4kb9 - Revision history

OCA at 15:57, 20 September 2023

OCA — Wed, 20 Sep 2023 15:57:09 GMT

←Older revision		Revision as of 15:57, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4kb9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KB9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KB9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4kb9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KB9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KB9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=G79:(3AR,3BR,4S,7AR,8AS)-DECAHYDROFURO[2,3-B][1]BENZOFURAN-4-YL+[(2S,3R)-3-HYDROXY-4-{[(4-METHOXYPHENYL)SULFONYL](2-METHYLPROPYL)AMINO}-1-PHENYLBUTAN-2-YL]CARBAMATE'>G79</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.29Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=G79:(3AR,3BR,4S,7AR,8AS)-DECAHYDROFURO[2,3-B][1]BENZOFURAN-4-YL+[(2S,3R)-3-HYDROXY-4-{[(4-METHOXYPHENYL)SULFONYL](2-METHYLPROPYL)AMINO}-1-PHENYLBUTAN-2-YL]CARBAMATE'>G79</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kb9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kb9 OCA], [https://pdbe.org/4kb9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kb9 RCSB], [https://www.ebi.ac.uk/pdbsum/4kb9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kb9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kb9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kb9 OCA], [https://pdbe.org/4kb9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kb9 RCSB], [https://www.ebi.ac.uk/pdbsum/4kb9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kb9 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 11:50, 30 November 2022

OCA — Wed, 30 Nov 2022 11:50:47 GMT

←Older revision		Revision as of 11:50, 30 November 2022
Line 1:		Line 1:

	==Crystal structure of wild-type HIV-1 protease with novel tricyclic P2-ligands GRL-0739A==		==Crystal structure of wild-type HIV-1 protease with novel tricyclic P2-ligands GRL-0739A==
-	<StructureSection load='4kb9' size='340' side='right' caption='[[4kb9]], [[Resolution\|resolution]] 1.29Å' scene=''>	+	<StructureSection load='4kb9' size='340' side='right'caption='[[4kb9]], [[Resolution\|resolution]] 1.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4kb9]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~9hiv1 9hiv1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KB9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4KB9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4kb9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KB9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KB9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=G79:(3AR,3BR,4S,7AR,8AS)-DECAHYDROFURO[2,3-B][1]BENZOFURAN-4-YL+[(2S,3R)-3-HYDROXY-4-{[(4-METHOXYPHENYL)SULFONYL](2-METHYLPROPYL)AMINO}-1-PHENYLBUTAN-2-YL]CARBAMATE'>G79</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=G79:(3AR,3BR,4S,7AR,8AS)-DECAHYDROFURO[2,3-B][1]BENZOFURAN-4-YL+[(2S,3R)-3-HYDROXY-4-{[(4-METHOXYPHENYL)SULFONYL](2-METHYLPROPYL)AMINO}-1-PHENYLBUTAN-2-YL]CARBAMATE'>G79</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ien\|2ien]], [[3ok9\|3ok9]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kb9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kb9 OCA], [https://pdbe.org/4kb9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kb9 RCSB], [https://www.ebi.ac.uk/pdbsum/4kb9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kb9 ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4kb9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kb9 OCA], [~~http~~://pdbe.org/4kb9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4kb9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4kb9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4kb9 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q7SSI0_9HIV1 Q7SSI0_9HIV1]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4kb9" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4kb9" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Immunodeficiency virus protease 3D structures\|Immunodeficiency virus protease 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~HIV-~~1 ~~retropepsin~~]]	+	[[Category: Human immunodeficiency virus 1]]
-	[[Category: ~~Agniswamy, J~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Wang, Y F~~]]	+	[[Category: Agniswamy J]]
-	[[Category: ~~Weber, I T]]~~	+	[[Category: Wang Y-F]]
-	~~[[Category: A novel tricyclic p2~~-~~ligand~~]]	+	[[Category: Weber IT]]
-	[[Category: ~~Hiv-1 protease inhibitor grl-0739a]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Spartic acid protease~~]]	+

OCA at 23:11, 4 August 2016

OCA — Thu, 04 Aug 2016 23:11:46 GMT

←Older revision		Revision as of 23:11, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of wild-type HIV-1 protease with novel tricyclic P2-ligands GRL-0739A==		==Crystal structure of wild-type HIV-1 protease with novel tricyclic P2-ligands GRL-0739A==
	<StructureSection load='4kb9' size='340' side='right' caption='[[4kb9]], [[Resolution\|resolution]] 1.29Å' scene=''>		<StructureSection load='4kb9' size='340' side='right' caption='[[4kb9]], [[Resolution\|resolution]] 1.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4kb9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Human_immunodeficiency_virus_1 Human immunodeficiency virus 1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KB9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KB9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4kb9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KB9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KB9 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=G79:(3AR,3BR,4S,7AR,8AS)-DECAHYDROFURO[2,3-B][1]BENZOFURAN-4-YL+[(2S,3R)-3-HYDROXY-4-{[(4-METHOXYPHENYL)SULFONYL](2-METHYLPROPYL)AMINO}-1-PHENYLBUTAN-2-YL]CARBAMATE'>G79</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=G79:(3AR,3BR,4S,7AR,8AS)-DECAHYDROFURO[2,3-B][1]BENZOFURAN-4-YL+[(2S,3R)-3-HYDROXY-4-{[(4-METHOXYPHENYL)SULFONYL](2-METHYLPROPYL)AMINO}-1-PHENYLBUTAN-2-YL]CARBAMATE'>G79</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ien\|2ien]], [[3ok9\|3ok9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ien\|2ien]], [[3ok9\|3ok9]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 ~~Human immunodeficiency virus 1~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kb9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kb9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kb9 RCSB], [http://www.ebi.ac.uk/pdbsum/4kb9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kb9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kb9 OCA], [http://pdbe.org/4kb9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kb9 RCSB], [http://www.ebi.ac.uk/pdbsum/4kb9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4kb9 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4kb9" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 22:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: HIV-1 retropepsin]]		[[Category: HIV-1 retropepsin]]
-	[[Category: Human immunodeficiency virus 1]]
	[[Category: Agniswamy, J]]		[[Category: Agniswamy, J]]
	[[Category: Wang, Y F]]		[[Category: Wang, Y F]]

OCA at 15:19, 21 December 2014

OCA — Sun, 21 Dec 2014 15:19:53 GMT

←Older revision		Revision as of 15:19, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4kb9\| PDB=4kb9 \| SCENE= }}~~	+	==Crystal structure of wild-type HIV-1 protease with novel tricyclic P2-ligands GRL-0739A==
-	===Crystal structure of wild-type HIV-1 protease with novel tricyclic P2-ligands GRL-0739A===	+	<StructureSection load='4kb9' size='340' side='right' caption='[[4kb9]], [[Resolution\|resolution]] 1.29Å' scene=''>
-	{~~{ABSTRACT_PUBMED_23947685}~~}	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4kb9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KB9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KB9 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=G79:(3AR,3BR,4S,7AR,8AS)-DECAHYDROFURO[2,3-B][1]BENZOFURAN-4-YL+[(2S,3R)-3-HYDROXY-4-{[(4-METHOXYPHENYL)SULFONYL](2-METHYLPROPYL)AMINO}-1-PHENYLBUTAN-2-YL]CARBAMATE'>G79</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2ien\|2ien]], [[3ok9\|3ok9]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kb9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kb9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kb9 RCSB], [http://www.ebi.ac.uk/pdbsum/4kb9 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The design, synthesis, and biological evaluation of a series of HIV-1 protease inhibitors incorporating stereochemically defined fused tricyclic P2 ligands are described. Various substituent effects were investigated to maximize the ligand-binding site interactions in the protease active site. Inhibitors 16a and 16f showed excellent enzyme inhibitory and antiviral activity, although the incorporation of sulfone functionality resulted in a decrease in potency. Both inhibitors 16a and 16f maintained activity against a panel of multidrug resistant HIV-1 variants. A high-resolution X-ray crystal structure of 16a-bound HIV-1 protease revealed important molecular insights into the ligand-binding site interactions, which may account for the inhibitor's potent antiviral activity and excellent resistance profiles.

-	~~==About this Structure==~~	+	Highly Potent HIV-1 Protease Inhibitors with Novel Tricyclic P2 Ligands: Design, Synthesis, and Protein-Ligand X-ray Studies.,Ghosh AK, Parham GL, Martyr CD, Nyalapatla PR, Osswald HL, Agniswamy J, Wang YF, Amano M, Weber IT, Mitsuya H J Med Chem. 2013 Aug 15. PMID:23947685<ref>PMID:23947685</ref>
-	~~[[4kb9]] is a 2 chain structure~~ with ~~sequence from [http~~:~~//en~~.~~wikipedia~~.~~org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]~~. ~~Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4KB9 OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:023947685</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: HIV-1 retropepsin]]		[[Category: HIV-1 retropepsin]]
	[[Category: Human immunodeficiency virus 1]]		[[Category: Human immunodeficiency virus 1]]
-	[[Category: Agniswamy, J.]]	+	[[Category: Agniswamy, J]]
-	[[Category: Wang, Y F.]]	+	[[Category: Wang, Y F]]
-	[[Category: Weber, I T.]]	+	[[Category: Weber, I T]]
	[[Category: A novel tricyclic p2-ligand]]		[[Category: A novel tricyclic p2-ligand]]
	[[Category: Hiv-1 protease inhibitor grl-0739a]]		[[Category: Hiv-1 protease inhibitor grl-0739a]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]
	[[Category: Spartic acid protease]]		[[Category: Spartic acid protease]]

OCA at 10:48, 4 September 2013

OCA — Wed, 04 Sep 2013 10:48:35 GMT

←Older revision		Revision as of 10:48, 4 September 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4kb9\| PDB=4kb9 \| SCENE= }}
		+	===Crystal structure of wild-type HIV-1 protease with novel tricyclic P2-ligands GRL-0739A===
		+	{{ABSTRACT_PUBMED_23947685}}

-	~~The entry~~ 4kb9 is ~~ON HOLD~~	+	==About this Structure==
		+	[[4kb9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KB9 OCA].

-	~~Authors~~: ~~Wang, Y.~~-~~F.,~~ Agniswamy, J., Weber, I.T.	+	==Reference==
-		+	<ref group="xtra">PMID:023947685</ref><references group="xtra"/><references/>
-	~~Description~~: ~~Crystal structure of wild-type HIV~~-1 protease ~~with novel tricyclic P2~~-~~ligands GRL~~-~~0739A~~	+	[[Category: HIV-1 retropepsin]]
		+	[[Category: Human immunodeficiency virus 1]]
		+	[[Category: Agniswamy, J.]]
		+	[[Category: Wang, Y F.]]
		+	[[Category: Weber, I T.]]
		+	[[Category: A novel tricyclic p2-ligand]]
		+	[[Category: Hiv-1 protease inhibitor grl-0739a]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
		+	[[Category: Spartic acid protease]]

OCA at 07:19, 8 May 2013

OCA — Wed, 08 May 2013 07:19:30 GMT

←Older revision		Revision as of 07:19, 8 May 2013
Line 3:		Line 3:
	The entry 4kb9 is ON HOLD		The entry 4kb9 is ON HOLD

-	Authors: Wang, Y.-F. , Agniswamy, J. , Weber, I.T.	+	Authors: Wang, Y.-F., Agniswamy, J., Weber, I.T.

	Description: Crystal structure of wild-type HIV-1 protease with novel tricyclic P2-ligands GRL-0739A		Description: Crystal structure of wild-type HIV-1 protease with novel tricyclic P2-ligands GRL-0739A

OCA: Protected "4kb9" [edit=sysop:move=sysop]

OCA — Thu, 02 May 2013 07:15:00 GMT

Protected "4kb9" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:15, 2 May 2013

OCA: New page: '''Unreleased structure''' The entry 4kb9 is ON HOLD Authors: Wang, Y.-F. , Agniswamy, J. , Weber, I.T. Description: Crystal structure of wild-type HIV-1 protease with novel tricyclic ...

OCA — Thu, 02 May 2013 07:14:59 GMT

New page: '''Unreleased structure''' The entry 4kb9 is ON HOLD Authors: Wang, Y.-F. , Agniswamy, J. , Weber, I.T. Description: Crystal structure of wild-type HIV-1 protease with novel tricyclic ...

New page

'''Unreleased structure'''

The entry 4kb9 is ON HOLD

Authors: Wang, Y.-F. , Agniswamy, J. , Weber, I.T.

Description: Crystal structure of wild-type HIV-1 protease with novel tricyclic P2-ligands GRL-0739A