4jyb - Revision history

OCA at 15:51, 20 September 2023

OCA — Wed, 20 Sep 2023 15:51:16 GMT

←Older revision		Revision as of 15:51, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4jyb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methylorubrum_extorquens_AM1 Methylorubrum extorquens AM1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JYB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JYB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4jyb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methylorubrum_extorquens_AM1 Methylorubrum extorquens AM1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JYB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JYB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jyb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jyb OCA], [https://pdbe.org/4jyb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jyb RCSB], [https://www.ebi.ac.uk/pdbsum/4jyb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jyb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jyb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jyb OCA], [https://pdbe.org/4jyb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jyb RCSB], [https://www.ebi.ac.uk/pdbsum/4jyb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jyb ProSAT]</span></td></tr>
	</table>		</table>

OCA at 11:30, 30 November 2022

OCA — Wed, 30 Nov 2022 11:30:49 GMT

←Older revision		Revision as of 11:30, 30 November 2022
Line 1:		Line 1:

	==MeaB, A Bacterial Homolog of MMAA, Bound to GMPPNP==		==MeaB, A Bacterial Homolog of MMAA, Bound to GMPPNP==
-	<StructureSection load='4jyb' size='340' side='right' caption='[[4jyb]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='4jyb' size='340' side='right'caption='[[4jyb]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4jyb]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Metea Metea~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JYB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4JYB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4jyb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methylorubrum_extorquens_AM1 Methylorubrum extorquens AM1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JYB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JYB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qm7\|2qm7]], [[2qm8\|2qm8]], [[4jyc\|4jyc]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jyb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jyb OCA], [https://pdbe.org/4jyb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jyb RCSB], [https://www.ebi.ac.uk/pdbsum/4jyb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jyb ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">meaB, MexAM1_META1p0188 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272630 METEA])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4jyb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jyb OCA], [~~http~~://pdbe.org/4jyb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4jyb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4jyb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4jyb ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/C5AP93_METEA C5AP93_METEA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Metea~~]]	+	[[Category: Large Structures]]
-	[[Category: Banerjee, R]]	+	[[Category: Methylorubrum extorquens AM1]]
-	[[Category: Koutmos, M]]	+	[[Category: Banerjee R]]
-	[[Category: Lofgren, M]]	+	[[Category: Koutmos M]]
-	[[Category: Padovani, D]]	+	[[Category: Lofgren M]]
-	~~[[Category: Alpha and beta protein]]~~	+	[[Category: Padovani D]]
-	~~[[Category: Gtpase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Metallochaperone]]~~	+
-	~~[[Category: P-loop containing nucleoside triphosphate hydrolase~~]]	+

OCA at 15:33, 11 August 2016

OCA — Thu, 11 Aug 2016 15:33:08 GMT

←Older revision		Revision as of 15:33, 11 August 2016
Line 1:		Line 1:
		+
	==MeaB, A Bacterial Homolog of MMAA, Bound to GMPPNP==		==MeaB, A Bacterial Homolog of MMAA, Bound to GMPPNP==
	<StructureSection load='4jyb' size='340' side='right' caption='[[4jyb]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4jyb' size='340' side='right' caption='[[4jyb]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4jyb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Methylobacterium_extorquens_am1 Methylobacterium extorquens am1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JYB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JYB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4jyb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Metea Metea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JYB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JYB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qm7\|2qm7]], [[2qm8\|2qm8]], [[4jyc\|4jyc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qm7\|2qm7]], [[2qm8\|2qm8]], [[4jyc\|4jyc]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">meaB, MexAM1_META1p0188 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272630 ~~Methylobacterium extorquens AM1~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">meaB, MexAM1_META1p0188 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272630 METEA])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jyb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jyb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jyb RCSB], [http://www.ebi.ac.uk/pdbsum/4jyb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jyb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jyb OCA], [http://pdbe.org/4jyb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jyb RCSB], [http://www.ebi.ac.uk/pdbsum/4jyb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jyb ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4jyb" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Methylobacterium extorquens am1~~]]	+	[[Category: Metea]]
	[[Category: Banerjee, R]]		[[Category: Banerjee, R]]
	[[Category: Koutmos, M]]		[[Category: Koutmos, M]]

OCA at 09:31, 20 January 2015

OCA — Tue, 20 Jan 2015 09:31:22 GMT

←Older revision		Revision as of 09:31, 20 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_4jyb\| PDB=4jyb \| SCENE= }}~~	+	==MeaB, A Bacterial Homolog of MMAA, Bound to GMPPNP==
-	===MeaB, A Bacterial Homolog of MMAA, Bound to GMPPNP===	+	<StructureSection load='4jyb' size='340' side='right' caption='[[4jyb]], [[Resolution\|resolution]] 2.10Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23873214}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4jyb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Methylobacterium_extorquens_am1 Methylobacterium extorquens am1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JYB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JYB FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2qm7\|2qm7]], [[2qm8\|2qm8]], [[4jyc\|4jyc]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">meaB, MexAM1_META1p0188 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272630 Methylobacterium extorquens AM1])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jyb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jyb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jyb RCSB], [http://www.ebi.ac.uk/pdbsum/4jyb PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Fidelity during cofactor assembly is essential for the proper functioning of metalloenzymes and is ensured by specific chaperones. MeaB, a G-protein chaperone for the coenzyme B12-dependent radical enzyme methylmalonyl-CoA mutase (MCM), uses the energy of GTP binding, hydrolysis or both to regulate cofactor loading into MCM, protect MCM from inactivation and rescue MCM that is inactivated during turnover. Typically, G proteins signal to client proteins using the conformationally mobile switch I and II loops. Crystallographic snapshots of MeaB reported herein reveal a new switch III element that has substantial conformational plasticity. Using alanine-scanning mutagenesis, we demonstrate that the switch III motif is critical for bidirectional signal transmission of the GTPase-activating protein activity of MCM and the chaperone functions of MeaB in the MeaB-MCM complex. Mutations in the switch III loop identified in patients corrupt this interprotein communication and lead to methylmalonic aciduria, an inborn error of metabolism.

-	~~==About this Structure==~~	+	A switch III motif relays signaling between a B enzyme and its G-protein chaperone.,Lofgren M, Padovani D, Koutmos M, Banerjee R Nat Chem Biol. 2013 Jul 21. doi: 10.1038/nchembio.1298. PMID:23873214<ref>PMID:23873214</ref>
-	~~[[4jyb]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Methylobacterium_extorquens_am1 Methylobacterium extorquens am1]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4JYB OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:023873214</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Methylobacterium extorquens am1]]		[[Category: Methylobacterium extorquens am1]]
-	[[Category: Banerjee, R.]]	+	[[Category: Banerjee, R]]
-	[[Category: Koutmos, M.]]	+	[[Category: Koutmos, M]]
-	[[Category: Lofgren, M.]]	+	[[Category: Lofgren, M]]
-	[[Category: Padovani, D.]]	+	[[Category: Padovani, D]]
	[[Category: Alpha and beta protein]]		[[Category: Alpha and beta protein]]
	[[Category: Gtpase]]		[[Category: Gtpase]]

OCA at 06:32, 14 August 2013

OCA — Wed, 14 Aug 2013 06:32:59 GMT

←Older revision		Revision as of 06:32, 14 August 2013
Line 1:		Line 1:
	{{STRUCTURE_4jyb\| PDB=4jyb \| SCENE= }}		{{STRUCTURE_4jyb\| PDB=4jyb \| SCENE= }}
	===MeaB, A Bacterial Homolog of MMAA, Bound to GMPPNP===		===MeaB, A Bacterial Homolog of MMAA, Bound to GMPPNP===
		+	{{ABSTRACT_PUBMED_23873214}}

	==About this Structure==		==About this Structure==
	[[4jyb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Methylobacterium_extorquens_am1 Methylobacterium extorquens am1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JYB OCA].		[[4jyb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Methylobacterium_extorquens_am1 Methylobacterium extorquens am1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JYB OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:023873214</ref><references group="xtra"/><references/>
	[[Category: Methylobacterium extorquens am1]]		[[Category: Methylobacterium extorquens am1]]
	[[Category: Banerjee, R.]]		[[Category: Banerjee, R.]]

OCA at 13:12, 24 July 2013

OCA — Wed, 24 Jul 2013 13:12:30 GMT

←Older revision		Revision as of 13:12, 24 July 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4jyb\| PDB=4jyb \| SCENE= }}
		+	===MeaB, A Bacterial Homolog of MMAA, Bound to GMPPNP===

-	~~The entry~~ 4jyb is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
-		+	[[4jyb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Methylobacterium_extorquens_am1 Methylobacterium extorquens am1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JYB OCA].
-	~~Authors~~: Koutmos, M., Lofgren, M., Padovani, D.~~, Banerjee, R.~~	+	[[Category: Methylobacterium extorquens am1]]
-		+	[[Category: Banerjee, R.]]
-	~~Description~~: ~~MeaB, A Bacterial Homolog of MMAA, Bound to GMPPNP~~	+	[[Category: Koutmos, M.]]
		+	[[Category: Lofgren, M.]]
		+	[[Category: Padovani, D.]]
		+	[[Category: Alpha and beta protein]]
		+	[[Category: Gtpase]]
		+	[[Category: Hydrolase]]
		+	[[Category: Metallochaperone]]
		+	[[Category: P-loop containing nucleoside triphosphate hydrolase]]

OCA at 13:03, 3 July 2013

OCA — Wed, 03 Jul 2013 13:03:39 GMT

←Older revision		Revision as of 13:03, 3 July 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4jyb is ON HOLD	+	The entry 4jyb is ON HOLD until Paper Publication

	Authors: Koutmos, M., Lofgren, M., Padovani, D., Banerjee, R.		Authors: Koutmos, M., Lofgren, M., Padovani, D., Banerjee, R.

	Description: MeaB, A Bacterial Homolog of MMAA, Bound to GMPPNP		Description: MeaB, A Bacterial Homolog of MMAA, Bound to GMPPNP

OCA: Protected "4jyb" [edit=sysop:move=sysop]

OCA — Wed, 17 Apr 2013 20:02:34 GMT

Protected "4jyb" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:02, 17 April 2013

OCA: New page: '''Unreleased structure''' The entry 4jyb is ON HOLD Authors: Koutmos, M., Lofgren, M., Padovani, D., Banerjee, R. Description: MeaB, A Bacterial Homolog of MMAA, Bound to GMPPNP

OCA — Wed, 17 Apr 2013 20:02:33 GMT

New page: '''Unreleased structure''' The entry 4jyb is ON HOLD Authors: Koutmos, M., Lofgren, M., Padovani, D., Banerjee, R. Description: MeaB, A Bacterial Homolog of MMAA, Bound to GMPPNP

New page

'''Unreleased structure'''

The entry 4jyb is ON HOLD

Authors: Koutmos, M., Lofgren, M., Padovani, D., Banerjee, R.

Description: MeaB, A Bacterial Homolog of MMAA, Bound to GMPPNP