4kne - Revision history

OCA at 12:14, 1 March 2024

OCA — Fri, 01 Mar 2024 12:14:08 GMT

←Older revision		Revision as of 12:14, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4kne]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KNE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KNE FirstGlance]. <br>		<table><tr><td colspan='2'>[[4kne]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KNE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KNE FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1CY:1-(4-CHLOROPHENYL)-6,6-DIMETHYL-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE'>1CY</scene>, <scene name='pdbligand=ATR:2-MONOPHOSPHOADENOSINE-5-DIPHOSPHATE'>ATR</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1CY:1-(4-CHLOROPHENYL)-6,6-DIMETHYL-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE'>1CY</scene>, <scene name='pdbligand=ATR:2-MONOPHOSPHOADENOSINE-5-DIPHOSPHATE'>ATR</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kne OCA], [https://pdbe.org/4kne PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kne RCSB], [https://www.ebi.ac.uk/pdbsum/4kne PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kne ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kne OCA], [https://pdbe.org/4kne PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kne RCSB], [https://www.ebi.ac.uk/pdbsum/4kne PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kne ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/DYR_MYCTU DYR_MYCTU] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.		[https://www.uniprot.org/uniprot/DYR_MYCTU DYR_MYCTU] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Inhibition of the biosynthesis of tetrahydrofolate (THF) has long been a focus in the treatment of both cancer and infectious diseases. Dihydrofolate reductase (DHFR), which catalyzes the last step, is one of the most thoroughly explored targets of this pathway, but there are no DHFR inhibitors used for tuberculosis treatment. Here, we report a structural, site-directed mutagenesis and calorimetric analysis of Mycobacterium tuberculosis DHFR (MtDHFR) in complex with classical DHFR inhibitors. Our study provides insights into the weak inhibition of MtDHFR by trimethoprim and other antifolate drugs, such as pyrimethamine and cycloguanil. The construction of the mutant Y100F, together with calorimetric studies, gives insights into low affinity of MtDHFR for classical DHFR inhibitors. Finally, the structures of MtDHFR in complex with pyrimethamine and cycloguanil define important interactions in the active site and provide clues to the more effective design of antibiotics targeted against MtDHFR.
-
-	Mycobacterium tuberculosis Dihydrofolate Reductase Reveals Two Conformational States and a Possible Low Affinity Mechanism to Antifolate Drugs.,Dias MV, Tyrakis P, Domingues RR, Leme AF, Blundell TL Structure. 2013 Nov 6. pii: S0969-2126(13)00395-X. doi:, 10.1016/j.str.2013.09.022. PMID:24210757<ref>PMID:24210757</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4kne" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Dihydrofolate reductase 3D structures\|Dihydrofolate reductase 3D structures]]		*[[Dihydrofolate reductase 3D structures\|Dihydrofolate reductase 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 09:02, 7 December 2022

OCA — Wed, 07 Dec 2022 09:02:28 GMT

←Older revision		Revision as of 09:02, 7 December 2022
Line 1:		Line 1:

	==Crystal structure of dihydrofolate reductase from Mycobacterium tuberculosis in complex with cycloguanil==		==Crystal structure of dihydrofolate reductase from Mycobacterium tuberculosis in complex with cycloguanil==
-	<StructureSection load='4kne' size='340' side='right' caption='[[4kne]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='4kne' size='340' side='right'caption='[[4kne]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4kne]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus~~ tuberculosis~~" (zopf 1883) klein 1884~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KNE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4KNE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4kne]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KNE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KNE FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1CY:1-(4-CHLOROPHENYL)-6,6-DIMETHYL-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE'>1CY</scene>, <scene name='pdbligand=ATR:2-MONOPHOSPHOADENOSINE-5-DIPHOSPHATE'>ATR</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1CY:1-(4-CHLOROPHENYL)-6,6-DIMETHYL-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE'>1CY</scene>, <scene name='pdbligand=ATR:2-MONOPHOSPHOADENOSINE-5-DIPHOSPHATE'>ATR</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4kl9\|4kl9]], [[4klx\|4klx]], [[4km0\|4km0]], [[4km2\|4km2]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kne OCA], [https://pdbe.org/4kne PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kne RCSB], [https://www.ebi.ac.uk/pdbsum/4kne PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kne ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dfrA, folA, MT2833, MTV002.28c, Rv2763c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4kne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kne OCA], [~~http~~://pdbe.org/4kne PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4kne RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4kne PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4kne ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/DYR_MYCTU DYR_MYCTU]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.	+	[https://www.uniprot.org/uniprot/DYR_MYCTU DYR_MYCTU] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4kne" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4kne" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Dihydrofolate reductase 3D structures\|Dihydrofolate reductase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Dihydrofolate reductase~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Blundell, T L~~]]	+	[[Category: Mycobacterium tuberculosis]]
-	[[Category: ~~Dias, M V.B~~]]	+	[[Category: Blundell TL]]
-	[[Category: ~~Tyrakis, P~~]]	+	[[Category: Dias MVB]]
-	[[Category: ~~Oxidoreductase]]~~	+	[[Category: Tyrakis P]]
-	~~[[Category: Reductase~~]]	+

OCA at 20:07, 24 January 2018

OCA — Wed, 24 Jan 2018 20:07:35 GMT

←Older revision		Revision as of 20:07, 24 January 2018
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 4kne" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4kne" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Dihydrofolate reductase\|Dihydrofolate reductase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:24, 4 August 2016

OCA — Thu, 04 Aug 2016 09:24:12 GMT

←Older revision		Revision as of 09:24, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of dihydrofolate reductase from Mycobacterium tuberculosis in complex with cycloguanil==		==Crystal structure of dihydrofolate reductase from Mycobacterium tuberculosis in complex with cycloguanil==
	<StructureSection load='4kne' size='340' side='right' caption='[[4kne]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4kne' size='340' side='right' caption='[[4kne]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dfrA, folA, MT2833, MTV002.28c, Rv2763c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dfrA, folA, MT2833, MTV002.28c, Rv2763c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kne OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kne RCSB], [http://www.ebi.ac.uk/pdbsum/4kne PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kne OCA], [http://pdbe.org/4kne PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kne RCSB], [http://www.ebi.ac.uk/pdbsum/4kne PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4kne ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4kne" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 08:12, 24 December 2014

OCA — Wed, 24 Dec 2014 08:12:21 GMT

←Older revision		Revision as of 08:12, 24 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4kne\| PDB=4kne \| SCENE= }}~~	+	==Crystal structure of dihydrofolate reductase from Mycobacterium tuberculosis in complex with cycloguanil==
-	===Crystal structure of dihydrofolate reductase from Mycobacterium tuberculosis in complex with cycloguanil===	+	<StructureSection load='4kne' size='340' side='right' caption='[[4kne]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24210757}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4kne]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KNE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KNE FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1CY:1-(4-CHLOROPHENYL)-6,6-DIMETHYL-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE'>1CY</scene>, <scene name='pdbligand=ATR:2-MONOPHOSPHOADENOSINE-5-DIPHOSPHATE'>ATR</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4kl9\|4kl9]], [[4klx\|4klx]], [[4km0\|4km0]], [[4km2\|4km2]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dfrA, folA, MT2833, MTV002.28c, Rv2763c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kne OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kne RCSB], [http://www.ebi.ac.uk/pdbsum/4kne PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/DYR_MYCTU DYR_MYCTU]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.		[[http://www.uniprot.org/uniprot/DYR_MYCTU DYR_MYCTU]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Inhibition of the biosynthesis of tetrahydrofolate (THF) has long been a focus in the treatment of both cancer and infectious diseases. Dihydrofolate reductase (DHFR), which catalyzes the last step, is one of the most thoroughly explored targets of this pathway, but there are no DHFR inhibitors used for tuberculosis treatment. Here, we report a structural, site-directed mutagenesis and calorimetric analysis of Mycobacterium tuberculosis DHFR (MtDHFR) in complex with classical DHFR inhibitors. Our study provides insights into the weak inhibition of MtDHFR by trimethoprim and other antifolate drugs, such as pyrimethamine and cycloguanil. The construction of the mutant Y100F, together with calorimetric studies, gives insights into low affinity of MtDHFR for classical DHFR inhibitors. Finally, the structures of MtDHFR in complex with pyrimethamine and cycloguanil define important interactions in the active site and provide clues to the more effective design of antibiotics targeted against MtDHFR.
		+
		+	Mycobacterium tuberculosis Dihydrofolate Reductase Reveals Two Conformational States and a Possible Low Affinity Mechanism to Antifolate Drugs.,Dias MV, Tyrakis P, Domingues RR, Leme AF, Blundell TL Structure. 2013 Nov 6. pii: S0969-2126(13)00395-X. doi:, 10.1016/j.str.2013.09.022. PMID:24210757<ref>PMID:24210757</ref>

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4kne]] is~~ a ~~2 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4KNE OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:024210757</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Dihydrofolate reductase\|Dihydrofolate reductase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Dihydrofolate reductase]]		[[Category: Dihydrofolate reductase]]
-	[[Category: Blundell, T L.]]	+	[[Category: Blundell, T L]]
	[[Category: Dias, M V.B]]		[[Category: Dias, M V.B]]
-	[[Category: Tyrakis, P.]]	+	[[Category: Tyrakis, P]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Reductase]]		[[Category: Reductase]]

OCA at 10:11, 25 December 2013

OCA — Wed, 25 Dec 2013 10:11:44 GMT

←Older revision		Revision as of 10:11, 25 December 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4kne\| PDB=4kne \| SCENE= }}
		+	===Crystal structure of dihydrofolate reductase from Mycobacterium tuberculosis in complex with cycloguanil===
		+	{{ABSTRACT_PUBMED_24210757}}

-	~~The entry 4kne is ON HOLD until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/DYR_MYCTU DYR_MYCTU]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

-	~~Authors: Dias, M~~.V.~~B, Tyrakis, P~~.~~, Blundell, T~~.L.	+	==About this Structure==
		+	[[4kne]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KNE OCA].

-	~~Description~~: ~~Crystal structure of dihydrofolate~~ reductase ~~from Mycobacterium tuberculosis in complex with cycloguanil~~	+	==Reference==
		+	<ref group="xtra">PMID:024210757</ref><references group="xtra"/><references/>
		+	[[Category: Dihydrofolate reductase]]
		+	[[Category: Blundell, T L.]]
		+	[[Category: Dias, M V.B]]
		+	[[Category: Tyrakis, P.]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Reductase]]

OCA at 08:51, 30 June 2013

OCA — Sun, 30 Jun 2013 08:51:57 GMT

←Older revision		Revision as of 08:51, 30 June 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4kne is ON HOLD	+	The entry 4kne is ON HOLD until Paper Publication

	Authors: Dias, M.V.B, Tyrakis, P., Blundell, T.L.		Authors: Dias, M.V.B, Tyrakis, P., Blundell, T.L.

	Description: Crystal structure of dihydrofolate reductase from Mycobacterium tuberculosis in complex with cycloguanil		Description: Crystal structure of dihydrofolate reductase from Mycobacterium tuberculosis in complex with cycloguanil

OCA at 11:47, 19 June 2013

OCA — Wed, 19 Jun 2013 11:47:07 GMT

←Older revision		Revision as of 11:47, 19 June 2013
Line 3:		Line 3:
	The entry 4kne is ON HOLD		The entry 4kne is ON HOLD

-	Authors: Dias, M.V.B, Tyrakis, P., Blundell , T.L.	+	Authors: Dias, M.V.B, Tyrakis, P., Blundell, T.L.

	Description: Crystal structure of dihydrofolate reductase from Mycobacterium tuberculosis in complex with cycloguanil		Description: Crystal structure of dihydrofolate reductase from Mycobacterium tuberculosis in complex with cycloguanil

OCA: Protected "4kne" [edit=sysop:move=sysop]

OCA — Thu, 16 May 2013 07:00:57 GMT

Protected "4kne" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:00, 16 May 2013

OCA: New page: '''Unreleased structure''' The entry 4kne is ON HOLD Authors: Dias, M.V.B, Tyrakis, P., Blundell , T.L. Description: Crystal structure of dihydrofolate reductase from Mycobacterium tub...

OCA — Thu, 16 May 2013 07:00:56 GMT

New page: '''Unreleased structure''' The entry 4kne is ON HOLD Authors: Dias, M.V.B, Tyrakis, P., Blundell , T.L. Description: Crystal structure of dihydrofolate reductase from Mycobacterium tub...

New page

'''Unreleased structure'''

The entry 4kne is ON HOLD

Authors: Dias, M.V.B, Tyrakis, P., Blundell , T.L.

Description: Crystal structure of dihydrofolate reductase from Mycobacterium tuberculosis in complex with cycloguanil