4k4o - Revision history

OCA at 15:53, 20 September 2023

OCA — Wed, 20 Sep 2023 15:53:56 GMT

←Older revision		Revision as of 15:53, 20 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4k4o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis_V583 Enterococcus faecalis V583]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K4O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4K4O FirstGlance]. <br>		<table><tr><td colspan='2'>[[4k4o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis_V583 Enterococcus faecalis V583]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K4O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4K4O FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DOO:6-FLUORO-4-[(3AR,6AR)-HEXAHYDROPYRROLO[3,4-B]PYRROL-5(1H)-YL]-N-METHYL-2-[(2-METHYLPYRIMIDIN-5-YL)OXY]-9H-PYRIMIDO[4,5-B]INDOL-8-AMINE'>DOO</scene>, <scene name='pdbligand=TBU:TERTIARY-BUTYL+ALCOHOL'>TBU</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DOO:6-FLUORO-4-[(3AR,6AR)-HEXAHYDROPYRROLO[3,4-B]PYRROL-5(1H)-YL]-N-METHYL-2-[(2-METHYLPYRIMIDIN-5-YL)OXY]-9H-PYRIMIDO[4,5-B]INDOL-8-AMINE'>DOO</scene>, <scene name='pdbligand=TBU:TERTIARY-BUTYL+ALCOHOL'>TBU</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4k4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k4o OCA], [https://pdbe.org/4k4o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4k4o RCSB], [https://www.ebi.ac.uk/pdbsum/4k4o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4k4o ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4k4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k4o OCA], [https://pdbe.org/4k4o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4k4o RCSB], [https://www.ebi.ac.uk/pdbsum/4k4o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4k4o ProSAT]</span></td></tr>
	</table>		</table>

OCA at 11:39, 30 November 2022

OCA — Wed, 30 Nov 2022 11:39:51 GMT

←Older revision		Revision as of 11:39, 30 November 2022
Line 1:		Line 1:

	==The DNA Gyrase B ATP binding domain of Enterococcus faecalis in complex with a small molecule inhibitor==		==The DNA Gyrase B ATP binding domain of Enterococcus faecalis in complex with a small molecule inhibitor==
-	<StructureSection load='4k4o' size='340' side='right' caption='[[4k4o]], [[Resolution\|resolution]] 1.30Å' scene=''>	+	<StructureSection load='4k4o' size='340' side='right'caption='[[4k4o]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4k4o]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Entfa Entfa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K4O OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4K4O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4k4o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis_V583 Enterococcus faecalis V583]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K4O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4K4O FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DOO:6-FLUORO-4-[(3AR,6AR)-HEXAHYDROPYRROLO[3,4-B]PYRROL-5(1H)-YL]-N-METHYL-2-[(2-METHYLPYRIMIDIN-5-YL)OXY]-9H-PYRIMIDO[4,5-B]INDOL-8-AMINE'>DOO</scene>, <scene name='pdbligand=TBU:TERTIARY-BUTYL+ALCOHOL'>TBU</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DOO:6-FLUORO-4-[(3AR,6AR)-HEXAHYDROPYRROLO[3,4-B]PYRROL-5(1H)-YL]-N-METHYL-2-[(2-METHYLPYRIMIDIN-5-YL)OXY]-9H-PYRIMIDO[4,5-B]INDOL-8-AMINE'>DOO</scene>, <scene name='pdbligand=TBU:TERTIARY-BUTYL+ALCOHOL'>TBU</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EF_0005, gyrB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=226185 ENTFA])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4k4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k4o OCA], [https://pdbe.org/4k4o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4k4o RCSB], [https://www.ebi.ac.uk/pdbsum/4k4o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4k4o ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4k4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k4o OCA], [~~http~~://pdbe.org/4k4o PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4k4o RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4k4o PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4k4o ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/Q839Z1_ENTFA Q839Z1_ENTFA]] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity).[HAMAP-Rule:MF_01898]	+	[https://www.uniprot.org/uniprot/GYRB_ENTFA GYRB_ENTFA]

	==See Also==		==See Also==
-	*[[Gyrase\|Gyrase]]	+	*[[Gyrase 3D Structures\|Gyrase 3D Structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Entfa~~]]	+	[[Category: Enterococcus faecalis V583]]
-	[[Category: Akers-Rodriguez, S]]	+	[[Category: Large Structures]]
-	[[Category: Bensen~~, D C~~]]	+	[[Category: Akers-Rodriguez S]]
-	[[Category: Lam, T]]	+	[[Category: Bensen DC]]
-	[[Category: Tari~~, L W]]~~	+	[[Category: Lam T]]
-	~~[[Category: Atp-binding]]~~	+	[[Category: Tari LW]]
-	~~[[Category: Atp-binding domain]]~~	+
-	~~[[Category: Cytosol]]~~	+
-	~~[[Category: Isomerase-isomerase inhibitor complex]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Topoisomerase~~]]	+

OCA at 17:48, 5 August 2016

OCA — Fri, 05 Aug 2016 17:48:31 GMT

←Older revision		Revision as of 17:48, 5 August 2016
Line 1:		Line 1:
		+
	==The DNA Gyrase B ATP binding domain of Enterococcus faecalis in complex with a small molecule inhibitor==		==The DNA Gyrase B ATP binding domain of Enterococcus faecalis in complex with a small molecule inhibitor==
	<StructureSection load='4k4o' size='340' side='right' caption='[[4k4o]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='4k4o' size='340' side='right' caption='[[4k4o]], [[Resolution\|resolution]] 1.30Å' scene=''>
Line 6:		Line 7:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EF_0005, gyrB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=226185 ENTFA])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EF_0005, gyrB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=226185 ENTFA])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k4o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4k4o RCSB], [http://www.ebi.ac.uk/pdbsum/4k4o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k4o OCA], [http://pdbe.org/4k4o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4k4o RCSB], [http://www.ebi.ac.uk/pdbsum/4k4o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4k4o ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 20:45, 25 December 2014

OCA — Thu, 25 Dec 2014 20:45:08 GMT

←Older revision		Revision as of 20:45, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k4o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4k4o RCSB], [http://www.ebi.ac.uk/pdbsum/4k4o PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k4o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4k4o RCSB], [http://www.ebi.ac.uk/pdbsum/4k4o PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q839Z1_ENTFA Q839Z1_ENTFA]] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity).[HAMAP-Rule:MF_01898]

	==See Also==		==See Also==

OCA at 18:36, 21 December 2014

OCA — Sun, 21 Dec 2014 18:36:39 GMT

←Older revision		Revision as of 18:36, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4k4o\| PDB=4k4o \| SCENE= }}~~	+	==The DNA Gyrase B ATP binding domain of Enterococcus faecalis in complex with a small molecule inhibitor==
-	===The DNA Gyrase B ATP binding domain of Enterococcus faecalis in complex with a small molecule inhibitor===	+	<StructureSection load='4k4o' size='340' side='right' caption='[[4k4o]], [[Resolution\|resolution]] 1.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4k4o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Entfa Entfa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K4O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4K4O FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DOO:6-FLUORO-4-[(3AR,6AR)-HEXAHYDROPYRROLO[3,4-B]PYRROL-5(1H)-YL]-N-METHYL-2-[(2-METHYLPYRIMIDIN-5-YL)OXY]-9H-PYRIMIDO[4,5-B]INDOL-8-AMINE'>DOO</scene>, <scene name='pdbligand=TBU:TERTIARY-BUTYL+ALCOHOL'>TBU</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EF_0005, gyrB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=226185 ENTFA])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k4o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4k4o RCSB], [http://www.ebi.ac.uk/pdbsum/4k4o PDBsum]</span></td></tr>
		+	</table>

-	==~~Function~~==	+	==See Also==
-	[[~~http://www.uniprot.org/uniprot/Q839Z1_ENTFA Q839Z1_ENTFA~~]] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity).[HAMAP-Rule:MF_01898]	+	*[[Gyrase\|Gyrase]]
-		+	__TOC__
-	~~==About this Structure==~~	+	</StructureSection>
-	[[~~4k4o~~]] ~~is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K4O OCA].~~	+	[[Category: Entfa]]
-	[[Category: Akers-Rodriguez, S.]]	+	[[Category: Akers-Rodriguez, S]]
-	[[Category: Bensen, D C.]]	+	[[Category: Bensen, D C]]
-	[[Category: Lam, T.]]	+	[[Category: Lam, T]]
-	[[Category: Tari, L W.]]	+	[[Category: Tari, L W]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Atp-binding domain]]		[[Category: Atp-binding domain]]

OCA at 08:23, 15 January 2014

OCA — Wed, 15 Jan 2014 08:23:14 GMT

←Older revision		Revision as of 08:23, 15 January 2014
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4k4o\| PDB=4k4o \| SCENE= }}
		+	===The DNA Gyrase B ATP binding domain of Enterococcus faecalis in complex with a small molecule inhibitor===

-	~~The entry 4k4o is ON HOLD until sometime~~ in the ~~future~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/Q839Z1_ENTFA Q839Z1_ENTFA]] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity).[HAMAP-Rule:MF_01898]

-	~~Authors~~: ~~Bensen, D~~.C., Akers-Rodriguez, S., Lam, T., Tari, L.W.	+	==About this Structure==
-		+	[[4k4o]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K4O OCA].
-	~~Description~~: ~~The DNA Gyrase B ATP~~ binding domain ~~of Enterococcus faecalis in complex with a small molecule~~ inhibitor	+	[[Category: Akers-Rodriguez, S.]]
		+	[[Category: Bensen, D C.]]
		+	[[Category: Lam, T.]]
		+	[[Category: Tari, L W.]]
		+	[[Category: Atp-binding]]
		+	[[Category: Atp-binding domain]]
		+	[[Category: Cytosol]]
		+	[[Category: Isomerase-isomerase inhibitor complex]]
		+	[[Category: Nucleotide-binding]]
		+	[[Category: Topoisomerase]]

OCA at 08:54, 8 January 2014

OCA — Wed, 08 Jan 2014 08:54:11 GMT

←Older revision		Revision as of 08:54, 8 January 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4k4o is ON HOLD until ~~Paper Publication~~	+	The entry 4k4o is ON HOLD until sometime in the future

	Authors: Bensen, D.C., Akers-Rodriguez, S., Lam, T., Tari, L.W.		Authors: Bensen, D.C., Akers-Rodriguez, S., Lam, T., Tari, L.W.

	Description: The DNA Gyrase B ATP binding domain of Enterococcus faecalis in complex with a small molecule inhibitor		Description: The DNA Gyrase B ATP binding domain of Enterococcus faecalis in complex with a small molecule inhibitor

OCA at 11:26, 19 June 2013

OCA — Wed, 19 Jun 2013 11:26:38 GMT

←Older revision		Revision as of 11:26, 19 June 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4k4o is ON HOLD	+	The entry 4k4o is ON HOLD until Paper Publication

	Authors: Bensen, D.C., Akers-Rodriguez, S., Lam, T., Tari, L.W.		Authors: Bensen, D.C., Akers-Rodriguez, S., Lam, T., Tari, L.W.

	Description: The DNA Gyrase B ATP binding domain of Enterococcus faecalis in complex with a small molecule inhibitor		Description: The DNA Gyrase B ATP binding domain of Enterococcus faecalis in complex with a small molecule inhibitor

OCA at 07:11, 2 May 2013

OCA — Thu, 02 May 2013 07:11:34 GMT

←Older revision		Revision as of 07:11, 2 May 2013
Line 3:		Line 3:
	The entry 4k4o is ON HOLD		The entry 4k4o is ON HOLD

-	Authors: Bensen D.C., Akers-Rodriguez S., Lam T., Tari L.W.	+	Authors: Bensen, D.C., Akers-Rodriguez, S., Lam, T., Tari, L.W.

	Description: The DNA Gyrase B ATP binding domain of Enterococcus faecalis in complex with a small molecule inhibitor		Description: The DNA Gyrase B ATP binding domain of Enterococcus faecalis in complex with a small molecule inhibitor

OCA: Protected "4k4o" [edit=sysop:move=sysop]

OCA — Wed, 24 Apr 2013 10:58:59 GMT

Protected "4k4o" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:58, 24 April 2013