4k1p - Revision history

OCA at 12:07, 1 March 2024

OCA — Fri, 01 Mar 2024 12:07:52 GMT

←Older revision		Revision as of 12:07, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4k1p]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_cereus Bacillus cereus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K1P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4K1P FirstGlance]. <br>		<table><tr><td colspan='2'>[[4k1p]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_cereus Bacillus cereus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K1P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4K1P FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.05Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4k1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k1p OCA], [https://pdbe.org/4k1p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4k1p RCSB], [https://www.ebi.ac.uk/pdbsum/4k1p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4k1p ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4k1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k1p OCA], [https://pdbe.org/4k1p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4k1p RCSB], [https://www.ebi.ac.uk/pdbsum/4k1p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4k1p ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/Q3Y6N6_BACCE Q3Y6N6_BACCE]		[https://www.uniprot.org/uniprot/Q3Y6N6_BACCE Q3Y6N6_BACCE]
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The structure of NheA, a component of the Bacillus cereus Nhe tripartite toxin, has been solved at 2.05 A resolution using selenomethionine multiple-wavelength anomalous dispersion (MAD). The structure shows it to have a fold that is similar to the Bacillus cereus Hbl-B and E. coli ClyA toxins, and it is therefore a member of the ClyA superfamily of alpha-helical pore forming toxins (alpha-PFTs), although its head domain is significantly enlarged compared with those of ClyA or Hbl-B. The hydrophobic beta-hairpin structure that is a characteristic of these toxins is replaced by an amphipathic beta-hairpin connected to the main structure via a beta-latch that is reminiscent of a similar structure in the beta-PFT Staphylococcus aureus alpha-hemolysin. Taken together these results suggest that, although it is a member of an archetypal alpha-PFT family of toxins, NheA may be capable of forming a beta rather than an alpha pore.
-
-	Structure of the NheA Component of the Nhe Toxin from Bacillus cereus: Implications for Function.,Ganash M, Phung D, Sedelnikova SE, Lindback T, Granum PE, Artymiuk PJ PLoS One. 2013 Sep 10;8(9):e74748. doi: 10.1371/journal.pone.0074748. PMID:24040335<ref>PMID:24040335</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4k1p" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 11:36, 30 November 2022

OCA — Wed, 30 Nov 2022 11:36:00 GMT

←Older revision		Revision as of 11:36, 30 November 2022
Line 1:		Line 1:

	==Structure of the NheA component of the Nhe toxin from Bacillus cereus==		==Structure of the NheA component of the Nhe toxin from Bacillus cereus==
-	<StructureSection load='4k1p' size='340' side='right' caption='[[4k1p]], [[Resolution\|resolution]] 2.05Å' scene=''>	+	<StructureSection load='4k1p' size='340' side='right'caption='[[4k1p]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4k1p]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_14579 Atcc 14579~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K1P OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4K1P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4k1p]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_cereus Bacillus cereus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K1P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4K1P FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nheA, nheABC (operon) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1396 ATCC 14579])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4k1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k1p OCA], [https://pdbe.org/4k1p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4k1p RCSB], [https://www.ebi.ac.uk/pdbsum/4k1p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4k1p ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4k1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k1p OCA], [~~http~~://pdbe.org/4k1p PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4k1p RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4k1p PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4k1p ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q3Y6N6_BACCE Q3Y6N6_BACCE]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Atcc 14579~~]]	+	[[Category: Bacillus cereus]]
-	[[Category: ~~Artymiuk, P J~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Ganash, M~~]]	+	[[Category: Artymiuk PJ]]
-	[[Category: ~~Phung, D~~]]	+	[[Category: Ganash M]]
-	[[Category: ~~Beta tongue]]~~	+	[[Category: Phung D]]
-	~~[[Category: Clya-like fold]]~~	+
-	~~[[Category: Helical bundle]]~~	+
-	~~[[Category: Pore-forming toxin component]]~~	+
-	~~[[Category: Toxin~~]]	+

OCA at 13:39, 5 August 2016

OCA — Fri, 05 Aug 2016 13:39:00 GMT

←Older revision		Revision as of 13:39, 5 August 2016
Line 1:		Line 1:
		+
	==Structure of the NheA component of the Nhe toxin from Bacillus cereus==		==Structure of the NheA component of the Nhe toxin from Bacillus cereus==
	<StructureSection load='4k1p' size='340' side='right' caption='[[4k1p]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='4k1p' size='340' side='right' caption='[[4k1p]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4k1p]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bacillus_cereus Bacillus cereus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K1P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4K1P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4k1p]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_14579 Atcc 14579]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K1P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4K1P FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nheA, nheABC (operon) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1396 ~~Bacillus cereus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nheA, nheABC (operon) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1396 ATCC 14579])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k1p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4k1p RCSB], [http://www.ebi.ac.uk/pdbsum/4k1p PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k1p OCA], [http://pdbe.org/4k1p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4k1p RCSB], [http://www.ebi.ac.uk/pdbsum/4k1p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4k1p ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4k1p" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus cereus~~]]	+	[[Category: Atcc 14579]]
	[[Category: Artymiuk, P J]]		[[Category: Artymiuk, P J]]
	[[Category: Ganash, M]]		[[Category: Ganash, M]]

OCA at 14:49, 21 December 2014

OCA — Sun, 21 Dec 2014 14:49:45 GMT

←Older revision		Revision as of 14:49, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4k1p\| PDB=4k1p \| SCENE= }}~~	+	==Structure of the NheA component of the Nhe toxin from Bacillus cereus==
-	===Structure of the NheA component of the Nhe toxin from Bacillus cereus===	+	<StructureSection load='4k1p' size='340' side='right' caption='[[4k1p]], [[Resolution\|resolution]] 2.05Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24040335}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4k1p]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_cereus Bacillus cereus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K1P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4K1P FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nheA, nheABC (operon) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1396 Bacillus cereus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k1p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4k1p RCSB], [http://www.ebi.ac.uk/pdbsum/4k1p PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The structure of NheA, a component of the Bacillus cereus Nhe tripartite toxin, has been solved at 2.05 A resolution using selenomethionine multiple-wavelength anomalous dispersion (MAD). The structure shows it to have a fold that is similar to the Bacillus cereus Hbl-B and E. coli ClyA toxins, and it is therefore a member of the ClyA superfamily of alpha-helical pore forming toxins (alpha-PFTs), although its head domain is significantly enlarged compared with those of ClyA or Hbl-B. The hydrophobic beta-hairpin structure that is a characteristic of these toxins is replaced by an amphipathic beta-hairpin connected to the main structure via a beta-latch that is reminiscent of a similar structure in the beta-PFT Staphylococcus aureus alpha-hemolysin. Taken together these results suggest that, although it is a member of an archetypal alpha-PFT family of toxins, NheA may be capable of forming a beta rather than an alpha pore.

-	~~==About this~~ Structure==	+	Structure of the NheA Component of the Nhe Toxin from Bacillus cereus: Implications for Function.,Ganash M, Phung D, Sedelnikova SE, Lindback T, Granum PE, Artymiuk PJ PLoS One. 2013 Sep 10;8(9):e74748. doi: 10.1371/journal.pone.0074748. PMID:24040335<ref>PMID:24040335</ref>
-	~~[[4k1p]] is a 8 chain structure with sequence~~ from ~~[http~~:~~//en~~.~~wikipedia~~.~~org/wiki/Bacillus_cereus Bacillus cereus]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4K1P OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024040335</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Bacillus cereus]]		[[Category: Bacillus cereus]]
-	[[Category: Artymiuk, P J.]]	+	[[Category: Artymiuk, P J]]
-	[[Category: Ganash, M.]]	+	[[Category: Ganash, M]]
-	[[Category: Phung, D.]]	+	[[Category: Phung, D]]
	[[Category: Beta tongue]]		[[Category: Beta tongue]]
	[[Category: Clya-like fold]]		[[Category: Clya-like fold]]

OCA at 05:56, 2 October 2013

OCA — Wed, 02 Oct 2013 05:56:12 GMT

←Older revision		Revision as of 05:56, 2 October 2013
Line 1:		Line 1:
	{{STRUCTURE_4k1p\| PDB=4k1p \| SCENE= }}		{{STRUCTURE_4k1p\| PDB=4k1p \| SCENE= }}
	===Structure of the NheA component of the Nhe toxin from Bacillus cereus===		===Structure of the NheA component of the Nhe toxin from Bacillus cereus===
-	{{~~ABSTRACT_PUBMED_22949198~~}}	+	{{ABSTRACT_PUBMED_24040335}}

	==About this Structure==		==About this Structure==
Line 7:		Line 7:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~022949198~~</ref><references group="xtra"/><references/>	+	<ref group="xtra">PMID:024040335</ref><references group="xtra"/><references/>
	[[Category: Bacillus cereus]]		[[Category: Bacillus cereus]]
	[[Category: Artymiuk, P J.]]		[[Category: Artymiuk, P J.]]

OCA at 04:07, 20 September 2013

OCA — Fri, 20 Sep 2013 04:07:50 GMT

←Older revision		Revision as of 04:07, 20 September 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4k1p\| PDB=4k1p \| SCENE= }}
		+	===Structure of the NheA component of the Nhe toxin from Bacillus cereus===
		+	{{ABSTRACT_PUBMED_22949198}}

-	~~The entry~~ 4k1p is ~~ON HOLD~~	+	==About this Structure==
		+	[[4k1p]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_cereus Bacillus cereus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K1P OCA].

-	~~Authors~~: Ganash, M., Phung, D.~~, Artymiuk, P.J.~~	+	==Reference==
-		+	<ref group="xtra">PMID:022949198</ref><references group="xtra"/><references/>
-	~~Description~~: ~~Structure of the NheA component of the Nhe~~ toxin ~~from Bacillus cereus~~	+	[[Category: Bacillus cereus]]
		+	[[Category: Artymiuk, P J.]]
		+	[[Category: Ganash, M.]]
		+	[[Category: Phung, D.]]
		+	[[Category: Beta tongue]]
		+	[[Category: Clya-like fold]]
		+	[[Category: Helical bundle]]
		+	[[Category: Pore-forming toxin component]]
		+	[[Category: Toxin]]

OCA at 07:10, 2 May 2013

OCA — Thu, 02 May 2013 07:10:38 GMT

←Older revision		Revision as of 07:10, 2 May 2013
Line 5:		Line 5:
	Authors: Ganash, M., Phung, D., Artymiuk, P.J.		Authors: Ganash, M., Phung, D., Artymiuk, P.J.

-	Description: ~~Toxin~~ component	+	Description: Structure of the NheA component of the Nhe toxin from Bacillus cereus

OCA: Protected "4k1p" [edit=sysop:move=sysop]

OCA — Wed, 17 Apr 2013 20:05:57 GMT

Protected "4k1p" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:05, 17 April 2013

OCA: New page: '''Unreleased structure''' The entry 4k1p is ON HOLD Authors: Ganash, M., Phung, D., Artymiuk, P.J. Description: Toxin component

OCA — Wed, 17 Apr 2013 20:05:56 GMT

New page: '''Unreleased structure''' The entry 4k1p is ON HOLD Authors: Ganash, M., Phung, D., Artymiuk, P.J. Description: Toxin component

New page

'''Unreleased structure'''

The entry 4k1p is ON HOLD

Authors: Ganash, M., Phung, D., Artymiuk, P.J.

Description: Toxin component