4kp4 - Revision history

OCA at 12:14, 1 March 2024

OCA — Fri, 01 Mar 2024 12:14:27 GMT

←Older revision		Revision as of 12:14, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4kp4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Thermotoga_maritima_MSB8 Thermotoga maritima MSB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KP4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KP4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4kp4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Thermotoga_maritima_MSB8 Thermotoga maritima MSB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KP4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KP4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kp4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kp4 OCA], [https://pdbe.org/4kp4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kp4 RCSB], [https://www.ebi.ac.uk/pdbsum/4kp4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kp4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kp4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kp4 OCA], [https://pdbe.org/4kp4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kp4 RCSB], [https://www.ebi.ac.uk/pdbsum/4kp4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kp4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/Q9WZV7_THEMA Q9WZV7_THEMA] [https://www.uniprot.org/uniprot/ENVZ_ECOLI ENVZ_ECOLI] Member of the two-component regulatory system EnvZ/OmpR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates OmpR in response to environmental signals.		[https://www.uniprot.org/uniprot/Q9WZV7_THEMA Q9WZV7_THEMA] [https://www.uniprot.org/uniprot/ENVZ_ECOLI ENVZ_ECOLI] Member of the two-component regulatory system EnvZ/OmpR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates OmpR in response to environmental signals.
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Reversible protein phosphorylation is the most widespread regulatory mechanism in signal transduction. Autophosphorylation in a dimeric sensor histidine kinase is the first step in two-component signalling, the predominant signal-transduction device in bacteria. Despite being the most abundant sensor kinases in nature, the molecular bases of the histidine kinase autophosphorylation mechanism are still unknown. Furthermore, it has been demonstrated that autophosphorylation can occur in two directions, cis (intrasubunit) or trans (intersubunit) within the dimeric histidine kinase. Here, we present the crystal structure of the complete catalytic machinery of a chimeric histidine kinase. The structure shows an asymmetric histidine kinase dimer where one subunit is caught performing the autophosphorylation reaction. A structure-guided functional analysis on HK853 and EnvZ, two prototypical cis- and trans-phosphorylating histidine kinases, has allowed us to decipher the catalytic mechanism of histidine kinase autophosphorylation, which seems to be common independently of the reaction directionality.
-
-	Visualizing autophosphorylation in histidine kinases.,Casino P, Miguel-Romero L, Marina A Nat Commun. 2014 Feb 6;5:3258. doi: 10.1038/ncomms4258. PMID:24500224<ref>PMID:24500224</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4kp4" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 09:04, 7 December 2022

OCA — Wed, 07 Dec 2022 09:04:40 GMT

←Older revision		Revision as of 09:04, 7 December 2022
Line 1:		Line 1:

	==Deciphering cis-trans directionality and visualizing autophosphorylation in histidine kinases.==		==Deciphering cis-trans directionality and visualizing autophosphorylation in histidine kinases.==
-	<StructureSection load='4kp4' size='340' side='right' caption='[[4kp4]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<StructureSection load='4kp4' size='340' side='right'caption='[[4kp4]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4kp4]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Ecoli Ecoli~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KP4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4KP4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4kp4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Thermotoga_maritima_MSB8 Thermotoga maritima MSB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KP4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KP4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">envZ, ThemaDRAFT_0449, TM_0853, b3404, JW3367, ompB, perA, tpo ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kp4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kp4 OCA], [https://pdbe.org/4kp4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kp4 RCSB], [https://www.ebi.ac.uk/pdbsum/4kp4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kp4 ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histidine_kinase Histidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.13.3 2.7.13.3] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4kp4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kp4 OCA], [~~http~~://pdbe.org/4kp4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4kp4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4kp4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4kp4 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ENVZ_ECOLI ENVZ_ECOLI]] Member of the two-component regulatory system EnvZ/OmpR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates OmpR in response to environmental signals.	+	[https://www.uniprot.org/uniprot/Q9WZV7_THEMA Q9WZV7_THEMA] [https://www.uniprot.org/uniprot/ENVZ_ECOLI ENVZ_ECOLI] Member of the two-component regulatory system EnvZ/OmpR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates OmpR in response to environmental signals.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Ecoli]]~~	+	[[Category: Escherichia coli K-12]]
-	~~[[Category: Histidine kinase]]~~	+	[[Category: Large Structures]]
-	~~[[Category: Casino, P]]~~	+	[[Category: Thermotoga maritima MSB8]]
-	~~[[Category: Marina, A]]~~	+	[[Category: Casino P]]
-	~~[[Category: Miguel~~-~~Romero, L~~]]	+	[[Category: Marina A]]
-	[[Category: ~~Atp binding~~]]	+	[[Category: Miguel-Romero L]]
-	[[Category: ~~Bergerat fold~~]]	+
-	[[Category: ~~Four helix-bundle~~]]	+
-	[[Category: ~~Kinase and phosphotransferase~~]]	+
-	[[Category: ~~Transferase~~-~~signaling protein complex~~]]	+

OCA at 11:42, 4 August 2016

OCA — Thu, 04 Aug 2016 11:42:47 GMT

←Older revision		Revision as of 11:42, 4 August 2016
Line 1:		Line 1:
		+
	==Deciphering cis-trans directionality and visualizing autophosphorylation in histidine kinases.==		==Deciphering cis-trans directionality and visualizing autophosphorylation in histidine kinases.==
	<StructureSection load='4kp4' size='340' side='right' caption='[[4kp4]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='4kp4' size='340' side='right' caption='[[4kp4]], [[Resolution\|resolution]] 3.00Å' scene=''>
Line 6:		Line 7:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">envZ, ThemaDRAFT_0449, TM_0853, b3404, JW3367, ompB, perA, tpo ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">envZ, ThemaDRAFT_0449, TM_0853, b3404, JW3367, ompB, perA, tpo ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histidine_kinase Histidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.13.3 2.7.13.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histidine_kinase Histidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.13.3 2.7.13.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kp4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kp4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kp4 RCSB], [http://www.ebi.ac.uk/pdbsum/4kp4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kp4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kp4 OCA], [http://pdbe.org/4kp4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kp4 RCSB], [http://www.ebi.ac.uk/pdbsum/4kp4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4kp4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4kp4" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:57, 25 December 2014

OCA — Thu, 25 Dec 2014 08:57:57 GMT

←Older revision		Revision as of 08:57, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4kp4\| PDB=4kp4 \| SCENE= }}~~	+	==Deciphering cis-trans directionality and visualizing autophosphorylation in histidine kinases.==
-	===Deciphering cis-trans directionality and visualizing autophosphorylation in histidine kinases.===	+	<StructureSection load='4kp4' size='340' side='right' caption='[[4kp4]], [[Resolution\|resolution]] 3.00Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24500224}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4kp4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KP4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KP4 FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">envZ, ThemaDRAFT_0449, TM_0853, b3404, JW3367, ompB, perA, tpo ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histidine_kinase Histidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.13.3 2.7.13.3] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kp4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kp4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kp4 RCSB], [http://www.ebi.ac.uk/pdbsum/4kp4 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/ENVZ_ECOLI ENVZ_ECOLI]] Member of the two-component regulatory system EnvZ/OmpR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates OmpR in response to environmental signals.		[[http://www.uniprot.org/uniprot/ENVZ_ECOLI ENVZ_ECOLI]] Member of the two-component regulatory system EnvZ/OmpR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates OmpR in response to environmental signals.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Reversible protein phosphorylation is the most widespread regulatory mechanism in signal transduction. Autophosphorylation in a dimeric sensor histidine kinase is the first step in two-component signalling, the predominant signal-transduction device in bacteria. Despite being the most abundant sensor kinases in nature, the molecular bases of the histidine kinase autophosphorylation mechanism are still unknown. Furthermore, it has been demonstrated that autophosphorylation can occur in two directions, cis (intrasubunit) or trans (intersubunit) within the dimeric histidine kinase. Here, we present the crystal structure of the complete catalytic machinery of a chimeric histidine kinase. The structure shows an asymmetric histidine kinase dimer where one subunit is caught performing the autophosphorylation reaction. A structure-guided functional analysis on HK853 and EnvZ, two prototypical cis- and trans-phosphorylating histidine kinases, has allowed us to decipher the catalytic mechanism of histidine kinase autophosphorylation, which seems to be common independently of the reaction directionality.

-	~~==About this Structure==~~	+	Visualizing autophosphorylation in histidine kinases.,Casino P, Miguel-Romero L, Marina A Nat Commun. 2014 Feb 6;5:3258. doi: 10.1038/ncomms4258. PMID:24500224<ref>PMID:24500224</ref>
-	~~[[4kp4]] is a 2 chain structure~~. ~~Full crystallographic information is available from [http~~:~~//oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4KP4 OCA]~~.	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024500224</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Ecoli]]
	[[Category: Histidine kinase]]		[[Category: Histidine kinase]]
-	[[Category: Casino, P.]]	+	[[Category: Casino, P]]
-	[[Category: Marina, A.]]	+	[[Category: Marina, A]]
-	[[Category: Miguel-Romero, L.]]	+	[[Category: Miguel-Romero, L]]
	[[Category: Atp binding]]		[[Category: Atp binding]]
	[[Category: Bergerat fold]]		[[Category: Bergerat fold]]

OCA at 14:42, 19 February 2014

OCA — Wed, 19 Feb 2014 14:42:05 GMT

←Older revision		Revision as of 14:42, 19 February 2014
Line 1:		Line 1:
	{{STRUCTURE_4kp4\| PDB=4kp4 \| SCENE= }}		{{STRUCTURE_4kp4\| PDB=4kp4 \| SCENE= }}
	===Deciphering cis-trans directionality and visualizing autophosphorylation in histidine kinases.===		===Deciphering cis-trans directionality and visualizing autophosphorylation in histidine kinases.===
		+	{{ABSTRACT_PUBMED_24500224}}

	==Function==		==Function==
Line 7:		Line 8:
	==About this Structure==		==About this Structure==
	[[4kp4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KP4 OCA].		[[4kp4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KP4 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:024500224</ref><references group="xtra"/><references/>
	[[Category: Histidine kinase]]		[[Category: Histidine kinase]]
	[[Category: Casino, P.]]		[[Category: Casino, P.]]

OCA at 05:18, 13 February 2014

OCA — Thu, 13 Feb 2014 05:18:09 GMT

←Older revision		Revision as of 05:18, 13 February 2014
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4kp4\| PDB=4kp4 \| SCENE= }}
		+	===Deciphering cis-trans directionality and visualizing autophosphorylation in histidine kinases.===

-	~~The entry 4kp4 is ON HOLD until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/ENVZ_ECOLI ENVZ_ECOLI]] Member of the two-component regulatory system EnvZ/OmpR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates OmpR in response to environmental signals.

-	~~Authors~~: Casino, P., Miguel-Romero, L.~~, Marina, A.~~	+	==About this Structure==
-		+	[[4kp4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KP4 OCA].
-	~~Description~~: ~~Deciphering cis~~-~~trans directionality~~ and ~~visualizing autophosphorylation in histidine kinases.~~	+	[[Category: Histidine kinase]]
		+	[[Category: Casino, P.]]
		+	[[Category: Marina, A.]]
		+	[[Category: Miguel-Romero, L.]]
		+	[[Category: Atp binding]]
		+	[[Category: Bergerat fold]]
		+	[[Category: Four helix-bundle]]
		+	[[Category: Kinase and phosphotransferase]]
		+	[[Category: Transferase-signaling protein complex]]

OCA at 08:52, 30 June 2013

OCA — Sun, 30 Jun 2013 08:52:26 GMT

←Older revision		Revision as of 08:52, 30 June 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4kp4 is ON HOLD	+	The entry 4kp4 is ON HOLD until Paper Publication

	Authors: Casino, P., Miguel-Romero, L., Marina, A.		Authors: Casino, P., Miguel-Romero, L., Marina, A.

	Description: Deciphering cis-trans directionality and visualizing autophosphorylation in histidine kinases.		Description: Deciphering cis-trans directionality and visualizing autophosphorylation in histidine kinases.

OCA: Protected "4kp4" [edit=sysop:move=sysop]

OCA — Wed, 19 Jun 2013 11:51:11 GMT

Protected "4kp4" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:51, 19 June 2013

OCA: New page: '''Unreleased structure''' The entry 4kp4 is ON HOLD Authors: Casino, P., Miguel-Romero, L., Marina, A. Description: Deciphering cis-trans directionality and visualizing autophosphoryl...

OCA — Wed, 19 Jun 2013 11:51:11 GMT

New page: '''Unreleased structure''' The entry 4kp4 is ON HOLD Authors: Casino, P., Miguel-Romero, L., Marina, A. Description: Deciphering cis-trans directionality and visualizing autophosphoryl...

New page

'''Unreleased structure'''

The entry 4kp4 is ON HOLD

Authors: Casino, P., Miguel-Romero, L., Marina, A.

Description: Deciphering cis-trans directionality and visualizing autophosphorylation in histidine kinases.