Stromelysin_1 Stromelysin 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.17 3.4.24.17] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ja1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ja1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ja1 RCSB], [http://www.ebi.ac.uk/pdbsum/4ja1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ja1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ja1 OCA], [http://pdbe.org/4ja1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ja1 RCSB], [http://www.ebi.ac.uk/pdbsum/4ja1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ja1 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 21:		Line 22:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4ja1" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 28:		Line 30:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Stromelysin 1]]		[[Category: Stromelysin 1]]
	[[Category: Arnesano, F]]		[[Category: Arnesano, F]]

OCA at 12:49, 21 December 2014

OCA — Sun, 21 Dec 2014 12:49:35 GMT

←Older revision		Revision as of 12:49, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4ja1\| PDB=4ja1 \| SCENE= }}~~	+	==Structure of MMP3 complexed with a platinum-based inhibitor==
-	===Structure of MMP3 complexed with a platinum-based inhibitor===	+	<StructureSection load='4ja1' size='340' side='right' caption='[[4ja1]], [[Resolution\|resolution]] 1.96Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23660647}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4ja1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JA1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JA1 FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NGH:N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL+HYDROXAMIC+ACID'>NGH</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4dpe\|4dpe]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MMP3, STMY1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Stromelysin_1 Stromelysin 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.17 3.4.24.17] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ja1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ja1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ja1 RCSB], [http://www.ebi.ac.uk/pdbsum/4ja1 PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/MMP3_HUMAN MMP3_HUMAN]] Defects in MMP3 are the cause of susceptibility to coronary heart disease type 6 (CHDS6) [MIM:[http://omim.org/entry/614466 614466]]. A multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of the coronary arteries. Note=A polymorphism in the MMP3 promoter region is associated with the risk of coronary heart disease and myocardial infarction, due to lower MMP3 proteolytic activity and higher extracellular matrix deposition in atherosclerotic lesions.<ref>PMID:8662692</ref> <ref>PMID:12477941</ref>		[[http://www.uniprot.org/uniprot/MMP3_HUMAN MMP3_HUMAN]] Defects in MMP3 are the cause of susceptibility to coronary heart disease type 6 (CHDS6) [MIM:[http://omim.org/entry/614466 614466]]. A multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of the coronary arteries. Note=A polymorphism in the MMP3 promoter region is associated with the risk of coronary heart disease and myocardial infarction, due to lower MMP3 proteolytic activity and higher extracellular matrix deposition in atherosclerotic lesions.<ref>PMID:8662692</ref> <ref>PMID:12477941</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MMP3_HUMAN MMP3_HUMAN]] Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	An X-ray investigation has been performed with the aim of characterizing the binding sites of a platinum-based inhibitor (K[PtCl3(DMSO)]) of matrix metalloproteinase-3 (stromelysin-1). The platinum complex targets His224 in the S1' specificity loop, representing the first step in the selective inhibition process (PDB ID code ).

-	~~==Function==~~	+	Structure of matrix metalloproteinase-3 with a platinum-based inhibitor.,Belviso BD, Caliandro R, Siliqi D, Calderone V, Arnesano F, Natile G Chem Commun (Camb). 2013 Jun 18;49(48):5492-4. doi: 10.1039/c3cc41278d. Epub 2013, May 10. PMID:23660647<ref>PMID:23660647</ref>
-	~~[[http://www~~.~~uniprot.org/uniprot/MMP3_HUMAN MMP3_HUMAN]] Can degrade fibronectin~~, ~~laminin~~, ~~gelatins of type I~~, ~~III~~, ~~IV, and~~ V~~; collagens III~~, IV, ~~X, and IX, and cartilage proteoglycans~~. ~~Activates procollagenase~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4ja1]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4JA1 OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:023660647</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Matrix metalloproteinase\|Matrix metalloproteinase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Stromelysin 1]]		[[Category: Stromelysin 1]]
-	[[Category: Arnesano, F.]]	+	[[Category: Arnesano, F]]
-	[[Category: Belviso, B D.]]	+	[[Category: Belviso, B D]]
-	[[Category: Calderone, V.]]	+	[[Category: Calderone, V]]
-	[[Category: Caliandro, R.]]	+	[[Category: Caliandro, R]]
-	[[Category: Natile, G.]]	+	[[Category: Natile, G]]
-	[[Category: Siliqi, D.]]	+	[[Category: Siliqi, D]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]
	[[Category: Matrix metalloprotease]]		[[Category: Matrix metalloprotease]]

OCA at 16:33, 19 June 2013

OCA — Wed, 19 Jun 2013 16:33:48 GMT

←Older revision		Revision as of 16:33, 19 June 2013
Line 1:		Line 1:
	{{STRUCTURE_4ja1\| PDB=4ja1 \| SCENE= }}		{{STRUCTURE_4ja1\| PDB=4ja1 \| SCENE= }}
	===Structure of MMP3 complexed with a platinum-based inhibitor===		===Structure of MMP3 complexed with a platinum-based inhibitor===
		+	{{ABSTRACT_PUBMED_23660647}}

	==Disease==		==Disease==
Line 12:		Line 13:

	==Reference==		==Reference==
-	<references group="xtra"/><references/>	+	<ref group="xtra">PMID:023660647</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Stromelysin 1]]		[[Category: Stromelysin 1]]
Line 21:		Line 22:
	[[Category: Natile, G.]]		[[Category: Natile, G.]]
	[[Category: Siliqi, D.]]		[[Category: Siliqi, D.]]
-	[[Category: Hydrolase-hydrolase ~~inihibitor~~ complex]]	+	[[Category: Hydrolase-hydrolase inhibitor complex]]
	[[Category: Matrix metalloprotease]]		[[Category: Matrix metalloprotease]]

OCA at 06:19, 16 May 2013

OCA — Thu, 16 May 2013 06:19:43 GMT

←Older revision		Revision as of 06:19, 16 May 2013
Line 1:		Line 1:
-	[[Image:4ja1.jpg\|left\|200px]]
-
	{{STRUCTURE_4ja1\| PDB=4ja1 \| SCENE= }}		{{STRUCTURE_4ja1\| PDB=4ja1 \| SCENE= }}
-
	===Structure of MMP3 complexed with a platinum-based inhibitor===		===Structure of MMP3 complexed with a platinum-based inhibitor===

		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/MMP3_HUMAN MMP3_HUMAN]] Defects in MMP3 are the cause of susceptibility to coronary heart disease type 6 (CHDS6) [MIM:[http://omim.org/entry/614466 614466]]. A multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of the coronary arteries. Note=A polymorphism in the MMP3 promoter region is associated with the risk of coronary heart disease and myocardial infarction, due to lower MMP3 proteolytic activity and higher extracellular matrix deposition in atherosclerotic lesions.<ref>PMID:8662692</ref> <ref>PMID:12477941</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/MMP3_HUMAN MMP3_HUMAN]] Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.

	==About this Structure==		==About this Structure==
	[[4ja1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JA1 OCA].		[[4ja1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JA1 OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Stromelysin 1]]		[[Category: Stromelysin 1]]

OCA: Protected "4ja1" [edit=sysop:move=sysop]

OCA — Wed, 27 Feb 2013 15:02:12 GMT

Protected "4ja1" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:02, 27 February 2013

OCA: New page: 200px {{STRUCTURE_4ja1| PDB=4ja1 | SCENE= }} ===Structure of MMP3 complexed with a platinum-based inhibitor=== ==About this Structure== 4ja1 is a 2 cha...

OCA — Wed, 27 Feb 2013 15:02:09 GMT

New page: 200px {{STRUCTURE_4ja1| PDB=4ja1 | SCENE= }} ===Structure of MMP3 complexed with a platinum-based inhibitor=== ==About this Structure== 4ja1 is a 2 cha...

New page

[[Image:4ja1.jpg|left|200px]]

{{STRUCTURE_4ja1| PDB=4ja1 | SCENE= }}

===Structure of MMP3 complexed with a platinum-based inhibitor===

==About this Structure==
[[4ja1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JA1 OCA].
[[Category: Homo sapiens]]
[[Category: Stromelysin 1]]
[[Category: Arnesano, F.]]
[[Category: Belviso, B D.]]
[[Category: Calderone, V.]]
[[Category: Caliandro, R.]]
[[Category: Natile, G.]]
[[Category: Siliqi, D.]]
[[Category: Hydrolase-hydrolase inihibitor complex]]
[[Category: Matrix metalloprotease]]