4k0t - Revision history

OCA at 15:52, 20 September 2023

OCA — Wed, 20 Sep 2023 15:52:23 GMT

←Older revision		Revision as of 15:52, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4k0t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K0T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4K0T FirstGlance]. <br>		<table><tr><td colspan='2'>[[4k0t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K0T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4K0T FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D9Z:5-(2-CHLOROPHENYL)-1,3,4-THIADIAZOLE-2-SULFONAMIDE'>D9Z</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.78Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D9Z:5-(2-CHLOROPHENYL)-1,3,4-THIADIAZOLE-2-SULFONAMIDE'>D9Z</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4k0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k0t OCA], [https://pdbe.org/4k0t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4k0t RCSB], [https://www.ebi.ac.uk/pdbsum/4k0t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4k0t ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4k0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k0t OCA], [https://pdbe.org/4k0t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4k0t RCSB], [https://www.ebi.ac.uk/pdbsum/4k0t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4k0t ProSAT]</span></td></tr>
	</table>		</table>

OCA at 11:34, 30 November 2022

OCA — Wed, 30 Nov 2022 11:34:53 GMT

←Older revision		Revision as of 11:34, 30 November 2022
Line 1:		Line 1:

	==Structure of HCAIX mimic (HCAII with 5 mutations in active site) in complex with chlorzolamide==		==Structure of HCAIX mimic (HCAII with 5 mutations in active site) in complex with chlorzolamide==
-	<StructureSection load='4k0t' size='340' side='right' caption='[[4k0t]], [[Resolution\|resolution]] 1.78Å' scene=''>	+	<StructureSection load='4k0t' size='340' side='right'caption='[[4k0t]], [[Resolution\|resolution]] 1.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4k0t]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K0T OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4K0T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4k0t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K0T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4K0T FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D9Z:5-(2-CHLOROPHENYL)-1,3,4-THIADIAZOLE-2-SULFONAMIDE'>D9Z</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D9Z:5-(2-CHLOROPHENYL)-1,3,4-THIADIAZOLE-2-SULFONAMIDE'>D9Z</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4k0s\|4k0s]], [[4k0z\|4k0z]], [[4k13\|4k13]], [[4k1q\|4k1q]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4k0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k0t OCA], [https://pdbe.org/4k0t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4k0t RCSB], [https://www.ebi.ac.uk/pdbsum/4k0t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4k0t ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4k0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k0t OCA], [~~http~~://pdbe.org/4k0t PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4k0t RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4k0t PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4k0t ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[~~http~~://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>	+	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[https://omim.org/entry/259730 259730]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>	+	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>

	==See Also==		==See Also==
-	*[[Carbonic anhydrase\|Carbonic anhydrase]]	+	*[[Carbonic anhydrase 3D structures\|Carbonic anhydrase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Carbonate dehydratase~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Human~~]]	+	[[Category: Large Structures]]
-	[[Category: Biswas, S]]	+	[[Category: Biswas S]]
-	[[Category: McKenna, R]]	+	[[Category: McKenna R]]
-	~~[[Category: Alpha beta fold]]~~	+
-	~~[[Category: Lyase~~]]	+

OCA at 13:40, 11 August 2016

OCA — Thu, 11 Aug 2016 13:40:23 GMT

←Older revision		Revision as of 13:40, 11 August 2016
Line 1:		Line 1:
		+
	==Structure of HCAIX mimic (HCAII with 5 mutations in active site) in complex with chlorzolamide==		==Structure of HCAIX mimic (HCAII with 5 mutations in active site) in complex with chlorzolamide==
	<StructureSection load='4k0t' size='340' side='right' caption='[[4k0t]], [[Resolution\|resolution]] 1.78Å' scene=''>		<StructureSection load='4k0t' size='340' side='right' caption='[[4k0t]], [[Resolution\|resolution]] 1.78Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k0t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4k0t RCSB], [http://www.ebi.ac.uk/pdbsum/4k0t PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k0t OCA], [http://pdbe.org/4k0t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4k0t RCSB], [http://www.ebi.ac.uk/pdbsum/4k0t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4k0t ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 13:		Line 14:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>		[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
		+
		+	==See Also==
		+	*[[Carbonic anhydrase\|Carbonic anhydrase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:01, 4 January 2015

OCA — Sun, 04 Jan 2015 14:01:35 GMT

←Older revision		Revision as of 14:01, 4 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_4k0t\| PDB=4k0t \| SCENE= }}~~	+	==Structure of HCAIX mimic (HCAII with 5 mutations in active site) in complex with chlorzolamide==
-	===Structure of HCAIX mimic (HCAII with 5 mutations in active site) in complex with chlorzolamide===	+	<StructureSection load='4k0t' size='340' side='right' caption='[[4k0t]], [[Resolution\|resolution]] 1.78Å' scene=''>
-		+	== Structural highlights ==
-	==Disease==	+	<table><tr><td colspan='2'>[[4k0t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K0T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4K0T FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D9Z:5-(2-CHLOROPHENYL)-1,3,4-THIADIAZOLE-2-SULFONAMIDE'>D9Z</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4k0s\|4k0s]], [[4k0z\|4k0z]], [[4k13\|4k13]], [[4k1q\|4k1q]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k0t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4k0t RCSB], [http://www.ebi.ac.uk/pdbsum/4k0t PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[http://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>		[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[http://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
-		+	== Function ==
-	==Function==	+
	[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>		[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
-		+	== References ==
-	==~~About this Structure==~~	+	<references/>
-	~~[[4k0t]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K0T OCA].~~	+	__TOC__
-		+	</StructureSection>
-	~~==Reference~~==	+
-	<references ~~group="xtra"~~/><~~references~~/>	+
	[[Category: Carbonate dehydratase]]		[[Category: Carbonate dehydratase]]
-	[[Category: Biswas, S.]]	+	[[Category: Human]]
-	[[Category: McKenna, R.]]	+	[[Category: Biswas, S]]
		+	[[Category: McKenna, R]]
	[[Category: Alpha beta fold]]		[[Category: Alpha beta fold]]
	[[Category: Lyase]]		[[Category: Lyase]]

OCA at 06:41, 9 April 2014

OCA — Wed, 09 Apr 2014 06:41:19 GMT

←Older revision		Revision as of 06:41, 9 April 2014
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4k0t\| PDB=4k0t \| SCENE= }}
		+	===Structure of HCAIX mimic (HCAII with 5 mutations in active site) in complex with chlorzolamide===

-	~~The~~ entry ~~4k0t~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[http://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>

-	~~Authors~~: ~~Biswas, S~~.~~, McKenna, R~~.	+	==Function==
		+	[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>

-	~~Description:~~ Structure ~~of HCAIX mimic (HCAII with 5 mutations in active site) in complex with chlorzolamide~~	+	==About this Structure==
		+	[[4k0t]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K0T OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Carbonate dehydratase]]
		+	[[Category: Biswas, S.]]
		+	[[Category: McKenna, R.]]
		+	[[Category: Alpha beta fold]]
		+	[[Category: Lyase]]

OCA at 08:30, 26 March 2014

OCA — Wed, 26 Mar 2014 08:30:37 GMT

←Older revision		Revision as of 08:30, 26 March 2014
Line 5:		Line 5:
	Authors: Biswas, S., McKenna, R.		Authors: Biswas, S., McKenna, R.

-	Description: ~~hCAII~~ with 5 mutations in active site in complex with chlorzolamide	+	Description: Structure of HCAIX mimic (HCAII with 5 mutations in active site) in complex with chlorzolamide

OCA: Protected "4k0t" [edit=sysop:move=sysop]

OCA — Wed, 17 Apr 2013 20:05:00 GMT

Protected "4k0t" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:05, 17 April 2013

OCA: New page: '''Unreleased structure''' The entry 4k0t is ON HOLD until Paper Publication Authors: Biswas, S., McKenna, R. Description: hCAII with 5 mutations in active site in complex with chlorzo...

OCA — Wed, 17 Apr 2013 20:04:59 GMT

New page: '''Unreleased structure''' The entry 4k0t is ON HOLD until Paper Publication Authors: Biswas, S., McKenna, R. Description: hCAII with 5 mutations in active site in complex with chlorzo...

New page

'''Unreleased structure'''

The entry 4k0t is ON HOLD until Paper Publication

Authors: Biswas, S., McKenna, R.

Description: hCAII with 5 mutations in active site in complex with chlorzolamide