4jgc - Revision history

OCA at 15:42, 20 September 2023

OCA — Wed, 20 Sep 2023 15:42:06 GMT

←Older revision		Revision as of 15:42, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4jgc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JGC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JGC FirstGlance]. <br>		<table><tr><td colspan='2'>[[4jgc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JGC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JGC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1RT:4-AMINO-2-OXO-1,2-DIHYDROPYRIMIDINE-5-CARBOXYLIC+ACID'>1RT</scene>, <scene name='pdbligand=ORP:2-DEOXY-5-PHOSPHONO-RIBOSE'>ORP</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.582Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1RT:4-AMINO-2-OXO-1,2-DIHYDROPYRIMIDINE-5-CARBOXYLIC+ACID'>1RT</scene>, <scene name='pdbligand=ORP:2-DEOXY-5-PHOSPHONO-RIBOSE'>ORP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jgc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jgc OCA], [https://pdbe.org/4jgc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jgc RCSB], [https://www.ebi.ac.uk/pdbsum/4jgc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jgc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jgc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jgc OCA], [https://pdbe.org/4jgc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jgc RCSB], [https://www.ebi.ac.uk/pdbsum/4jgc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jgc ProSAT]</span></td></tr>
	</table>		</table>

OCA at 11:11, 24 November 2022

OCA — Thu, 24 Nov 2022 11:11:43 GMT

←Older revision		Revision as of 11:11, 24 November 2022
Line 1:		Line 1:

	==Human TDG N140A mutant IN A COMPLEX WITH 5-carboxylcytosine (5caC)==		==Human TDG N140A mutant IN A COMPLEX WITH 5-carboxylcytosine (5caC)==
-	<StructureSection load='4jgc' size='340' side='right' caption='[[4jgc]], [[Resolution\|resolution]] 2.58Å' scene=''>	+	<StructureSection load='4jgc' size='340' side='right'caption='[[4jgc]], [[Resolution\|resolution]] 2.58Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4jgc]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JGC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4JGC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4jgc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JGC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JGC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1RT:4-AMINO-2-OXO-1,2-DIHYDROPYRIMIDINE-5-CARBOXYLIC+ACID'>1RT</scene>, <scene name='pdbligand=ORP:2-DEOXY-5-PHOSPHONO-RIBOSE'>ORP</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1RT:4-AMINO-2-OXO-1,2-DIHYDROPYRIMIDINE-5-CARBOXYLIC+ACID'>1RT</scene>, <scene name='pdbligand=ORP:2-DEOXY-5-PHOSPHONO-RIBOSE'>ORP</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fnc\|4fnc]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jgc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jgc OCA], [https://pdbe.org/4jgc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jgc RCSB], [https://www.ebi.ac.uk/pdbsum/4jgc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jgc ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TDG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymine-DNA_glycosylase Thymine-DNA glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.29 3.2.2.29] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4jgc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jgc OCA], [~~http~~://pdbe.org/4jgc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4jgc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4jgc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4jgc ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TDG_HUMAN TDG_HUMAN]] In the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. This enzyme corrects G/T mispairs to G/C pairs. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine.	+	[https://www.uniprot.org/uniprot/TDG_HUMAN TDG_HUMAN] In the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. This enzyme corrects G/T mispairs to G/C pairs. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 20:

	==See Also==		==See Also==
-	*[[DNA glycosylase\|DNA glycosylase]]	+	*[[DNA glycosylase 3D structures\|DNA glycosylase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Thymine-DNA glycosylase~~]]	+	[[Category: Large Structures]]
-	[[Category: Cheng, X]]	+	[[Category: Cheng X]]
-	[[Category: Hashimoto, H]]	+	[[Category: Hashimoto H]]
-	[[Category: Zhang, X]]	+	[[Category: Zhang X]]
-	~~[[Category: 5-carboxylcytosine]]~~	+
-	~~[[Category: Dna 5mc oxidation]]~~	+
-	~~[[Category: Dna demethylation]]~~	+
-	~~[[Category: Dna modification]]~~	+
-	~~[[Category: Epigenetic regulation]]~~	+
-	~~[[Category: Hydrolase-dna complex]]~~	+
-	~~[[Category: Thymine dna glycosylase~~]]	+

OCA at 12:53, 5 August 2016

OCA — Fri, 05 Aug 2016 12:53:31 GMT

←Older revision		Revision as of 12:53, 5 August 2016
Line 1:		Line 1:
		+
	==Human TDG N140A mutant IN A COMPLEX WITH 5-carboxylcytosine (5caC)==		==Human TDG N140A mutant IN A COMPLEX WITH 5-carboxylcytosine (5caC)==
	<StructureSection load='4jgc' size='340' side='right' caption='[[4jgc]], [[Resolution\|resolution]] 2.58Å' scene=''>		<StructureSection load='4jgc' size='340' side='right' caption='[[4jgc]], [[Resolution\|resolution]] 2.58Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4jgc]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JGC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JGC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4jgc]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JGC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JGC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1RT:4-AMINO-2-OXO-1,2-DIHYDROPYRIMIDINE-5-CARBOXYLIC+ACID'>1RT</scene>, <scene name='pdbligand=ORP:2-DEOXY-5-PHOSPHONO-RIBOSE'>ORP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1RT:4-AMINO-2-OXO-1,2-DIHYDROPYRIMIDINE-5-CARBOXYLIC+ACID'>1RT</scene>, <scene name='pdbligand=ORP:2-DEOXY-5-PHOSPHONO-RIBOSE'>ORP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fnc\|4fnc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fnc\|4fnc]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TDG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TDG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymine-DNA_glycosylase Thymine-DNA glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.29 3.2.2.29] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymine-DNA_glycosylase Thymine-DNA glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.29 3.2.2.29] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jgc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jgc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jgc RCSB], [http://www.ebi.ac.uk/pdbsum/4jgc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jgc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jgc OCA], [http://pdbe.org/4jgc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jgc RCSB], [http://www.ebi.ac.uk/pdbsum/4jgc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jgc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4jgc" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[DNA glycosylase\|DNA glycosylase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Thymine-DNA glycosylase]]		[[Category: Thymine-DNA glycosylase]]
	[[Category: Cheng, X]]		[[Category: Cheng, X]]

OCA at 19:00, 25 December 2014

OCA — Thu, 25 Dec 2014 19:00:09 GMT

←Older revision		Revision as of 19:00, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4jgc\| PDB=4jgc \| SCENE= }}~~	+	==Human TDG N140A mutant IN A COMPLEX WITH 5-carboxylcytosine (5caC)==
-	===Human TDG N140A mutant IN A COMPLEX WITH 5-carboxylcytosine (5caC)===	+	<StructureSection load='4jgc' size='340' side='right' caption='[[4jgc]], [[Resolution\|resolution]] 2.58Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23680598}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4jgc]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JGC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JGC FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1RT:4-AMINO-2-OXO-1,2-DIHYDROPYRIMIDINE-5-CARBOXYLIC+ACID'>1RT</scene>, <scene name='pdbligand=ORP:2-DEOXY-5-PHOSPHONO-RIBOSE'>ORP</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4fnc\|4fnc]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TDG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymine-DNA_glycosylase Thymine-DNA glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.29 3.2.2.29] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jgc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jgc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jgc RCSB], [http://www.ebi.ac.uk/pdbsum/4jgc PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/TDG_HUMAN TDG_HUMAN]] In the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. This enzyme corrects G/T mispairs to G/C pairs. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine.		[[http://www.uniprot.org/uniprot/TDG_HUMAN TDG_HUMAN]] In the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. This enzyme corrects G/T mispairs to G/C pairs. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The mammalian thymine DNA glycosylase (TDG) excises 5-carboxylcytosine (5caC) when paired with a guanine in a CpG sequence, in addition to mismatched bases. Here we present a complex structure of the human TDG catalytic mutant, asparagine 140 to alanine (N140A), with a 28-base pair DNA containing a G:5caC pair at pH 4.6. TDG interacts with the carboxylate moiety of target nucleotide 5caC using the side chain of asparagine 230 (N230), instead of asparagine 157 (N157) as previously reported. Mutation of either N157 or N230 residues to aspartate has minimal effect on G:5caC activity while significantly reducing activity on G:U substrate. Combination of both the asparagine-to-aspartate mutations (N157D/N230D) resulted in complete loss of activity on G:5caC while retaining measurable activity on G:U, implying that 5caC can adopt alternative conformations (either N157-interacting or N230-interacting) in the TDG active site to interact with either of the two asparagine side chain for 5caC excision.

-	~~==About this Structure==~~	+	Activity and crystal structure of human thymine DNA glycosylase mutant N140A with 5-carboxylcytosine DNA at low pH.,Hashimoto H, Zhang X, Cheng X DNA Repair (Amst). 2013 May 13. pii: S1568-7864(13)00084-0. doi:, 10.1016/j.dnarep.2013.04.003. PMID:23680598<ref>PMID:23680598</ref>
-	~~[[4jgc]] is a 3 chain~~ structure with ~~sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.~~il/oca-bin/ocashort?id=4JGC OCA]~~.	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:023680598</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Thymine-DNA glycosylase]]		[[Category: Thymine-DNA glycosylase]]
-	[[Category: Cheng, X.]]	+	[[Category: Cheng, X]]
-	[[Category: Hashimoto, H.]]	+	[[Category: Hashimoto, H]]
-	[[Category: Zhang, X.]]	+	[[Category: Zhang, X]]
	[[Category: 5-carboxylcytosine]]		[[Category: 5-carboxylcytosine]]
	[[Category: Dna 5mc oxidation]]		[[Category: Dna 5mc oxidation]]

OCA at 16:11, 19 June 2013

OCA — Wed, 19 Jun 2013 16:11:07 GMT

←Older revision		Revision as of 16:11, 19 June 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4jgc\| PDB=4jgc \| SCENE= }}
		+	===Human TDG N140A mutant IN A COMPLEX WITH 5-carboxylcytosine (5caC)===
		+	{{ABSTRACT_PUBMED_23680598}}

-	~~The entry 4jgc~~ is ~~ON HOLD~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/TDG_HUMAN TDG_HUMAN]] In the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. This enzyme corrects G/T mispairs to G/C pairs. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine.

-	~~Authors~~: ~~Hashimoto, H~~.~~, Zhang, X~~.~~, Cheng, X~~.	+	==About this Structure==
		+	[[4jgc]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JGC OCA].

-	~~Description~~: ~~Human TDG N140A mutant IN A COMPLEX WITH~~ 5-carboxylcytosine ~~(5caC)~~	+	==Reference==
		+	<ref group="xtra">PMID:023680598</ref><references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Thymine-DNA glycosylase]]
		+	[[Category: Cheng, X.]]
		+	[[Category: Hashimoto, H.]]
		+	[[Category: Zhang, X.]]
		+	[[Category: 5-carboxylcytosine]]
		+	[[Category: Dna 5mc oxidation]]
		+	[[Category: Dna demethylation]]
		+	[[Category: Dna modification]]
		+	[[Category: Epigenetic regulation]]
		+	[[Category: Hydrolase-dna complex]]
		+	[[Category: Thymine dna glycosylase]]

OCA at 07:06, 2 May 2013

OCA — Thu, 02 May 2013 07:06:18 GMT

←Older revision		Revision as of 07:06, 2 May 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4jgc is ON HOLD ~~until sometime in the future~~	+	The entry 4jgc is ON HOLD

	Authors: Hashimoto, H., Zhang, X., Cheng, X.		Authors: Hashimoto, H., Zhang, X., Cheng, X.

	Description: Human TDG N140A mutant IN A COMPLEX WITH 5-carboxylcytosine (5caC)		Description: Human TDG N140A mutant IN A COMPLEX WITH 5-carboxylcytosine (5caC)

OCA at 00:52, 4 April 2013

OCA — Thu, 04 Apr 2013 00:52:54 GMT

←Older revision		Revision as of 00:52, 4 April 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4jgc is ON HOLD	+	The entry 4jgc is ON HOLD until sometime in the future

	Authors: Hashimoto, H., Zhang, X., Cheng, X.		Authors: Hashimoto, H., Zhang, X., Cheng, X.

	Description: Human TDG N140A mutant IN A COMPLEX WITH 5-carboxylcytosine (5caC)		Description: Human TDG N140A mutant IN A COMPLEX WITH 5-carboxylcytosine (5caC)

OCA: Protected "4jgc" [edit=sysop:move=sysop]

OCA — Wed, 06 Mar 2013 13:55:52 GMT

Protected "4jgc" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:55, 6 March 2013

OCA: New page: '''Unreleased structure''' The entry 4jgc is ON HOLD Authors: Hashimoto, H., Zhang, X., Cheng, X. Description: Human TDG N140A mutant IN A COMPLEX WITH 5-carboxylcytosine (5caC)

OCA — Wed, 06 Mar 2013 13:55:51 GMT

New page: '''Unreleased structure''' The entry 4jgc is ON HOLD Authors: Hashimoto, H., Zhang, X., Cheng, X. Description: Human TDG N140A mutant IN A COMPLEX WITH 5-carboxylcytosine (5caC)

New page

'''Unreleased structure'''

The entry 4jgc is ON HOLD

Authors: Hashimoto, H., Zhang, X., Cheng, X.

Description: Human TDG N140A mutant IN A COMPLEX WITH 5-carboxylcytosine (5caC)