4ktt - Revision history

OCA at 16:05, 20 September 2023

OCA — Wed, 20 Sep 2023 16:05:18 GMT

←Older revision		Revision as of 16:05, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ktt]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KTT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KTT FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ktt]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KTT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KTT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.59Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ktt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ktt OCA], [https://pdbe.org/4ktt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ktt RCSB], [https://www.ebi.ac.uk/pdbsum/4ktt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ktt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ktt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ktt OCA], [https://pdbe.org/4ktt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ktt RCSB], [https://www.ebi.ac.uk/pdbsum/4ktt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ktt ProSAT]</span></td></tr>
	</table>		</table>

OCA at 09:13, 7 December 2022

OCA — Wed, 07 Dec 2022 09:13:17 GMT

←Older revision		Revision as of 09:13, 7 December 2022
Line 3:		Line 3:
	<StructureSection load='4ktt' size='340' side='right'caption='[[4ktt]], [[Resolution\|resolution]] 2.59Å' scene=''>		<StructureSection load='4ktt' size='340' side='right'caption='[[4ktt]], [[Resolution\|resolution]] 2.59Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ktt]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KTT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4KTT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ktt]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KTT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KTT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p02\|2p02]], [[2ydx\|2ydx]], [[4ktv\|4ktv]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ktt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ktt OCA], [https://pdbe.org/4ktt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ktt RCSB], [https://www.ebi.ac.uk/pdbsum/4ktt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ktt ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAT2A, AMS2, MATA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), MAT2B, TGR, MSTP045, Nbla02999, UNQ2435/PRO4995 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionine_adenosyltransferase Methionine adenosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.6 2.5.1.6] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ktt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ktt OCA], [~~http~~://pdbe.org/4ktt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ktt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ktt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ktt ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/METK2_HUMAN METK2_HUMAN]] Catalyzes the formation of S-adenosylmethionine from methionine and ATP. [[http://www.uniprot.org/uniprot/MAT2B_HUMAN MAT2B_HUMAN]] Non-catalytic regulatory subunit of S-adenosylmethionine synthetase 2 (MAT2A), an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates the activity of S-adenosylmethionine synthetase 2 by changing its kinetic properties, rendering the enzyme more susceptible to S-adenosylmethionine inhibition.<ref>PMID:10644686</ref>	+	[https://www.uniprot.org/uniprot/METK2_HUMAN METK2_HUMAN] Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Methionine adenosyltransferase]]~~	+	[[Category: Antonyuk SV]]
-	[[Category: Antonyuk~~, S V~~]]	+	[[Category: Hasnain SS]]
-	[[Category: Hasnain~~, S S~~]]	+	[[Category: Lu SC]]
-	[[Category: Lu~~, S C~~]]	+	[[Category: Marina A]]
-	[[Category: Marina, A]]	+	[[Category: Mato JM]]
-	[[Category: Mato~~, J M~~]]	+	[[Category: Murray B]]
-	[[Category: Murray, B]]	+	[[Category: Rojas AL]]
-	[[Category: Rojas~~, A L]]~~	+
-	~~[[Category: Same synthesis]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 09:26, 3 April 2019

OCA — Wed, 03 Apr 2019 09:26:41 GMT

←Older revision		Revision as of 09:26, 3 April 2019
Line 1:		Line 1:

	==Structural insights of MAT enzymes: MATa2b complexed with SAM==		==Structural insights of MAT enzymes: MATa2b complexed with SAM==
-	<StructureSection load='4ktt' size='340' side='right' caption='[[4ktt]], [[Resolution\|resolution]] 2.59Å' scene=''>	+	<StructureSection load='4ktt' size='340' side='right'caption='[[4ktt]], [[Resolution\|resolution]] 2.59Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ktt]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KTT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KTT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ktt]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KTT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KTT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p02\|2p02]], [[2ydx\|2ydx]], [[4ktv\|4ktv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p02\|2p02]], [[2ydx\|2ydx]], [[4ktv\|4ktv]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAT2A, AMS2, MATA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), MAT2B, TGR, MSTP045, Nbla02999, UNQ2435/PRO4995 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionine_adenosyltransferase Methionine adenosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.6 2.5.1.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionine_adenosyltransferase Methionine adenosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.6 2.5.1.6] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ktt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ktt OCA], [http://pdbe.org/4ktt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ktt RCSB], [http://www.ebi.ac.uk/pdbsum/4ktt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ktt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ktt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ktt OCA], [http://pdbe.org/4ktt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ktt RCSB], [http://www.ebi.ac.uk/pdbsum/4ktt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ktt ProSAT]</span></td></tr>
Line 24:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Methionine adenosyltransferase]]		[[Category: Methionine adenosyltransferase]]
	[[Category: Antonyuk, S V]]		[[Category: Antonyuk, S V]]

OCA at 19:06, 5 August 2016

OCA — Fri, 05 Aug 2016 19:06:50 GMT

←Older revision		Revision as of 19:06, 5 August 2016
Line 1:		Line 1:
		+
	==Structural insights of MAT enzymes: MATa2b complexed with SAM==		==Structural insights of MAT enzymes: MATa2b complexed with SAM==
	<StructureSection load='4ktt' size='340' side='right' caption='[[4ktt]], [[Resolution\|resolution]] 2.59Å' scene=''>		<StructureSection load='4ktt' size='340' side='right' caption='[[4ktt]], [[Resolution\|resolution]] 2.59Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p02\|2p02]], [[2ydx\|2ydx]], [[4ktv\|4ktv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p02\|2p02]], [[2ydx\|2ydx]], [[4ktv\|4ktv]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionine_adenosyltransferase Methionine adenosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.6 2.5.1.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionine_adenosyltransferase Methionine adenosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.6 2.5.1.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ktt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ktt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ktt RCSB], [http://www.ebi.ac.uk/pdbsum/4ktt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ktt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ktt OCA], [http://pdbe.org/4ktt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ktt RCSB], [http://www.ebi.ac.uk/pdbsum/4ktt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ktt ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4ktt" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:04, 25 December 2014

OCA — Thu, 25 Dec 2014 05:04:43 GMT

←Older revision		Revision as of 05:04, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ktt]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KTT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KTT FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ktt]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KTT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KTT FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p02\|2p02]], [[2ydx\|2ydx]], [[4ktv\|4ktv]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p02\|2p02]], [[2ydx\|2ydx]], [[4ktv\|4ktv]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionine_adenosyltransferase Methionine adenosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.6 2.5.1.6] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionine_adenosyltransferase Methionine adenosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.6 2.5.1.6] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ktt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ktt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ktt RCSB], [http://www.ebi.ac.uk/pdbsum/4ktt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ktt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ktt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ktt RCSB], [http://www.ebi.ac.uk/pdbsum/4ktt PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/METK2_HUMAN METK2_HUMAN]] Catalyzes the formation of S-adenosylmethionine from methionine and ATP. [[http://www.uniprot.org/uniprot/MAT2B_HUMAN MAT2B_HUMAN]] Non-catalytic regulatory subunit of S-adenosylmethionine synthetase 2 (MAT2A), an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates the activity of S-adenosylmethionine synthetase 2 by changing its kinetic properties, rendering the enzyme more susceptible to S-adenosylmethionine inhibition.<ref>PMID:10644686</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Methionine adenosyltransferase]]		[[Category: Methionine adenosyltransferase]]
-	[[Category: Antonyuk, S V.]]	+	[[Category: Antonyuk, S V]]
-	[[Category: Hasnain, S S.]]	+	[[Category: Hasnain, S S]]
-	[[Category: Lu, S C.]]	+	[[Category: Lu, S C]]
-	[[Category: Marina, A.]]	+	[[Category: Marina, A]]
-	[[Category: Mato, J M.]]	+	[[Category: Mato, J M]]
-	[[Category: Murray, B.]]	+	[[Category: Murray, B]]
-	[[Category: Rojas, A L.]]	+	[[Category: Rojas, A L]]
	[[Category: Same synthesis]]		[[Category: Same synthesis]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 06:50, 24 September 2014

OCA — Wed, 24 Sep 2014 06:50:50 GMT

←Older revision		Revision as of 06:50, 24 September 2014
Line 8:		Line 8:
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ktt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ktt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ktt RCSB], [http://www.ebi.ac.uk/pdbsum/4ktt PDBsum]</span></td></tr>		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ktt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ktt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ktt RCSB], [http://www.ebi.ac.uk/pdbsum/4ktt PDBsum]</span></td></tr>
	<table>		<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	S-Adenosylmethionine (SAMe) is the principal methyl donor of the cell and is synthesized via an ATP-driven process by methionine adenosyltransferase (MAT) enzymes. It is tightly linked with cell proliferation in liver and colon cancer. In humans, there are three genes, mat1A, mat2A and mat2B, which encode MAT enzymes. mat2A and mat2B transcribe MATalpha2 and MATbeta enzyme subunits, respectively, with catalytic and regulatory roles. The MATalpha2beta complex is expressed in nearly all tissues and is thought to be essential in providing the necessary SAMe flux for methylation of DNA and various proteins including histones. In human hepatocellular carcinoma mat2A and mat2B genes are upregulated, highlighting the importance of the MATalpha2beta complex in liver disease. The individual subunits have been structurally characterized but the nature of the complex has remained elusive despite its existence having been postulated for more than 20 years and the observation that MATbeta is often co-localized with MATalpha2. Though SAMe can be produced by MAT(alpha2)4 alone, this paper shows that the V max of the MATalpha2beta complex is three- to fourfold higher depending on the variants of MATbeta that participate in complex formation. Using X-ray crystallography and solution X-ray scattering, the first structures are provided of this 258 kDa functional complex both in crystals and solution with an unexpected stoichiometry of 4alpha2 and 2betaV2 subunits. It is demonstrated that the N-terminal regulates the activity of the complex and it is shown that complex formation takes place surprisingly via the C-terminal of MATbetaV2 that buries itself in a tunnel created at the interface of the MAT(alpha2)2. The structural data suggest a unique mechanism of regulation and provide a gateway for structure-based drug design in anticancer therapies.
		+
		+	Structure and function study of the complex that synthesizes S-adenosylmethionine.,Murray B, Antonyuk SV, Marina A, Van Liempd SM, Lu SC, Mato JM, Hasnain SS, Rojas AL IUCrJ. 2014 Jun 12;1(Pt 4):240-9. doi: 10.1107/S2052252514012585. eCollection, 2014 Jul 1. PMID:25075345<ref>PMID:25075345</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 06:43, 23 July 2014

OCA — Wed, 23 Jul 2014 06:43:28 GMT

←Older revision		Revision as of 06:43, 23 July 2014
Line 1:		Line 1:
-	==Structural insights of MAT enzymes==	+	==Structural insights of MAT enzymes: MATa2b complexed with SAM==
	<StructureSection load='4ktt' size='340' side='right' caption='[[4ktt]], [[Resolution\|resolution]] 2.59Å' scene=''>		<StructureSection load='4ktt' size='340' side='right' caption='[[4ktt]], [[Resolution\|resolution]] 2.59Å' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 10:26, 16 July 2014

OCA — Wed, 16 Jul 2014 10:26:40 GMT

←Older revision		Revision as of 10:26, 16 July 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Structural insights of MAT enzymes==
-		+	<StructureSection load='4ktt' size='340' side='right' caption='[[4ktt]], [[Resolution\|resolution]] 2.59Å' scene=''>
-	~~The entry~~ 4ktt is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4ktt]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KTT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KTT FirstGlance]. <br>
-	~~Authors~~: ~~Murray~~, B., ~~Antonyuk~~, S.V., ~~Marina~~, A., Lu, S.C., Mato, J.M., ~~Hasnain, S~~.~~S.,~~ Rojas, A.L.	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2p02\|2p02]], [[2ydx\|2ydx]], [[4ktv\|4ktv]]</td></tr>
-	~~Description~~: ~~Structural insights of MAT enzymes~~	+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionine_adenosyltransferase Methionine adenosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.6 2.5.1.6] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ktt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ktt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ktt RCSB], [http://www.ebi.ac.uk/pdbsum/4ktt PDBsum]</span></td></tr>
		+	<table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Methionine adenosyltransferase]]
		+	[[Category: Antonyuk, S V.]]
		+	[[Category: Hasnain, S S.]]
		+	[[Category: Lu, S C.]]
		+	[[Category: Marina, A.]]
		+	[[Category: Mato, J M.]]
		+	[[Category: Murray, B.]]
		+	[[Category: Rojas, A L.]]
		+	[[Category: Same synthesis]]
		+	[[Category: Transferase]]

OCA at 07:32, 15 January 2014

OCA — Wed, 15 Jan 2014 07:32:19 GMT

←Older revision		Revision as of 07:32, 15 January 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4ktt is ON HOLD until ~~sometime in the future~~	+	The entry 4ktt is ON HOLD until Paper Publication

	Authors: Murray, B., Antonyuk, S.V., Marina, A., Lu, S.C., Mato, J.M., Hasnain, S.S., Rojas, A.L.		Authors: Murray, B., Antonyuk, S.V., Marina, A., Lu, S.C., Mato, J.M., Hasnain, S.S., Rojas, A.L.

	Description: Structural insights of MAT enzymes		Description: Structural insights of MAT enzymes

OCA at 06:38, 28 August 2013

OCA — Wed, 28 Aug 2013 06:38:59 GMT

←Older revision		Revision as of 06:38, 28 August 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4ktt is ON HOLD	+	The entry 4ktt is ON HOLD until sometime in the future

	Authors: Murray, B., Antonyuk, S.V., Marina, A., Lu, S.C., Mato, J.M., Hasnain, S.S., Rojas, A.L.		Authors: Murray, B., Antonyuk, S.V., Marina, A., Lu, S.C., Mato, J.M., Hasnain, S.S., Rojas, A.L.

	Description: Structural insights of MAT enzymes		Description: Structural insights of MAT enzymes