4jup - Revision history

OCA at 11:26, 30 November 2022

OCA — Wed, 30 Nov 2022 11:26:06 GMT

←Older revision		Revision as of 11:26, 30 November 2022
Line 1:		Line 1:

	==Dimeric structure of CARMA1 CARD==		==Dimeric structure of CARMA1 CARD==
-	<StructureSection load='4jup' size='340' side='right' caption='[[4jup]], [[Resolution\|resolution]] 3.20Å' scene=''>	+	<StructureSection load='4jup' size='340' side='right'caption='[[4jup]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4jup]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JUP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4JUP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4jup]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JUP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JUP FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CARD11, CARMA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jup OCA], [https://pdbe.org/4jup PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jup RCSB], [https://www.ebi.ac.uk/pdbsum/4jup PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jup ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4jup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jup OCA], [~~http~~://pdbe.org/4jup PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4jup RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4jup PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4jup ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/CAR11_HUMAN CAR11_HUMAN]] Persistent polyclonal B-cell lymphocytosis. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/CAR11_HUMAN CAR11_HUMAN] Persistent polyclonal B-cell lymphocytosis. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CAR11_HUMAN CAR11_HUMAN]] Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.	+	[https://www.uniprot.org/uniprot/CAR11_HUMAN CAR11_HUMAN] Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Park, H H~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Protein binding]]~~	+	[[Category: Park HH]]
-	~~[[Category: Protein interaction~~]]	+

OCA at 05:55, 5 August 2016

OCA — Fri, 05 Aug 2016 05:55:29 GMT

←Older revision		Revision as of 05:55, 5 August 2016
Line 1:		Line 1:
		+
	==Dimeric structure of CARMA1 CARD==		==Dimeric structure of CARMA1 CARD==
	<StructureSection load='4jup' size='340' side='right' caption='[[4jup]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='4jup' size='340' side='right' caption='[[4jup]], [[Resolution\|resolution]] 3.20Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4jup]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JUP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JUP FirstGlance]. <br>		<table><tr><td colspan='2'>[[4jup]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JUP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JUP FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CARD11, CARMA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CARD11, CARMA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jup OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jup RCSB], [http://www.ebi.ac.uk/pdbsum/4jup PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jup OCA], [http://pdbe.org/4jup PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jup RCSB], [http://www.ebi.ac.uk/pdbsum/4jup PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jup ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4jup" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:01, 21 December 2014

OCA — Sun, 21 Dec 2014 17:01:29 GMT

←Older revision		Revision as of 17:01, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4jup\| PDB~~=4jup \| ~~SCENE~~= }}	+	==Dimeric structure of CARMA1 CARD==
-	===~~Dimeric~~ structure of CARMA1 ~~CARD~~===	+	<StructureSection load='4jup' size='340' side='right' caption='[[4jup]], [[Resolution\|resolution]] 3.20Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24224005}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4jup]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JUP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JUP FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CARD11, CARMA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jup OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jup RCSB], [http://www.ebi.ac.uk/pdbsum/4jup PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/CAR11_HUMAN CAR11_HUMAN]] Persistent polyclonal B-cell lymphocytosis. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.		[[http://www.uniprot.org/uniprot/CAR11_HUMAN CAR11_HUMAN]] Persistent polyclonal B-cell lymphocytosis. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
-		+	== Function ==
-	==Function==	+
	[[http://www.uniprot.org/uniprot/CAR11_HUMAN CAR11_HUMAN]] Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.		[[http://www.uniprot.org/uniprot/CAR11_HUMAN CAR11_HUMAN]] Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	CARMA1, BCL10 and MALT1 form a large molecular complex known as the CARMA1 signalosome during lymphocyte activation. Lymphocyte activation via the CARMA1 signalosome is critical to immune response and linked to many immune diseases. Despite the important role of the CARMA1 signalosome during lymphocyte activation and proliferation, limited structural information is available. Here, we report the dimeric structure of CARMA1 CARD at a resolution of 3.2 A. Interestingly, although CARMA1 CARD has a canonical six helical-bundles structural fold similar to other CARDs, CARMA1 CARD shows the first homo-dimeric structure of CARD formed by a disulfide bond and reveals a possible biologically important homo-dimerization mechanism.

-	~~==About this Structure==~~	+	Novel disulfide bond-mediated dimerization of the CARD domain was revealed by the crystal structure of CARMA1 CARD.,Jang TH, Park JH, Park HH PLoS One. 2013 Nov 5;8(11):e79778. doi: 10.1371/journal.pone.0079778. eCollection, 2013. PMID:24224005<ref>PMID:24224005</ref>
-	~~[[4jup]] is a 2 chain~~ structure. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.~~il/oca-bin/ocashort?id=4JUP OCA]~~.	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024224005</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
-	[[Category: Park, H H.]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Park, H H]]
	[[Category: Protein binding]]		[[Category: Protein binding]]
	[[Category: Protein interaction]]		[[Category: Protein interaction]]

OCA at 11:03, 5 February 2014

OCA — Wed, 05 Feb 2014 11:03:25 GMT

←Older revision		Revision as of 11:03, 5 February 2014
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4jup\| PDB=4jup \| SCENE= }}
		+	===Dimeric structure of CARMA1 CARD===
		+	{{ABSTRACT_PUBMED_24224005}}

-	The entry ~~4jup~~ is ~~ON HOLD~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/CAR11_HUMAN CAR11_HUMAN]] Persistent polyclonal B-cell lymphocytosis. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.

-	~~Authors~~: ~~Park, H~~.H.	+	==Function==
		+	[[http://www.uniprot.org/uniprot/CAR11_HUMAN CAR11_HUMAN]] Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.

-	~~Description: Dimeric~~ structure ~~of CARMA1 CARD~~	+	==About this Structure==
		+	[[4jup]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JUP OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:024224005</ref><references group="xtra"/><references/>
		+	[[Category: Park, H H.]]
		+	[[Category: Protein binding]]
		+	[[Category: Protein interaction]]

OCA at 20:00, 17 April 2013

OCA — Wed, 17 Apr 2013 20:00:27 GMT

←Older revision		Revision as of 20:00, 17 April 2013
Line 3:		Line 3:
	The entry 4jup is ON HOLD		The entry 4jup is ON HOLD

-	Authors: Park, H.H	+	Authors: Park, H.H.

	Description: Dimeric structure of CARMA1 CARD		Description: Dimeric structure of CARMA1 CARD

OCA: Protected "4jup" [edit=sysop:move=sysop]

OCA — Thu, 04 Apr 2013 01:03:30 GMT

Protected "4jup" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:03, 4 April 2013

OCA: New page: '''Unreleased structure''' The entry 4jup is ON HOLD Authors: Park, H.H Description: Dimeric structure of CARMA1 CARD

OCA — Thu, 04 Apr 2013 01:03:29 GMT

New page: '''Unreleased structure''' The entry 4jup is ON HOLD Authors: Park, H.H Description: Dimeric structure of CARMA1 CARD

New page

'''Unreleased structure'''

The entry 4jup is ON HOLD

Authors: Park, H.H

Description: Dimeric structure of CARMA1 CARD