4k7j - Revision history

OCA at 11:43, 30 November 2022

OCA — Wed, 30 Nov 2022 11:43:52 GMT

←Older revision		Revision as of 11:43, 30 November 2022
Line 3:		Line 3:
	<StructureSection load='4k7j' size='340' side='right'caption='[[4k7j]], [[Resolution\|resolution]] 1.97Å' scene=''>		<StructureSection load='4k7j' size='340' side='right'caption='[[4k7j]], [[Resolution\|resolution]] 1.97Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4k7j]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Neisseria_meningitidis_4119 Neisseria meningitidis 4119]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K7J OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4K7J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4k7j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_meningitidis_4119 Neisseria meningitidis 4119]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K7J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4K7J FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4k3u\|4k3u]], [[4k40\|4k40]], [[4k7s\|4k7s]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4k7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k7j OCA], [https://pdbe.org/4k7j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4k7j RCSB], [https://www.ebi.ac.uk/pdbsum/4k7j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4k7j ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Neisseria meningitidis, NM4119_1198 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1095679 Neisseria meningitidis 4119])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4k7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k7j OCA], [~~http~~://pdbe.org/4k7j PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4k7j RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4k7j PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4k7j ProSAT]</span></td></tr>	+
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Neisseria meningitidis 4119]]		[[Category: Neisseria meningitidis 4119]]
-	[[Category: Boneca, I ~~Gomperts~~]]	+	[[Category: Gomperts Boneca I]]
-	[[Category: Williams~~, A H]]~~	+	[[Category: Williams AH]]
-	~~[[Category: Alpha/beta fold]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Peptidoglycan hydrolase~~]]	+

OCA at 08:31, 3 April 2019

OCA — Wed, 03 Apr 2019 08:31:37 GMT

←Older revision		Revision as of 08:31, 3 April 2019
Line 1:		Line 1:

	==Peptidoglycan O-acetylesterase in action, 5 min==		==Peptidoglycan O-acetylesterase in action, 5 min==
-	<StructureSection load='4k7j' size='340' side='right' caption='[[4k7j]], [[Resolution\|resolution]] 1.97Å' scene=''>	+	<StructureSection load='4k7j' size='340' side='right'caption='[[4k7j]], [[Resolution\|resolution]] 1.97Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4k7j]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K7J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4K7J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4k7j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Neisseria_meningitidis_4119 Neisseria meningitidis 4119]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K7J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4K7J FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4k3u\|4k3u]], [[4k40\|4k40]], [[4k7s\|4k7s]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4k3u\|4k3u]], [[4k40\|4k40]], [[4k7s\|4k7s]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Neisseria meningitidis, NM4119_1198 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1095679 Neisseria meningitidis 4119])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k7j OCA], [http://pdbe.org/4k7j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4k7j RCSB], [http://www.ebi.ac.uk/pdbsum/4k7j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4k7j ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k7j OCA], [http://pdbe.org/4k7j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4k7j RCSB], [http://www.ebi.ac.uk/pdbsum/4k7j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4k7j ProSAT]</span></td></tr>
	</table>		</table>
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Neisseria meningitidis 4119]]
	[[Category: Boneca, I Gomperts]]		[[Category: Boneca, I Gomperts]]
	[[Category: Williams, A H]]		[[Category: Williams, A H]]

OCA at 19:32, 11 August 2016

OCA — Thu, 11 Aug 2016 19:32:21 GMT

←Older revision		Revision as of 19:32, 11 August 2016
Line 1:		Line 1:
		+
	==Peptidoglycan O-acetylesterase in action, 5 min==		==Peptidoglycan O-acetylesterase in action, 5 min==
	<StructureSection load='4k7j' size='340' side='right' caption='[[4k7j]], [[Resolution\|resolution]] 1.97Å' scene=''>		<StructureSection load='4k7j' size='340' side='right' caption='[[4k7j]], [[Resolution\|resolution]] 1.97Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4k3u\|4k3u]], [[4k40\|4k40]], [[4k7s\|4k7s]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4k3u\|4k3u]], [[4k40\|4k40]], [[4k7s\|4k7s]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k7j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4k7j RCSB], [http://www.ebi.ac.uk/pdbsum/4k7j PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k7j OCA], [http://pdbe.org/4k7j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4k7j RCSB], [http://www.ebi.ac.uk/pdbsum/4k7j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4k7j ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4k7j" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:50, 25 January 2015

OCA — Sun, 25 Jan 2015 07:50:13 GMT

←Older revision		Revision as of 07:50, 25 January 2015
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Boneca, I Gomperts.]]	+	[[Category: Boneca, I Gomperts]]
-	[[Category: Williams, A H.]]	+	[[Category: Williams, A H]]
	[[Category: Alpha/beta fold]]		[[Category: Alpha/beta fold]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Peptidoglycan hydrolase]]		[[Category: Peptidoglycan hydrolase]]

OCA at 08:16, 22 October 2014

OCA — Wed, 22 Oct 2014 08:16:37 GMT

←Older revision		Revision as of 08:16, 22 October 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4k7j]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K7J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4K7J FirstGlance]. <br>		<table><tr><td colspan='2'>[[4k7j]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K7J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4K7J FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4k3u\|4k3u]], [[4k40\|4k40]], [[4k7s\|4k7s]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4k3u\|4k3u]], [[4k40\|4k40]], [[4k7s\|4k7s]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k7j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4k7j RCSB], [http://www.ebi.ac.uk/pdbsum/4k7j PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k7j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4k7j RCSB], [http://www.ebi.ac.uk/pdbsum/4k7j PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Peptidoglycan O-acetylesterase (Ape1), which is required for host survival in Neisseria sp., belongs to the diverse SGNH hydrolase superfamily, which includes important viral and bacterial virulence factors. Here, multi-domain crystal structures of Ape1 with an SGNH catalytic domain and a newly identified putative peptidoglycan-detection module are reported. Enzyme catalysis was performed in Ape1 crystals and key catalytic intermediates along the SGNH esterase hydrolysis reaction pathway were visualized, revealing a substrate-induced productive conformation of the catalytic triad, a mechanistic detail that has not previously been observed. This substrate-induced productive conformation of the catalytic triad shifts the established dogma on these enzymes, generating valuable insight into the structure-based design of drugs targeting the SGNH esterase superfamily.
		+
		+	Visualization of a substrate-induced productive conformation of the catalytic triad of the Neisseria meningitidis peptidoglycan O-acetylesterase reveals mechanistic conservation in SGNH esterase family members.,Williams AH, Veyrier FJ, Bonis M, Michaud Y, Raynal B, Taha MK, White SW, Haouz A, Boneca IG Acta Crystallogr D Biol Crystallogr. 2014 Oct 1;70(Pt 10):2631-9. doi:, 10.1107/S1399004714016770. Epub 2014 Sep 27. PMID:25286847<ref>PMID:25286847</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 06:04, 4 September 2014

OCA — Thu, 04 Sep 2014 06:04:01 GMT

←Older revision		Revision as of 06:04, 4 September 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Peptidoglycan O-acetylesterase in action, 5 min==
-		+	<StructureSection load='4k7j' size='340' side='right' caption='[[4k7j]], [[Resolution\|resolution]] 1.97Å' scene=''>
-	~~The entry~~ 4k7j is ~~ON HOLD until Aug 28 2015~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4k7j]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K7J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4K7J FirstGlance]. <br>
-	~~Authors~~: ~~Williams~~, A.H., ~~Gomperts~~ Boneca, I.	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4k3u\|4k3u]], [[4k40\|4k40]], [[4k7s\|4k7s]]</td></tr>
-	~~Description~~: ~~Peptidoglycan~~ Hydrolase ~~in action~~	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k7j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4k7j RCSB], [http://www.ebi.ac.uk/pdbsum/4k7j PDBsum]</span></td></tr>
		+	<table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Boneca, I Gomperts.]]
		+	[[Category: Williams, A H.]]
		+	[[Category: Alpha/beta fold]]
		+	[[Category: Hydrolase]]
		+	[[Category: Peptidoglycan hydrolase]]

OCA at 14:06, 20 August 2014

OCA — Wed, 20 Aug 2014 14:06:11 GMT

←Older revision		Revision as of 14:06, 20 August 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4k7j is ON HOLD until Aug 20 2015	+	The entry 4k7j is ON HOLD until Aug 28 2015

	Authors: Williams, A.H., Gomperts Boneca, I.		Authors: Williams, A.H., Gomperts Boneca, I.

	Description: Peptidoglycan Hydrolase in action		Description: Peptidoglycan Hydrolase in action

OCA at 07:07, 13 August 2014

OCA — Wed, 13 Aug 2014 07:07:59 GMT

←Older revision		Revision as of 07:07, 13 August 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4k7j is ON HOLD until Aug 13 2015	+	The entry 4k7j is ON HOLD until Aug 20 2015

	Authors: Williams, A.H., Gomperts Boneca, I.		Authors: Williams, A.H., Gomperts Boneca, I.

	Description: Peptidoglycan Hydrolase in action		Description: Peptidoglycan Hydrolase in action

OCA at 06:03, 18 June 2014

OCA — Wed, 18 Jun 2014 06:03:24 GMT

←Older revision		Revision as of 06:03, 18 June 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4k7j is ON HOLD until ~~Jun 18~~ 2015	+	The entry 4k7j is ON HOLD until Aug 13 2015

	Authors: Williams, A.H., Gomperts Boneca, I.		Authors: Williams, A.H., Gomperts Boneca, I.

	Description: Peptidoglycan Hydrolase in action		Description: Peptidoglycan Hydrolase in action

OCA at 07:34, 11 June 2014

OCA — Wed, 11 Jun 2014 07:34:26 GMT

←Older revision		Revision as of 07:34, 11 June 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4k7j is ON HOLD until Jun 11 2015	+	The entry 4k7j is ON HOLD until Jun 18 2015

	Authors: Williams, A.H., Gomperts Boneca, I.		Authors: Williams, A.H., Gomperts Boneca, I.

	Description: Peptidoglycan Hydrolase in action		Description: Peptidoglycan Hydrolase in action