4jvh - Revision history

OCA at 11:27, 30 November 2022

OCA — Wed, 30 Nov 2022 11:27:22 GMT

←Older revision		Revision as of 11:27, 30 November 2022
Line 1:		Line 1:

	==Structure of the star domain of quaking protein in complex with RNA==		==Structure of the star domain of quaking protein in complex with RNA==
-	<StructureSection load='4jvh' size='340' side='right' caption='[[4jvh]], [[Resolution\|resolution]] 3.50Å' scene=''>	+	<StructureSection load='4jvh' size='340' side='right'caption='[[4jvh]], [[Resolution\|resolution]] 3.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4jvh]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JVH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4JVH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4jvh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JVH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JVH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr~~ id~~='NonStdRes'><td class~~="~~sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat~~"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene><~~/td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jvh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jvh OCA], [https://pdbe.org/4jvh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jvh RCSB], [https://www.ebi.ac.uk/pdbsum/4jvh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jvh ProSAT]</span></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat">[[4jvy\|4jvy]]</td></tr>~~	+
-	~~<tr id='gene~~'>~~<td class="sblockLbl"><b>[[Gene\|Gene:]]~~</b>~~</td><td class="sblockDat">QKI, HKQ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4jvh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jvh OCA], [~~http~~://pdbe.org/4jvh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4jvh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4jvh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4jvh ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/QKI_HUMAN QKI_HUMAN]] RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity).<ref>PMID:16641098</ref>	+	[https://www.uniprot.org/uniprot/QKI_HUMAN QKI_HUMAN] RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity).<ref>PMID:16641098</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: Essig, K]]	+	[[Category: Large Structures]]
-	[[Category: Hafner, M]]	+	[[Category: Essig K]]
-	[[Category: Patel~~, D J~~]]	+	[[Category: Hafner M]]
-	[[Category: Teplov, D]]	+	[[Category: Patel DJ]]
-	[[Category: Teplova, M]]	+	[[Category: Teplov D]]
-	[[Category: Tuschl, T]]	+	[[Category: Teplova M]]
-	~~[[Category: Rna binding protein]]~~	+	[[Category: Tuschl T]]
-	~~[[Category: Rna regulator]]~~	+
-	~~[[Category: Star domain]]~~	+
-	~~[[Category: Translation~~]]	+

OCA at 07:44, 4 August 2016

OCA — Thu, 04 Aug 2016 07:44:51 GMT

←Older revision		Revision as of 07:44, 4 August 2016
Line 1:		Line 1:
		+
	==Structure of the star domain of quaking protein in complex with RNA==		==Structure of the star domain of quaking protein in complex with RNA==
	<StructureSection load='4jvh' size='340' side='right' caption='[[4jvh]], [[Resolution\|resolution]] 3.50Å' scene=''>		<StructureSection load='4jvh' size='340' side='right' caption='[[4jvh]], [[Resolution\|resolution]] 3.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4jvh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JVH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JVH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4jvh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JVH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JVH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4jvy\|4jvy]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4jvy\|4jvy]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">QKI, HKQ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">QKI, HKQ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jvh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jvh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jvh RCSB], [http://www.ebi.ac.uk/pdbsum/4jvh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jvh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jvh OCA], [http://pdbe.org/4jvh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jvh RCSB], [http://www.ebi.ac.uk/pdbsum/4jvh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jvh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4jvh" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Essig, K]]		[[Category: Essig, K]]
	[[Category: Hafner, M]]		[[Category: Hafner, M]]

OCA at 07:08, 24 December 2014

OCA — Wed, 24 Dec 2014 07:08:58 GMT

←Older revision		Revision as of 07:08, 24 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4jvh\| PDB=4jvh \| SCENE= }}~~	+	==Structure of the star domain of quaking protein in complex with RNA==
-	===Structure of the star domain of quaking protein in complex with RNA===	+	<StructureSection load='4jvh' size='340' side='right' caption='[[4jvh]], [[Resolution\|resolution]] 3.50Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23630077}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4jvh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JVH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JVH FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4jvy\|4jvy]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">QKI, HKQ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jvh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jvh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jvh RCSB], [http://www.ebi.ac.uk/pdbsum/4jvh PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/QKI_HUMAN QKI_HUMAN]] RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity).<ref>PMID:16641098</ref>		[[http://www.uniprot.org/uniprot/QKI_HUMAN QKI_HUMAN]] RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity).<ref>PMID:16641098</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mammalian Quaking (QKI) and its Caenorhabditis elegans homolog, GLD-1 (defective in germ line development), are evolutionarily conserved RNA-binding proteins, which post-transcriptionally regulate target genes essential for developmental processes and myelination. We present X-ray structures of the STAR (signal transduction and activation of RNA) domain, composed of Qua1, K homology (KH), and Qua2 motifs of QKI and GLD-1 bound to high-affinity in vivo RNA targets containing YUAAY RNA recognition elements (RREs). The KH and Qua2 motifs of the STAR domain synergize to specifically interact with bases and sugar-phosphate backbones of the bound RRE. Qua1-mediated homodimerization generates a scaffold that enables concurrent recognition of two RREs, thereby plausibly targeting tandem RREs present in many QKI-targeted transcripts. Structure-guided mutations reduced QKI RNA-binding affinity in vitro and in vivo, and expression of QKI mutants in human embryonic kidney cells (HEK293) significantly decreased the abundance of QKI target mRNAs. Overall, our studies define principles underlying RNA target selection by STAR homodimers and provide insights into the post-transcriptional regulatory function of mammalian QKI proteins.

-	~~==About this~~ Structure==	+	Structure-function studies of STAR family Quaking proteins bound to their in vivo RNA target sites.,Teplova M, Hafner M, Teplov D, Essig K, Tuschl T, Patel DJ Genes Dev. 2013 Apr 15;27(8):928-40. doi: 10.1101/gad.216531.113. PMID:23630077<ref>PMID:23630077</ref>
-	~~[[4jvh]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4JVH OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Essig, K.]]	+	[[Category: Essig, K]]
-	[[Category: Hafner, M.]]	+	[[Category: Hafner, M]]
-	[[Category: Patel, D J.]]	+	[[Category: Patel, D J]]
-	[[Category: Teplov, D.]]	+	[[Category: Teplov, D]]
-	[[Category: Teplova, M.]]	+	[[Category: Teplova, M]]
-	[[Category: Tuschl, T.]]	+	[[Category: Tuschl, T]]
	[[Category: Rna binding protein]]		[[Category: Rna binding protein]]
	[[Category: Rna regulator]]		[[Category: Rna regulator]]
	[[Category: Star domain]]		[[Category: Star domain]]
	[[Category: Translation]]		[[Category: Translation]]

OCA at 07:44, 8 May 2013

OCA — Wed, 08 May 2013 07:44:35 GMT

←Older revision		Revision as of 07:44, 8 May 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4jvh\| PDB=4jvh \| SCENE= }}
		+	===Structure of the star domain of quaking protein in complex with RNA===
		+	{{ABSTRACT_PUBMED_23630077}}

-	~~The entry 4jvh is ON HOLD~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/QKI_HUMAN QKI_HUMAN]] RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity).<ref>PMID:16641098</ref>

-	~~Authors~~: ~~Teplova, M~~.~~, Hafner, M~~.~~, Teplov, D~~.~~, Essig, K~~.~~, Tuschl, T~~.~~, Patel, D~~.J.	+	==About this Structure==
		+	[[4jvh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JVH OCA].

-	~~Description~~: ~~Structure of STAR~~ domain ~~1 in complex with RNA~~	+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Essig, K.]]
		+	[[Category: Hafner, M.]]
		+	[[Category: Patel, D J.]]
		+	[[Category: Teplov, D.]]
		+	[[Category: Teplova, M.]]
		+	[[Category: Tuschl, T.]]
		+	[[Category: Rna binding protein]]
		+	[[Category: Rna regulator]]
		+	[[Category: Star domain]]
		+	[[Category: Translation]]

OCA at 20:00, 17 April 2013

OCA — Wed, 17 Apr 2013 20:00:58 GMT

←Older revision		Revision as of 20:00, 17 April 2013
Line 3:		Line 3:
	The entry 4jvh is ON HOLD		The entry 4jvh is ON HOLD

-	Authors: Teplova, M., Hafner, M., Teplov, D., Essig, K., Tuschl, T., Patel,D.J.	+	Authors: Teplova, M., Hafner, M., Teplov, D., Essig, K., Tuschl, T., Patel, D.J.

	Description: Structure of STAR domain 1 in complex with RNA		Description: Structure of STAR domain 1 in complex with RNA

OCA: Protected "4jvh" [edit=sysop:move=sysop]

OCA — Thu, 04 Apr 2013 01:04:47 GMT

Protected "4jvh" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:04, 4 April 2013

OCA: New page: '''Unreleased structure''' The entry 4jvh is ON HOLD Authors: Teplova, M., Hafner, M., Teplov, D., Essig, K., Tuschl, T., Patel,D.J. Description: Structure of STAR domain 1 in complex ...

OCA — Thu, 04 Apr 2013 01:04:46 GMT

New page: '''Unreleased structure''' The entry 4jvh is ON HOLD Authors: Teplova, M., Hafner, M., Teplov, D., Essig, K., Tuschl, T., Patel,D.J. Description: Structure of STAR domain 1 in complex ...

New page

'''Unreleased structure'''

The entry 4jvh is ON HOLD

Authors: Teplova, M., Hafner, M., Teplov, D., Essig, K., Tuschl, T., Patel,D.J.

Description: Structure of STAR domain 1 in complex with RNA