4krg - Revision history

OCA at 09:09, 7 December 2022

OCA — Wed, 07 Dec 2022 09:09:33 GMT

←Older revision		Revision as of 09:09, 7 December 2022
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	<StructureSection load='4krg' size='340' side='right'caption='[[4krg]], [[Resolution\|resolution]] 1.68Å' scene=''>		<StructureSection load='4krg' size='340' side='right'caption='[[4krg]], [[Resolution\|resolution]] 1.68Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4krg]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Barber_pole_worm Barber pole worm~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KRG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4KRG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4krg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemonchus_contortus Haemonchus contortus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KRG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KRG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=OPE:PHOSPHORIC+ACID+MONO-(2-AMINO-ETHYL)+ESTER'>OPE</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=OPE:PHOSPHORIC+ACID+MONO-(2-AMINO-ETHYL)+ESTER'>OPE</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4krg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4krg OCA], [https://pdbe.org/4krg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4krg RCSB], [https://www.ebi.ac.uk/pdbsum/4krg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4krg ProSAT]</span></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4krh\|4krh]], [[4kri\|4kri]]~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4krg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4krg OCA], [~~http~~://pdbe.org/4krg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4krg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4krg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4krg ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/U5HK46_HAECO U5HK46_HAECO]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Barber pole worm~~]]	+	[[Category: Haemonchus contortus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Jez~~, J M~~]]	+	[[Category: Jez JM]]
-	[[Category: Lee~~, S G]]~~	+	[[Category: Lee SG]]
-	~~[[Category: Methyltransferase]]~~	+
-	~~[[Category: Phosphoethanolamine]]~~	+
-	~~[[Category: S-adenosylmethionine]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 08:48, 3 April 2019

OCA — Wed, 03 Apr 2019 08:48:55 GMT

←Older revision		Revision as of 08:48, 3 April 2019
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	==SeMet Haemonchus contortus Phosphoethanolamine N-methyltransferase 1 in complex with phosphoethanolamine and S-adenosylhomocysteine==		==SeMet Haemonchus contortus Phosphoethanolamine N-methyltransferase 1 in complex with phosphoethanolamine and S-adenosylhomocysteine==
-	<StructureSection load='4krg' size='340' side='right' caption='[[4krg]], [[Resolution\|resolution]] 1.68Å' scene=''>	+	<StructureSection load='4krg' size='340' side='right'caption='[[4krg]], [[Resolution\|resolution]] 1.68Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4krg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Barber_pole_worm Barber pole worm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KRG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KRG FirstGlance]. <br>		<table><tr><td colspan='2'>[[4krg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Barber_pole_worm Barber pole worm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KRG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KRG FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Barber pole worm]]		[[Category: Barber pole worm]]
		+	[[Category: Large Structures]]
	[[Category: Jez, J M]]		[[Category: Jez, J M]]
	[[Category: Lee, S G]]		[[Category: Lee, S G]]

OCA at 14:47, 4 August 2016

OCA — Thu, 04 Aug 2016 14:47:19 GMT

←Older revision		Revision as of 14:47, 4 August 2016
Line 1:		Line 1:
		+
	==SeMet Haemonchus contortus Phosphoethanolamine N-methyltransferase 1 in complex with phosphoethanolamine and S-adenosylhomocysteine==		==SeMet Haemonchus contortus Phosphoethanolamine N-methyltransferase 1 in complex with phosphoethanolamine and S-adenosylhomocysteine==
	<StructureSection load='4krg' size='340' side='right' caption='[[4krg]], [[Resolution\|resolution]] 1.68Å' scene=''>		<StructureSection load='4krg' size='340' side='right' caption='[[4krg]], [[Resolution\|resolution]] 1.68Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4krg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Haemonchus_contortus Haemonchus contortus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KRG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KRG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4krg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Barber_pole_worm Barber pole worm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KRG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KRG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=OPE:PHOSPHORIC+ACID+MONO-(2-AMINO-ETHYL)+ESTER'>OPE</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=OPE:PHOSPHORIC+ACID+MONO-(2-AMINO-ETHYL)+ESTER'>OPE</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4krh\|4krh]], [[4kri\|4kri]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4krh\|4krh]], [[4kri\|4kri]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4krg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4krg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4krg RCSB], [http://www.ebi.ac.uk/pdbsum/4krg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4krg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4krg OCA], [http://pdbe.org/4krg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4krg RCSB], [http://www.ebi.ac.uk/pdbsum/4krg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4krg ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4krg" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Haemonchus contortus~~]]	+	[[Category: Barber pole worm]]
	[[Category: Jez, J M]]		[[Category: Jez, J M]]
	[[Category: Lee, S G]]		[[Category: Lee, S G]]

OCA at 14:38, 21 December 2014

OCA — Sun, 21 Dec 2014 14:38:45 GMT

←Older revision		Revision as of 14:38, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4krg\| PDB=4krg \| SCENE= }}~~	+	==SeMet Haemonchus contortus Phosphoethanolamine N-methyltransferase 1 in complex with phosphoethanolamine and S-adenosylhomocysteine==
-	===SeMet Haemonchus contortus Phosphoethanolamine N-methyltransferase 1 in complex with phosphoethanolamine and S-adenosylhomocysteine===	+	<StructureSection load='4krg' size='340' side='right' caption='[[4krg]], [[Resolution\|resolution]] 1.68Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24012478}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4krg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Haemonchus_contortus Haemonchus contortus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KRG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KRG FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=OPE:PHOSPHORIC+ACID+MONO-(2-AMINO-ETHYL)+ESTER'>OPE</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4krh\|4krh]], [[4kri\|4kri]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4krg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4krg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4krg RCSB], [http://www.ebi.ac.uk/pdbsum/4krg PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The phosphobase methylation pathway is the major route for supplying phosphocholine to phospholipid biosynthesis in plants, nematodes, and Plasmodium. In this pathway, phosphoethanolamine N-methyltransferase (PMT) catalyzes the sequential methylation of phosphoethanolamine to phosphocholine. In the PMT, one domain (MT1) catalyzes methylation of phosphoethanolamine to phosphomonomethylethanolamine and a second domain (MT2) completes the synthesis of phosphocholine. The X-ray crystal structures of the di-domain PMT from the parasitic nematode Haemonchus contortus (HcPMT1 and HcPMT2) reveal that the catalytic domains of these proteins are structurally distinct and allow for selective methylation of phosphobase substrates using different active site architectures. These structures also reveal changes leading to loss of function in the vestigial domains of the nematode PMT. Divergence of function in the two nematode PMTs provides two distinct antiparasitic inhibitor targets within the same essential metabolic pathway. The PMTs from nematodes, plants, and Plasmodium also highlight adaptable metabolic modularity in evolutionarily diverse organisms.

-	~~==About this~~ Structure==	+	Evolution of Structure and Mechanistic Divergence in Di-Domain Methyltransferases from Nematode Phosphocholine Biosynthesis.,Lee SG, Jez JM Structure. 2013 Sep 4. pii: S0969-2126(13)00291-8. doi:, 10.1016/j.str.2013.07.023. PMID:24012478<ref>PMID:24012478</ref>
-	~~[[4krg]] is a 2 chain structure with sequence~~ from ~~[http://en~~.~~wikipedia~~.~~org/wiki/Haemonchus_contortus Haemonchus contortus]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.~~il/oca-bin/ocashort?id=4KRG OCA]~~.	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024012478</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Haemonchus contortus]]		[[Category: Haemonchus contortus]]
-	[[Category: Jez, J M.]]	+	[[Category: Jez, J M]]
-	[[Category: Lee, S G.]]	+	[[Category: Lee, S G]]
	[[Category: Methyltransferase]]		[[Category: Methyltransferase]]
	[[Category: Phosphoethanolamine]]		[[Category: Phosphoethanolamine]]
	[[Category: S-adenosylmethionine]]		[[Category: S-adenosylmethionine]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 08:13, 29 September 2013

OCA — Sun, 29 Sep 2013 08:13:00 GMT

←Older revision		Revision as of 08:13, 29 September 2013
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-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4krg\| PDB=4krg \| SCENE= }}
		+	===SeMet Haemonchus contortus Phosphoethanolamine N-methyltransferase 1 in complex with phosphoethanolamine and S-adenosylhomocysteine===
		+	{{ABSTRACT_PUBMED_24012478}}

-	~~The entry~~ 4krg is ~~ON HOLD~~	+	==About this Structure==
		+	[[4krg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Haemonchus_contortus Haemonchus contortus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KRG OCA].

-	~~Authors~~: ~~Lee, S.G.,~~ Jez, J.M.	+	==Reference==
-		+	<ref group="xtra">PMID:024012478</ref><references group="xtra"/><references/>
-	~~Description~~: ~~SeMet Haemonchus contortus~~ Phosphoethanolamine ~~N-methyltransferase 1 in complex with phosphoethanolamine and~~ S-~~adenosylhomocysteine~~	+	[[Category: Haemonchus contortus]]
		+	[[Category: Jez, J M.]]
		+	[[Category: Lee, S G.]]
		+	[[Category: Methyltransferase]]
		+	[[Category: Phosphoethanolamine]]
		+	[[Category: S-adenosylmethionine]]
		+	[[Category: Transferase]]

OCA: Protected "4krg" [edit=sysop:move=sysop]

OCA — Wed, 19 Jun 2013 11:56:53 GMT

Protected "4krg" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:56, 19 June 2013

OCA: New page: '''Unreleased structure''' The entry 4krg is ON HOLD Authors: Lee, S.G., Jez, J.M. Description: SeMet Haemonchus contortus Phosphoethanolamine N-methyltransferase 1 in complex with pho...

OCA — Wed, 19 Jun 2013 11:56:52 GMT

New page: '''Unreleased structure''' The entry 4krg is ON HOLD Authors: Lee, S.G., Jez, J.M. Description: SeMet Haemonchus contortus Phosphoethanolamine N-methyltransferase 1 in complex with pho...

New page

'''Unreleased structure'''

The entry 4krg is ON HOLD

Authors: Lee, S.G., Jez, J.M.

Description: SeMet Haemonchus contortus Phosphoethanolamine N-methyltransferase 1 in complex with phosphoethanolamine and S-adenosylhomocysteine