4k8u - Revision history

OCA at 08:54, 20 March 2024

OCA — Wed, 20 Mar 2024 08:54:32 GMT

←Older revision		Revision as of 08:54, 20 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4k8u]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K8U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4K8U FirstGlance]. <br>		<table><tr><td colspan='2'>[[4k8u]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K8U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4K8U FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4k8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k8u OCA], [https://pdbe.org/4k8u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4k8u RCSB], [https://www.ebi.ac.uk/pdbsum/4k8u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4k8u ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.302Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4k8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k8u OCA], [https://pdbe.org/4k8u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4k8u RCSB], [https://www.ebi.ac.uk/pdbsum/4k8u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4k8u ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/TRAF4_HUMAN TRAF4_HUMAN] Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions.<ref>PMID:12023963</ref> <ref>PMID:12801526</ref> <ref>PMID:16052631</ref> <ref>PMID:16157600</ref> <ref>PMID:18953416</ref> <ref>PMID:19937093</ref>		[https://www.uniprot.org/uniprot/TRAF4_HUMAN TRAF4_HUMAN] Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions.<ref>PMID:12023963</ref> <ref>PMID:12801526</ref> <ref>PMID:16052631</ref> <ref>PMID:16157600</ref> <ref>PMID:18953416</ref> <ref>PMID:19937093</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The TNF receptor-associated factor (TRAF) proteins are structurally similar scaffold proteins that mediate between members of the TNF receptor (TNFR) family and downstream effector molecules such as kinases in the immune signalling pathway. Seven TRAFs have been identified, including TRAF4, which is a unique member that participates in many ontogenic processes, including nerve-system development. TRAFs commonly contain the TRAF domain, which mediates interaction with target receptors and effectors. As a first step towards elucidating the molecular mechanisms of the TRAF4-mediated signalling pathway, the first crystal structure of the human TRAF4 TRAF domain with a coiled-coil domain is reported at 2.3 A resolution.
-
-	Structure of the TRAF4 TRAF domain with a coiled-coil domain and its implications for the TRAF4 signalling pathway.,Yoon JH, Cho YJ, Park HH Acta Crystallogr D Biol Crystallogr. 2014 Jan;70(Pt 1):2-10. doi:, 10.1107/S139900471302333X. Epub 2013 Dec 24. PMID:24419373<ref>PMID:24419373</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4k8u" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 11:45, 30 November 2022

OCA — Wed, 30 Nov 2022 11:45:51 GMT

←Older revision		Revision as of 11:45, 30 November 2022
Line 3:		Line 3:
	<StructureSection load='4k8u' size='340' side='right'caption='[[4k8u]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4k8u' size='340' side='right'caption='[[4k8u]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4k8u]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K8U OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4K8U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4k8u]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K8U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4K8U FirstGlance]. <br>
-	</td></tr>~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRAF4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4k8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k8u OCA], [https://pdbe.org/4k8u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4k8u RCSB], [https://www.ebi.ac.uk/pdbsum/4k8u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4k8u ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4k8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k8u OCA], [~~http~~://pdbe.org/4k8u PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4k8u RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4k8u PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4k8u ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TRAF4_HUMAN TRAF4_HUMAN]] Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions.<ref>PMID:12023963</ref> <ref>PMID:12801526</ref> <ref>PMID:16052631</ref> <ref>PMID:16157600</ref> <ref>PMID:18953416</ref> <ref>PMID:19937093</ref>	+	[https://www.uniprot.org/uniprot/TRAF4_HUMAN TRAF4_HUMAN] Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions.<ref>PMID:12023963</ref> <ref>PMID:12801526</ref> <ref>PMID:16052631</ref> <ref>PMID:16157600</ref> <ref>PMID:18953416</ref> <ref>PMID:19937093</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 19:

	==See Also==		==See Also==
-	*[[TNF receptor-associated factor\|TNF receptor-associated factor]]	+	*[[TNF receptor-associated factor 3D structures\|TNF receptor-associated factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Park~~, H H~~]]	+	[[Category: Park HH]]
-	[[Category: Yoon~~, J H]]~~	+	[[Category: Yoon JH]]
-	~~[[Category: Protein interaction]]~~	+
-	~~[[Category: Signaling molecule binding]]~~	+
-	~~[[Category: Signaling protein]]~~	+
-	~~[[Category: Traf domain]]~~	+
-	~~[[Category: Traf fold~~]]	+

OCA at 08:37, 1 January 2020

OCA — Wed, 01 Jan 2020 08:37:50 GMT

←Older revision		Revision as of 08:37, 1 January 2020
Line 1:		Line 1:

	==Crystal structure of TRAF4 TRAF domain==		==Crystal structure of TRAF4 TRAF domain==
-	<StructureSection load='4k8u' size='340' side='right' caption='[[4k8u]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='4k8u' size='340' side='right'caption='[[4k8u]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4k8u]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K8U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4K8U FirstGlance]. <br>		<table><tr><td colspan='2'>[[4k8u]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K8U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4K8U FirstGlance]. <br>
Line 9:		Line 9:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/TRAF4_HUMAN TRAF4_HUMAN]] Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions.<ref>PMID:12023963</ref> <ref>PMID:12801526</ref> <ref>PMID:16052631</ref> <ref>PMID:16157600</ref> <ref>PMID:18953416</ref> <ref>PMID:19937093</ref>		[[http://www.uniprot.org/uniprot/TRAF4_HUMAN TRAF4_HUMAN]] Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions.<ref>PMID:12023963</ref> <ref>PMID:12801526</ref> <ref>PMID:16052631</ref> <ref>PMID:16157600</ref> <ref>PMID:18953416</ref> <ref>PMID:19937093</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The TNF receptor-associated factor (TRAF) proteins are structurally similar scaffold proteins that mediate between members of the TNF receptor (TNFR) family and downstream effector molecules such as kinases in the immune signalling pathway. Seven TRAFs have been identified, including TRAF4, which is a unique member that participates in many ontogenic processes, including nerve-system development. TRAFs commonly contain the TRAF domain, which mediates interaction with target receptors and effectors. As a first step towards elucidating the molecular mechanisms of the TRAF4-mediated signalling pathway, the first crystal structure of the human TRAF4 TRAF domain with a coiled-coil domain is reported at 2.3 A resolution.
		+
		+	Structure of the TRAF4 TRAF domain with a coiled-coil domain and its implications for the TRAF4 signalling pathway.,Yoon JH, Cho YJ, Park HH Acta Crystallogr D Biol Crystallogr. 2014 Jan;70(Pt 1):2-10. doi:, 10.1107/S139900471302333X. Epub 2013 Dec 24. PMID:24419373<ref>PMID:24419373</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4k8u" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[TNF receptor-associated factor\|TNF receptor-associated factor]]
	== References ==		== References ==
	<references/>		<references/>
Line 14:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Park, H H]]		[[Category: Park, H H]]
	[[Category: Yoon, J H]]		[[Category: Yoon, J H]]

OCA at 20:22, 5 August 2016

OCA — Fri, 05 Aug 2016 20:22:18 GMT

←Older revision		Revision as of 20:22, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of TRAF4 TRAF domain==		==Crystal structure of TRAF4 TRAF domain==
	<StructureSection load='4k8u' size='340' side='right' caption='[[4k8u]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4k8u' size='340' side='right' caption='[[4k8u]], [[Resolution\|resolution]] 2.30Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4k8u]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K8U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4K8U FirstGlance]. <br>		<table><tr><td colspan='2'>[[4k8u]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K8U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4K8U FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRAF4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRAF4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k8u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4k8u RCSB], [http://www.ebi.ac.uk/pdbsum/4k8u PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k8u OCA], [http://pdbe.org/4k8u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4k8u RCSB], [http://www.ebi.ac.uk/pdbsum/4k8u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4k8u ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 05:34, 25 December 2014

OCA — Thu, 25 Dec 2014 05:34:42 GMT

←Older revision		Revision as of 05:34, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k8u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4k8u RCSB], [http://www.ebi.ac.uk/pdbsum/4k8u PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k8u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4k8u RCSB], [http://www.ebi.ac.uk/pdbsum/4k8u PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TRAF4_HUMAN TRAF4_HUMAN]] Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions.<ref>PMID:12023963</ref> <ref>PMID:12801526</ref> <ref>PMID:16052631</ref> <ref>PMID:16157600</ref> <ref>PMID:18953416</ref> <ref>PMID:19937093</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 18:25, 21 December 2014

OCA — Sun, 21 Dec 2014 18:25:14 GMT

←Older revision		Revision as of 18:25, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4k8u\| PDB=4k8u \| SCENE= }}~~	+	==Crystal structure of TRAF4 TRAF domain==
-	===Crystal structure of TRAF4 TRAF domain===	+	<StructureSection load='4k8u' size='340' side='right' caption='[[4k8u]], [[Resolution\|resolution]] 2.30Å' scene=''>
-		+	== Structural highlights ==
-	==~~Function~~==	+	<table><tr><td colspan='2'>[[4k8u]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K8U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4K8U FirstGlance]. <br>
-	[[http://~~www~~.~~uniprot~~.org/~~uniprot~~/~~TRAF4_HUMAN TRAF4_HUMAN~~]] ~~Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways~~. ~~Plays~~ a ~~role in~~ the ~~activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis~~. ~~Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors~~. ~~Required for normal skeleton development, and for normal development of the respiratory tract (By similarity)~~. ~~Required for activation of RPS6KB1 in response to TNF signaling~~. ~~Modulates TRAF6 functions~~.<~~ref~~>~~PMID:12023963~~</~~ref~~> <~~ref~~>~~PMID:12801526~~<~~/ref~~> <~~ref~~>~~PMID~~:~~16052631~~</~~ref~~> <~~ref~~>~~PMID~~:~~16157600~~</~~ref~~> <~~ref~~>~~PMID:18953416~~<~~/ref~~> <~~ref~~>~~PMID~~:~~19937093~~</~~ref~~>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRAF4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k8u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4k8u RCSB], [http://www.ebi.ac.uk/pdbsum/4k8u PDBsum]</span></td></tr>
-	==~~About this Structure==~~	+	</table>
-	[[4k8u]~~] is a 3 chain structure. Full crystallographic information is available from~~ [http://oca.weizmann.ac.il/oca-bin/~~ocashort~~?id=~~4K8U~~ OCA].	+	__TOC__
-		+	</StructureSection>
-	~~==Reference=~~=	+	[[Category: Human]]
-	<~~references group="xtra"~~/><~~references~~/>	+	[[Category: Park, H H]]
-	[[Category: Park, H H.]]	+	[[Category: Yoon, J H]]
-	[[Category: Yoon, J H.]]	+
	[[Category: Protein interaction]]		[[Category: Protein interaction]]
	[[Category: Signaling molecule binding]]		[[Category: Signaling molecule binding]]

OCA at 08:23, 15 January 2014

OCA — Wed, 15 Jan 2014 08:23:18 GMT

←Older revision		Revision as of 08:23, 15 January 2014
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4k8u\| PDB=4k8u \| SCENE= }}
		+	===Crystal structure of TRAF4 TRAF domain===

-	~~The entry 4k8u is ON HOLD~~ ~~until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/TRAF4_HUMAN TRAF4_HUMAN]] Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions.<ref>PMID:12023963</ref> <ref>PMID:12801526</ref> <ref>PMID:16052631</ref> <ref>PMID:16157600</ref> <ref>PMID:18953416</ref> <ref>PMID:19937093</ref>

-	~~Authors~~: ~~Park, H~~.H.~~, Yoon, J~~.H.	+	==About this Structure==
		+	[[4k8u]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K8U OCA].

-	~~Description~~: ~~Crystal structure of TRAF4 TRAF~~ domain	+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Park, H H.]]
		+	[[Category: Yoon, J H.]]
		+	[[Category: Protein interaction]]
		+	[[Category: Signaling molecule binding]]
		+	[[Category: Signaling protein]]
		+	[[Category: Traf domain]]
		+	[[Category: Traf fold]]

OCA at 08:54, 8 January 2014

OCA — Wed, 08 Jan 2014 08:54:35 GMT

←Older revision		Revision as of 08:54, 8 January 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4k8u is ON HOLD	+	The entry 4k8u is ON HOLD until Paper Publication

	Authors: Park, H.H., Yoon, J.H.		Authors: Park, H.H., Yoon, J.H.

	Description: Crystal structure of TRAF4 TRAF domain		Description: Crystal structure of TRAF4 TRAF domain

OCA at 07:18, 8 May 2013

OCA — Wed, 08 May 2013 07:18:45 GMT

←Older revision		Revision as of 07:18, 8 May 2013
Line 3:		Line 3:
	The entry 4k8u is ON HOLD		The entry 4k8u is ON HOLD

-	Authors: Park, H.H, Yoon, J.H	+	Authors: Park, H.H., Yoon, J.H.

	Description: Crystal structure of TRAF4 TRAF domain		Description: Crystal structure of TRAF4 TRAF domain

OCA: Protected "4k8u" [edit=sysop:move=sysop]

OCA — Wed, 24 Apr 2013 11:03:19 GMT

Protected "4k8u" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:03, 24 April 2013