4jj8 - Revision history

OCA at 09:17, 15 November 2023

OCA — Wed, 15 Nov 2023 09:17:57 GMT

←Older revision		Revision as of 09:17, 15 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4jj8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JJ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JJ8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4jj8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JJ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JJ8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1MH:3-PYRIDIN-3-YL-L-ALANINE'>1MH</scene>, <scene name='pdbligand=1U8:(3S)-3-AMINO-5-[(2,6-DIMETHYLBENZOYL)OXY]-4-OXOPENTANOIC+ACID'>1U8</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=B3L:(3S)-3-AMINO-5-METHYLHEXANOIC+ACID'>B3L</scene>, <scene name='pdbligand=HLX:5-METHYL-L-NORLEUCINE'>HLX</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.937Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1MH:3-PYRIDIN-3-YL-L-ALANINE'>1MH</scene>, <scene name='pdbligand=1U8:(3S)-3-AMINO-5-[(2,6-DIMETHYLBENZOYL)OXY]-4-OXOPENTANOIC+ACID'>1U8</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=B3L:(3S)-3-AMINO-5-METHYLHEXANOIC+ACID'>B3L</scene>, <scene name='pdbligand=HLX:5-METHYL-L-NORLEUCINE'>HLX</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jj8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jj8 OCA], [https://pdbe.org/4jj8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jj8 RCSB], [https://www.ebi.ac.uk/pdbsum/4jj8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jj8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jj8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jj8 OCA], [https://pdbe.org/4jj8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jj8 RCSB], [https://www.ebi.ac.uk/pdbsum/4jj8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jj8 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 11:16, 24 November 2022

OCA — Thu, 24 Nov 2022 11:16:13 GMT

←Older revision		Revision as of 11:16, 24 November 2022
Line 1:		Line 1:

	==Caspase-3 specific unnatural amino acid peptides==		==Caspase-3 specific unnatural amino acid peptides==
-	<StructureSection load='4jj8' size='340' side='right' caption='[[4jj8]], [[Resolution\|resolution]] 2.94Å' scene=''>	+	<StructureSection load='4jj8' size='340' side='right'caption='[[4jj8]], [[Resolution\|resolution]] 2.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4jj8]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JJ8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4JJ8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4jj8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JJ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JJ8 FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=1MH:3-PYRIDIN-3-YL-L-ALANINE'>1MH</scene>, <scene name='pdbligand=1U8:(3S)-3-AMINO-5-[(2,6-DIMETHYLBENZOYL)OXY]-4-OXOPENTANOIC+ACID'>1U8</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=B3L:(3S)-3-AMINO-5-METHYLHEXANOIC+ACID'>B3L</scene>, <scene name='pdbligand=HLX:5-METHYL-L-NORLEUCINE'>HLX</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1MH:3-PYRIDIN-3-YL-L-ALANINE'>1MH</scene>, <scene name='pdbligand=1U8:(3S)-3-AMINO-5-[(2,6-DIMETHYLBENZOYL)OXY]-4-OXOPENTANOIC+ACID'>1U8</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=B3L:(3S)-3-AMINO-5-METHYLHEXANOIC+ACID'>B3L</scene>, <scene name='pdbligand=HLX:5-METHYL-L-NORLEUCINE'>HLX</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4jj7\|4jj7]], [[1f1j\|1f1j]], [[2ql5\|2ql5]], [[3ibc\|3ibc]], [[4jje\|4jje]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jj8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jj8 OCA], [https://pdbe.org/4jj8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jj8 RCSB], [https://www.ebi.ac.uk/pdbsum/4jj8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jj8 ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP7, Caspase-7 Mch-3, MCH3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-7 Caspase-7], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.60 3.4.22.60] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4jj8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jj8 OCA], [~~http~~://pdbe.org/4jj8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4jj8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4jj8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4jj8 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Overexpression promotes programmed cell death.	+	[https://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Overexpression promotes programmed cell death.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 20:

	==See Also==		==See Also==
-	*[[Caspase\|Caspase]]	+	*[[Caspase 3D structures\|Caspase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Caspase-7~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Human~~]]	+	[[Category: Large Structures]]
-	[[Category: Gonzalez-Paez~~, G E~~]]	+	[[Category: Gonzalez-Paez GE]]
-	[[Category: Vickers~~, C J~~]]	+	[[Category: Vickers CJ]]
-	[[Category: Wolan~~, D W]]~~	+	[[Category: Wolan DW]]
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Protease~~]]	+

OCA at 17:16, 4 August 2016

OCA — Thu, 04 Aug 2016 17:16:44 GMT

←Older revision		Revision as of 17:16, 4 August 2016
Line 1:		Line 1:
		+
	==Caspase-3 specific unnatural amino acid peptides==		==Caspase-3 specific unnatural amino acid peptides==
	<StructureSection load='4jj8' size='340' side='right' caption='[[4jj8]], [[Resolution\|resolution]] 2.94Å' scene=''>		<StructureSection load='4jj8' size='340' side='right' caption='[[4jj8]], [[Resolution\|resolution]] 2.94Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP7, Caspase-7 Mch-3, MCH3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP7, Caspase-7 Mch-3, MCH3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-7 Caspase-7], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.60 3.4.22.60] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-7 Caspase-7], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.60 3.4.22.60] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jj8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jj8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jj8 RCSB], [http://www.ebi.ac.uk/pdbsum/4jj8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jj8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jj8 OCA], [http://pdbe.org/4jj8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jj8 RCSB], [http://www.ebi.ac.uk/pdbsum/4jj8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jj8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4jj8" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 17:27, 24 December 2014

OCA — Wed, 24 Dec 2014 17:27:53 GMT

←Older revision		Revision as of 17:27, 24 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jj8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jj8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jj8 RCSB], [http://www.ebi.ac.uk/pdbsum/4jj8 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jj8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jj8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jj8 RCSB], [http://www.ebi.ac.uk/pdbsum/4jj8 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Overexpression promotes programmed cell death.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 16:47, 21 December 2014

OCA — Sun, 21 Dec 2014 16:47:39 GMT

←Older revision		Revision as of 16:47, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4jj8~~\| ~~PDB~~=4jj8 \| ~~SCENE~~= }}	+	==Caspase-3 specific unnatural amino acid peptides==
-	===Caspase-3 ~~specific unnatural amino acid peptides~~===	+	<StructureSection load='4jj8' size='340' side='right' caption='[[4jj8]], [[Resolution\|resolution]] 2.94Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23614665}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4jj8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JJ8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JJ8 FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=1MH:3-PYRIDIN-3-YL-L-ALANINE'>1MH</scene>, <scene name='pdbligand=1U8:(3S)-3-AMINO-5-[(2,6-DIMETHYLBENZOYL)OXY]-4-OXOPENTANOIC+ACID'>1U8</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=B3L:(3S)-3-AMINO-5-METHYLHEXANOIC+ACID'>B3L</scene>, <scene name='pdbligand=HLX:5-METHYL-L-NORLEUCINE'>HLX</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4jj7\|4jj7]], [[1f1j\|1f1j]], [[2ql5\|2ql5]], [[3ibc\|3ibc]], [[4jje\|4jje]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP7, Caspase-7 Mch-3, MCH3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-7 Caspase-7], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.60 3.4.22.60] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jj8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jj8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jj8 RCSB], [http://www.ebi.ac.uk/pdbsum/4jj8 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Caspases are required for essential biological functions, most notably apoptosis and pyroptosis, but also cytokine production, cell proliferation, and differentiation. One of the most well studied members of this cysteine protease family includes executioner caspase-3, which plays a central role in cell apoptosis and differentiation. Unfortunately, there exists a dearth of chemical tools to selectively monitor caspase-3 activity under complex cellular and in vivo conditions due to its close homology with executioner caspase-7. Commercially available activity-based probes and substrates rely on the canonical DEVD tetrapeptide sequence, which both caspases-3 and -7 recognize with similar affinity, and thus the individual contributions of caspase-3 and/or -7 toward important cellular processes are irresolvable. Here, we analyzed a variety of permutations of the DEVD peptide sequence in order to discover peptides with biased activity and recognition of caspase-3 versus caspases-6, -7, -8, and -9. Through this study, we identify fluorescent and biotinylated probes capable of selective detection of caspase-3 using key unnatural amino acids. Likewise, we determined the X-ray crystal structures of caspases-3, -7, and -8 in complex with our lead peptide inhibitor to elucidate the binding mechanism and active site interactions that promote the selective recognition of caspase-3 over other highly homologous caspase family members.

-	~~==Function==~~	+	Selective Detection of Caspase-3 versus Caspase-7 Using Activity-Based Probes with Key Unnatural Amino Acids.,Vickers CJ, Gonzalez-Paez GE, Wolan DW ACS Chem Biol. 2013 May 3. PMID:23614665<ref>PMID:23614665</ref>
-	~~[[http://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN]] Involved in the activation cascade~~ of ~~caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP~~-~~ribose) polymerase (PARP) at a '216~~-~~Asp~~-\|-~~Gly-217' bond~~. ~~Overexpression promotes programmed cell death~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4jj8]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Human Human]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4JJ8 OCA].~~	+	</div>

	==See Also==		==See Also==
	*[[Caspase\|Caspase]]		*[[Caspase\|Caspase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:023614665</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Caspase-7]]		[[Category: Caspase-7]]
	[[Category: Human]]		[[Category: Human]]
-	[[Category: Gonzalez-Paez, G E.]]	+	[[Category: Gonzalez-Paez, G E]]
-	[[Category: Vickers, C J.]]	+	[[Category: Vickers, C J]]
-	[[Category: Wolan, D W.]]	+	[[Category: Wolan, D W]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]
	[[Category: Protease]]		[[Category: Protease]]

OCA at 15:04, 19 February 2014

OCA — Wed, 19 Feb 2014 15:04:21 GMT

←Older revision		Revision as of 15:04, 19 February 2014
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[4jj8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JJ8 OCA].	+	[[4jj8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JJ8 OCA].
		+
		+	==See Also==
		+	*[[Caspase\|Caspase]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:023614665</ref><references group="xtra"/><references/>		<ref group="xtra">PMID:023614665</ref><references group="xtra"/><references/>
	[[Category: Caspase-7]]		[[Category: Caspase-7]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Gonzalez-Paez, G E.]]		[[Category: Gonzalez-Paez, G E.]]
	[[Category: Vickers, C J.]]		[[Category: Vickers, C J.]]

OCA at 13:58, 19 June 2013

OCA — Wed, 19 Jun 2013 13:58:05 GMT

←Older revision		Revision as of 13:58, 19 June 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4jj8\| PDB=4jj8 \| SCENE= }}
		+	===Caspase-3 specific unnatural amino acid peptides===
		+	{{ABSTRACT_PUBMED_23614665}}

-	~~The entry 4jj8 is ON HOLD~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Overexpression promotes programmed cell death.

-	~~Authors~~: ~~Vickers, C~~.J.~~, Gonzalez-Paez, G~~.E.~~, Wolan, D~~.W.	+	==About this Structure==
		+	[[4jj8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JJ8 OCA].

-	~~Description~~: Caspase-~~3 specific unnatural amino acid peptides~~	+	==Reference==
		+	<ref group="xtra">PMID:023614665</ref><references group="xtra"/><references/>
		+	[[Category: Caspase-7]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Gonzalez-Paez, G E.]]
		+	[[Category: Vickers, C J.]]
		+	[[Category: Wolan, D W.]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
		+	[[Category: Protease]]

OCA at 19:54, 17 April 2013

OCA — Wed, 17 Apr 2013 19:54:56 GMT

←Older revision		Revision as of 19:54, 17 April 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4jj8 is ON HOLD ~~until sometime in the future~~	+	The entry 4jj8 is ON HOLD

	Authors: Vickers, C.J., Gonzalez-Paez, G.E., Wolan, D.W.		Authors: Vickers, C.J., Gonzalez-Paez, G.E., Wolan, D.W.

	Description: Caspase-3 specific unnatural amino acid peptides		Description: Caspase-3 specific unnatural amino acid peptides

OCA at 00:54, 4 April 2013

OCA — Thu, 04 Apr 2013 00:54:46 GMT

←Older revision		Revision as of 00:54, 4 April 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4jj8 is ON HOLD	+	The entry 4jj8 is ON HOLD until sometime in the future

	Authors: Vickers, C.J., Gonzalez-Paez, G.E., Wolan, D.W.		Authors: Vickers, C.J., Gonzalez-Paez, G.E., Wolan, D.W.

	Description: Caspase-3 specific unnatural amino acid peptides		Description: Caspase-3 specific unnatural amino acid peptides

OCA: Protected "4jj8" [edit=sysop:move=sysop]

OCA — Wed, 13 Mar 2013 10:03:51 GMT

Protected "4jj8" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:03, 13 March 2013