4kn0 - Revision history

OCA at 16:02, 20 September 2023

OCA — Wed, 20 Sep 2023 16:02:04 GMT

←Older revision		Revision as of 16:02, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4kn0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KN0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KN0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4kn0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KN0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KN0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kn0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kn0 OCA], [https://pdbe.org/4kn0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kn0 RCSB], [https://www.ebi.ac.uk/pdbsum/4kn0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kn0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kn0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kn0 OCA], [https://pdbe.org/4kn0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kn0 RCSB], [https://www.ebi.ac.uk/pdbsum/4kn0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kn0 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 09:01, 7 December 2022

OCA — Wed, 07 Dec 2022 09:01:29 GMT

←Older revision		Revision as of 09:01, 7 December 2022
Line 1:		Line 1:

	==Human folate receptor beta (FOLR2) in complex with the antifolate methotrexate==		==Human folate receptor beta (FOLR2) in complex with the antifolate methotrexate==
-	<StructureSection load='4kn0' size='340' side='right' caption='[[4kn0]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='4kn0' size='340' side='right'caption='[[4kn0]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4kn0]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KN0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4KN0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4kn0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KN0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KN0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4km6\|4km6]], [[4km7\|4km7]], [[4kmx\|4kmx]], [[4kmy\|4kmy]], [[4kmz\|4kmz]], [[4kn1\|4kn1]], [[4kn2\|4kn2]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kn0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kn0 OCA], [https://pdbe.org/4kn0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kn0 RCSB], [https://www.ebi.ac.uk/pdbsum/4kn0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kn0 ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FOLR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4kn0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kn0 OCA], [~~http~~://pdbe.org/4kn0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4kn0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4kn0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4kn0 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/FOLR2_HUMAN FOLR2_HUMAN]] Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells.	+	[https://www.uniprot.org/uniprot/FOLR2_HUMAN FOLR2_HUMAN] Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~III, C E.Dann~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Wibowo, A S~~]]	+	[[Category: Dann III CE]]
-	[[Category: ~~5-methyltetrahydrofolate]]~~	+	[[Category: Wibowo AS]]
-	~~[[Category: Antifolate]]~~	+
-	~~[[Category: Folate receptor]]~~	+
-	~~[[Category: Folate receptor beta]]~~	+
-	~~[[Category: Folate-conjugate]]~~	+
-	~~[[Category: Folate]]~~	+
-	~~[[Category: Folic acid]]~~	+
-	~~[[Category: Folr2]]~~	+
-	~~[[Category: Gpi-anchored protein on eukaryotic membrane]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 10:24, 5 August 2016

OCA — Fri, 05 Aug 2016 10:24:23 GMT

←Older revision		Revision as of 10:24, 5 August 2016
Line 1:		Line 1:
		+
	==Human folate receptor beta (FOLR2) in complex with the antifolate methotrexate==		==Human folate receptor beta (FOLR2) in complex with the antifolate methotrexate==
	<StructureSection load='4kn0' size='340' side='right' caption='[[4kn0]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4kn0' size='340' side='right' caption='[[4kn0]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4kn0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KN0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KN0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4kn0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KN0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KN0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4km6\|4km6]], [[4km7\|4km7]], [[4kmx\|4kmx]], [[4kmy\|4kmy]], [[4kmz\|4kmz]], [[4kn1\|4kn1]], [[4kn2\|4kn2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4km6\|4km6]], [[4km7\|4km7]], [[4kmx\|4kmx]], [[4kmy\|4kmy]], [[4kmz\|4kmz]], [[4kn1\|4kn1]], [[4kn2\|4kn2]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FOLR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FOLR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kn0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kn0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kn0 RCSB], [http://www.ebi.ac.uk/pdbsum/4kn0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kn0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kn0 OCA], [http://pdbe.org/4kn0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kn0 RCSB], [http://www.ebi.ac.uk/pdbsum/4kn0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4kn0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4kn0" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: III, C E.Dann]]		[[Category: III, C E.Dann]]
	[[Category: Wibowo, A S]]		[[Category: Wibowo, A S]]

OCA at 18:01, 25 December 2014

OCA — Thu, 25 Dec 2014 18:01:12 GMT

←Older revision		Revision as of 18:01, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kn0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kn0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kn0 RCSB], [http://www.ebi.ac.uk/pdbsum/4kn0 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kn0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kn0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kn0 RCSB], [http://www.ebi.ac.uk/pdbsum/4kn0 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FOLR2_HUMAN FOLR2_HUMAN]] Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 15:37, 21 December 2014

OCA — Sun, 21 Dec 2014 15:37:53 GMT

←Older revision		Revision as of 15:37, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4kn0\| PDB=4kn0 \| SCENE= }}~~	+	==Human folate receptor beta (FOLR2) in complex with the antifolate methotrexate==
-	===Human folate receptor beta (FOLR2) in complex with the antifolate methotrexate===	+	<StructureSection load='4kn0' size='340' side='right' caption='[[4kn0]], [[Resolution\|resolution]] 2.10Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23934049}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4kn0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KN0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KN0 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4km6\|4km6]], [[4km7\|4km7]], [[4kmx\|4kmx]], [[4kmy\|4kmy]], [[4kmz\|4kmz]], [[4kn1\|4kn1]], [[4kn2\|4kn2]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FOLR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kn0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kn0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kn0 RCSB], [http://www.ebi.ac.uk/pdbsum/4kn0 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Antifolates, folate analogs that inhibit vitamin B9 (folic acid)-using cellular enzymes, have been used over several decades for the treatment of cancer and inflammatory diseases. Cellular uptake of the antifolates in clinical use occurs primarily via widely expressed facilitative membrane transporters. More recently, human folate receptors (FRs), high affinity receptors that transport folate via endocytosis, have been proposed as targets for the specific delivery of new classes of antifolates or folate conjugates to tumors or sites of inflammation. The development of specific, FR-targeted antifolates would be accelerated if additional biophysical data, particularly structural models of the receptors, were available. Here we describe six distinct crystallographic models that provide insight into biological trafficking of FRs and distinct binding modes of folate and antifolates to these receptors. From comparison of the structures, we delineate discrete structural conformations representative of key stages in the endocytic trafficking of FRs and propose models for pH-dependent conformational changes. Additionally, we describe the molecular details of human FR in complex with three clinically prevalent antifolates, pemetrexed (also Alimta), aminopterin, and methotrexate. On the whole, our data form the basis for rapid design and implementation of unique, FR-targeted, folate-based drugs for the treatment of cancer and inflammatory diseases.

-	~~==Function==~~	+	Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition.,Wibowo AS, Singh M, Reeder KM, Carter JJ, Kovach AR, Meng W, Ratnam M, Zhang F, Dann CE 3rd Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):15180-8. doi:, 10.1073/pnas.1308827110. Epub 2013 Aug 9. PMID:23934049<ref>PMID:23934049</ref>
-	~~[[http://www.uniprot.org/uniprot/FOLR2_HUMAN FOLR2_HUMAN]] Binds to~~ folate and ~~reduced folic acid derivatives~~ and ~~mediates delivery of 5~~-~~methyltetrahydrofolate to the interior of cells~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4kn0]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4KN0 OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:023934049</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: III, C E.Dann.]]	+	[[Category: III, C E.Dann]]
-	[[Category: Wibowo, A S.]]	+	[[Category: Wibowo, A S]]
	[[Category: 5-methyltetrahydrofolate]]		[[Category: 5-methyltetrahydrofolate]]
	[[Category: Antifolate]]		[[Category: Antifolate]]

OCA at 06:17, 2 October 2013

OCA — Wed, 02 Oct 2013 06:17:25 GMT

←Older revision		Revision as of 06:17, 2 October 2013
Line 1:		Line 1:
	{{STRUCTURE_4kn0\| PDB=4kn0 \| SCENE= }}		{{STRUCTURE_4kn0\| PDB=4kn0 \| SCENE= }}
	===Human folate receptor beta (FOLR2) in complex with the antifolate methotrexate===		===Human folate receptor beta (FOLR2) in complex with the antifolate methotrexate===
		+	{{ABSTRACT_PUBMED_23934049}}

	==Function==		==Function==
Line 7:		Line 8:
	==About this Structure==		==About this Structure==
	[[4kn0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KN0 OCA].		[[4kn0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KN0 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:023934049</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: III, C E.Dann.]]		[[Category: III, C E.Dann.]]

OCA at 21:03, 7 August 2013

OCA — Wed, 07 Aug 2013 21:03:45 GMT

←Older revision		Revision as of 21:03, 7 August 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4kn0\| PDB=4kn0 \| SCENE= }}
		+	===Human folate receptor beta (FOLR2) in complex with the antifolate methotrexate===

-	~~The entry 4kn0 is ON HOLD~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/FOLR2_HUMAN FOLR2_HUMAN]] Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells.

-	~~Authors~~: ~~Wibowo, A~~.S.~~, Dann~~ III, C.E.	+	==About this Structure==
-		+	[[4kn0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KN0 OCA].
-	~~Description~~: ~~Human folate~~ receptor beta ~~(FOLR2) in complex with the antifolate methotrexate~~	+	[[Category: Homo sapiens]]
		+	[[Category: III, C E.Dann.]]
		+	[[Category: Wibowo, A S.]]
		+	[[Category: 5-methyltetrahydrofolate]]
		+	[[Category: Antifolate]]
		+	[[Category: Folate receptor]]
		+	[[Category: Folate receptor beta]]
		+	[[Category: Folate-conjugate]]
		+	[[Category: Folate]]
		+	[[Category: Folic acid]]
		+	[[Category: Folr2]]
		+	[[Category: Gpi-anchored protein on eukaryotic membrane]]
		+	[[Category: Membrane protein]]
		+	[[Category: Transport protein]]

OCA at 11:46, 19 June 2013

OCA — Wed, 19 Jun 2013 11:46:34 GMT

←Older revision		Revision as of 11:46, 19 June 2013
Line 3:		Line 3:
	The entry 4kn0 is ON HOLD		The entry 4kn0 is ON HOLD

-	Authors: Wibowo, ~~Ardian Soca~~, Dann III, ~~Charles~~ E.	+	Authors: Wibowo, A.S., Dann III, C.E.

	Description: Human folate receptor beta (FOLR2) in complex with the antifolate methotrexate		Description: Human folate receptor beta (FOLR2) in complex with the antifolate methotrexate

OCA: Protected "4kn0" [edit=sysop:move=sysop]

OCA — Thu, 16 May 2013 07:00:32 GMT

Protected "4kn0" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:00, 16 May 2013

OCA: New page: '''Unreleased structure''' The entry 4kn0 is ON HOLD Authors: Wibowo, Ardian Soca, Dann III, Charles E. Description: Human folate receptor beta (FOLR2) in complex with the antifolate m...

OCA — Thu, 16 May 2013 07:00:31 GMT

New page: '''Unreleased structure''' The entry 4kn0 is ON HOLD Authors: Wibowo, Ardian Soca, Dann III, Charles E. Description: Human folate receptor beta (FOLR2) in complex with the antifolate m...

New page

'''Unreleased structure'''

The entry 4kn0 is ON HOLD

Authors: Wibowo, Ardian Soca, Dann III, Charles E.

Description: Human folate receptor beta (FOLR2) in complex with the antifolate methotrexate