4kg8 - Revision history

OCA at 15:59, 20 September 2023

OCA — Wed, 20 Sep 2023 15:59:00 GMT

←Older revision		Revision as of 15:59, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4kg8]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KG8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KG8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4kg8]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KG8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KG8 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kg8 OCA], [https://pdbe.org/4kg8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kg8 RCSB], [https://www.ebi.ac.uk/pdbsum/4kg8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kg8 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.25Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kg8 OCA], [https://pdbe.org/4kg8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kg8 RCSB], [https://www.ebi.ac.uk/pdbsum/4kg8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kg8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 11:57, 30 November 2022

OCA — Wed, 30 Nov 2022 11:57:11 GMT

←Older revision		Revision as of 11:57, 30 November 2022
Line 1:		Line 1:

	==Crystal structure of light mutant==		==Crystal structure of light mutant==
-	<StructureSection load='4kg8' size='340' side='right' caption='[[4kg8]], [[Resolution\|resolution]] 2.25Å' scene=''>	+	<StructureSection load='4kg8' size='340' side='right'caption='[[4kg8]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4kg8]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KG8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4KG8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4kg8]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KG8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KG8 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4en0\|4en0]], [[4j6g\|4j6g]], [[4fhq\|4fhq]], [[3k51\|3k51]], [[3mi8\|3mi8]], [[3mhd\|3mhd]]</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kg8 OCA], [https://pdbe.org/4kg8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kg8 RCSB], [https://www.ebi.ac.uk/pdbsum/4kg8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kg8 ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TNFSF14, HVEML, LIGHT, UNQ391/PRO726 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4kg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kg8 OCA], [~~http~~://pdbe.org/4kg8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4kg8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4kg8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4kg8 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TNF14_HUMAN TNF14_HUMAN]] Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.	+	[https://www.uniprot.org/uniprot/TNF14_HUMAN TNF14_HUMAN] Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 19:

	==See Also==		==See Also==
-	*[[Tumor necrosis factor receptor\|Tumor necrosis factor receptor]]	+	*[[Tumor necrosis factor ligand superfamily 3D structures\|Tumor necrosis factor ligand superfamily 3D structures]]
		+	*[[Tumor necrosis factor receptor 3D structures\|Tumor necrosis factor receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Almo, S C~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Bonanno, J B~~]]	+	[[Category: Almo SC]]
-	[[Category: ~~IFN, Atoms-to-Animals:.The Immune Function Network~~]]	+	[[Category: Bonanno JB]]
-	[[Category: Kumar~~, P R~~]]	+	[[Category: Kumar PR]]
-	[[Category: Liu, W]]	+	[[Category: Liu W]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Nathenson SG]]
-	[[Category: Nathenson~~, S G~~]]	+	[[Category: Zhan C]]
-	[[Category: Zhan, C]]	+
-	~~[[Category: Atoms-to-animals: the immune function network]]~~	+
-	~~[[Category: Bind tnf receptor hvem and ltbr]]~~	+
-	~~[[Category: Cytokine]]~~	+
-	~~[[Category: Dcr3]]~~	+
-	~~[[Category: Hvem]]~~	+
-	~~[[Category: Ifn]]~~	+
-	~~[[Category: Immunity]]~~	+
-	~~[[Category: Jelly-roll fold]]~~	+
-	~~[[Category: Ltbr]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: N-glycosylation]]~~	+
-	~~[[Category: Nysgrc]]~~	+
-	~~[[Category: PSI, Protein structure initiative]]~~	+
-	~~[[Category: Psi-biology]]~~	+
-	~~[[Category: Secreted protein]]~~	+
-	~~[[Category: Tnf superfamily~~]]	+

OCA at 14:43, 5 August 2016

OCA — Fri, 05 Aug 2016 14:43:23 GMT

←Older revision		Revision as of 14:43, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of light mutant==		==Crystal structure of light mutant==
	<StructureSection load='4kg8' size='340' side='right' caption='[[4kg8]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='4kg8' size='340' side='right' caption='[[4kg8]], [[Resolution\|resolution]] 2.25Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4en0\|4en0]], [[4j6g\|4j6g]], [[4fhq\|4fhq]], [[3k51\|3k51]], [[3mi8\|3mi8]], [[3mhd\|3mhd]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4en0\|4en0]], [[4j6g\|4j6g]], [[4fhq\|4fhq]], [[3k51\|3k51]], [[3mi8\|3mi8]], [[3mhd\|3mhd]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TNFSF14, HVEML, LIGHT, UNQ391/PRO726 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TNFSF14, HVEML, LIGHT, UNQ391/PRO726 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kg8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kg8 RCSB], [http://www.ebi.ac.uk/pdbsum/4kg8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kg8 OCA], [http://pdbe.org/4kg8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kg8 RCSB], [http://www.ebi.ac.uk/pdbsum/4kg8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4kg8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4kg8" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Tumor necrosis factor receptor\|Tumor necrosis factor receptor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:28, 31 December 2014

OCA — Wed, 31 Dec 2014 09:28:41 GMT

←Older revision		Revision as of 09:28, 31 December 2014
Line 2:		Line 2:
	<StructureSection load='4kg8' size='340' side='right' caption='[[4kg8]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='4kg8' size='340' side='right' caption='[[4kg8]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4kg8]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KG8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KG8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4kg8]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KG8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KG8 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4en0\|4en0]], [[4j6g\|4j6g]], [[4fhq\|4fhq]], [[3k51\|3k51]], [[3mi8\|3mi8]], [[3mhd\|3mhd]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4en0\|4en0]], [[4j6g\|4j6g]], [[4fhq\|4fhq]], [[3k51\|3k51]], [[3mi8\|3mi8]], [[3mhd\|3mhd]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TNFSF14, HVEML, LIGHT, UNQ391/PRO726 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TNFSF14, HVEML, LIGHT, UNQ391/PRO726 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kg8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kg8 RCSB], [http://www.ebi.ac.uk/pdbsum/4kg8 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kg8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kg8 RCSB], [http://www.ebi.ac.uk/pdbsum/4kg8 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/TNF14_HUMAN TNF14_HUMAN]] Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.		[[http://www.uniprot.org/uniprot/TNF14_HUMAN TNF14_HUMAN]] Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	LIGHT initiates intracellular signaling via engagement of the two TNF receptors, HVEM and LTbetaR. In humans, LIGHT is neutralized by DcR3, a unique soluble member of the TNFR superfamily, which tightly binds LIGHT and inhibits its interactions with HVEM and LTbetaR. DcR3 also neutralizes two other TNF ligands, FasL and TL1A. Due to its ability to neutralize three distinct different ligands, DcR3 contributes to a wide range of biological and pathological processes, including cancer and autoimmune diseases. However, the mechanisms that support the broad specificity of DcR3 remain to be fully defined. We report the structures of LIGHT and the LIGHT:DcR3 complex, which reveal the structural basis for the DcR3-mediated neutralization of LIGHT and afford insights into DcR3 function and binding promiscuity. Based on these structures, we designed LIGHT mutants with altered affinities for DcR3 and HVEM, which may represent mechanistically informative probe reagents.
		+
		+	Mechanistic basis for functional promiscuity in the TNF and TNF receptor superfamilies: structure of the LIGHT:DcR3 assembly.,Liu W, Zhan C, Cheng H, Kumar PR, Bonanno JB, Nathenson SG, Almo SC Structure. 2014 Sep 2;22(9):1252-62. doi: 10.1016/j.str.2014.06.013. Epub 2014, Jul 31. PMID:25087510<ref>PMID:25087510</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Almo, S C]]		[[Category: Almo, S C]]
	[[Category: Bonanno, J B]]		[[Category: Bonanno, J B]]

OCA at 03:21, 25 December 2014

OCA — Thu, 25 Dec 2014 03:21:03 GMT

←Older revision		Revision as of 03:21, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4kg8\| PDB~~=4kg8 \| ~~SCENE~~= }}	+	==Crystal structure of light mutant==
-	===~~Crystal~~ structure ~~of light mutant~~===	+	<StructureSection load='4kg8' size='340' side='right' caption='[[4kg8]], [[Resolution\|resolution]] 2.25Å' scene=''>
-		+	== Structural highlights ==
-	==Function==	+	<table><tr><td colspan='2'>[[4kg8]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KG8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KG8 FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4en0\|4en0]], [[4j6g\|4j6g]], [[4fhq\|4fhq]], [[3k51\|3k51]], [[3mi8\|3mi8]], [[3mhd\|3mhd]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TNFSF14, HVEML, LIGHT, UNQ391/PRO726 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kg8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kg8 RCSB], [http://www.ebi.ac.uk/pdbsum/4kg8 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/TNF14_HUMAN TNF14_HUMAN]] Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.		[[http://www.uniprot.org/uniprot/TNF14_HUMAN TNF14_HUMAN]] Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.
-		+	__TOC__
-	~~==About this Structure==~~	+	</StructureSection>
-	~~[[4kg8]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin~~/~~ocashort?id=4KG8 OCA].~~	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Almo, S C.]]	+	[[Category: Almo, S C]]
-	[[Category: Bonanno, J B.]]	+	[[Category: Bonanno, J B]]
-	[[Category: IFN, Atoms-to-Animals:.The Immune Function Network.]]	+	[[Category: IFN, Atoms-to-Animals:.The Immune Function Network]]
-	[[Category: Kumar, P R.]]	+	[[Category: Kumar, P R]]
-	[[Category: Liu, W.]]	+	[[Category: Liu, W]]
-	[[Category: ~~NYSGRC, New York~~ Structural ~~Genomics Research Consortium.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Nathenson, S G.]]	+	[[Category: Nathenson, S G]]
-	[[Category: Zhan, C.]]	+	[[Category: Zhan, C]]
	[[Category: Atoms-to-animals: the immune function network]]		[[Category: Atoms-to-animals: the immune function network]]
	[[Category: Bind tnf receptor hvem and ltbr]]		[[Category: Bind tnf receptor hvem and ltbr]]
Line 27:		Line 31:
	[[Category: Membrane]]		[[Category: Membrane]]
	[[Category: N-glycosylation]]		[[Category: N-glycosylation]]
-	[[Category: New york structural genomics research consortium]]
	[[Category: Nysgrc]]		[[Category: Nysgrc]]
-	[[Category: Protein structure initiative]]	+	[[Category: PSI, Protein structure initiative]]
	[[Category: Psi-biology]]		[[Category: Psi-biology]]
	[[Category: Secreted protein]]		[[Category: Secreted protein]]
-	[[Category: Structural genomic]]
	[[Category: Tnf superfamily]]		[[Category: Tnf superfamily]]

OCA at 02:49, 20 September 2013

OCA — Fri, 20 Sep 2013 02:49:20 GMT

←Older revision		Revision as of 02:49, 20 September 2013
Line 11:		Line 11:
	[[Category: Bonanno, J B.]]		[[Category: Bonanno, J B.]]
	[[Category: IFN, Atoms-to-Animals:.The Immune Function Network.]]		[[Category: IFN, Atoms-to-Animals:.The Immune Function Network.]]
		+	[[Category: Kumar, P R.]]
	[[Category: Liu, W.]]		[[Category: Liu, W.]]
	[[Category: NYSGRC, New York Structural Genomics Research Consortium.]]		[[Category: NYSGRC, New York Structural Genomics Research Consortium.]]
	[[Category: Nathenson, S G.]]		[[Category: Nathenson, S G.]]
-	[[Category: Rajesh, P.]]
	[[Category: Zhan, C.]]		[[Category: Zhan, C.]]
	[[Category: Atoms-to-animals: the immune function network]]		[[Category: Atoms-to-animals: the immune function network]]

OCA at 21:03, 7 August 2013

OCA — Wed, 07 Aug 2013 21:03:22 GMT

←Older revision		Revision as of 21:03, 7 August 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4kg8\| PDB=4kg8 \| SCENE= }}
		+	===Crystal structure of light mutant===

-	~~The entry 4kg8 is ON HOLD~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/TNF14_HUMAN TNF14_HUMAN]] Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.

-	~~Authors~~: ~~Liu, W~~.~~, Zhan, C~~.~~, Rajesh, P~~., Bonanno, J.B., ~~Nathenson, S~~.G., ~~Almo, S.C~~., New York Structural Genomics Research Consortium ~~(NYSGRC)~~, Atoms-to-~~Animals~~: ~~The Immune Function Network (IFN)~~	+	==About this Structure==
-		+	[[4kg8]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KG8 OCA].
-	~~Description~~: ~~Crystal~~ structure ~~of light mutant~~	+	[[Category: Homo sapiens]]
		+	[[Category: Almo, S C.]]
		+	[[Category: Bonanno, J B.]]
		+	[[Category: IFN, Atoms-to-Animals:.The Immune Function Network.]]
		+	[[Category: Liu, W.]]
		+	[[Category: NYSGRC, New York Structural Genomics Research Consortium.]]
		+	[[Category: Nathenson, S G.]]
		+	[[Category: Rajesh, P.]]
		+	[[Category: Zhan, C.]]
		+	[[Category: Atoms-to-animals: the immune function network]]
		+	[[Category: Bind tnf receptor hvem and ltbr]]
		+	[[Category: Cytokine]]
		+	[[Category: Dcr3]]
		+	[[Category: Hvem]]
		+	[[Category: Ifn]]
		+	[[Category: Immunity]]
		+	[[Category: Jelly-roll fold]]
		+	[[Category: Ltbr]]
		+	[[Category: Membrane]]
		+	[[Category: N-glycosylation]]
		+	[[Category: New york structural genomics research consortium]]
		+	[[Category: Nysgrc]]
		+	[[Category: Protein structure initiative]]
		+	[[Category: Psi-biology]]
		+	[[Category: Secreted protein]]
		+	[[Category: Structural genomic]]
		+	[[Category: Tnf superfamily]]

OCA: Protected "4kg8" [edit=sysop:move=sysop]

OCA — Wed, 08 May 2013 07:22:33 GMT

Protected "4kg8" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:22, 8 May 2013

OCA: New page: '''Unreleased structure''' The entry 4kg8 is ON HOLD Authors: Liu, W., Zhan, C., Rajesh, P., Bonanno, J.B., Nathenson, S.G., Almo, S.C., New York Structural Genomics Research Consortium...

OCA — Wed, 08 May 2013 07:22:32 GMT

New page: '''Unreleased structure''' The entry 4kg8 is ON HOLD Authors: Liu, W., Zhan, C., Rajesh, P., Bonanno, J.B., Nathenson, S.G., Almo, S.C., New York Structural Genomics Research Consortium...

New page

'''Unreleased structure'''

The entry 4kg8 is ON HOLD

Authors: Liu, W., Zhan, C., Rajesh, P., Bonanno, J.B., Nathenson, S.G., Almo, S.C., New York Structural Genomics Research Consortium (NYSGRC), Atoms-to-Animals: The Immune Function Network (IFN)

Description: Crystal structure of light mutant