4kuz - Revision history

OCA at 16:05, 20 September 2023

OCA — Wed, 20 Sep 2023 16:05:48 GMT

←Older revision		Revision as of 16:05, 20 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4kuz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KUZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KUZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4kuz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KUZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KUZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kuz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kuz OCA], [https://pdbe.org/4kuz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kuz RCSB], [https://www.ebi.ac.uk/pdbsum/4kuz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kuz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kuz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kuz OCA], [https://pdbe.org/4kuz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kuz RCSB], [https://www.ebi.ac.uk/pdbsum/4kuz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kuz ProSAT]</span></td></tr>
	</table>		</table>

OCA at 09:15, 7 December 2022

OCA — Wed, 07 Dec 2022 09:15:41 GMT

←Older revision		Revision as of 09:15, 7 December 2022
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	<StructureSection load='4kuz' size='340' side='right'caption='[[4kuz]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='4kuz' size='340' side='right'caption='[[4kuz]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4kuz]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KUZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4KUZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4kuz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KUZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KUZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4kuz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kuz OCA], [~~http~~://pdbe.org/4kuz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4kuz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4kuz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4kuz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kuz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kuz OCA], [https://pdbe.org/4kuz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kuz RCSB], [https://www.ebi.ac.uk/pdbsum/4kuz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kuz ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	==See Also==		==See Also==
	*[[Antibody 3D structures\|Antibody 3D structures]]		*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[Sandbox 20009\|Sandbox 20009]]
		+	*[[3D structures of non-human antibody\|3D structures of non-human antibody]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Gilliland~~, G L~~]]	+	[[Category: Gilliland GL]]
-	[[Category: Obmolova, G]]	+	[[Category: Obmolova G]]
-	[[Category: Teplyakov, A]]	+	[[Category: Teplyakov A]]
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Immunoglobulin fold~~]]	+

OCA at 09:26, 3 April 2019

OCA — Wed, 03 Apr 2019 09:26:03 GMT

←Older revision		Revision as of 09:26, 3 April 2019
Line 1:		Line 1:

	==Crystal structure of anti-emmprin antibody 4A5 Fab in trigonal form==		==Crystal structure of anti-emmprin antibody 4A5 Fab in trigonal form==
-	<StructureSection load='4kuz' size='340' side='right' caption='[[4kuz]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='4kuz' size='340' side='right'caption='[[4kuz]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4kuz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KUZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KUZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4kuz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KUZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KUZ FirstGlance]. <br>
Line 16:		Line 16:
	</div>		</div>
	<div class="pdbe-citations 4kuz" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4kuz" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Gilliland, G L]]		[[Category: Gilliland, G L]]

OCA at 18:17, 11 August 2016

OCA — Thu, 11 Aug 2016 18:17:01 GMT

←Older revision		Revision as of 18:17, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of anti-emmprin antibody 4A5 Fab in trigonal form==		==Crystal structure of anti-emmprin antibody 4A5 Fab in trigonal form==
	<StructureSection load='4kuz' size='340' side='right' caption='[[4kuz]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='4kuz' size='340' side='right' caption='[[4kuz]], [[Resolution\|resolution]] 2.70Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4kuz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KUZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KUZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4kuz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KUZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KUZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kuz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kuz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kuz RCSB], [http://www.ebi.ac.uk/pdbsum/4kuz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kuz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kuz OCA], [http://pdbe.org/4kuz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kuz RCSB], [http://www.ebi.ac.uk/pdbsum/4kuz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4kuz ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4kuz" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:47, 5 January 2015

OCA — Mon, 05 Jan 2015 14:47:05 GMT

←Older revision		Revision as of 14:47, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4kuz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KUZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KUZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4kuz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KUZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KUZ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kuz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kuz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kuz RCSB], [http://www.ebi.ac.uk/pdbsum/4kuz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kuz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kuz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kuz RCSB], [http://www.ebi.ac.uk/pdbsum/4kuz PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
-	[[Category: Gilliland, G L.]]	+	[[Category: Gilliland, G L]]
-	[[Category: Obmolova, G.]]	+	[[Category: Obmolova, G]]
-	[[Category: Teplyakov, A.]]	+	[[Category: Teplyakov, A]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Immunoglobulin fold]]		[[Category: Immunoglobulin fold]]

OCA at 02:55, 7 August 2014

OCA — Thu, 07 Aug 2014 02:55:52 GMT

←Older revision		Revision as of 02:55, 7 August 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4kuz\| PDB=4kuz \| SCENE= }}~~	+	==Crystal structure of anti-emmprin antibody 4A5 Fab in trigonal form==
-	===Crystal structure of anti-emmprin antibody 4A5 Fab in trigonal form===	+	<StructureSection load='4kuz' size='340' side='right' caption='[[4kuz]], [[Resolution\|resolution]] 2.70Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24470236}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4kuz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KUZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KUZ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kuz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kuz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kuz RCSB], [http://www.ebi.ac.uk/pdbsum/4kuz PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Three Fab structures used as targets in the Antibody Modeling Assessment presented a challenge for modeling CDR-L3 due to deviations from the most typical canonical structure. In all three antibodies CDR-L3 has eight residues, which is one residue shorter than usual, and has a conformation that is rarely observed in crystal structures. We analyzed the sequence and structural determinants of this conformation and found that the "short" CDR-L3 is remarkably rigid and retains the conformation in the interactions with antigens and neighboring CDRs. Proteins 2014. (c) 2014 Wiley Periodicals, Inc.

-	~~==About this Structure==~~	+	Structural evidence for a constrained conformation of short CDR-L3 in antibodies.,Teplyakov A, Obmolova G, Malia TJ, Luo J, Gilliland GL Proteins. 2014 Jan 27. doi: 10.1002/prot.24522. PMID:24470236<ref>PMID:24470236</ref>
-	~~[[4kuz]] is~~ a ~~2 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4KUZ OCA]~~.	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024470236</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Gilliland, G L.]]		[[Category: Gilliland, G L.]]
	[[Category: Obmolova, G.]]		[[Category: Obmolova, G.]]

OCA at 09:25, 26 March 2014

OCA — Wed, 26 Mar 2014 09:25:42 GMT

←Older revision		Revision as of 09:25, 26 March 2014
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4kuz\| PDB=4kuz \| SCENE= }}
		+	===Crystal structure of anti-emmprin antibody 4A5 Fab in trigonal form===
		+	{{ABSTRACT_PUBMED_24470236}}

-	~~The entry~~ 4kuz is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
		+	[[4kuz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KUZ OCA].

-	~~Authors~~: ~~Teplyakov~~, A., Obmolova, G., ~~Gilliland, G.L~~.	+	==Reference==
-		+	<ref group="xtra">PMID:024470236</ref><references group="xtra"/><references/>
-	~~Description~~: ~~Crystal structure of anti-emmprin antibody 4A5 Fab in trigonal form~~	+	[[Category: Gilliland, G L.]]
		+	[[Category: Obmolova, G.]]
		+	[[Category: Teplyakov, A.]]
		+	[[Category: Immune system]]
		+	[[Category: Immunoglobulin fold]]

OCA at 07:12, 14 August 2013

OCA — Wed, 14 Aug 2013 07:12:39 GMT

←Older revision		Revision as of 07:12, 14 August 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4kuz is ON HOLD	+	The entry 4kuz is ON HOLD until Paper Publication

	Authors: Teplyakov, A., Obmolova, G., Gilliland, G.L.		Authors: Teplyakov, A., Obmolova, G., Gilliland, G.L.

	Description: Crystal structure of anti-emmprin antibody 4A5 Fab in trigonal form		Description: Crystal structure of anti-emmprin antibody 4A5 Fab in trigonal form

OCA at 04:44, 18 July 2013

OCA — Thu, 18 Jul 2013 04:44:51 GMT

←Older revision		Revision as of 04:44, 18 July 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4kuz is ON HOLD ~~until Paper Publication~~	+	The entry 4kuz is ON HOLD

	Authors: Teplyakov, A., Obmolova, G., Gilliland, G.L.		Authors: Teplyakov, A., Obmolova, G., Gilliland, G.L.

	Description: Crystal structure of anti-emmprin antibody 4A5 Fab in trigonal form		Description: Crystal structure of anti-emmprin antibody 4A5 Fab in trigonal form

OCA at 13:15, 3 July 2013

OCA — Wed, 03 Jul 2013 13:15:38 GMT

←Older revision		Revision as of 13:15, 3 July 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4kuz is ON HOLD	+	The entry 4kuz is ON HOLD until Paper Publication

	Authors: Teplyakov, A., Obmolova, G., Gilliland, G.L.		Authors: Teplyakov, A., Obmolova, G., Gilliland, G.L.

	Description: Crystal structure of anti-emmprin antibody 4A5 Fab in trigonal form		Description: Crystal structure of anti-emmprin antibody 4A5 Fab in trigonal form