4k3n - Revision history

OCA at 15:53, 20 September 2023

OCA — Wed, 20 Sep 2023 15:53:36 GMT

←Older revision		Revision as of 15:53, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4k3n]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K3N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4K3N FirstGlance]. <br>		<table><tr><td colspan='2'>[[4k3n]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K3N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4K3N FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1OT:{(R)-AMINO[4-(1H-PYRAZOL-1-YL)PHENYL]METHYL}PHOSPHONIC+ACID'>1OT</scene>, <scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=2PE:NONAETHYLENE+GLYCOL'>2PE</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1OT:{(R)-AMINO[4-(1H-PYRAZOL-1-YL)PHENYL]METHYL}PHOSPHONIC+ACID'>1OT</scene>, <scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=2PE:NONAETHYLENE+GLYCOL'>2PE</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4k3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k3n OCA], [https://pdbe.org/4k3n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4k3n RCSB], [https://www.ebi.ac.uk/pdbsum/4k3n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4k3n ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4k3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k3n OCA], [https://pdbe.org/4k3n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4k3n RCSB], [https://www.ebi.ac.uk/pdbsum/4k3n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4k3n ProSAT]</span></td></tr>
	</table>		</table>

OCA at 11:38, 30 November 2022

OCA — Wed, 30 Nov 2022 11:38:39 GMT

←Older revision		Revision as of 11:38, 30 November 2022
Line 1:		Line 1:
-	~~{{Large structure}}~~	+
	==Phosphonic Arginine Mimetics as Inhibitors of the M17 Aminopeptidases from Plasmodium falciparum==		==Phosphonic Arginine Mimetics as Inhibitors of the M17 Aminopeptidases from Plasmodium falciparum==
-	<StructureSection load='4k3n' size='340' side='right' caption='[[4k3n]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='4k3n' size='340' side='right'caption='[[4k3n]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4k3n]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Plaf7 Plaf7~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K3N OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4K3N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4k3n]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K3N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4K3N FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1OT:{(R)-AMINO[4-(1H-PYRAZOL-1-YL)PHENYL]METHYL}PHOSPHONIC+ACID'>1OT</scene>, <scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=2PE:NONAETHYLENE+GLYCOL'>2PE</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1OT:{(R)-AMINO[4-(1H-PYRAZOL-1-YL)PHENYL]METHYL}PHOSPHONIC+ACID'>1OT</scene>, <scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=2PE:NONAETHYLENE+GLYCOL'>2PE</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LAP, PF14_0439 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4k3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k3n OCA], [https://pdbe.org/4k3n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4k3n RCSB], [https://www.ebi.ac.uk/pdbsum/4k3n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4k3n ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4k3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k3n OCA], [~~http~~://pdbe.org/4k3n PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4k3n RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4k3n PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4k3n ProSAT]</span></td></tr>	+
	</table>		</table>
-	~~{{Large structure}}~~	+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8IL11_PLAF7 Q8IL11_PLAF7]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[Aminopeptidase\|Aminopeptidase]]	+	*[[Aminopeptidase 3D structures\|Aminopeptidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Plaf7~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~McGowan, S~~]]	+	[[Category: Plasmodium falciparum 3D7]]
-	[[Category: ~~Aminopeptidase]]~~	+	[[Category: McGowan S]]
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Leucyl aminopeptidase]]~~	+
-	~~[[Category: Protease~~]]	+

OCA at 19:24, 5 August 2016

OCA — Fri, 05 Aug 2016 19:24:36 GMT

←Older revision		Revision as of 19:24, 5 August 2016
Line 1:		Line 1:
		+	{{Large structure}}
	==Phosphonic Arginine Mimetics as Inhibitors of the M17 Aminopeptidases from Plasmodium falciparum==		==Phosphonic Arginine Mimetics as Inhibitors of the M17 Aminopeptidases from Plasmodium falciparum==
	<StructureSection load='4k3n' size='340' side='right' caption='[[4k3n]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4k3n' size='340' side='right' caption='[[4k3n]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4k3n]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Plasmodium_falciparum_3d7 Plasmodium falciparum 3d7~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K3N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4K3N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4k3n]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K3N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4K3N FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1OT:{(R)-AMINO[4-(1H-PYRAZOL-1-YL)PHENYL]METHYL}PHOSPHONIC+ACID'>1OT</scene>, <scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=2PE:NONAETHYLENE+GLYCOL'>2PE</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1OT:{(R)-AMINO[4-(1H-PYRAZOL-1-YL)PHENYL]METHYL}PHOSPHONIC+ACID'>1OT</scene>, <scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=2PE:NONAETHYLENE+GLYCOL'>2PE</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LAP, PF14_0439 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 ~~Plasmodium falciparum 3D7~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LAP, PF14_0439 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k3n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4k3n RCSB], [http://www.ebi.ac.uk/pdbsum/4k3n PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k3n OCA], [http://pdbe.org/4k3n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4k3n RCSB], [http://www.ebi.ac.uk/pdbsum/4k3n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4k3n ProSAT]</span></td></tr>
	</table>		</table>
		+	{{Large structure}}
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 15:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4k3n" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 22:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Plasmodium falciparum 3d7~~]]	+	[[Category: Plaf7]]
	[[Category: McGowan, S]]		[[Category: McGowan, S]]
	[[Category: Aminopeptidase]]		[[Category: Aminopeptidase]]

OCA at 15:01, 21 December 2014

OCA — Sun, 21 Dec 2014 15:01:54 GMT

←Older revision		Revision as of 15:01, 21 December 2014
Line 1:		Line 1:
-	~~{{Large structure}}~~	+	==Phosphonic Arginine Mimetics as Inhibitors of the M17 Aminopeptidases from Plasmodium falciparum==
-	~~{{STRUCTURE_4k3n\| PDB=4k3n \| SCENE= }}~~	+	<StructureSection load='4k3n' size='340' side='right' caption='[[4k3n]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	===Phosphonic Arginine Mimetics as Inhibitors of the M17 Aminopeptidases from Plasmodium falciparum===	+	== Structural highlights ==
-	{~~{ABSTRACT_PUBMED_23713488}~~}	+	<table><tr><td colspan='2'>[[4k3n]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum_3d7 Plasmodium falciparum 3d7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K3N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4K3N FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1OT:{(R)-AMINO[4-(1H-PYRAZOL-1-YL)PHENYL]METHYL}PHOSPHONIC+ACID'>1OT</scene>, <scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=2PE:NONAETHYLENE+GLYCOL'>2PE</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LAP, PF14_0439 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 Plasmodium falciparum 3D7])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k3n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4k3n RCSB], [http://www.ebi.ac.uk/pdbsum/4k3n PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The malaria parasite <i>Plasmodium falciparum</i> employs two metallo-aminopeptidases, P<i>f</i>A-M1 and P<I>f</i>A-M17, which are essential for parasite survival. Compounds that inhibit the activity of either enzyme represent leads for the development of new anti-malarial drugs. Here we report the synthesis and structure-activity-relationships of a small library of phosphonic acid arginine mimetics that probe the S1 pocket of both enzymes, and map the necessary interactions that would be important for a dual inhibitor.

-	~~==About this~~ Structure==	+	Synthesis and Structure-Activity Relationships of Phosphonic Arginine Mimetics as Inhibitors of the M1 and M17 Aminopeptidases from <i>Plasmodium falciparum</i>,Kannan Sivaraman K, Paiardini A, Sienczyk M, Ruggeri C, Oellig CA, Dalton JP, Scammells PJ, Drag M, McGowan S J Med Chem. 2013 May 28. PMID:23713488<ref>PMID:23713488</ref>
-	~~[[4k3n]] is a 12 chain structure with sequence~~ from ~~[http://en.wikipedia.org/wiki/Plasmodium_falciparum_3d7~~ Plasmodium falciparum ~~3d7]. Full crystallographic information is available from [http:~~/~~/oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4K3N OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group~~=~~"xtra">PMID:023713488</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+
		+	==See Also==
		+	*[[Aminopeptidase\|Aminopeptidase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Plasmodium falciparum 3d7]]		[[Category: Plasmodium falciparum 3d7]]
-	[[Category: McGowan, S.]]	+	[[Category: McGowan, S]]
	[[Category: Aminopeptidase]]		[[Category: Aminopeptidase]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]
	[[Category: Leucyl aminopeptidase]]		[[Category: Leucyl aminopeptidase]]
	[[Category: Protease]]		[[Category: Protease]]

OCA at 15:04, 19 June 2013

OCA — Wed, 19 Jun 2013 15:04:00 GMT

←Older revision		Revision as of 15:04, 19 June 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{Large structure}}
		+	{{STRUCTURE_4k3n\| PDB=4k3n \| SCENE= }}
		+	===Phosphonic Arginine Mimetics as Inhibitors of the M17 Aminopeptidases from Plasmodium falciparum===
		+	{{ABSTRACT_PUBMED_23713488}}

-	~~The entry~~ 4k3n is ~~ON HOLD~~	+	==About this Structure==
		+	[[4k3n]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum_3d7 Plasmodium falciparum 3d7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K3N OCA].

-	~~Authors~~: McGowan, S.	+	==Reference==
-		+	<ref group="xtra">PMID:023713488</ref><references group="xtra"/><references/>
-	~~Description~~: ~~Phosphonic Arginine Mimetics as Inhibitors of the M17 Aminopeptidases from Plasmodium falciparum~~	+	[[Category: Plasmodium falciparum 3d7]]
		+	[[Category: McGowan, S.]]
		+	[[Category: Aminopeptidase]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
		+	[[Category: Leucyl aminopeptidase]]
		+	[[Category: Protease]]

OCA: Protected "4k3n" [edit=sysop:move=sysop]

OCA — Wed, 17 Apr 2013 20:08:02 GMT

Protected "4k3n" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:08, 17 April 2013

OCA: New page: '''Unreleased structure''' The entry 4k3n is ON HOLD Authors: McGowan, S. Description: Phosphonic Arginine Mimetics as Inhibitors of the M17 Aminopeptidases from Plasmodium falciparum

OCA — Wed, 17 Apr 2013 20:08:01 GMT

New page: '''Unreleased structure''' The entry 4k3n is ON HOLD Authors: McGowan, S. Description: Phosphonic Arginine Mimetics as Inhibitors of the M17 Aminopeptidases from Plasmodium falciparum

New page

'''Unreleased structure'''

The entry 4k3n is ON HOLD

Authors: McGowan, S.

Description: Phosphonic Arginine Mimetics as Inhibitors of the M17 Aminopeptidases from Plasmodium falciparum