4jcj - Revision history

OCA at 11:04, 24 November 2022

OCA — Thu, 24 Nov 2022 11:04:55 GMT

←Older revision		Revision as of 11:04, 24 November 2022
Line 1:		Line 1:

	==Crystal structure of Isl1 LIM domains with Ldb1 LIM-interaction domain==		==Crystal structure of Isl1 LIM domains with Ldb1 LIM-interaction domain==
-	<StructureSection load='4jcj' size='340' side='right' caption='[[4jcj]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<StructureSection load='4jcj' size='340' side='right'caption='[[4jcj]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4jcj]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JCJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4JCJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4jcj]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JCJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JCJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ldb1, Nli ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jcj OCA], [https://pdbe.org/4jcj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jcj RCSB], [https://www.ebi.ac.uk/pdbsum/4jcj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jcj ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4jcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jcj OCA], [~~http~~://pdbe.org/4jcj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4jcj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4jcj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4jcj ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ISL1_MOUSE ISL1_MOUSE]] Binds and regulates the promoters of the insulin, glucagon and somatostatin genes. Involved in the specificarion of motor neurons in cooperation with LHX3 and LDB1.	+	[https://www.uniprot.org/uniprot/ISL1_MOUSE ISL1_MOUSE] Binds and regulates the promoters of the insulin, glucagon and somatostatin genes. Involved in the specificarion of motor neurons in cooperation with LHX3 and LDB1.[https://www.uniprot.org/uniprot/LDB1_MOUSE LDB1_MOUSE] Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. May play a role in the development of motor neurons. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state.<ref>PMID:8918878</ref> <ref>PMID:8876198</ref> <ref>PMID:9192866</ref> <ref>PMID:9391090</ref> <ref>PMID:16815859</ref> <ref>PMID:9315627</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Gadd, M S~~]]	+	[[Category: Mus musculus]]
-	[[Category: ~~Guss, J M~~]]	+	[[Category: Gadd MS]]
-	[[Category: ~~Jacques, D A~~]]	+	[[Category: Guss JM]]
-	[[Category: ~~Matthews, J M~~]]	+	[[Category: Jacques DA]]
-	[[Category: ~~Nucleus]]~~	+	[[Category: Matthews JM]]
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: Transcriptional complex]]~~	+
-	~~[[Category: Zinc binding]]~~	+
-	~~[[Category: Zinc finger~~]]	+

OCA at 09:08, 15 November 2017

OCA — Wed, 15 Nov 2017 09:08:29 GMT

←Older revision		Revision as of 09:08, 15 November 2017
Line 3:		Line 3:
	<StructureSection load='4jcj' size='340' side='right' caption='[[4jcj]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='4jcj' size='340' side='right' caption='[[4jcj]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4jcj]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JCJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JCJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4jcj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JCJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JCJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ldb1, Nli ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jcj OCA], [http://pdbe.org/4jcj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jcj RCSB], [http://www.ebi.ac.uk/pdbsum/4jcj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jcj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jcj OCA], [http://pdbe.org/4jcj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jcj RCSB], [http://www.ebi.ac.uk/pdbsum/4jcj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jcj ProSAT]</span></td></tr>
	</table>		</table>
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Gadd, M S]]		[[Category: Gadd, M S]]
	[[Category: Guss, J M]]		[[Category: Guss, J M]]

OCA at 11:18, 3 August 2017

OCA — Thu, 03 Aug 2017 11:18:49 GMT

←Older revision		Revision as of 11:18, 3 August 2017
Line 3:		Line 3:
	<StructureSection load='4jcj' size='340' side='right' caption='[[4jcj]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='4jcj' size='340' side='right' caption='[[4jcj]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4jcj]] is a 3 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JCJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JCJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4jcj]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JCJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JCJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Insulin gene enhancer protein Isl1, Isl1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jcj OCA], [http://pdbe.org/4jcj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jcj RCSB], [http://www.ebi.ac.uk/pdbsum/4jcj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jcj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jcj OCA], [http://pdbe.org/4jcj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jcj RCSB], [http://www.ebi.ac.uk/pdbsum/4jcj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jcj ProSAT]</span></td></tr>
	</table>		</table>
Line 23:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Lk3 transgenic mice]]
	[[Category: Gadd, M S]]		[[Category: Gadd, M S]]
	[[Category: Guss, J M]]		[[Category: Guss, J M]]

OCA at 14:03, 4 August 2016

OCA — Thu, 04 Aug 2016 14:03:27 GMT

←Older revision		Revision as of 14:03, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of Isl1 LIM domains with Ldb1 LIM-interaction domain==		==Crystal structure of Isl1 LIM domains with Ldb1 LIM-interaction domain==
	<StructureSection load='4jcj' size='340' side='right' caption='[[4jcj]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='4jcj' size='340' side='right' caption='[[4jcj]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4jcj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JCJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JCJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4jcj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JCJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JCJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Insulin gene enhancer protein Isl1, Isl1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Insulin gene enhancer protein Isl1, Isl1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jcj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jcj RCSB], [http://www.ebi.ac.uk/pdbsum/4jcj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jcj OCA], [http://pdbe.org/4jcj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jcj RCSB], [http://www.ebi.ac.uk/pdbsum/4jcj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jcj ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4jcj" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Gadd, M S]]		[[Category: Gadd, M S]]
	[[Category: Guss, J M]]		[[Category: Guss, J M]]

OCA at 09:58, 25 December 2014

OCA — Thu, 25 Dec 2014 09:58:41 GMT

←Older revision		Revision as of 09:58, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jcj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jcj RCSB], [http://www.ebi.ac.uk/pdbsum/4jcj PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jcj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jcj RCSB], [http://www.ebi.ac.uk/pdbsum/4jcj PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ISL1_MOUSE ISL1_MOUSE]] Binds and regulates the promoters of the insulin, glucagon and somatostatin genes. Involved in the specificarion of motor neurons in cooperation with LHX3 and LDB1.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:49, 21 December 2014

OCA — Sun, 21 Dec 2014 12:49:30 GMT

←Older revision		Revision as of 12:49, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4jcj\| PDB=4jcj \| SCENE= }}~~	+	==Crystal structure of Isl1 LIM domains with Ldb1 LIM-interaction domain==
-	===Crystal structure of Isl1 LIM domains with Ldb1 LIM-interaction domain===	+	<StructureSection load='4jcj' size='340' side='right' caption='[[4jcj]], [[Resolution\|resolution]] 3.00Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23750000}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4jcj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JCJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JCJ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Insulin gene enhancer protein Isl1, Isl1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jcj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jcj RCSB], [http://www.ebi.ac.uk/pdbsum/4jcj PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Islet 1 (Isl1) is a transcription factor of the LIM-homeodomain (LIM-HD) protein family and is essential for many developmental processes. LIM-HD proteins all contain two protein-interacting LIM domains, a DNA-binding homeodomain (HD), and a C-terminal region. In Isl1, the C-terminal region also contains the LIM homeobox 3 (Lhx3)-binding domain (LBD), which interacts with the LIM domains of Lhx3. The LIM domains of Isl1 have been implicated in inhibition of DNA binding potentially through an intramolecular interaction with or close to the HD. Here we investigate the LBD as a candidate intramolecular interaction domain. Competitive yeast-two hybrid experiments indicate that the LIM domains and LBD from Isl1 can interact with apparently low affinity, consistent with no detection of an intermolecular interaction in the same system. Nuclear magnetic resonance studies show that the interaction is specific, whereas substitution of the LBD with peptides of the same amino acid composition but different sequence is not specific. We solved the crystal structure of a similar but higher affinity complex between the LIM domains of Isl1 and the LIM interaction domain from the LIM-HD cofactor protein LIM domain-binding protein 1 (Ldb1) and used these coordinates to generate a homology model of the intramolecular interaction that indicates poorer complementarity for the weak intramolecular interaction. The intramolecular interaction in Isl1 may provide protection against aggregation, minimize unproductive DNA binding, and facilitate cofactor exchange within the cell.

-	~~==Function==~~	+	A structural basis for the regulation of the LIM-homeodomain protein islet 1 (Isl1) by intra- and intermolecular interactions.,Gadd MS, Jacques DA, Nisevic I, Craig VJ, Kwan AH, Guss JM, Matthews JM J Biol Chem. 2013 Jul 26;288(30):21924-35. doi: 10.1074/jbc.M113.478586. Epub, 2013 Jun 9. PMID:23750000<ref>PMID:23750000</ref>
-	~~[[http://www.uniprot.org/uniprot/ISL1_MOUSE ISL1_MOUSE]] Binds and regulates~~ the ~~promoters~~ of the ~~insulin, glucagon~~ and ~~somatostatin genes~~. ~~Involved in the specificarion of motor neurons in cooperation with LHX3 and LDB1~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4jcj]] is~~ a ~~3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4JCJ OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:023750000</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Gadd, M S.]]	+	[[Category: Gadd, M S]]
-	[[Category: Guss, J M.]]	+	[[Category: Guss, J M]]
-	[[Category: Jacques, D A.]]	+	[[Category: Jacques, D A]]
-	[[Category: Matthews, J M.]]	+	[[Category: Matthews, J M]]
	[[Category: Nucleus]]		[[Category: Nucleus]]
	[[Category: Protein binding]]		[[Category: Protein binding]]

OCA at 05:04, 10 October 2013

OCA — Thu, 10 Oct 2013 05:04:30 GMT

←Older revision		Revision as of 05:04, 10 October 2013
Line 1:		Line 1:
	{{STRUCTURE_4jcj\| PDB=4jcj \| SCENE= }}		{{STRUCTURE_4jcj\| PDB=4jcj \| SCENE= }}
	===Crystal structure of Isl1 LIM domains with Ldb1 LIM-interaction domain===		===Crystal structure of Isl1 LIM domains with Ldb1 LIM-interaction domain===
		+	{{ABSTRACT_PUBMED_23750000}}

	==Function==		==Function==
Line 7:		Line 8:
	==About this Structure==		==About this Structure==
	[[4jcj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JCJ OCA].		[[4jcj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JCJ OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:023750000</ref><references group="xtra"/><references/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Gadd, M S.]]		[[Category: Gadd, M S.]]

OCA at 07:25, 20 June 2013

OCA — Thu, 20 Jun 2013 07:25:23 GMT

←Older revision		Revision as of 07:25, 20 June 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4jcj\| PDB=4jcj \| SCENE= }}
		+	===Crystal structure of Isl1 LIM domains with Ldb1 LIM-interaction domain===

-	~~The entry 4jcj is ON HOLD until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/ISL1_MOUSE ISL1_MOUSE]] Binds and regulates the promoters of the insulin, glucagon and somatostatin genes. Involved in the specificarion of motor neurons in cooperation with LHX3 and LDB1.

-	~~Authors~~: Gadd, M.S., Jacques, D.A.~~, Guss~~, J~~.M., Matthews J.~~M.	+	==About this Structure==
-		+	[[4jcj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JCJ OCA].
-	~~Description~~: ~~Crystal structure of Isl1 LIM domains with Ldb1 LIM-interaction domain~~	+	[[Category: Mus musculus]]
		+	[[Category: Gadd, M S.]]
		+	[[Category: Guss, J M.]]
		+	[[Category: Jacques, D A.]]
		+	[[Category: Matthews, J M.]]
		+	[[Category: Nucleus]]
		+	[[Category: Protein binding]]
		+	[[Category: Transcriptional complex]]
		+	[[Category: Zinc binding]]
		+	[[Category: Zinc finger]]

OCA at 08:15, 27 March 2013

OCA — Wed, 27 Mar 2013 08:15:53 GMT

←Older revision		Revision as of 08:15, 27 March 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4jcj is ON HOLD	+	The entry 4jcj is ON HOLD until Paper Publication

	Authors: Gadd, M.S., Jacques, D.A., Guss, J.M., Matthews J.M.		Authors: Gadd, M.S., Jacques, D.A., Guss, J.M., Matthews J.M.

	Description: Crystal structure of Isl1 LIM domains with Ldb1 LIM-interaction domain		Description: Crystal structure of Isl1 LIM domains with Ldb1 LIM-interaction domain

OCA: Protected "4jcj" [edit=sysop:move=sysop]

OCA — Wed, 27 Feb 2013 14:29:39 GMT

Protected "4jcj" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:29, 27 February 2013