4kq3 - Revision history

OCA at 09:06, 7 December 2022

OCA — Wed, 07 Dec 2022 09:06:41 GMT

←Older revision		Revision as of 09:06, 7 December 2022
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	<StructureSection load='4kq3' size='340' side='right'caption='[[4kq3]], [[Resolution\|resolution]] 1.92Å' scene=''>		<StructureSection load='4kq3' size='340' side='right'caption='[[4kq3]], [[Resolution\|resolution]] 1.92Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4kq3]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KQ3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4KQ3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4kq3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KQ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KQ3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene>~~</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kq3 OCA], [https://pdbe.org/4kq3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kq3 RCSB], [https://www.ebi.ac.uk/pdbsum/4kq3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kq3 ProSAT]</span></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4kq4\|4kq4]]~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4kq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kq3 OCA], [~~http~~://pdbe.org/4kq3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4kq3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4kq3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4kq3 ProSAT]</span></td></tr>	+
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gilliland~~, G L~~]]	+	[[Category: Gilliland GL]]
-	[[Category: Malia, T]]	+	[[Category: Malia T]]
-	[[Category: Obmolova, G]]	+	[[Category: Obmolova G]]
-	[[Category: Teplyakov, A]]	+	[[Category: Teplyakov A]]
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Immunoglobulin fold~~]]	+

OCA at 09:45, 3 April 2019

OCA — Wed, 03 Apr 2019 09:45:11 GMT

←Older revision		Revision as of 09:45, 3 April 2019
Line 1:		Line 1:

	==Crystal structure of Anti-IL-17A antibody CNTO3186==		==Crystal structure of Anti-IL-17A antibody CNTO3186==
-	<StructureSection load='4kq3' size='340' side='right' caption='[[4kq3]], [[Resolution\|resolution]] 1.92Å' scene=''>	+	<StructureSection load='4kq3' size='340' side='right'caption='[[4kq3]], [[Resolution\|resolution]] 1.92Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4kq3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KQ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KQ3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4kq3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KQ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KQ3 FirstGlance]. <br>
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Gilliland, G L]]		[[Category: Gilliland, G L]]
	[[Category: Malia, T]]		[[Category: Malia, T]]

OCA at 19:27, 11 August 2016

OCA — Thu, 11 Aug 2016 19:27:58 GMT

←Older revision		Revision as of 19:27, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of Anti-IL-17A antibody CNTO3186==		==Crystal structure of Anti-IL-17A antibody CNTO3186==
	<StructureSection load='4kq3' size='340' side='right' caption='[[4kq3]], [[Resolution\|resolution]] 1.92Å' scene=''>		<StructureSection load='4kq3' size='340' side='right' caption='[[4kq3]], [[Resolution\|resolution]] 1.92Å' scene=''>
Line 6:		Line 7:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4kq4\|4kq4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4kq4\|4kq4]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kq3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kq3 RCSB], [http://www.ebi.ac.uk/pdbsum/4kq3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kq3 OCA], [http://pdbe.org/4kq3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kq3 RCSB], [http://www.ebi.ac.uk/pdbsum/4kq3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4kq3 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4kq3" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 15:01, 5 January 2015

OCA — Mon, 05 Jan 2015 15:01:13 GMT

←Older revision		Revision as of 15:01, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4kq3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KQ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KQ3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4kq3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KQ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KQ3 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4kq4\|4kq4]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4kq4\|4kq4]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kq3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kq3 RCSB], [http://www.ebi.ac.uk/pdbsum/4kq3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kq3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kq3 RCSB], [http://www.ebi.ac.uk/pdbsum/4kq3 PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
-	[[Category: Gilliland, G L.]]	+	[[Category: Gilliland, G L]]
-	[[Category: Malia, T.]]	+	[[Category: Malia, T]]
-	[[Category: Obmolova, G.]]	+	[[Category: Obmolova, G]]
-	[[Category: Teplyakov, A.]]	+	[[Category: Teplyakov, A]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Immunoglobulin fold]]		[[Category: Immunoglobulin fold]]

OCA at 02:55, 7 August 2014

OCA — Thu, 07 Aug 2014 02:55:40 GMT

←Older revision		Revision as of 02:55, 7 August 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4kq3\| PDB=4kq3 \| SCENE= }}~~	+	==Crystal structure of Anti-IL-17A antibody CNTO3186==
-	===Crystal structure of Anti-IL-17A antibody CNTO3186===	+	<StructureSection load='4kq3' size='340' side='right' caption='[[4kq3]], [[Resolution\|resolution]] 1.92Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24470236}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4kq3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KQ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KQ3 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4kq4\|4kq4]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kq3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kq3 RCSB], [http://www.ebi.ac.uk/pdbsum/4kq3 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Three Fab structures used as targets in the Antibody Modeling Assessment presented a challenge for modeling CDR-L3 due to deviations from the most typical canonical structure. In all three antibodies CDR-L3 has eight residues, which is one residue shorter than usual, and has a conformation that is rarely observed in crystal structures. We analyzed the sequence and structural determinants of this conformation and found that the "short" CDR-L3 is remarkably rigid and retains the conformation in the interactions with antigens and neighboring CDRs. Proteins 2014. (c) 2014 Wiley Periodicals, Inc.

-	~~==About this Structure==~~	+	Structural evidence for a constrained conformation of short CDR-L3 in antibodies.,Teplyakov A, Obmolova G, Malia TJ, Luo J, Gilliland GL Proteins. 2014 Jan 27. doi: 10.1002/prot.24522. PMID:24470236<ref>PMID:24470236</ref>
-	~~[[4kq3]] is~~ a ~~2 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4KQ3 OCA]~~.	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024470236</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Human]]
	[[Category: Gilliland, G L.]]		[[Category: Gilliland, G L.]]
	[[Category: Malia, T.]]		[[Category: Malia, T.]]

OCA at 09:25, 26 March 2014

OCA — Wed, 26 Mar 2014 09:25:32 GMT

←Older revision		Revision as of 09:25, 26 March 2014
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4kq3\| PDB=4kq3 \| SCENE= }}
		+	===Crystal structure of Anti-IL-17A antibody CNTO3186===
		+	{{ABSTRACT_PUBMED_24470236}}

-	~~The entry~~ 4kq3 is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
		+	[[4kq3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KQ3 OCA].

-	~~Authors~~: ~~Teplyakov, A., Obmolova~~, G., Malia, T.~~, Gilliland~~, G.L.	+	==Reference==
-		+	<ref group="xtra">PMID:024470236</ref><references group="xtra"/><references/>
-	~~Description~~: ~~Crystal structure of Anti-IL-17A antibody CNTO3186~~	+	[[Category: Gilliland, G L.]]
		+	[[Category: Malia, T.]]
		+	[[Category: Obmolova, G.]]
		+	[[Category: Teplyakov, A.]]
		+	[[Category: Immune system]]
		+	[[Category: Immunoglobulin fold]]

OCA at 06:48, 6 November 2013

OCA — Wed, 06 Nov 2013 06:48:09 GMT

←Older revision		Revision as of 06:48, 6 November 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4kq3 is ON HOLD	+	The entry 4kq3 is ON HOLD until Paper Publication

	Authors: Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L.		Authors: Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L.

	Description: Crystal structure of Anti-IL-17A antibody CNTO3186		Description: Crystal structure of Anti-IL-17A antibody CNTO3186

OCA: Protected "4kq3" [edit=sysop:move=sysop]

OCA — Wed, 19 Jun 2013 11:53:47 GMT

Protected "4kq3" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:53, 19 June 2013

OCA: New page: '''Unreleased structure''' The entry 4kq3 is ON HOLD Authors: Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L. Description: Crystal structure of Anti-IL-17A antibody CNTO3186

OCA — Wed, 19 Jun 2013 11:53:44 GMT

New page: '''Unreleased structure''' The entry 4kq3 is ON HOLD Authors: Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L. Description: Crystal structure of Anti-IL-17A antibody CNTO3186

New page

'''Unreleased structure'''

The entry 4kq3 is ON HOLD

Authors: Teplyakov, A., Obmolova, G., Malia, T., Gilliland, G.L.

Description: Crystal structure of Anti-IL-17A antibody CNTO3186