4ksa - Revision history

OCA at 09:10, 7 December 2022

OCA — Wed, 07 Dec 2022 09:10:39 GMT

←Older revision		Revision as of 09:10, 7 December 2022
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	==Crystal Structure of Malonyl-CoA decarboxylase from Rhodopseudomonas palustris, Northeast Structural Genomics Consortium Target RpR127==		==Crystal Structure of Malonyl-CoA decarboxylase from Rhodopseudomonas palustris, Northeast Structural Genomics Consortium Target RpR127==
-	<StructureSection load='4ksa' size='340' side='right' caption='[[4ksa]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='4ksa' size='340' side='right'caption='[[4ksa]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ksa]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Rhopa Rhopa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KSA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4KSA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ksa]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodopseudomonas_palustris_CGA009 Rhodopseudomonas palustris CGA009]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KSA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KSA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene~~></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ksa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ksa OCA], [https://pdbe.org/4ksa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ksa RCSB], [https://www.ebi.ac.uk/pdbsum/4ksa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ksa ProSAT]</span></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ks9\|4ks9]], [[4ksf\|4ksf]]</td></tr>~~	+
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MLYCD (RPA0560), MLYCD/MCD, RPA0560 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=258594 RHOPA])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Malonyl-CoA_decarboxylase Malonyl-CoA decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.9 4.1.1.9] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ksa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ksa OCA], [~~http~~://pdbe.org/4ksa PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ksa RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ksa PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ksa ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q6NCB2_RHOPA Q6NCB2_RHOPA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Malonyl-CoA decarboxylase~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Rhopa~~]]	+	[[Category: Rhodopseudomonas palustris CGA009]]
-	[[Category: Acton~~, T B~~]]	+	[[Category: Acton TB]]
-	[[Category: Ciccosanti, C]]	+	[[Category: Ciccosanti C]]
-	[[Category: Everett~~, J K~~]]	+	[[Category: Everett JK]]
-	[[Category: Forouhar, F]]	+	[[Category: Forouhar F]]
-	[[Category: Hunt~~, J F~~]]	+	[[Category: Hunt JF]]
-	[[Category: Montelione~~, G T]]~~	+	[[Category: Montelione GT]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Neely H]]
-	[[Category: Neely, H]]	+	[[Category: Patel DJ]]
-	[[Category: Patel~~, D J~~]]	+	[[Category: Sahdev S]]
-	[[Category: Sahdev, S]]	+	[[Category: Seetharaman J]]
-	[[Category: Seetharaman, J]]	+	[[Category: Tong L]]
-	[[Category: Tong, L]]	+	[[Category: Wang D]]
-	[[Category: Wang, D]]	+	[[Category: Xiao R]]
-	[[Category: Xiao, R]]	+
-	~~[[Category: Alpha-beta two-domained protein]]~~	+
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: Nesgc]]~~	+
-	~~[[Category: Psi-biology~~]]	+

OCA at 07:45, 4 August 2016

OCA — Thu, 04 Aug 2016 07:45:00 GMT

←Older revision		Revision as of 07:45, 4 August 2016
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-	{{STRUCTURE_4ksa\| PDB=4ksa \| SCENE= }}
-	===Crystal Structure of Malonyl-CoA decarboxylase from Rhodopseudomonas palustris, Northeast Structural Genomics Consortium Target RpR127===
-	{{ABSTRACT_PUBMED_23791943}}

-	==~~About this~~ Structure==	+	==Crystal Structure of Malonyl-CoA decarboxylase from Rhodopseudomonas palustris, Northeast Structural Genomics Consortium Target RpR127==
-	[[4ksa]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rhodopseudomonas_palustris_cga009 Rhodopseudomonas palustris cga009~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KSA OCA].	+	<StructureSection load='4ksa' size='340' side='right' caption='[[4ksa]], [[Resolution\|resolution]] 2.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4ksa]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhopa Rhopa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KSA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KSA FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ks9\|4ks9]], [[4ksf\|4ksf]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MLYCD (RPA0560), MLYCD/MCD, RPA0560 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=258594 RHOPA])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Malonyl-CoA_decarboxylase Malonyl-CoA decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.9 4.1.1.9] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ksa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ksa OCA], [http://pdbe.org/4ksa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ksa RCSB], [http://www.ebi.ac.uk/pdbsum/4ksa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ksa ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Malonyl-coenzyme A decarboxylase (MCD) is found from bacteria to humans, has important roles in regulating fatty acid metabolism and food intake, and is an attractive target for drug discovery. We report here four crystal structures of MCD from human, Rhodopseudomonas palustris, Agrobacterium vitis, and Cupriavidus metallidurans at up to 2.3 A resolution. The MCD monomer contains an N-terminal helical domain involved in oligomerization and a C-terminal catalytic domain. The four structures exhibit substantial differences in the organization of the helical domains and, consequently, the oligomeric states and intersubunit interfaces. Unexpectedly, the MCD catalytic domain is structurally homologous to those of the GCN5-related N-acetyltransferase superfamily, especially the curacin A polyketide synthase catalytic module, with a conserved His-Ser/Thr dyad important for catalysis. Our structures, along with mutagenesis and kinetic studies, provide a molecular basis for understanding pathogenic mutations and catalysis, as well as a template for structure-based drug design.

-	~~==Reference==~~	+	Crystal structures of malonyl-coenzyme a decarboxylase provide insights into its catalytic mechanism and disease-causing mutations.,Froese DS, Forouhar F, Tran TH, Vollmar M, Kim YS, Lew S, Neely H, Seetharaman J, Shen Y, Xiao R, Acton TB, Everett JK, Cannone G, Puranik S, Savitsky P, Krojer T, Pilka ES, Kiyani W, Lee WH, Marsden BD, von Delft F, Allerston CK, Spagnolo L, Gileadi O, Montelione GT, Oppermann U, Yue WW, Tong L Structure. 2013 Jul 2;21(7):1182-92. doi: 10.1016/j.str.2013.05.001. Epub 2013, Jun 20. PMID:23791943<ref>PMID:23791943</ref>
-	<ref ~~group="xtra"~~>PMID:~~023791943~~</ref><~~references group~~="~~xtra~~"/><references/>	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4ksa" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Malonyl-CoA decarboxylase]]		[[Category: Malonyl-CoA decarboxylase]]
-	[[Category: ~~Rhodopseudomonas palustris cga009~~]]	+	[[Category: Rhopa]]
-	[[Category: Acton, T B.]]	+	[[Category: Acton, T B]]
-	[[Category: Ciccosanti, C.]]	+	[[Category: Ciccosanti, C]]
-	[[Category: Everett, J K.]]	+	[[Category: Everett, J K]]
-	[[Category: Forouhar, F.]]	+	[[Category: Forouhar, F]]
-	[[Category: Hunt, J F.]]	+	[[Category: Hunt, J F]]
-	[[Category: Montelione, G T.]]	+	[[Category: Montelione, G T]]
-	[[Category: ~~NESG, Northeast~~ Structural ~~Genomics Consortium.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Neely, H.]]	+	[[Category: Neely, H]]
-	[[Category: Patel, D J.]]	+	[[Category: Patel, D J]]
-	[[Category: Sahdev, S.]]	+	[[Category: Sahdev, S]]
-	[[Category: Seetharaman, J.]]	+	[[Category: Seetharaman, J]]
-	[[Category: Tong, L.]]	+	[[Category: Tong, L]]
-	[[Category: Wang, D.]]	+	[[Category: Wang, D]]
-	[[Category: Xiao, R.]]	+	[[Category: Xiao, R]]
	[[Category: Alpha-beta two-domained protein]]		[[Category: Alpha-beta two-domained protein]]
	[[Category: Lyase]]		[[Category: Lyase]]
	[[Category: Nesgc]]		[[Category: Nesgc]]
-	[[Category: Northeast structural genomics consortium]]
	[[Category: Psi-biology]]		[[Category: Psi-biology]]
-	[[Category: Structural genomic]]

OCA at 14:31, 10 July 2013

OCA — Wed, 10 Jul 2013 14:31:02 GMT

←Older revision		Revision as of 14:31, 10 July 2013
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	{{STRUCTURE_4ksa\| PDB=4ksa \| SCENE= }}		{{STRUCTURE_4ksa\| PDB=4ksa \| SCENE= }}
	===Crystal Structure of Malonyl-CoA decarboxylase from Rhodopseudomonas palustris, Northeast Structural Genomics Consortium Target RpR127===		===Crystal Structure of Malonyl-CoA decarboxylase from Rhodopseudomonas palustris, Northeast Structural Genomics Consortium Target RpR127===
		+	{{ABSTRACT_PUBMED_23791943}}

	==About this Structure==		==About this Structure==
	[[4ksa]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodopseudomonas_palustris_cga009 Rhodopseudomonas palustris cga009]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KSA OCA].		[[4ksa]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodopseudomonas_palustris_cga009 Rhodopseudomonas palustris cga009]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KSA OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:023791943</ref><references group="xtra"/><references/>
	[[Category: Malonyl-CoA decarboxylase]]		[[Category: Malonyl-CoA decarboxylase]]
	[[Category: Rhodopseudomonas palustris cga009]]		[[Category: Rhodopseudomonas palustris cga009]]

OCA: Protected "4ksa" [edit=sysop:move=sysop]

OCA — Thu, 20 Jun 2013 07:28:06 GMT

Protected "4ksa" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:28, 20 June 2013

OCA: New page: {{STRUCTURE_4ksa| PDB=4ksa | SCENE= }} ===Crystal Structure of Malonyl-CoA decarboxylase from Rhodopseudomonas palustris, Northeast Structural Genomics Consortium Target RpR127=== ==...

OCA — Thu, 20 Jun 2013 07:28:05 GMT

New page: {{STRUCTURE_4ksa| PDB=4ksa | SCENE= }} ===Crystal Structure of Malonyl-CoA decarboxylase from Rhodopseudomonas palustris, Northeast Structural Genomics Consortium Target RpR127=== ==...

New page

{{STRUCTURE_4ksa| PDB=4ksa | SCENE= }}
===Crystal Structure of Malonyl-CoA decarboxylase from Rhodopseudomonas palustris, Northeast Structural Genomics Consortium Target RpR127===

==About this Structure==
[[4ksa]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodopseudomonas_palustris_cga009 Rhodopseudomonas palustris cga009]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KSA OCA].
[[Category: Malonyl-CoA decarboxylase]]
[[Category: Rhodopseudomonas palustris cga009]]
[[Category: Acton, T B.]]
[[Category: Ciccosanti, C.]]
[[Category: Everett, J K.]]
[[Category: Forouhar, F.]]
[[Category: Hunt, J F.]]
[[Category: Montelione, G T.]]
[[Category: NESG, Northeast Structural Genomics Consortium.]]
[[Category: Neely, H.]]
[[Category: Patel, D J.]]
[[Category: Sahdev, S.]]
[[Category: Seetharaman, J.]]
[[Category: Tong, L.]]
[[Category: Wang, D.]]
[[Category: Xiao, R.]]
[[Category: Alpha-beta two-domained protein]]
[[Category: Lyase]]
[[Category: Nesgc]]
[[Category: Northeast structural genomics consortium]]
[[Category: Psi-biology]]
[[Category: Structural genomic]]