4jmh - Revision history

OCA at 15:45, 20 September 2023

OCA — Wed, 20 Sep 2023 15:45:19 GMT

←Older revision		Revision as of 15:45, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4jmh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JMH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JMH FirstGlance]. <br>		<table><tr><td colspan='2'>[[4jmh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JMH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JMH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.408Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jmh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jmh OCA], [https://pdbe.org/4jmh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jmh RCSB], [https://www.ebi.ac.uk/pdbsum/4jmh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jmh ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jmh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jmh OCA], [https://pdbe.org/4jmh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jmh RCSB], [https://www.ebi.ac.uk/pdbsum/4jmh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jmh ProSAT]</span></td></tr>
	</table>		</table>

OCA at 11:23, 24 November 2022

OCA — Thu, 24 Nov 2022 11:23:06 GMT

←Older revision		Revision as of 11:23, 24 November 2022
Line 1:		Line 1:

	==Crystal structure of synthetic protein in complex with double pY peptide==		==Crystal structure of synthetic protein in complex with double pY peptide==
-	<StructureSection load='4jmh' size='340' side='right' caption='[[4jmh]], [[Resolution\|resolution]] 2.41Å' scene=''>	+	<StructureSection load='4jmh' size='340' side='right'caption='[[4jmh]], [[Resolution\|resolution]] 2.41Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4jmh]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~] and [~~http~~://en.wikipedia.org/wiki/~~Synthetic_construct_sequences~~ Synthetic construct ~~sequences~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JMH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4JMH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4jmh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JMH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JMH FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4jmg\|4jmg]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jmh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jmh OCA], [https://pdbe.org/4jmh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jmh RCSB], [https://www.ebi.ac.uk/pdbsum/4jmh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jmh ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SHC, SHC1, SHCA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4jmh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jmh OCA], [~~http~~://pdbe.org/4jmh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4jmh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4jmh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4jmh ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SHC1_HUMAN SHC1_HUMAN]] Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.<ref>PMID:14665640</ref>	+	[https://www.uniprot.org/uniprot/SHC1_HUMAN SHC1_HUMAN] Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.<ref>PMID:14665640</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: Synthetic construct ~~sequences~~]]	+	[[Category: Large Structures]]
-	[[Category: Koide, S]]	+	[[Category: Synthetic construct]]
-	[[Category: Smith, L]]	+	[[Category: Koide S]]
-	[[Category: Yasui, N]]	+	[[Category: Smith L]]
-	~~[[Category: Binding to double py containing sequence]]~~	+	[[Category: Yasui N]]
-	~~[[Category: De novo protein]]~~	+
-	~~[[Category: Synthetic protein~~]]	+

OCA at 09:56, 4 August 2016

OCA — Thu, 04 Aug 2016 09:56:07 GMT

←Older revision		Revision as of 09:56, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of synthetic protein in complex with double pY peptide==		==Crystal structure of synthetic protein in complex with double pY peptide==
	<StructureSection load='4jmh' size='340' side='right' caption='[[4jmh]], [[Resolution\|resolution]] 2.41Å' scene=''>		<StructureSection load='4jmh' size='340' side='right' caption='[[4jmh]], [[Resolution\|resolution]] 2.41Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4jmg\|4jmg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4jmg\|4jmg]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SHC, SHC1, SHCA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SHC, SHC1, SHCA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jmh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jmh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jmh RCSB], [http://www.ebi.ac.uk/pdbsum/4jmh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jmh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jmh OCA], [http://pdbe.org/4jmh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jmh RCSB], [http://www.ebi.ac.uk/pdbsum/4jmh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jmh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4jmh" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:36, 24 December 2014

OCA — Wed, 24 Dec 2014 08:36:51 GMT

←Older revision		Revision as of 08:36, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4jmh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Synthetic_construct_sequences Synthetic construct sequences]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JMH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JMH FirstGlance]. <br>		<table><tr><td colspan='2'>[[4jmh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Synthetic_construct_sequences Synthetic construct sequences]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JMH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JMH FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4jmg\|4jmg]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4jmg\|4jmg]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SHC, SHC1, SHCA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SHC, SHC1, SHCA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jmh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jmh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jmh RCSB], [http://www.ebi.ac.uk/pdbsum/4jmh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jmh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jmh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jmh RCSB], [http://www.ebi.ac.uk/pdbsum/4jmh PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SHC1_HUMAN SHC1_HUMAN]] Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.<ref>PMID:14665640</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 24:
	[[Category: Human]]		[[Category: Human]]
	[[Category: Synthetic construct sequences]]		[[Category: Synthetic construct sequences]]
-	[[Category: Koide, S.]]	+	[[Category: Koide, S]]
-	[[Category: Smith, L.]]	+	[[Category: Smith, L]]
-	[[Category: Yasui, N.]]	+	[[Category: Yasui, N]]
	[[Category: Binding to double py containing sequence]]		[[Category: Binding to double py containing sequence]]
	[[Category: De novo protein]]		[[Category: De novo protein]]
	[[Category: Synthetic protein]]		[[Category: Synthetic protein]]

OCA at 06:41, 30 July 2014

OCA — Wed, 30 Jul 2014 06:41:09 GMT

←Older revision		Revision as of 06:41, 30 July 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4jmh\| PDB=4jmh \| SCENE= }}~~	+	==Crystal structure of synthetic protein in complex with double pY peptide==
-	===Crystal structure of synthetic protein in complex with double pY peptide===	+	<StructureSection load='4jmh' size='340' side='right' caption='[[4jmh]], [[Resolution\|resolution]] 2.41Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4jmh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Synthetic_construct_sequences Synthetic construct sequences]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JMH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JMH FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4jmg\|4jmg]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SHC, SHC1, SHCA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jmh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jmh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jmh RCSB], [http://www.ebi.ac.uk/pdbsum/4jmh PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cell signaling depends on dynamic protein-protein interaction (PPI) networks, often assembled through modular domains each interacting with multiple peptide motifs. This complexity raises a conceptual challenge, namely to define whether a particular cellular response requires assembly of the complete PPI network of interest or can be driven by a specific interaction. To address this issue, we designed variants of the Grb2 SH2 domain ("pY-clamps") whose specificity is highly biased toward a single phosphotyrosine (pY) motif among many potential pYXNX Grb2-binding sites. Surprisingly, directing Grb2 predominantly to a single pY site of the Ptpn11/Shp2 phosphatase, but not other sites tested, was sufficient for differentiation of the essential primitive endoderm lineage from embryonic stem cells. Our data suggest that discrete connections within complex PPI networks can underpin regulation of particular biological events. We propose that this directed wiring approach will be of general utility in functionally annotating specific PPIs.

-	~~==Function==~~	+	Directed network wiring identifies a key protein interaction in embryonic stem cell differentiation.,Yasui N, Findlay GM, Gish GD, Hsiung MS, Huang J, Tucholska M, Taylor L, Smith L, Boldridge WC, Koide A, Pawson T, Koide S Mol Cell. 2014 Jun 19;54(6):1034-41. doi: 10.1016/j.molcel.2014.05.002. Epub 2014, Jun 5. PMID:24910098<ref>PMID:24910098</ref>
-	~~[[http://www.uniprot.org/uniprot/SHC1_HUMAN SHC1_HUMAN]] Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates~~ in ~~a signaling cascade initiated by activated KIT and KITLG/SCF~~. ~~Isoform p46Shc and isoform p52Shc~~, ~~once phosphorylated~~, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, ~~cytochrome c release and apoptosis~~. ~~The expression of isoform p66Shc has been correlated with life span~~ (~~By similarity~~). ~~Participates in signaling downstream of the angiopoietin receptor TEK~~/~~TIE2~~, ~~and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis~~.<ref>PMID:~~14665640~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4jmh]] is~~ a ~~2 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4JMH OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Synthetic construct sequences]]
	[[Category: Koide, S.]]		[[Category: Koide, S.]]
	[[Category: Smith, L.]]		[[Category: Smith, L.]]

OCA at 07:52, 23 April 2014

OCA — Wed, 23 Apr 2014 07:52:44 GMT

←Older revision		Revision as of 07:52, 23 April 2014
Line 1:		Line 1:
-	~~WITHDRAWN~~: The ~~PDB entry~~ 4JMH ~~was withdrawn~~.	+	{{STRUCTURE_4jmh\| PDB=4jmh \| SCENE= }}
		+	===Crystal structure of synthetic protein in complex with double pY peptide===
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/SHC1_HUMAN SHC1_HUMAN]] Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.<ref>PMID:14665640</ref>
		+
		+	==About this Structure==
		+	[[4jmh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JMH OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Koide, S.]]
		+	[[Category: Smith, L.]]
		+	[[Category: Yasui, N.]]
		+	[[Category: Binding to double py containing sequence]]
		+	[[Category: De novo protein]]
		+	[[Category: Synthetic protein]]

OCA at 09:08, 26 March 2014

OCA — Wed, 26 Mar 2014 09:08:11 GMT

←Older revision		Revision as of 09:08, 26 March 2014
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	WITHDRAWN: The PDB entry 4JMH was withdrawn.
-		+
-	The entry ~~4jmh is ON HOLD until Paper Publication~~	+
-		+
-	~~Authors: Yasui, N~~.~~, Smith, L., Koide, S.~~	+
-		+
-	~~Description: Crystal structure of synthetic protein in complex with double pY peptide~~	+

OCA at 07:07, 2 May 2013

OCA — Thu, 02 May 2013 07:07:25 GMT

←Older revision		Revision as of 07:07, 2 May 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4jmh is ON HOLD	+	The entry 4jmh is ON HOLD until Paper Publication

	Authors: Yasui, N., Smith, L., Koide, S.		Authors: Yasui, N., Smith, L., Koide, S.

	Description: Crystal structure of synthetic protein in complex with double pY peptide		Description: Crystal structure of synthetic protein in complex with double pY peptide

OCA at 08:18, 27 March 2013

OCA — Wed, 27 Mar 2013 08:18:55 GMT

←Older revision		Revision as of 08:18, 27 March 2013
Line 3:		Line 3:
	The entry 4jmh is ON HOLD		The entry 4jmh is ON HOLD

-	Authors: Yasui, N, Smith, L, Koide, S	+	Authors: Yasui, N., Smith, L., Koide, S.

	Description: Crystal structure of synthetic protein in complex with double pY peptide		Description: Crystal structure of synthetic protein in complex with double pY peptide

OCA: Protected "4jmh" [edit=sysop:move=sysop]

OCA — Wed, 20 Mar 2013 16:23:31 GMT

Protected "4jmh" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:23, 20 March 2013