4kpc - Revision history

OCA at 12:14, 1 March 2024

OCA — Fri, 01 Mar 2024 12:14:32 GMT

←Older revision		Revision as of 12:14, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4kpc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_braziliensis Leishmania braziliensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KPC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KPC FirstGlance]. <br>		<table><tr><td colspan='2'>[[4kpc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_braziliensis Leishmania braziliensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KPC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KPC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kpc OCA], [https://pdbe.org/4kpc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kpc RCSB], [https://www.ebi.ac.uk/pdbsum/4kpc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kpc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kpc OCA], [https://pdbe.org/4kpc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kpc RCSB], [https://www.ebi.ac.uk/pdbsum/4kpc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kpc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/A4HKT8_LEIBR A4HKT8_LEIBR]		[https://www.uniprot.org/uniprot/A4HKT8_LEIBR A4HKT8_LEIBR]
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	BACKGROUND: Nucleoside diphosphate kinase (NDK) is a housekeeping enzyme that plays key roles in nucleotide recycling and homeostasis in trypanosomatids. It is also secreted by the intracellular parasite Leishmania to modulate the host response. These functions make NDK an attractive target for drug design and for studies aiming at a better understanding of the mechanisms mediating host-pathogen interactions. RESULTS: We report the crystal structure and biophysical characterization of the NDK from Leishmania braziliensis (LbNDK). The subunit consists of six alpha-helices along with a core of four beta-strands arranged in a beta2beta3beta1beta4 antiparallel topology order. In contrast to the NDK from L. major, the LbNDK C-terminal extension is partially unfolded. SAXS data showed that LbNDK forms hexamers in solution in the pH range from 7.0 to 4.0, a hydrodynamic behavior conserved in most eukaryotic NDKs. However, DSF assays show that acidification and alkalization decrease the hexamer stability. CONCLUSIONS: Our results support that LbNDK remains hexameric in pH conditions akin to that faced by this enzyme when secreted by Leishmania amastigotes in the parasitophorous vacuoles (pH 4.7 to 5.3). The unusual unfolded conformation of LbNDK C-terminus decreases the surface buried in the trimer interface exposing new regions that might be explored for the development of compounds designed to disturb enzyme oligomerization, which may impair the important nucleotide salvage pathway in these parasites.
-
-	Crystal structure and biophysical characterization of the nucleoside diphosphate kinase from Leishmania braziliensis.,Vieira PS, de Giuseppe PO, Murakami MT, de Oliveira AH BMC Struct Biol. 2015 Feb 3;15:2. doi: 10.1186/s12900-015-0030-8. PMID:25643978<ref>PMID:25643978</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4kpc" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Nucleoside diphosphate kinase 3D structures\|Nucleoside diphosphate kinase 3D structures]]		*[[Nucleoside diphosphate kinase 3D structures\|Nucleoside diphosphate kinase 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 09:04, 7 December 2022

OCA — Wed, 07 Dec 2022 09:04:54 GMT

←Older revision		Revision as of 09:04, 7 December 2022
Line 3:		Line 3:
	<StructureSection load='4kpc' size='340' side='right'caption='[[4kpc]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='4kpc' size='340' side='right'caption='[[4kpc]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4kpc]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Leibr Leibr~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KPC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4KPC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4kpc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_braziliensis Leishmania braziliensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KPC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KPC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LBRM_32_3210 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5660 LEIBR])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kpc OCA], [https://pdbe.org/4kpc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kpc RCSB], [https://www.ebi.ac.uk/pdbsum/4kpc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kpc ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nucleoside-diphosphate_kinase Nucleoside-diphosphate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.6 2.7.4.6] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4kpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kpc OCA], [~~http~~://pdbe.org/4kpc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4kpc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4kpc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4kpc ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A4HKT8_LEIBR A4HKT8_LEIBR]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[Nucleoside diphosphate kinase\|Nucleoside diphosphate kinase]]	+	*[[Nucleoside diphosphate kinase 3D structures\|Nucleoside diphosphate kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Leibr]]~~	+	[[Category: Leishmania braziliensis]]
-	~~[[Category: Nucleoside-diphosphate kinase~~]]	+	[[Category: Cunha EMF]]
-	[[Category: Cunha~~, E M.F~~]]	+	[[Category: Giuseppe PO]]
-	[[Category: Giuseppe~~, P O~~]]	+	[[Category: Murakami MT]]
-	[[Category: Murakami~~, M T]]~~	+	[[Category: Santos CR]]
-	~~[[Category: Oliveira, A H.C de~~]]	+	[[Category: Vieira PS]]
-	[[Category: Santos~~, C R~~]]	+	[[Category: De Oliveira AHC]]
-	[[Category: Vieira~~, P S~~]]	+
-	[[Category: ~~Ndpk superfamily]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 08:55, 3 April 2019

OCA — Wed, 03 Apr 2019 08:55:55 GMT

←Older revision		Revision as of 08:55, 3 April 2019
Line 1:		Line 1:

	==Crystal structure of the nucleoside diphosphate kinase b from Leishmania braziliensis==		==Crystal structure of the nucleoside diphosphate kinase b from Leishmania braziliensis==
-	<StructureSection load='4kpc' size='340' side='right' caption='[[4kpc]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='4kpc' size='340' side='right'caption='[[4kpc]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4kpc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KPC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KPC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4kpc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Leibr Leibr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KPC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KPC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LBRM_32_3210 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5660 LEIBR])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nucleoside-diphosphate_kinase Nucleoside-diphosphate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.6 2.7.4.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nucleoside-diphosphate_kinase Nucleoside-diphosphate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.6 2.7.4.6] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kpc OCA], [http://pdbe.org/4kpc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kpc RCSB], [http://www.ebi.ac.uk/pdbsum/4kpc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4kpc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kpc OCA], [http://pdbe.org/4kpc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kpc RCSB], [http://www.ebi.ac.uk/pdbsum/4kpc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4kpc ProSAT]</span></td></tr>
Line 17:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4kpc" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4kpc" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Nucleoside diphosphate kinase\|Nucleoside diphosphate kinase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Leibr]]
	[[Category: Nucleoside-diphosphate kinase]]		[[Category: Nucleoside-diphosphate kinase]]
	[[Category: Cunha, E M.F]]		[[Category: Cunha, E M.F]]

OCA at 17:03, 22 March 2017

OCA — Wed, 22 Mar 2017 17:03:55 GMT

←Older revision		Revision as of 17:03, 22 March 2017
Line 1:		Line 1:
		+
	==Crystal structure of the nucleoside diphosphate kinase b from Leishmania braziliensis==		==Crystal structure of the nucleoside diphosphate kinase b from Leishmania braziliensis==
	<StructureSection load='4kpc' size='340' side='right' caption='[[4kpc]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='4kpc' size='340' side='right' caption='[[4kpc]], [[Resolution\|resolution]] 2.70Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nucleoside-diphosphate_kinase Nucleoside-diphosphate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.6 2.7.4.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nucleoside-diphosphate_kinase Nucleoside-diphosphate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.6 2.7.4.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kpc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kpc RCSB], [http://www.ebi.ac.uk/pdbsum/4kpc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kpc OCA], [http://pdbe.org/4kpc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kpc RCSB], [http://www.ebi.ac.uk/pdbsum/4kpc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4kpc ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4kpc" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:20, 17 June 2015

OCA — Wed, 17 Jun 2015 08:20:56 GMT

←Older revision		Revision as of 08:20, 17 June 2015
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kpc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kpc RCSB], [http://www.ebi.ac.uk/pdbsum/4kpc PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kpc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kpc RCSB], [http://www.ebi.ac.uk/pdbsum/4kpc PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	BACKGROUND: Nucleoside diphosphate kinase (NDK) is a housekeeping enzyme that plays key roles in nucleotide recycling and homeostasis in trypanosomatids. It is also secreted by the intracellular parasite Leishmania to modulate the host response. These functions make NDK an attractive target for drug design and for studies aiming at a better understanding of the mechanisms mediating host-pathogen interactions. RESULTS: We report the crystal structure and biophysical characterization of the NDK from Leishmania braziliensis (LbNDK). The subunit consists of six alpha-helices along with a core of four beta-strands arranged in a beta2beta3beta1beta4 antiparallel topology order. In contrast to the NDK from L. major, the LbNDK C-terminal extension is partially unfolded. SAXS data showed that LbNDK forms hexamers in solution in the pH range from 7.0 to 4.0, a hydrodynamic behavior conserved in most eukaryotic NDKs. However, DSF assays show that acidification and alkalization decrease the hexamer stability. CONCLUSIONS: Our results support that LbNDK remains hexameric in pH conditions akin to that faced by this enzyme when secreted by Leishmania amastigotes in the parasitophorous vacuoles (pH 4.7 to 5.3). The unusual unfolded conformation of LbNDK C-terminus decreases the surface buried in the trimer interface exposing new regions that might be explored for the development of compounds designed to disturb enzyme oligomerization, which may impair the important nucleotide salvage pathway in these parasites.
		+
		+	Crystal structure and biophysical characterization of the nucleoside diphosphate kinase from Leishmania braziliensis.,Vieira PS, de Giuseppe PO, Murakami MT, de Oliveira AH BMC Struct Biol. 2015 Feb 3;15:2. doi: 10.1186/s12900-015-0030-8. PMID:25643978<ref>PMID:25643978</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 12:38, 5 January 2015

OCA — Mon, 05 Jan 2015 12:38:56 GMT

←Older revision		Revision as of 12:38, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4kpc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KPC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KPC FirstGlance]. <br>		<table><tr><td colspan='2'>[[4kpc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KPC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KPC FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nucleoside-diphosphate_kinase Nucleoside-diphosphate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.6 2.7.4.6] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nucleoside-diphosphate_kinase Nucleoside-diphosphate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.6 2.7.4.6] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kpc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kpc RCSB], [http://www.ebi.ac.uk/pdbsum/4kpc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kpc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kpc RCSB], [http://www.ebi.ac.uk/pdbsum/4kpc PDBsum]</span></td></tr>
-	<table>	+	</table>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Nucleoside-diphosphate kinase]]		[[Category: Nucleoside-diphosphate kinase]]
-	[[Category: Cunha, E M.F.]]	+	[[Category: Cunha, E M.F]]
-	[[Category: Giuseppe, P O.]]	+	[[Category: Giuseppe, P O]]
-	[[Category: Murakami, M T.]]	+	[[Category: Murakami, M T]]
-	[[Category: Oliveira, A H.C de.]]	+	[[Category: Oliveira, A H.C de]]
-	[[Category: Santos, C R.]]	+	[[Category: Santos, C R]]
-	[[Category: Vieira, P S.]]	+	[[Category: Vieira, P S]]
	[[Category: Ndpk superfamily]]		[[Category: Ndpk superfamily]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 07:30, 9 July 2014

OCA — Wed, 09 Jul 2014 07:30:57 GMT

←Older revision		Revision as of 07:30, 9 July 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal structure of the nucleoside diphosphate kinase b from Leishmania braziliensis==
-		+	<StructureSection load='4kpc' size='340' side='right' caption='[[4kpc]], [[Resolution\|resolution]] 2.70Å' scene=''>
-	~~The entry~~ 4kpc is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4kpc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KPC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KPC FirstGlance]. <br>
-	~~Authors~~: ~~Vieira~~, P.S., ~~Giuseppe, P~~.O., ~~Santos, C~~.R., Cunha, E.M.F., de Oliveira, A.H.C., ~~Murakami~~, ~~M.T~~.	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>
-		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nucleoside-diphosphate_kinase Nucleoside-diphosphate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.6 2.7.4.6] </span></td></tr>
-	~~Description~~: ~~Crystal structure of the nucleoside diphosphate kinase b from Leishmania braziliensis~~	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kpc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kpc RCSB], [http://www.ebi.ac.uk/pdbsum/4kpc PDBsum]</span></td></tr>
		+	<table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Nucleoside-diphosphate kinase]]
		+	[[Category: Cunha, E M.F.]]
		+	[[Category: Giuseppe, P O.]]
		+	[[Category: Murakami, M T.]]
		+	[[Category: Oliveira, A H.C de.]]
		+	[[Category: Santos, C R.]]
		+	[[Category: Vieira, P S.]]
		+	[[Category: Ndpk superfamily]]
		+	[[Category: Transferase]]

OCA at 13:13, 3 July 2013

OCA — Wed, 03 Jul 2013 13:13:43 GMT

←Older revision		Revision as of 13:13, 3 July 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4kpc is ON HOLD	+	The entry 4kpc is ON HOLD until Paper Publication

	Authors: Vieira, P.S., Giuseppe, P.O., Santos, C.R., Cunha, E.M.F., de Oliveira, A.H.C., Murakami, M.T.		Authors: Vieira, P.S., Giuseppe, P.O., Santos, C.R., Cunha, E.M.F., de Oliveira, A.H.C., Murakami, M.T.

	Description: Crystal structure of the nucleoside diphosphate kinase b from Leishmania braziliensis		Description: Crystal structure of the nucleoside diphosphate kinase b from Leishmania braziliensis

OCA: Protected "4kpc" [edit=sysop:move=sysop]

OCA — Wed, 19 Jun 2013 11:51:51 GMT

Protected "4kpc" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:51, 19 June 2013

OCA: New page: '''Unreleased structure''' The entry 4kpc is ON HOLD Authors: Vieira, P.S., Giuseppe, P.O., Santos, C.R., Cunha, E.M.F., de Oliveira, A.H.C., Murakami, M.T. Description: Crystal struct...

OCA — Wed, 19 Jun 2013 11:51:50 GMT

New page: '''Unreleased structure''' The entry 4kpc is ON HOLD Authors: Vieira, P.S., Giuseppe, P.O., Santos, C.R., Cunha, E.M.F., de Oliveira, A.H.C., Murakami, M.T. Description: Crystal struct...

New page

'''Unreleased structure'''

The entry 4kpc is ON HOLD

Authors: Vieira, P.S., Giuseppe, P.O., Santos, C.R., Cunha, E.M.F., de Oliveira, A.H.C., Murakami, M.T.

Description: Crystal structure of the nucleoside diphosphate kinase b from Leishmania braziliensis