4jcx - Revision history

OCA at 15:40, 20 September 2023

OCA — Wed, 20 Sep 2023 15:40:28 GMT

←Older revision		Revision as of 15:40, 20 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4jcx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Citrobacter_sp._RFL231 Citrobacter sp. RFL231]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JCX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JCX FirstGlance]. <br>		<table><tr><td colspan='2'>[[4jcx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Citrobacter_sp._RFL231 Citrobacter sp. RFL231]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JCX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JCX FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jcx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jcx OCA], [https://pdbe.org/4jcx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jcx RCSB], [https://www.ebi.ac.uk/pdbsum/4jcx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jcx ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jcx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jcx OCA], [https://pdbe.org/4jcx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jcx RCSB], [https://www.ebi.ac.uk/pdbsum/4jcx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jcx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 11:05, 24 November 2022

OCA — Thu, 24 Nov 2022 11:05:41 GMT

←Older revision		Revision as of 11:05, 24 November 2022
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	<StructureSection load='4jcx' size='340' side='right'caption='[[4jcx]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4jcx' size='340' side='right'caption='[[4jcx]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4jcx]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Citrobacter_sp.~~_rfl231~~ Citrobacter sp. ~~rfl231~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JCX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4JCX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4jcx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Citrobacter_sp._RFL231 Citrobacter sp. RFL231]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JCX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JCX FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3lfp\|3lfp]], [[3lis\|3lis]], [[4jcy\|4jcy]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jcx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jcx OCA], [https://pdbe.org/4jcx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jcx RCSB], [https://www.ebi.ac.uk/pdbsum/4jcx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jcx ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4jcx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jcx OCA], [~~http~~://pdbe.org/4jcx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4jcx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4jcx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4jcx ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q32WH4_9ENTR Q32WH4_9ENTR]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Citrobacter sp. ~~rfl231~~]]	+	[[Category: Citrobacter sp. RFL231]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Kneale~~, G G~~]]	+	[[Category: Kneale GG]]
-	[[Category: Mcgeehan~~, J E~~]]	+	[[Category: Mcgeehan JE]]
-	[[Category: Shevtsov~~, M B~~]]	+	[[Category: Shevtsov MB]]
-	[[Category: Streeter~~, S D~~]]	+	[[Category: Streeter SD]]
-	[[Category: Thresh~~, S J]]~~	+	[[Category: Thresh SJ]]
-	~~[[Category: C controller protein]]~~	+
-	~~[[Category: Dna binding protein-dna complex]]~~	+
-	~~[[Category: Helix-turn-helix]]~~	+
-	~~[[Category: Restriction-modification system]]~~	+
-	~~[[Category: Transcriptional regulation~~]]	+

OCA at 09:29, 3 April 2019

OCA — Wed, 03 Apr 2019 09:29:22 GMT

←Older revision		Revision as of 09:29, 3 April 2019
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	==Crystal structure of the Restriction-Modification Controller Protein C.Csp231I OL operator complex==		==Crystal structure of the Restriction-Modification Controller Protein C.Csp231I OL operator complex==
-	<StructureSection load='4jcx' size='340' side='right' caption='[[4jcx]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='4jcx' size='340' side='right'caption='[[4jcx]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4jcx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Citrobacter_sp._rfl231 Citrobacter sp. rfl231]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JCX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JCX FirstGlance]. <br>		<table><tr><td colspan='2'>[[4jcx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Citrobacter_sp._rfl231 Citrobacter sp. rfl231]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JCX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JCX FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Citrobacter sp. rfl231]]		[[Category: Citrobacter sp. rfl231]]
		+	[[Category: Large Structures]]
	[[Category: Kneale, G G]]		[[Category: Kneale, G G]]
	[[Category: Mcgeehan, J E]]		[[Category: Mcgeehan, J E]]

OCA at 17:25, 18 January 2017

OCA — Wed, 18 Jan 2017 17:25:48 GMT

←Older revision		Revision as of 17:25, 18 January 2017
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		+
	==Crystal structure of the Restriction-Modification Controller Protein C.Csp231I OL operator complex==		==Crystal structure of the Restriction-Modification Controller Protein C.Csp231I OL operator complex==
	<StructureSection load='4jcx' size='340' side='right' caption='[[4jcx]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4jcx' size='340' side='right' caption='[[4jcx]], [[Resolution\|resolution]] 2.30Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4jcx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Citrobacter_sp._rfl231 Citrobacter sp. rfl231]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JCX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JCX FirstGlance]. <br>		<table><tr><td colspan='2'>[[4jcx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Citrobacter_sp._rfl231 Citrobacter sp. rfl231]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JCX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JCX FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3lfp\|3lfp]], [[3lis\|3lis]], [[4jcy\|4jcy]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3lfp\|3lfp]], [[3lis\|3lis]], [[4jcy\|4jcy]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jcx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jcx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jcx RCSB], [http://www.ebi.ac.uk/pdbsum/4jcx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jcx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jcx OCA], [http://pdbe.org/4jcx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jcx RCSB], [http://www.ebi.ac.uk/pdbsum/4jcx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jcx ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4jcx" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:45, 15 April 2015

OCA — Wed, 15 Apr 2015 06:45:04 GMT

←Older revision		Revision as of 06:45, 15 April 2015
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jcx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jcx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jcx RCSB], [http://www.ebi.ac.uk/pdbsum/4jcx PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jcx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jcx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jcx RCSB], [http://www.ebi.ac.uk/pdbsum/4jcx PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In a wide variety of bacterial restriction-modification systems, a regulatory `controller' protein (or C-protein) is required for effective transcription of its own gene and for transcription of the endonuclease gene found on the same operon. We have recently turned our attention to a new class of controller proteins (exemplified by C.Csp231I) that have quite novel features, including a much larger DNA-binding site with an 18 bp ( approximately 60 A) spacer between the two palindromic DNA-binding sequences and a very different recognition sequence from the canonical GACT/AGTC. Using X-ray crystallography, the structure of the protein in complex with its 21 bp DNA-recognition sequence was solved to 1.8 A resolution, and the molecular basis of sequence recognition in this class of proteins was elucidated. An unusual aspect of the promoter sequence is the extended spacer between the dimer binding sites, suggesting a novel interaction between the two C-protein dimers when bound to both recognition sites correctly spaced on the DNA. A U-bend model is proposed for this tetrameric complex, based on the results of gel-mobility assays, hydrodynamic analysis and the observation of key contacts at the interface between dimers in the crystal.
		+
		+	Structural analysis of DNA binding by C.Csp231I, a member of a novel class of R-M controller proteins regulating gene expression.,Shevtsov MB, Streeter SD, Thresh SJ, Swiderska A, McGeehan JE, Kneale GG Acta Crystallogr D Biol Crystallogr. 2015 Feb;71(Pt 2):398-407. doi:, 10.1107/S139900471402690X. Epub 2015 Jan 23. PMID:25664751<ref>PMID:25664751</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 13:11, 4 January 2015

OCA — Sun, 04 Jan 2015 13:11:32 GMT

←Older revision		Revision as of 13:11, 4 January 2015
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-	~~{{STRUCTURE_4jcx\| PDB=4jcx \| SCENE= }}~~	+	==Crystal structure of the Restriction-Modification Controller Protein C.Csp231I OL operator complex==
-	===Crystal structure of the Restriction-Modification Controller Protein C.Csp231I OL operator complex===	+	<StructureSection load='4jcx' size='340' side='right' caption='[[4jcx]], [[Resolution\|resolution]] 2.30Å' scene=''>
-		+	== Structural highlights ==
-	==~~About this Structure~~==	+	<table><tr><td colspan='2'>[[4jcx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Citrobacter_sp._rfl231 Citrobacter sp. rfl231]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JCX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JCX FirstGlance]. <br>
-	[[4jcx]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JCX OCA].	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3lfp\|3lfp]], [[3lis\|3lis]], [[4jcy\|4jcy]]</td></tr>
-	[[Category: Kneale, G G.]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jcx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jcx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jcx RCSB], [http://www.ebi.ac.uk/pdbsum/4jcx PDBsum]</span></td></tr>
-	[[Category: Mcgeehan, J E.]]	+	</table>
-	[[Category: Shevtsov, M B.]]	+	__TOC__
-	[[Category: Streeter, S D.]]	+	</StructureSection>
-	[[Category: Thresh, S J.]]	+	[[Category: Citrobacter sp. rfl231]]
		+	[[Category: Kneale, G G]]
		+	[[Category: Mcgeehan, J E]]
		+	[[Category: Shevtsov, M B]]
		+	[[Category: Streeter, S D]]
		+	[[Category: Thresh, S J]]
	[[Category: C controller protein]]		[[Category: C controller protein]]
	[[Category: Dna binding protein-dna complex]]		[[Category: Dna binding protein-dna complex]]

OCA at 18:20, 3 March 2014

OCA — Mon, 03 Mar 2014 18:20:31 GMT

←Older revision		Revision as of 18:20, 3 March 2014
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-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4jcx\| PDB=4jcx \| SCENE= }}
		+	===Crystal structure of the Restriction-Modification Controller Protein C.Csp231I OL operator complex===

-	~~The entry~~ 4jcx is ~~ON HOLD until Feb 26 2015~~	+	==About this Structure==
-		+	[[4jcx]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JCX OCA].
-	~~Authors~~: Shevtsov, M.B., Streeter, S.D., Thresh, S.J.~~, Mcgeehan, J.E., Kneale, G.G.~~	+	[[Category: Kneale, G G.]]
-		+	[[Category: Mcgeehan, J E.]]
-	~~Description~~: ~~Crystal structure of the Restriction~~-~~Modification Controller Protein C.Csp231I OL operator~~ complex	+	[[Category: Shevtsov, M B.]]
		+	[[Category: Streeter, S D.]]
		+	[[Category: Thresh, S J.]]
		+	[[Category: C controller protein]]
		+	[[Category: Dna binding protein-dna complex]]
		+	[[Category: Helix-turn-helix]]
		+	[[Category: Restriction-modification system]]
		+	[[Category: Transcriptional regulation]]

OCA at 07:29, 15 January 2014

OCA — Wed, 15 Jan 2014 07:29:14 GMT

←Older revision		Revision as of 07:29, 15 January 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4jcx is ON HOLD until ~~Paper Publication~~	+	The entry 4jcx is ON HOLD until Feb 26 2015

	Authors: Shevtsov, M.B., Streeter, S.D., Thresh, S.J., Mcgeehan, J.E., Kneale, G.G.		Authors: Shevtsov, M.B., Streeter, S.D., Thresh, S.J., Mcgeehan, J.E., Kneale, G.G.

	Description: Crystal structure of the Restriction-Modification Controller Protein C.Csp231I OL operator complex		Description: Crystal structure of the Restriction-Modification Controller Protein C.Csp231I OL operator complex

OCA at 09:58, 13 March 2013

OCA — Wed, 13 Mar 2013 09:58:43 GMT

←Older revision		Revision as of 09:58, 13 March 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4jcx is ON HOLD	+	The entry 4jcx is ON HOLD until Paper Publication

-	Authors: Shevtsov, M.B., Streeter, S.D., Thresh, S.J., ~~McGeehan~~, J.E., Kneale, G.G.	+	Authors: Shevtsov, M.B., Streeter, S.D., Thresh, S.J., Mcgeehan, J.E., Kneale, G.G.

	Description: Crystal structure of the Restriction-Modification Controller Protein C.Csp231I OL operator complex		Description: Crystal structure of the Restriction-Modification Controller Protein C.Csp231I OL operator complex

OCA: Protected "4jcx" [edit=sysop:move=sysop]

OCA — Wed, 06 Mar 2013 13:52:13 GMT

Protected "4jcx" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:52, 6 March 2013