4k1e - Revision history

OCA at 14:26, 8 November 2023

OCA — Wed, 08 Nov 2023 14:26:54 GMT

←Older revision		Revision as of 14:26, 8 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4k1e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Helianthus_annuus Helianthus annuus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K1E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4K1E FirstGlance]. <br>		<table><tr><td colspan='2'>[[4k1e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Helianthus_annuus Helianthus annuus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K1E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4K1E FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LI:LITHIUM+ION'>LI</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LI:LITHIUM+ION'>LI</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4k1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k1e OCA], [https://pdbe.org/4k1e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4k1e RCSB], [https://www.ebi.ac.uk/pdbsum/4k1e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4k1e ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4k1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k1e OCA], [https://pdbe.org/4k1e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4k1e RCSB], [https://www.ebi.ac.uk/pdbsum/4k1e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4k1e ProSAT]</span></td></tr>
	</table>		</table>

OCA at 11:35, 30 November 2022

OCA — Wed, 30 Nov 2022 11:35:28 GMT

←Older revision		Revision as of 11:35, 30 November 2022
Line 1:		Line 1:

	==Atomic resolution crystal structures of Kallikrein-Related Peptidase 4 complexed with a modified SFTI inhibitor FCQR==		==Atomic resolution crystal structures of Kallikrein-Related Peptidase 4 complexed with a modified SFTI inhibitor FCQR==
-	<StructureSection load='4k1e' size='340' side='right' caption='[[4k1e]], [[Resolution\|resolution]] 1.30Å' scene=''>	+	<StructureSection load='4k1e' size='340' side='right'caption='[[4k1e]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4k1e]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K1E OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4K1E FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4k1e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Helianthus_annuus Helianthus annuus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K1E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4K1E FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LI:LITHIUM+ION'>LI</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LI:LITHIUM+ION'>LI</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bdg\|2bdg]], [[2bdi\|2bdi]], [[2bdh\|2bdh]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4k1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k1e OCA], [https://pdbe.org/4k1e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4k1e RCSB], [https://www.ebi.ac.uk/pdbsum/4k1e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4k1e ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KLK4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4k1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k1e OCA], [~~http~~://pdbe.org/4k1e PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4k1e RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4k1e PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4k1e ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/KLK4_HUMAN KLK4_HUMAN]] Defects in KLK4 are the cause of amelogenesis imperfecta hypomaturation type 2A1 (AI2A1) [MIM:[~~http~~://omim.org/entry/204700 204700]]. AI2A1 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.<ref>PMID:15235027</ref>	+	[https://www.uniprot.org/uniprot/KLK4_HUMAN KLK4_HUMAN] Defects in KLK4 are the cause of amelogenesis imperfecta hypomaturation type 2A1 (AI2A1) [MIM:[https://omim.org/entry/204700 204700]. AI2A1 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.<ref>PMID:15235027</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/KLK4_HUMAN KLK4_HUMAN]] Involved in enamel formation.<ref>PMID:15235027</ref> ~~[[http://www.uniprot.org/uniprot/SFTI1_HELAN SFTI1_HELAN]] Inhibits trypsin, cathepsin G, elastase, chymotrypsin and thrombin. Does not inhibit factor Xa.<ref>PMID:10390350</ref>~~	+	[https://www.uniprot.org/uniprot/KLK4_HUMAN KLK4_HUMAN] Involved in enamel formation.<ref>PMID:15235027</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4k1e" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4k1e" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Kallikrein 3D structures\|Kallikrein 3D structures]]
		+	*[[Trypsin inhibitor 3D structures\|Trypsin inhibitor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Helianthus annuus]]
-	[[Category: ~~Buckle, A M~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Harris, J M~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Ilyichova, O V~~]]	+	[[Category: Buckle AM]]
-	[[Category: ~~Sit, K C~~]]	+	[[Category: Harris JM]]
-	[[Category: ~~Swedberg, J E~~]]	+	[[Category: Ilyichova OV]]
-	[[Category: ~~Veer, S J.de~~]]	+	[[Category: Sit KC]]
-	[[Category: ~~Bowman-birk inhibitor~~]]	+	[[Category: Swedberg JE]]
-	[[Category: ~~Hydrolase-hydrolase inhibitor complex]]~~	+	[[Category: De Veer SJ]]
-	~~[[Category: Protease]]~~	+
-	~~[[Category: Protease inhibitor]]~~	+
-	~~[[Category: Protein-peptide complex~~]]	+

OCA at 09:17, 15 November 2017

OCA — Wed, 15 Nov 2017 09:17:34 GMT

←Older revision		Revision as of 09:17, 15 November 2017
Line 22:		Line 22:
	</div>		</div>
	<div class="pdbe-citations 4k1e" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4k1e" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Kallikrein\|Kallikrein]]
-	*[[Trypsin inhibitor\|Trypsin inhibitor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:06, 2 November 2016

OCA — Wed, 02 Nov 2016 11:06:22 GMT

←Older revision		Revision as of 11:06, 2 November 2016
Line 7:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bdg\|2bdg]], [[2bdi\|2bdi]], [[2bdh\|2bdh]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bdg\|2bdg]], [[2bdi\|2bdi]], [[2bdh\|2bdh]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KLK4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KLK4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k1e OCA], [http://pdbe.org/4k1e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4k1e RCSB], [http://www.ebi.ac.uk/pdbsum/4k1e PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k1e OCA], [http://pdbe.org/4k1e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4k1e RCSB], [http://www.ebi.ac.uk/pdbsum/4k1e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4k1e ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 13:		Line 13:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/KLK4_HUMAN KLK4_HUMAN]] Involved in enamel formation.<ref>PMID:15235027</ref> [[http://www.uniprot.org/uniprot/SFTI1_HELAN SFTI1_HELAN]] Inhibits trypsin, cathepsin G, elastase, chymotrypsin and thrombin. Does not inhibit factor Xa.<ref>PMID:10390350</ref>		[[http://www.uniprot.org/uniprot/KLK4_HUMAN KLK4_HUMAN]] Involved in enamel formation.<ref>PMID:15235027</ref> [[http://www.uniprot.org/uniprot/SFTI1_HELAN SFTI1_HELAN]] Inhibits trypsin, cathepsin G, elastase, chymotrypsin and thrombin. Does not inhibit factor Xa.<ref>PMID:10390350</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The kallikrein-related peptidase (KLK) family of proteases is involved in many aspects of human health and disease. One member of this family, KLK4, has been implicated in cancer development and metastasis. Understanding mechanisms of inactivation are critical to developing selective KLK4 inhibitors. We have determined the X-ray crystal structures of KLK4 in complex with both sunflower trypsin inhibitor-1 (SFTI-1) and a rationally designed SFTI-1 derivative to atomic (~1 A) resolution, as well as with bound nickel. These structures offer a structural rationalization for the potency and selectivity of these inhibitors, and together with MD simulation and computational analysis, reveal a dynamic pathway between the metal binding exosite and the active site, providing key details of a previously proposed allosteric mode of inhibition. Collectively, this work provides insight into both direct and indirect mechanisms of inhibition for KLK4 that have broad implications for the enzymology of the serine protease superfamily, and may potentially be exploited for the design of therapeutic inhibitors.
		+
		+	Direct and indirect mechanisms of KLK4 inhibition revealed by structure and dynamics.,Riley BT, Ilyichova O, Costa MG, Porebski BT, de Veer SJ, Swedberg JE, Kass I, Harris JM, Hoke DE, Buckle AM Sci Rep. 2016 Oct 21;6:35385. doi: 10.1038/srep35385. PMID:27767076<ref>PMID:27767076</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4k1e" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 19:53, 9 March 2016

OCA — Wed, 09 Mar 2016 19:53:46 GMT

←Older revision		Revision as of 19:53, 9 March 2016
Line 1:		Line 1:
		+
	==Atomic resolution crystal structures of Kallikrein-Related Peptidase 4 complexed with a modified SFTI inhibitor FCQR==		==Atomic resolution crystal structures of Kallikrein-Related Peptidase 4 complexed with a modified SFTI inhibitor FCQR==
	<StructureSection load='4k1e' size='340' side='right' caption='[[4k1e]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='4k1e' size='340' side='right' caption='[[4k1e]], [[Resolution\|resolution]] 1.30Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bdg\|2bdg]], [[2bdi\|2bdi]], [[2bdh\|2bdh]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bdg\|2bdg]], [[2bdi\|2bdi]], [[2bdh\|2bdh]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KLK4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KLK4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k1e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4k1e RCSB], [http://www.ebi.ac.uk/pdbsum/4k1e PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k1e OCA], [http://pdbe.org/4k1e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4k1e RCSB], [http://www.ebi.ac.uk/pdbsum/4k1e PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 13:39, 4 January 2015

OCA — Sun, 04 Jan 2015 13:39:28 GMT

←Older revision		Revision as of 13:39, 4 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_4k1e\| PDB=4k1e \| SCENE= }}~~	+	==Atomic resolution crystal structures of Kallikrein-Related Peptidase 4 complexed with a modified SFTI inhibitor FCQR==
-	===Atomic resolution crystal structures of Kallikrein-Related Peptidase 4 complexed with a modified SFTI inhibitor FCQR===	+	<StructureSection load='4k1e' size='340' side='right' caption='[[4k1e]], [[Resolution\|resolution]] 1.30Å' scene=''>
-		+	== Structural highlights ==
-	==Disease==	+	<table><tr><td colspan='2'>[[4k1e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K1E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4K1E FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LI:LITHIUM+ION'>LI</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bdg\|2bdg]], [[2bdi\|2bdi]], [[2bdh\|2bdh]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KLK4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k1e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4k1e RCSB], [http://www.ebi.ac.uk/pdbsum/4k1e PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/KLK4_HUMAN KLK4_HUMAN]] Defects in KLK4 are the cause of amelogenesis imperfecta hypomaturation type 2A1 (AI2A1) [MIM:[http://omim.org/entry/204700 204700]]. AI2A1 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.<ref>PMID:15235027</ref>		[[http://www.uniprot.org/uniprot/KLK4_HUMAN KLK4_HUMAN]] Defects in KLK4 are the cause of amelogenesis imperfecta hypomaturation type 2A1 (AI2A1) [MIM:[http://omim.org/entry/204700 204700]]. AI2A1 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.<ref>PMID:15235027</ref>
-		+	== Function ==
-	==Function==	+
	[[http://www.uniprot.org/uniprot/KLK4_HUMAN KLK4_HUMAN]] Involved in enamel formation.<ref>PMID:15235027</ref> [[http://www.uniprot.org/uniprot/SFTI1_HELAN SFTI1_HELAN]] Inhibits trypsin, cathepsin G, elastase, chymotrypsin and thrombin. Does not inhibit factor Xa.<ref>PMID:10390350</ref>		[[http://www.uniprot.org/uniprot/KLK4_HUMAN KLK4_HUMAN]] Involved in enamel formation.<ref>PMID:15235027</ref> [[http://www.uniprot.org/uniprot/SFTI1_HELAN SFTI1_HELAN]] Inhibits trypsin, cathepsin G, elastase, chymotrypsin and thrombin. Does not inhibit factor Xa.<ref>PMID:10390350</ref>

-	==~~About this Structure~~==	+	==See Also==
-	[[~~4k1e~~]] ~~is a 2 chain structure. Full crystallographic information is available from~~ [~~http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K1E OCA~~].	+	*[[Kallikrein\|Kallikrein]]
-		+	*[[Trypsin inhibitor\|Trypsin inhibitor]]
-	==~~Reference~~==	+	== References ==
-	<references ~~group="xtra"~~/><~~references~~/>	+	<references/>
-	[[Category: Buckle, A M.]]	+	__TOC__
-	[[Category: Harris, J M.]]	+	</StructureSection>
-	[[Category: Ilyichova, O V.]]	+	[[Category: Human]]
-	[[Category: Sit, K C.]]	+	[[Category: Buckle, A M]]
-	[[Category: Swedberg, J E.]]	+	[[Category: Harris, J M]]
-	[[Category: Veer, S J.de.]]	+	[[Category: Ilyichova, O V]]
		+	[[Category: Sit, K C]]
		+	[[Category: Swedberg, J E]]
		+	[[Category: Veer, S J.de]]
	[[Category: Bowman-birk inhibitor]]		[[Category: Bowman-birk inhibitor]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]

OCA at 06:41, 9 April 2014

OCA — Wed, 09 Apr 2014 06:41:54 GMT

←Older revision		Revision as of 06:41, 9 April 2014
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4k1e\| PDB=4k1e \| SCENE= }}
		+	===Atomic resolution crystal structures of Kallikrein-Related Peptidase 4 complexed with a modified SFTI inhibitor FCQR===

-	~~The~~ entry ~~4k1e~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/KLK4_HUMAN KLK4_HUMAN]] Defects in KLK4 are the cause of amelogenesis imperfecta hypomaturation type 2A1 (AI2A1) [MIM:[http://omim.org/entry/204700 204700]]. AI2A1 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.<ref>PMID:15235027</ref>

-	~~Authors~~: ~~Ilyichova, O~~.V.~~, Swedberg, J~~.E.~~, de Veer, S.J~~., ~~Sit~~, ~~K.C.~~, ~~Harris, J~~.~~M., Buckle, A.M~~.	+	==Function==
		+	[[http://www.uniprot.org/uniprot/KLK4_HUMAN KLK4_HUMAN]] Involved in enamel formation.<ref>PMID:15235027</ref> [[http://www.uniprot.org/uniprot/SFTI1_HELAN SFTI1_HELAN]] Inhibits trypsin, cathepsin G, elastase, chymotrypsin and thrombin. Does not inhibit factor Xa.<ref>PMID:10390350</ref>

-	~~Description~~: ~~Atomic resolution crystal structures of Kallikrein~~-~~Related Peptidase 4 complexed with a modified SFTI~~ inhibitor ~~FCQR~~	+	==About this Structure==
		+	[[4k1e]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K1E OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Buckle, A M.]]
		+	[[Category: Harris, J M.]]
		+	[[Category: Ilyichova, O V.]]
		+	[[Category: Sit, K C.]]
		+	[[Category: Swedberg, J E.]]
		+	[[Category: Veer, S J.de.]]
		+	[[Category: Bowman-birk inhibitor]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
		+	[[Category: Protease]]
		+	[[Category: Protease inhibitor]]
		+	[[Category: Protein-peptide complex]]

OCA at 08:53, 8 January 2014

OCA — Wed, 08 Jan 2014 08:53:51 GMT

←Older revision		Revision as of 08:53, 8 January 2014
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4k1e is ON HOLD	+	The entry 4k1e is ON HOLD until Paper Publication

	Authors: Ilyichova, O.V., Swedberg, J.E., de Veer, S.J., Sit, K.C., Harris, J.M., Buckle, A.M.		Authors: Ilyichova, O.V., Swedberg, J.E., de Veer, S.J., Sit, K.C., Harris, J.M., Buckle, A.M.

	Description: Atomic resolution crystal structures of Kallikrein-Related Peptidase 4 complexed with a modified SFTI inhibitor FCQR		Description: Atomic resolution crystal structures of Kallikrein-Related Peptidase 4 complexed with a modified SFTI inhibitor FCQR

OCA: Protected "4k1e" [edit=sysop:move=sysop]

OCA — Wed, 17 Apr 2013 20:05:39 GMT

Protected "4k1e" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:05, 17 April 2013

OCA: New page: '''Unreleased structure''' The entry 4k1e is ON HOLD Authors: Ilyichova, O.V., Swedberg, J.E., de Veer, S.J., Sit, K.C., Harris, J.M., Buckle, A.M. Description: Atomic resolution cryst...

OCA — Wed, 17 Apr 2013 20:05:38 GMT

New page: '''Unreleased structure''' The entry 4k1e is ON HOLD Authors: Ilyichova, O.V., Swedberg, J.E., de Veer, S.J., Sit, K.C., Harris, J.M., Buckle, A.M. Description: Atomic resolution cryst...

New page

'''Unreleased structure'''

The entry 4k1e is ON HOLD

Authors: Ilyichova, O.V., Swedberg, J.E., de Veer, S.J., Sit, K.C., Harris, J.M., Buckle, A.M.

Description: Atomic resolution crystal structures of Kallikrein-Related Peptidase 4 complexed with a modified SFTI inhibitor FCQR