4jke - Revision history

OCA at 15:44, 20 September 2023

OCA — Wed, 20 Sep 2023 15:44:32 GMT

←Older revision		Revision as of 15:44, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4jke]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JKE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JKE FirstGlance]. <br>		<table><tr><td colspan='2'>[[4jke]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JKE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JKE FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.65Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jke OCA], [https://pdbe.org/4jke PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jke RCSB], [https://www.ebi.ac.uk/pdbsum/4jke PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jke ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jke OCA], [https://pdbe.org/4jke PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jke RCSB], [https://www.ebi.ac.uk/pdbsum/4jke PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jke ProSAT]</span></td></tr>
	</table>		</table>

OCA at 11:17, 24 November 2022

OCA — Thu, 24 Nov 2022 11:17:48 GMT

←Older revision		Revision as of 11:17, 24 November 2022
Line 1:		Line 1:

	==Open and closed forms of T1789P human PRP8 RNase H-like domain with bound Mg ion==		==Open and closed forms of T1789P human PRP8 RNase H-like domain with bound Mg ion==
-	<StructureSection load='4jke' size='340' side='right' caption='[[4jke]], [[Resolution\|resolution]] 1.65Å' scene=''>	+	<StructureSection load='4jke' size='340' side='right'caption='[[4jke]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4jke]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JKE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4JKE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4jke]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JKE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JKE FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3enb\|3enb]], [[4jk7\|4jk7]], [[4jk8\|4jk8]], [[4jk9\|4jk9]], [[4jka\|4jka]], [[4jkb\|4jkb]], [[4jkc\|4jkc]], [[4jkd\|4jkd]], [[4jkf\|4jkf]], [[4jkg\|4jkg]], [[4jkh\|4jkh]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jke OCA], [https://pdbe.org/4jke PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jke RCSB], [https://www.ebi.ac.uk/pdbsum/4jke PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jke ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRP8, PRPC8, PRPF8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4jke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jke OCA], [~~http~~://pdbe.org/4jke PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4jke RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4jke PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4jke ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/PRP8_HUMAN PRP8_HUMAN]] Defects in PRPF8 are the cause of retinitis pigmentosa type 13 (RP13) [MIM:[~~http~~://omim.org/entry/600059 600059]]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP13 inheritance is autosomal dominant.<ref>PMID:17317632</ref> <ref>PMID:11468273</ref> [:]<ref>PMID:11910553</ref> <ref>PMID:12714658</ref>	+	[https://www.uniprot.org/uniprot/PRP8_HUMAN PRP8_HUMAN] Defects in PRPF8 are the cause of retinitis pigmentosa type 13 (RP13) [MIM:[https://omim.org/entry/600059 600059]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP13 inheritance is autosomal dominant.<ref>PMID:17317632</ref> <ref>PMID:11468273</ref> [:]<ref>PMID:11910553</ref> <ref>PMID:12714658</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PRP8_HUMAN PRP8_HUMAN]] Central component of the spliceosome, which may play a role in aligning the pre-mRNA 5'- and 3'-exons for ligation. Interacts with U5 snRNA, and with pre-mRNA 5'-splice sites in B spliceosomes and 3'-splice sites in C spliceosomes.	+	[https://www.uniprot.org/uniprot/PRP8_HUMAN PRP8_HUMAN] Central component of the spliceosome, which may play a role in aligning the pre-mRNA 5'- and 3'-exons for ligation. Interacts with U5 snRNA, and with pre-mRNA 5'-splice sites in B spliceosomes and 3'-splice sites in C spliceosomes.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 22:

	==See Also==		==See Also==
-	*[[Pre-mRNA-splicing ~~factor~~\|Pre-mRNA-splicing ~~factor~~]]	+	*[[Pre-mRNA splicing factors 3D structures\|Pre-mRNA splicing factors 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Atta, K A~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~MacMillan, A M~~]]	+	[[Category: Atta KA]]
-	[[Category: ~~Ritchie, D B~~]]	+	[[Category: MacMillan AM]]
-	[[Category: ~~Schellenberg, M J~~]]	+	[[Category: Ritchie DB]]
-	[[Category: ~~Wu, T~~]]	+	[[Category: Schellenberg MJ]]
-	[[Category: ~~Conformational change]]~~	+	[[Category: Wu T]]
-	~~[[Category: Metalloprotein]]~~	+
-	~~[[Category: Rna binding protein~~]]	+

OCA at 17:31, 4 August 2016

OCA — Thu, 04 Aug 2016 17:31:29 GMT

←Older revision		Revision as of 17:31, 4 August 2016
Line 1:		Line 1:
		+
	==Open and closed forms of T1789P human PRP8 RNase H-like domain with bound Mg ion==		==Open and closed forms of T1789P human PRP8 RNase H-like domain with bound Mg ion==
	<StructureSection load='4jke' size='340' side='right' caption='[[4jke]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='4jke' size='340' side='right' caption='[[4jke]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4jke]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JKE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JKE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4jke]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JKE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JKE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3enb\|3enb]], [[4jk7\|4jk7]], [[4jk8\|4jk8]], [[4jk9\|4jk9]], [[4jka\|4jka]], [[4jkb\|4jkb]], [[4jkc\|4jkc]], [[4jkd\|4jkd]], [[4jkf\|4jkf]], [[4jkg\|4jkg]], [[4jkh\|4jkh]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3enb\|3enb]], [[4jk7\|4jk7]], [[4jk8\|4jk8]], [[4jk9\|4jk9]], [[4jka\|4jka]], [[4jkb\|4jkb]], [[4jkc\|4jkc]], [[4jkd\|4jkd]], [[4jkf\|4jkf]], [[4jkg\|4jkg]], [[4jkh\|4jkh]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRP8, PRPC8, PRPF8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRP8, PRPC8, PRPF8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jke OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jke RCSB], [http://www.ebi.ac.uk/pdbsum/4jke PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jke OCA], [http://pdbe.org/4jke PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jke RCSB], [http://www.ebi.ac.uk/pdbsum/4jke PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jke ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 21:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4jke" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 27:		Line 29:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Atta, K A]]		[[Category: Atta, K A]]
	[[Category: MacMillan, A M]]		[[Category: MacMillan, A M]]

OCA at 14:51, 21 December 2014

OCA — Sun, 21 Dec 2014 14:51:28 GMT

←Older revision		Revision as of 14:51, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4jke\| PDB=4jke \| SCENE= }}~~	+	==Open and closed forms of T1789P human PRP8 RNase H-like domain with bound Mg ion==
-	===Open and closed forms of T1789P human PRP8 RNase H-like domain with bound Mg ion===	+	<StructureSection load='4jke' size='340' side='right' caption='[[4jke]], [[Resolution\|resolution]] 1.65Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23686287}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4jke]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JKE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JKE FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3enb\|3enb]], [[4jk7\|4jk7]], [[4jk8\|4jk8]], [[4jk9\|4jk9]], [[4jka\|4jka]], [[4jkb\|4jkb]], [[4jkc\|4jkc]], [[4jkd\|4jkd]], [[4jkf\|4jkf]], [[4jkg\|4jkg]], [[4jkh\|4jkh]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRP8, PRPC8, PRPF8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jke OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jke RCSB], [http://www.ebi.ac.uk/pdbsum/4jke PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/PRP8_HUMAN PRP8_HUMAN]] Defects in PRPF8 are the cause of retinitis pigmentosa type 13 (RP13) [MIM:[http://omim.org/entry/600059 600059]]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP13 inheritance is autosomal dominant.<ref>PMID:17317632</ref> <ref>PMID:11468273</ref> [:]<ref>PMID:11910553</ref> <ref>PMID:12714658</ref>		[[http://www.uniprot.org/uniprot/PRP8_HUMAN PRP8_HUMAN]] Defects in PRPF8 are the cause of retinitis pigmentosa type 13 (RP13) [MIM:[http://omim.org/entry/600059 600059]]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP13 inheritance is autosomal dominant.<ref>PMID:17317632</ref> <ref>PMID:11468273</ref> [:]<ref>PMID:11910553</ref> <ref>PMID:12714658</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PRP8_HUMAN PRP8_HUMAN]] Central component of the spliceosome, which may play a role in aligning the pre-mRNA 5'- and 3'-exons for ligation. Interacts with U5 snRNA, and with pre-mRNA 5'-splice sites in B spliceosomes and 3'-splice sites in C spliceosomes.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Splicing of pre-mRNAs in eukaryotes is catalyzed by the spliceosome, a large RNA-protein metalloenzyme. The catalytic center of the spliceosome involves a structure comprising the U2 and U6 snRNAs and includes a metal bound by U6 snRNA. The precise architecture of the splicesome active site, however, and the question of whether it includes protein components, remains unresolved. A wealth of evidence places the protein PRP8 at the heart of the spliceosome through assembly and catalysis. Here we provide evidence that the RNase H domain of PRP8 undergoes a conformational switch between the two steps of splicing, rationalizing yeast prp8 alleles that promote either the first or second step. We also show that this switch unmasks a metal-binding site involved in the second step. Together, these data establish that PRP8 is a metalloprotein that promotes exon ligation within the spliceosome.

-	~~==Function==~~	+	A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation.,Schellenberg MJ, Wu T, Ritchie DB, Fica S, Staley JP, Atta KA, Lapointe P, Macmillan AM Nat Struct Mol Biol. 2013 May 19. doi: 10.1038/nsmb.2556. PMID:23686287<ref>PMID:23686287</ref>
-	~~[[http://www.uniprot.org/uniprot/PRP8_HUMAN PRP8_HUMAN]] Central component of the spliceosome, which may play a role~~ in ~~aligning the~~ pre-mRNA ~~5'- and 3'-exons for~~ ligation. ~~Interacts with U5 snRNA~~, ~~and with pre-mRNA 5'-splice sites in B spliceosomes and 3'-splice sites in C spliceosomes~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4jke]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4JKE OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:023686287</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Pre-mRNA-splicing factor\|Pre-mRNA-splicing factor]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Atta, K A.]]	+	[[Category: Atta, K A]]
-	[[Category: MacMillan, A M.]]	+	[[Category: MacMillan, A M]]
-	[[Category: Ritchie, D B.]]	+	[[Category: Ritchie, D B]]
-	[[Category: Schellenberg, M J.]]	+	[[Category: Schellenberg, M J]]
-	[[Category: Wu, T.]]	+	[[Category: Wu, T]]
	[[Category: Conformational change]]		[[Category: Conformational change]]
	[[Category: Metalloprotein]]		[[Category: Metalloprotein]]
	[[Category: Rna binding protein]]		[[Category: Rna binding protein]]

OCA at 08:16, 19 June 2013

OCA — Wed, 19 Jun 2013 08:16:19 GMT

←Older revision		Revision as of 08:16, 19 June 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4jke\| PDB=4jke \| SCENE= }}
		+	===Open and closed forms of T1789P human PRP8 RNase H-like domain with bound Mg ion===
		+	{{ABSTRACT_PUBMED_23686287}}

-	~~The~~ entry ~~4jke~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/PRP8_HUMAN PRP8_HUMAN]] Defects in PRPF8 are the cause of retinitis pigmentosa type 13 (RP13) [MIM:[http://omim.org/entry/600059 600059]]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP13 inheritance is autosomal dominant.<ref>PMID:17317632</ref> <ref>PMID:11468273</ref> [:]<ref>PMID:11910553</ref> <ref>PMID:12714658</ref>

-	~~Authors~~: ~~Schellenberg, M~~.J., ~~Wu, T~~., ~~Ritchie, D.~~B~~., Atta, K.A., MacMillan, A.M~~.	+	==Function==
		+	[[http://www.uniprot.org/uniprot/PRP8_HUMAN PRP8_HUMAN]] Central component of the spliceosome, which may play a role in aligning the pre-mRNA 5'- and 3'-exons for ligation. Interacts with U5 snRNA, and with pre-mRNA 5'-splice sites in B spliceosomes and 3'-splice sites in C spliceosomes.

-	~~Description~~: ~~Open and closed forms of T1789P human PRP8 RNase H~~-~~like domain with bound Mg ion~~	+	==About this Structure==
		+	[[4jke]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JKE OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:023686287</ref><references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Atta, K A.]]
		+	[[Category: MacMillan, A M.]]
		+	[[Category: Ritchie, D B.]]
		+	[[Category: Schellenberg, M J.]]
		+	[[Category: Wu, T.]]
		+	[[Category: Conformational change]]
		+	[[Category: Metalloprotein]]
		+	[[Category: Rna binding protein]]

OCA at 08:18, 27 March 2013

OCA — Wed, 27 Mar 2013 08:18:12 GMT

←Older revision		Revision as of 08:18, 27 March 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4jke is ON HOLD	+	The entry 4jke is ON HOLD until Paper Publication

	Authors: Schellenberg, M.J., Wu, T., Ritchie, D.B., Atta, K.A., MacMillan, A.M.		Authors: Schellenberg, M.J., Wu, T., Ritchie, D.B., Atta, K.A., MacMillan, A.M.

	Description: Open and closed forms of T1789P human PRP8 RNase H-like domain with bound Mg ion		Description: Open and closed forms of T1789P human PRP8 RNase H-like domain with bound Mg ion

OCA: Protected "4jke" [edit=sysop:move=sysop]

OCA — Wed, 20 Mar 2013 16:21:17 GMT

Protected "4jke" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:21, 20 March 2013

OCA: New page: '''Unreleased structure''' The entry 4jke is ON HOLD Authors: Schellenberg, M.J., Wu, T., Ritchie, D.B., Atta, K.A., MacMillan, A.M. Description: Open and closed forms of T1789P human ...

OCA — Wed, 20 Mar 2013 16:21:16 GMT

New page: '''Unreleased structure''' The entry 4jke is ON HOLD Authors: Schellenberg, M.J., Wu, T., Ritchie, D.B., Atta, K.A., MacMillan, A.M. Description: Open and closed forms of T1789P human ...

New page

'''Unreleased structure'''

The entry 4jke is ON HOLD

Authors: Schellenberg, M.J., Wu, T., Ritchie, D.B., Atta, K.A., MacMillan, A.M.

Description: Open and closed forms of T1789P human PRP8 RNase H-like domain with bound Mg ion