4klg - Revision history

OCA at 16:01, 20 September 2023

OCA — Wed, 20 Sep 2023 16:01:08 GMT

←Older revision		Revision as of 16:01, 20 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4klg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KLG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KLG FirstGlance]. <br>		<table><tr><td colspan='2'>[[4klg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KLG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KLG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PPV:PYROPHOSPHATE'>PPV</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.701Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PPV:PYROPHOSPHATE'>PPV</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4klg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4klg OCA], [https://pdbe.org/4klg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4klg RCSB], [https://www.ebi.ac.uk/pdbsum/4klg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4klg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4klg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4klg OCA], [https://pdbe.org/4klg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4klg RCSB], [https://www.ebi.ac.uk/pdbsum/4klg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4klg ProSAT]</span></td></tr>
	</table>		</table>
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	</div>		</div>
	<div class="pdbe-citations 4klg" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4klg" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[DNA polymerase 3D structures\|DNA polymerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:58, 7 December 2022

OCA — Wed, 07 Dec 2022 08:58:27 GMT

←Older revision		Revision as of 08:58, 7 December 2022
Line 1:		Line 1:

	==DNA polymerase beta matched product complex with Mg2+, 40 s==		==DNA polymerase beta matched product complex with Mg2+, 40 s==
-	<StructureSection load='4klg' size='340' side='right' caption='[[4klg]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='4klg' size='340' side='right'caption='[[4klg]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4klg]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KLG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4KLG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4klg]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KLG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KLG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PPV:PYROPHOSPHATE'>PPV</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PPV:PYROPHOSPHATE'>PPV</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4kld\|4kld]], [[4kle\|4kle]], [[4klf\|4klf]], [[4klh\|4klh]], [[4kli\|4kli]], [[4klj\|4klj]], [[4kll\|4kll]], [[4klm\|4klm]], [[4klo\|4klo]], [[4klp\|4klp]], [[4klq\|4klq]], [[4kls\|4kls]], [[4klt\|4klt]], [[4klu\|4klu]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4klg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4klg OCA], [https://pdbe.org/4klg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4klg RCSB], [https://www.ebi.ac.uk/pdbsum/4klg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4klg ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Polb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4klg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4klg OCA], [~~http~~://pdbe.org/4klg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4klg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4klg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4klg ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/DPOLB_HUMAN DPOLB_HUMAN]] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.<ref>PMID:9207062</ref> <ref>PMID:9572863</ref> <ref>PMID:11805079</ref> <ref>PMID:21362556</ref>	+	[https://www.uniprot.org/uniprot/DPOLB_HUMAN DPOLB_HUMAN] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.<ref>PMID:9207062</ref> <ref>PMID:9572863</ref> <ref>PMID:11805079</ref> <ref>PMID:21362556</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Beard, W A~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Freudenthal, B D~~]]	+	[[Category: Beard WA]]
-	[[Category: ~~Shock, D D~~]]	+	[[Category: Freudenthal BD]]
-	[[Category: ~~Wilson, S H~~]]	+	[[Category: Shock DD]]
-	[[Category: ~~Dna polymerase]]~~	+	[[Category: Wilson SH]]
-	~~[[Category: Lyase-dna complex]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 09:22, 15 November 2017

OCA — Wed, 15 Nov 2017 09:22:51 GMT

←Older revision		Revision as of 09:22, 15 November 2017
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4klg" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4klg" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[DNA polymerase\|DNA polymerase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 19:27, 5 August 2016

OCA — Fri, 05 Aug 2016 19:27:19 GMT

←Older revision		Revision as of 19:27, 5 August 2016
Line 1:		Line 1:
		+
	==DNA polymerase beta matched product complex with Mg2+, 40 s==		==DNA polymerase beta matched product complex with Mg2+, 40 s==
	<StructureSection load='4klg' size='340' side='right' caption='[[4klg]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='4klg' size='340' side='right' caption='[[4klg]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4klg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KLG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KLG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4klg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KLG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KLG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PPV:PYROPHOSPHATE'>PPV</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PPV:PYROPHOSPHATE'>PPV</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4kld\|4kld]], [[4kle\|4kle]], [[4klf\|4klf]], [[4klh\|4klh]], [[4kli\|4kli]], [[4klj\|4klj]], [[4kll\|4kll]], [[4klm\|4klm]], [[4klo\|4klo]], [[4klp\|4klp]], [[4klq\|4klq]], [[4kls\|4kls]], [[4klt\|4klt]], [[4klu\|4klu]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4kld\|4kld]], [[4kle\|4kle]], [[4klf\|4klf]], [[4klh\|4klh]], [[4kli\|4kli]], [[4klj\|4klj]], [[4kll\|4kll]], [[4klm\|4klm]], [[4klo\|4klo]], [[4klp\|4klp]], [[4klq\|4klq]], [[4kls\|4kls]], [[4klt\|4klt]], [[4klu\|4klu]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Polb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Polb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4klg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4klg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4klg RCSB], [http://www.ebi.ac.uk/pdbsum/4klg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4klg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4klg OCA], [http://pdbe.org/4klg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4klg RCSB], [http://www.ebi.ac.uk/pdbsum/4klg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4klg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4klg" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Beard, W A]]		[[Category: Beard, W A]]
	[[Category: Freudenthal, B D]]		[[Category: Freudenthal, B D]]

OCA at 21:18, 25 December 2014

OCA — Thu, 25 Dec 2014 21:18:36 GMT

←Older revision		Revision as of 21:18, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4klg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4klg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4klg RCSB], [http://www.ebi.ac.uk/pdbsum/4klg PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4klg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4klg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4klg RCSB], [http://www.ebi.ac.uk/pdbsum/4klg PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DPOLB_HUMAN DPOLB_HUMAN]] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.<ref>PMID:9207062</ref> <ref>PMID:9572863</ref> <ref>PMID:11805079</ref> <ref>PMID:21362556</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 15:03, 21 December 2014

OCA — Sun, 21 Dec 2014 15:03:16 GMT

←Older revision		Revision as of 15:03, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4klg\| PDB=4klg \| SCENE= }}~~	+	==DNA polymerase beta matched product complex with Mg2+, 40 s==
-	===DNA polymerase beta matched product complex with Mg2+, 40 s===	+	<StructureSection load='4klg' size='340' side='right' caption='[[4klg]], [[Resolution\|resolution]] 1.70Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23827680}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4klg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KLG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KLG FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PPV:PYROPHOSPHATE'>PPV</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4kld\|4kld]], [[4kle\|4kle]], [[4klf\|4klf]], [[4klh\|4klh]], [[4kli\|4kli]], [[4klj\|4klj]], [[4kll\|4kll]], [[4klm\|4klm]], [[4klo\|4klo]], [[4klp\|4klp]], [[4klq\|4klq]], [[4kls\|4kls]], [[4klt\|4klt]], [[4klu\|4klu]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Polb ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4klg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4klg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4klg RCSB], [http://www.ebi.ac.uk/pdbsum/4klg PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	DNA polymerase (pol) beta is a model polymerase involved in gap-filling DNA synthesis utilizing two metals to facilitate nucleotidyl transfer. Previous structural studies have trapped catalytic intermediates by utilizing substrate analogs (dideoxy-terminated primer or nonhydrolysable incoming nucleotide). To identify additional intermediates during catalysis, we now employ natural substrates (correct and incorrect nucleotides) and follow product formation in real time with 15 different crystal structures. We are able to observe molecular adjustments at the active site that hasten correct nucleotide insertion and deter incorrect insertion not appreciated previously. A third metal binding site is transiently formed during correct, but not incorrect, nucleotide insertion. Additionally, long incubations indicate that pyrophosphate more easily dissociates after incorrect, compared to correct, nucleotide insertion. This appears to be coupled to subdomain repositioning that is required for catalytic activation/deactivation. The structures provide insights into a fundamental chemical reaction that impacts polymerase fidelity and genome stability.

-	~~==Function==~~	+	Observing a DNA polymerase choose right from wrong.,Freudenthal BD, Beard WA, Shock DD, Wilson SH Cell. 2013 Jul 3;154(1):157-68. doi: 10.1016/j.cell.2013.05.048. PMID:23827680<ref>PMID:23827680</ref>
-	~~[[http://www~~.~~uniprot~~.~~org/uniprot/DPOLB_HUMAN DPOLB_HUMAN]] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase~~ (~~dRP lyase~~) ~~activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single~~-~~nucleotide gap~~. ~~Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases~~.~~<ref>PMID:9207062<~~/~~ref> <ref>~~PMID:~~9572863</ref> <ref>PMID:11805079</ref>~~ <ref>PMID:~~21362556~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4klg]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4KLG OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:023827680</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[DNA polymerase\|DNA polymerase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Beard, W A.]]	+	[[Category: Beard, W A]]
-	[[Category: Freudenthal, B D.]]	+	[[Category: Freudenthal, B D]]
-	[[Category: Shock, D D.]]	+	[[Category: Shock, D D]]
-	[[Category: Wilson, S H.]]	+	[[Category: Wilson, S H]]
	[[Category: Dna polymerase]]		[[Category: Dna polymerase]]
	[[Category: Lyase-dna complex]]		[[Category: Lyase-dna complex]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 05:00, 18 July 2013

OCA — Thu, 18 Jul 2013 05:00:30 GMT

←Older revision		Revision as of 05:00, 18 July 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4klg\| PDB=4klg \| SCENE= }}
		+	===DNA polymerase beta matched product complex with Mg2+, 40 s===
		+	{{ABSTRACT_PUBMED_23827680}}

-	~~The entry 4klg is ON HOLD~~ ~~until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/DPOLB_HUMAN DPOLB_HUMAN]] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.<ref>PMID:9207062</ref> <ref>PMID:9572863</ref> <ref>PMID:11805079</ref> <ref>PMID:21362556</ref>

-	~~Authors~~: ~~Freudenthal, B~~.D.~~, Beard, W~~.~~A., Shock, D~~.D.~~, Wilson, S~~.H.	+	==About this Structure==
		+	[[4klg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KLG OCA].

-	~~Description~~: ~~DNA~~ polymerase ~~beta matched product~~ complex ~~with Mg2+, 40 s~~	+	==Reference==
		+	<ref group="xtra">PMID:023827680</ref><references group="xtra"/><references/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Beard, W A.]]
		+	[[Category: Freudenthal, B D.]]
		+	[[Category: Shock, D D.]]
		+	[[Category: Wilson, S H.]]
		+	[[Category: Dna polymerase]]
		+	[[Category: Lyase-dna complex]]
		+	[[Category: Transferase]]

OCA at 11:43, 19 June 2013

OCA — Wed, 19 Jun 2013 11:43:36 GMT

←Older revision		Revision as of 11:43, 19 June 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4klg is ON HOLD	+	The entry 4klg is ON HOLD until Paper Publication

	Authors: Freudenthal, B.D., Beard, W.A., Shock, D.D., Wilson, S.H.		Authors: Freudenthal, B.D., Beard, W.A., Shock, D.D., Wilson, S.H.

	Description: DNA polymerase beta matched product complex with Mg2+, 40 s		Description: DNA polymerase beta matched product complex with Mg2+, 40 s

OCA: Protected "4klg" [edit=sysop:move=sysop]

OCA — Thu, 16 May 2013 06:58:54 GMT

Protected "4klg" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:58, 16 May 2013

OCA: New page: '''Unreleased structure''' The entry 4klg is ON HOLD Authors: Freudenthal, B.D., Beard, W.A., Shock, D.D., Wilson, S.H. Description: DNA polymerase beta matched product complex with Mg...

OCA — Thu, 16 May 2013 06:58:53 GMT

New page: '''Unreleased structure''' The entry 4klg is ON HOLD Authors: Freudenthal, B.D., Beard, W.A., Shock, D.D., Wilson, S.H. Description: DNA polymerase beta matched product complex with Mg...

New page

'''Unreleased structure'''

The entry 4klg is ON HOLD

Authors: Freudenthal, B.D., Beard, W.A., Shock, D.D., Wilson, S.H.

Description: DNA polymerase beta matched product complex with Mg2+, 40 s