4ksd - Revision history

OCA at 09:10, 7 December 2022

OCA — Wed, 07 Dec 2022 09:10:51 GMT

←Older revision		Revision as of 09:10, 7 December 2022
Line 3:		Line 3:
	<StructureSection load='4ksd' size='340' side='right'caption='[[4ksd]], [[Resolution\|resolution]] 4.10Å' scene=''>		<StructureSection load='4ksd' size='340' side='right'caption='[[4ksd]], [[Resolution\|resolution]] 4.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ksd]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Camelus_glama Camelus~~ glama] and [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KSD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4KSD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ksd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lama_glama Lama glama] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KSD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KSD FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ksb\|4ksb]], [[4ksc\|4ksc]], [[4lsg\|4lsg]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ksd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ksd OCA], [https://pdbe.org/4ksd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ksd RCSB], [https://www.ebi.ac.uk/pdbsum/4ksd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ksd ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Abcb1a, Abcb4, Mdr1a, Mdr3, Pgy-3, Pgy3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), r2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9844 Camelus glama])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Xenobiotic-transporting_ATPase Xenobiotic-transporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.44 3.6.3.44] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ksd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ksd OCA], [~~http~~://pdbe.org/4ksd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ksd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ksd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ksd ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MDR1A_MOUSE MDR1A_MOUSE]] Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.<ref>PMID:19325113</ref>	+	[https://www.uniprot.org/uniprot/MDR1A_MOUSE MDR1A_MOUSE] Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.<ref>PMID:19325113</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Camelus~~ glama]]	+	[[Category: Lama glama]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice]]~~	+	[[Category: Mus musculus]]
-	~~[[Category: Xenobiotic-transporting ATPase~~]]	+	[[Category: Caya A]]
-	[[Category: Caya, A]]	+	[[Category: Chang G]]
-	[[Category: Chang, G]]	+	[[Category: Cregger C]]
-	[[Category: Cregger, C]]	+	[[Category: Doshi R]]
-	[[Category: Doshi, R]]	+	[[Category: Falson P]]
-	[[Category: Falson, P]]	+	[[Category: Govaerts C]]
-	[[Category: Govaerts, C]]	+	[[Category: Grimard V]]
-	[[Category: Grimard, V]]	+	[[Category: Lee C-W]]
-	[[Category: Lee, C W]]	+	[[Category: Martinez L]]
-	[[Category: Martinez, L]]	+	[[Category: Pardon E]]
-	[[Category: Pardon, E]]	+	[[Category: Steyaert J]]
-	[[Category: Steyaert, J]]	+	[[Category: Swartz DJ]]
-	[[Category: Swartz~~, D J~~]]	+	[[Category: Szewczyk P]]
-	[[Category: Szewczyk, P]]	+	[[Category: Urbatsch I]]
-	[[Category: Urbatsch, I]]	+	[[Category: Villaluz M]]
-	[[Category: Villaluz, M]]	+	[[Category: Ward A]]
-	[[Category: Ward, A]]	+
-	~~[[Category: Atp binding]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Transport protein]]~~	+
-	~~[[Category: Transporter~~]]	+

OCA at 12:03, 17 July 2019

OCA — Wed, 17 Jul 2019 12:03:52 GMT

←Older revision		Revision as of 12:03, 17 July 2019
Line 1:		Line 1:
		+
	==Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain==		==Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain==
-	<StructureSection load='4ksd' size='340' side='right' caption='[[4ksd]], [[Resolution\|resolution]] 4.10Å' scene=''>	+	<StructureSection load='4ksd' size='340' side='right'caption='[[4ksd]], [[Resolution\|resolution]] 4.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ksd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Camelus_glama Camelus glama] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KSD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KSD FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ksd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Camelus_glama Camelus glama] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KSD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KSD FirstGlance]. <br>
Line 6:		Line 7:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Abcb1a, Abcb4, Mdr1a, Mdr3, Pgy-3, Pgy3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), r2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9844 Camelus glama])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Abcb1a, Abcb4, Mdr1a, Mdr3, Pgy-3, Pgy3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), r2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9844 Camelus glama])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Xenobiotic-transporting_ATPase Xenobiotic-transporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.44 3.6.3.44] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Xenobiotic-transporting_ATPase Xenobiotic-transporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.44 3.6.3.44] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ksd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ksd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ksd RCSB], [http://www.ebi.ac.uk/pdbsum/4ksd PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ksd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ksd OCA], [http://pdbe.org/4ksd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ksd RCSB], [http://www.ebi.ac.uk/pdbsum/4ksd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ksd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4ksd" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 23:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Camelus glama]]		[[Category: Camelus glama]]
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Xenobiotic-transporting ATPase]]		[[Category: Xenobiotic-transporting ATPase]]

OCA at 04:54, 9 September 2015

OCA — Wed, 09 Sep 2015 04:54:28 GMT

←Older revision		Revision as of 04:54, 9 September 2015
Line 2:		Line 2:
	<StructureSection load='4ksd' size='340' side='right' caption='[[4ksd]], [[Resolution\|resolution]] 4.10Å' scene=''>		<StructureSection load='4ksd' size='340' side='right' caption='[[4ksd]], [[Resolution\|resolution]] 4.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ksd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Lama_glama Lama~~ glama] and [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KSD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KSD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ksd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Camelus_glama Camelus glama] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KSD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KSD FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ksb\|4ksb]], [[4ksc\|4ksc]], [[4lsg\|4lsg]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ksb\|4ksb]], [[4ksc\|4ksc]], [[4lsg\|4lsg]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Abcb1a, Abcb4, Mdr1a, Mdr3, Pgy-3, Pgy3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~]), r2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9844 ~~Lama~~ glama])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Abcb1a, Abcb4, Mdr1a, Mdr3, Pgy-3, Pgy3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), r2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9844 Camelus glama])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Xenobiotic-transporting_ATPase Xenobiotic-transporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.44 3.6.3.44] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Xenobiotic-transporting_ATPase Xenobiotic-transporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.44 3.6.3.44] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ksd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ksd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ksd RCSB], [http://www.ebi.ac.uk/pdbsum/4ksd PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ksd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ksd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ksd RCSB], [http://www.ebi.ac.uk/pdbsum/4ksd PDBsum]</span></td></tr>
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Lama~~ glama]]	+	[[Category: Camelus glama]]
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Xenobiotic-transporting ATPase]]		[[Category: Xenobiotic-transporting ATPase]]
	[[Category: Caya, A]]		[[Category: Caya, A]]
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	[[Category: Govaerts, C]]		[[Category: Govaerts, C]]
	[[Category: Grimard, V]]		[[Category: Grimard, V]]
-	[[Category: Lee, C-W]]	+	[[Category: Lee, C W]]
	[[Category: Martinez, L]]		[[Category: Martinez, L]]
	[[Category: Pardon, E]]		[[Category: Pardon, E]]

OCA at 20:38, 24 December 2014

OCA — Wed, 24 Dec 2014 20:38:18 GMT

←Older revision		Revision as of 20:38, 24 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4ksd\| PDB=4ksd \| SCENE= }}~~	+	==Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain==
-	===Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain===	+	<StructureSection load='4ksd' size='340' side='right' caption='[[4ksd]], [[Resolution\|resolution]] 4.10Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23901103}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4ksd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lama_glama Lama glama] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KSD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KSD FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ksb\|4ksb]], [[4ksc\|4ksc]], [[4lsg\|4lsg]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Abcb1a, Abcb4, Mdr1a, Mdr3, Pgy-3, Pgy3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), r2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9844 Lama glama])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Xenobiotic-transporting_ATPase Xenobiotic-transporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.44 3.6.3.44] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ksd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ksd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ksd RCSB], [http://www.ebi.ac.uk/pdbsum/4ksd PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/MDR1A_MOUSE MDR1A_MOUSE]] Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.<ref>PMID:19325113</ref>		[[http://www.uniprot.org/uniprot/MDR1A_MOUSE MDR1A_MOUSE]] Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.<ref>PMID:19325113</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	P-glycoprotein (P-gp) is one of the best-known mediators of drug efflux-based multidrug resistance in many cancers. This validated therapeutic target is a prototypic, plasma membrane resident ATP-Binding Cassette transporter that pumps xenobiotic compounds out of cells. The large, polyspecific drug-binding pocket of P-gp recognizes a variety of structurally unrelated compounds. The transport of these drugs across the membrane is coincident with changes in the size and shape of this pocket during the course of the transport cycle. Here, we present the crystal structures of three inward-facing conformations of mouse P-gp derived from two different crystal forms. One structure has a nanobody bound to the C-terminal side of the first nucleotide-binding domain. This nanobody strongly inhibits the ATP hydrolysis activity of mouse P-gp by hindering the formation of a dimeric complex between the ATP-binding domains, which is essential for nucleotide hydrolysis. Together, these inward-facing conformational snapshots of P-gp demonstrate a range of flexibility exhibited by this transporter, which is likely an essential feature for the binding and transport of large, diverse substrates. The nanobody-bound structure also reveals a unique epitope on P-gp.

-	~~==About this Structure==~~	+	Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain.,Ward AB, Szewczyk P, Grimard V, Lee CW, Martinez L, Doshi R, Caya A, Villaluz M, Pardon E, Cregger C, Swartz DJ, Falson PG, Urbatsch IL, Govaerts C, Steyaert J, Chang G Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13386-91. doi:, 10.1073/pnas.1309275110. Epub 2013 Jul 30. PMID:23901103<ref>PMID:23901103</ref>
-	~~[[4ksd]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Lama_glama Lama glama] and [http~~:~~//en~~.~~wikipedia~~.~~org~~/~~wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4KSD OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:023901103</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Lama glama]]		[[Category: Lama glama]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Xenobiotic-transporting ATPase]]		[[Category: Xenobiotic-transporting ATPase]]
-	[[Category: Caya, A.]]	+	[[Category: Caya, A]]
-	[[Category: Chang, G.]]	+	[[Category: Chang, G]]
-	[[Category: Cregger, C.]]	+	[[Category: Cregger, C]]
-	[[Category: Doshi, R.]]	+	[[Category: Doshi, R]]
-	[[Category: Falson, P.]]	+	[[Category: Falson, P]]
-	[[Category: Govaerts, C.]]	+	[[Category: Govaerts, C]]
-	[[Category: Grimard, V.]]	+	[[Category: Grimard, V]]
-	[[Category: Lee, C-W.]]	+	[[Category: Lee, C-W]]
-	[[Category: Martinez, L.]]	+	[[Category: Martinez, L]]
-	[[Category: Pardon, E.]]	+	[[Category: Pardon, E]]
-	[[Category: Steyaert, J.]]	+	[[Category: Steyaert, J]]
-	[[Category: Swartz, D J.]]	+	[[Category: Swartz, D J]]
-	[[Category: Szewczyk, P.]]	+	[[Category: Szewczyk, P]]
-	[[Category: Urbatsch, I.]]	+	[[Category: Urbatsch, I]]
-	[[Category: Villaluz, M.]]	+	[[Category: Villaluz, M]]
-	[[Category: Ward, A.]]	+	[[Category: Ward, A]]
	[[Category: Atp binding]]		[[Category: Atp binding]]
	[[Category: Membrane]]		[[Category: Membrane]]

OCA at 08:22, 21 August 2013

OCA — Wed, 21 Aug 2013 08:22:35 GMT

←Older revision		Revision as of 08:22, 21 August 2013
Line 1:		Line 1:
	{{STRUCTURE_4ksd\| PDB=4ksd \| SCENE= }}		{{STRUCTURE_4ksd\| PDB=4ksd \| SCENE= }}
	===Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain===		===Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain===
		+	{{ABSTRACT_PUBMED_23901103}}

	==Function==		==Function==
Line 9:		Line 10:

	==Reference==		==Reference==
-	<references group="xtra"/><references/>	+	<ref group="xtra">PMID:023901103</ref><references group="xtra"/><references/>
	[[Category: Lama glama]]		[[Category: Lama glama]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]

OCA at 05:23, 1 August 2013

OCA — Thu, 01 Aug 2013 05:23:00 GMT

←Older revision		Revision as of 05:23, 1 August 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4ksd\| PDB=4ksd \| SCENE= }}
		+	===Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain===

-	~~The entry 4ksd is ON HOLD~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/MDR1A_MOUSE MDR1A_MOUSE]] Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.<ref>PMID:19325113</ref>

-	~~Authors~~: ~~Ward, A~~.~~, Szewczyk, P~~.~~, Grimard, V~~.~~, Lee, C-W~~.~~, Martinez, L~~.~~, Doshi, R~~.~~, Caya, A~~.~~, Villaluz, M~~.~~, Pardon, E., Cregger, C., Swartz, D.J., Falson, P., Urbatsch, I., Govaerts, C., Steyaert, J., Chang, G~~.	+	==About this Structure==
		+	[[4ksd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lama_glama Lama glama] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KSD OCA].

-	~~Description~~: ~~Crystal structure of MDR transporter 3 with nanobody~~	+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Lama glama]]
		+	[[Category: Mus musculus]]
		+	[[Category: Xenobiotic-transporting ATPase]]
		+	[[Category: Caya, A.]]
		+	[[Category: Chang, G.]]
		+	[[Category: Cregger, C.]]
		+	[[Category: Doshi, R.]]
		+	[[Category: Falson, P.]]
		+	[[Category: Govaerts, C.]]
		+	[[Category: Grimard, V.]]
		+	[[Category: Lee, C-W.]]
		+	[[Category: Martinez, L.]]
		+	[[Category: Pardon, E.]]
		+	[[Category: Steyaert, J.]]
		+	[[Category: Swartz, D J.]]
		+	[[Category: Szewczyk, P.]]
		+	[[Category: Urbatsch, I.]]
		+	[[Category: Villaluz, M.]]
		+	[[Category: Ward, A.]]
		+	[[Category: Atp binding]]
		+	[[Category: Membrane]]
		+	[[Category: Membrane protein]]
		+	[[Category: Transport protein]]
		+	[[Category: Transporter]]

OCA: Protected "4ksd" [edit=sysop:move=sysop]

OCA — Wed, 19 Jun 2013 11:58:57 GMT

Protected "4ksd" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:58, 19 June 2013

OCA: New page: '''Unreleased structure''' The entry 4ksd is ON HOLD Authors: Ward, A., Szewczyk, P., Grimard, V., Lee, C-W., Martinez, L., Doshi, R., Caya, A., Villaluz, M., Pardon, E., Cregger, C., S...

OCA — Wed, 19 Jun 2013 11:58:53 GMT

New page: '''Unreleased structure''' The entry 4ksd is ON HOLD Authors: Ward, A., Szewczyk, P., Grimard, V., Lee, C-W., Martinez, L., Doshi, R., Caya, A., Villaluz, M., Pardon, E., Cregger, C., S...

New page

'''Unreleased structure'''

The entry 4ksd is ON HOLD

Authors: Ward, A., Szewczyk, P., Grimard, V., Lee, C-W., Martinez, L., Doshi, R., Caya, A., Villaluz, M., Pardon, E., Cregger, C., Swartz, D.J., Falson, P., Urbatsch, I., Govaerts, C., Steyaert, J., Chang, G.

Description: Crystal structure of MDR transporter 3 with nanobody