4jjk - Revision history

OCA at 15:44, 20 September 2023

OCA — Wed, 20 Sep 2023 15:44:06 GMT

←Older revision		Revision as of 15:44, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4jjk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Moorella_thermoacetica_ATCC_39073 Moorella thermoacetica ATCC 39073]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3qb6 3qb6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JJK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JJK FirstGlance]. <br>		<table><tr><td colspan='2'>[[4jjk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Moorella_thermoacetica_ATCC_39073 Moorella thermoacetica ATCC 39073]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3qb6 3qb6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JJK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JJK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TOE:2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXYL'>TOE</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TOE:2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXYL'>TOE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jjk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jjk OCA], [https://pdbe.org/4jjk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jjk RCSB], [https://www.ebi.ac.uk/pdbsum/4jjk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jjk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jjk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jjk OCA], [https://pdbe.org/4jjk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jjk RCSB], [https://www.ebi.ac.uk/pdbsum/4jjk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jjk ProSAT]</span></td></tr>
	</table>		</table>

OCA at 11:16, 24 November 2022

OCA — Thu, 24 Nov 2022 11:16:53 GMT

←Older revision		Revision as of 11:16, 24 November 2022
Line 3:		Line 3:
	<StructureSection load='4jjk' size='340' side='right'caption='[[4jjk]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='4jjk' size='340' side='right'caption='[[4jjk]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4jjk]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Moota Moota~~]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3qb6 3qb6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JJK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=4JJK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4jjk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Moorella_thermoacetica_ATCC_39073 Moorella thermoacetica ATCC 39073]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3qb6 3qb6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JJK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JJK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TOE:2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXYL'>TOE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TOE:2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXYL'>TOE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3pzx\|3pzx]], [[4jim\|4jim]], [[3rbo\|3rbo]], [[3sin\|3sin]], [[3qb6\|3qb6]], [[4jki\|4jki]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jjk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jjk OCA], [https://pdbe.org/4jjk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jjk RCSB], [https://www.ebi.ac.uk/pdbsum/4jjk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jjk ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fhs, moorella, Moth_0109 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=264732 MOOTA])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Formate--tetrahydrofolate_ligase Formate--tetrahydrofolate ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.3 6.3.4.3] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=4jjk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jjk OCA], [~~http~~://pdbe.org/4jjk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4jjk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4jjk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4jjk ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/FTHS_MOOTA FTHS_MOOTA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Formate--tetrahydrofolate ligase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Moota~~]]	+	[[Category: Moorella thermoacetica ATCC 39073]]
-	[[Category: Celeste~~, L R~~]]	+	[[Category: Celeste LR]]
-	[[Category: Lebioda, L]]	+	[[Category: Lebioda L]]
-	[[Category: Lovelace~~, L L]]~~	+	[[Category: Lovelace LL]]
-	~~[[Category: Ligase~~]]	+

OCA at 09:43, 9 September 2020

OCA — Wed, 09 Sep 2020 09:43:42 GMT

←Older revision		Revision as of 09:43, 9 September 2020
Line 1:		Line 1:

-	==Crystal ~~Strucutre~~ of N10-Formyltetrahydrofolate Synthetase with Folate==	+	==Crystal Structure of N10-Formyltetrahydrofolate Synthetase with Folate==
-	<StructureSection load='4jjk' size='340' side='right' caption='[[4jjk]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<StructureSection load='4jjk' size='340' side='right'caption='[[4jjk]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4jjk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Moota Moota]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3qb6 3qb6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JJK OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4JJK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4jjk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Moota Moota]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3qb6 3qb6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JJK OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=4JJK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TOE:2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXYL'>TOE</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TOE:2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXYL'>TOE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3pzx\|3pzx]], [[4jim\|4jim]], [[3rbo\|3rbo]], [[3sin\|3sin]], [[3qb6\|3qb6]], [[4jki\|4jki]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3pzx\|3pzx]], [[4jim\|4jim]], [[3rbo\|3rbo]], [[3sin\|3sin]], [[3qb6\|3qb6]], [[4jki\|4jki]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fhs, moorella, Moth_0109 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=264732 MOOTA])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fhs, moorella, Moth_0109 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=264732 MOOTA])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Formate--tetrahydrofolate_ligase Formate--tetrahydrofolate ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.3 6.3.4.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Formate--tetrahydrofolate_ligase Formate--tetrahydrofolate ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.3 6.3.4.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4jjk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jjk OCA], [http://pdbe.org/4jjk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jjk RCSB], [http://www.ebi.ac.uk/pdbsum/4jjk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jjk ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=4jjk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jjk OCA], [http://pdbe.org/4jjk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jjk RCSB], [http://www.ebi.ac.uk/pdbsum/4jjk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jjk ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Formate--tetrahydrofolate ligase]]		[[Category: Formate--tetrahydrofolate ligase]]
		+	[[Category: Large Structures]]
	[[Category: Moota]]		[[Category: Moota]]
	[[Category: Celeste, L R]]		[[Category: Celeste, L R]]

OCA at 09:11, 15 November 2017

OCA — Wed, 15 Nov 2017 09:11:07 GMT

←Older revision		Revision as of 09:11, 15 November 2017
Line 1:		Line 1:
		+
	==Crystal Strucutre of N10-Formyltetrahydrofolate Synthetase with Folate==		==Crystal Strucutre of N10-Formyltetrahydrofolate Synthetase with Folate==
	<StructureSection load='4jjk' size='340' side='right' caption='[[4jjk]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='4jjk' size='340' side='right' caption='[[4jjk]], [[Resolution\|resolution]] 3.00Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fhs, moorella, Moth_0109 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=264732 MOOTA])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fhs, moorella, Moth_0109 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=264732 MOOTA])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Formate--tetrahydrofolate_ligase Formate--tetrahydrofolate ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.3 6.3.4.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Formate--tetrahydrofolate_ligase Formate--tetrahydrofolate ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.3 6.3.4.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jjk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jjk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jjk RCSB], [http://www.ebi.ac.uk/pdbsum/4jjk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jjk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jjk OCA], [http://pdbe.org/4jjk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jjk RCSB], [http://www.ebi.ac.uk/pdbsum/4jjk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jjk ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4jjk" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 24:		Line 26:
	[[Category: Moota]]		[[Category: Moota]]
	[[Category: Celeste, L R]]		[[Category: Celeste, L R]]
-	[[Category: L L., Lovelace]]
	[[Category: Lebioda, L]]		[[Category: Lebioda, L]]
		+	[[Category: Lovelace, L L]]
	[[Category: Ligase]]		[[Category: Ligase]]

OCA at 08:40, 18 December 2014

OCA — Thu, 18 Dec 2014 08:40:50 GMT

←Older revision		Revision as of 08:40, 18 December 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal Strucutre of N10-Formyltetrahydrofolate Synthetase with Folate==
		+	<StructureSection load='4jjk' size='340' side='right' caption='[[4jjk]], [[Resolution\|resolution]] 3.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4jjk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Moota Moota]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3qb6 3qb6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JJK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JJK FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TOE:2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXYL'>TOE</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3pzx\|3pzx]], [[4jim\|4jim]], [[3rbo\|3rbo]], [[3sin\|3sin]], [[3qb6\|3qb6]], [[4jki\|4jki]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fhs, moorella, Moth_0109 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=264732 MOOTA])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Formate--tetrahydrofolate_ligase Formate--tetrahydrofolate ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.3 6.3.4.3] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jjk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jjk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jjk RCSB], [http://www.ebi.ac.uk/pdbsum/4jjk PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	N(10) -formyltetrahydrofolate synthetase (FTHFS) is a folate enzyme that catalyzes the formylation of tetrahydrofolate (THF) in an ATP dependent manner. Structures of FTHFS from the thermophilic homoacetogen, Moorella thermoacetica, complexed with 1) a catalytic intermediate - formylphosphate (XPO) and product - ADP; 2) with an inhibitory substrate analog - folate; 3) with XPO and an inhibitory THF analog, ZD9331, were used to analyze the enzyme mechanism. Nucleophilic attack of the formate ion on the gamma phosphate of ATP leads to the formation of XPO and the first product ADP. A channel that leads to the putative formate binding pocket allows for the binding of ATP and formate in random order. Formate binding is due to interactions with the gamma-phosphate moiety of ATP and additionally to two hydrogen bonds from the backbone nitrogen of Ala276 and the side chain of Arg97. Upon ADP dissociation, XPO reorients and moves to the position previously occupied by the beta-phosphate of ATP. Conformational changes that occur due to the XPO presence apparently allow for the recruitment of the third substrate, THF, with its pterin moiety positioned between Phe384 and Trp412. This position overlaps with that of the bound nucleoside, which is consistent with a catalytic mechanism hypothesis that FTHFS works via a sequential ping-pong mechanism. More specifically, a random bi uni uni bi ping-pong ter ter mechanism is proposed. Additionally, the native structure originally reported at a 2.5 A resolution was redetermined at a 2.2 A resolution.

-	~~The entry 4jjk is ON HOLD~~	+	Mechanism of N(10) -formyltetrahydrofolate synthetase derived from complexes with intermediates and inhibitors.,Celeste LR, Chai G, Bielak M, Minor W, Lovelace LL, Lebioda L Protein Sci. 2011 Nov 22. doi: 10.1002/pro.2005. PMID:22109967<ref>PMID:22109967</ref>

-	~~Authors~~: Celeste, L.R~~., Lovelace~~ L.L., Lebioda, L.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal Strucutre of N10-Formyltetrahydrofolate Synthetase with Folate~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Formate--tetrahydrofolate ligase]]
		+	[[Category: Moota]]
		+	[[Category: Celeste, L R]]
		+	[[Category: L L., Lovelace]]
		+	[[Category: Lebioda, L]]
		+	[[Category: Ligase]]

OCA: Protected "4jjk" [edit=sysop:move=sysop]

OCA — Wed, 13 Mar 2013 10:04:17 GMT

Protected "4jjk" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:04, 13 March 2013

OCA: New page: '''Unreleased structure''' The entry 4jjk is ON HOLD Authors: Celeste, L.R., Lovelace L.L., Lebioda, L. Description: Crystal Strucutre of N10-Formyltetrahydrofolate Synthetase with Fol...

OCA — Wed, 13 Mar 2013 10:04:16 GMT

New page: '''Unreleased structure''' The entry 4jjk is ON HOLD Authors: Celeste, L.R., Lovelace L.L., Lebioda, L. Description: Crystal Strucutre of N10-Formyltetrahydrofolate Synthetase with Fol...

New page

'''Unreleased structure'''

The entry 4jjk is ON HOLD

Authors: Celeste, L.R., Lovelace L.L., Lebioda, L.

Description: Crystal Strucutre of N10-Formyltetrahydrofolate Synthetase with Folate